Defending Cognitive Liberty in an Age of Moral Engineering

In 2009, Mark Walker first proposed the Genetic Virtue Project, advancing that science should explore using genetic engineering to eliminate moral evils just as it attempts to eliminate natural ones like disease. This seemed like an issue for the far future given the unique challenges. Walker focused on the wrong aspect of personhood, however, as moral engineering of the brain appears to be a more likely possibility. As early aspects of moral engineering the brain are in development, especially through the manipulation of the neural correlates of religious and political beliefs, emotions, and behaviors, I consider several issues surrounding this project so as to protect individual rights and prevent future harms. I advance an internal criterion for the field called Acceptability Across Ideologies to serve as a guide to protect against coercive and harmful technologies and analyze how current laws protecting cognitive liberty are lacking and in need of revision.     

Genetic Virtue Program: An Unfeasible Neo-Pelagian Theodicy?

In his article, “Genetic Engineering, Virtue-First Enhancement, and Neo-Irenaean Theodicy,” Mark Walker has ventured farther into science more than most when it comes to exploring theodicy. After exposing the Achilles heel of the traditional free-will defense, Walker develops the Irenaean and Augustinian responses to the anthropic problem. Most importantly for this discussion, Walker proceeds to propose Genetic-First-Enhancement as part of his neo-Irenaean theodicy formulation. Overall, there are two major concerns I raised: the impossibility of a gradient morality in the presence of free will, and the scientific impossibility of Genetic Virtue Program. However, my claims are falsifiable if future genetic modifications do indeed improve morality. Before that is proven, I agree with Walker that, yes, we should play God, albeit, with his proposed virtue-first program.     

The Baldwin Effect and the persistent problem of Preformation versus Epigenesis

Despite the relatively recent ascendency of epigenetics as a subfield in biology, the issues at its heart have a much longer past. Similarly, psychology's part in this discussion is not new. This article examines one of the earliest engagements of a psychologist with what is now known as epigenetics. Briefly: in 1896, American developmental psychologist James Mark Baldwin proposed an evolutionary theory that has come to be known as the “Baldwin Effect” (so coined by Simpson, 1953). Baldwin's theory asserts that learning may set the course of biological evolution in a non-Lamarckian manner. In proposing this theory he provided a needed intermediate to Darwinian natural selection and the Lamarckian inheritance of acquired characteristics. The value of detailing how Baldwin came to put forward this theory, in light of recent advances, is that it illuminates some of the persistent arguments in the Preformation versus Epigenesis debate. Insofar as these debates continue, examining the origins of the Baldwin Effect provides useful insights.     

“Make no provision for the flesh”: recognizing the incarnation in and after Augustine

This article argues for the importance of the intelligibility of the sexed body to incarnational theology. Building on Mark Jordan's reading of Augustine, I focus on the paradox of the incarnation as both the bodily sign (signa) of God and God Godself as the thing that the sign signifies (res). Through an analysis of the debates around Leo Steinberg's work on the meaning of Christ's genitals in Renaissance art, I explore the ways in which depicting the incarnation is a paradoxical exercise of depicting God's fully human body. I argue that attention to the paradox of the incarnation as both sign and thing can disrupt ideologies of sexual difference that force bodies to be intelligible as unambiguously sexed, while the question of sexual difference can work within incarnational theology to disturb the equivalence of full humanity and unambiguous maleness.     

Genetic Moral Enhancement? Yes. Holiness? No

As moral human beings, we deplore our violence and try to rein it in through moral suasion and post-hoc restraint. Could genetic engineering help? Moral enhancement through genetic engineering might predispose us to performing good acts, good deeds. However, good acts alone, theologically speaking, do not count as either morality or holiness. Becoming a good and holy person-in-community is a process of freely chosen character development. While re-creating ourselves genetically to eliminate aggressive acts is not insignificant, such interventions constitute a starting point, not the endpoint, of living a meaningful life in relation to God. Bernard Lonergan’s notion of moral agency requires moral conversion and religious conversion, neither of which could be achieved through gene expression alone. Conversion requires free and intentional participation in moral character development. Finally, we note that salvation according to Christianity is not earned, regardless of a person’s good acts or good moral character.     

迎接生物学世纪的曙光

现代生物工程技术是以基因工程、细胞工程、发酵工程酶工程为主体的高新技术。生产工程产业主要包括生物工程药业和生物工程农业两个重要部分。生物工程产业化都需要经过研究、开发、产业化和商业化四个步骤。生物工程产业发展经过了生物工程技术的突破阶段、完善和产业化的开始阶段、大规模产业化的开始阶段、大规模产业化的成熟阶段。其中第三阶段对我国的生物工程产业来说是为关键的。知识产权机会、商业机会为这个阶段我国生物工     

Seeking Perfection: A Kantian Look at Human Genetic Engineering

It is tempting to argue that Kantian moral philosophy justifies prohibiting both human germ-line genetic engineering and non-therapeutic genetic engineering because they fail to respect human dignity. There are, however, good reasons for resisting this temptation. In fact, Kant’s moral philosophy provides reasons that support genetic engineering—even germ-line and non-therapeutic. This is true of Kant’s imperfect duties to seek one’s own perfection and the happiness of others. It is also true of the categorical imperative. Kant’s moral philosophy does, however, provide limits to justifiable genetic engineering.     

基因工程药物发展的历史及启示

基因工程诞生20余年,运用于医药行业,研制和开发工程药物,已取得长足进展,迄今为止,已有近100个基因工程新药上市,并有数百种正在研制和开发中,可以预计,基因工程药物的发展具有无比强大的生命力。就基因工程药物发展史进行概述,会从中得到许多启示。     

Ethical challenges in a technological environment: The perspective of engineers versus managers

In his article ‘Better Communication Between Engineers and Managers: Some Ways to Prevent Many Ethically Hard Choices’¹ Michael Davis analyzes the causes of the disaster in terms of a communications gap between management and engineers. When the communication between (representatives of) both groups breaks down, the organization is in (moral) trouble. Crucial information gets stuck somewhere in the organization prohibiting a careful discussion and weighing of all (moral) arguments. The resulting judgment has therefore little (moral) quality. In this paper I would like to comment on some of Michael Davis’s interesting and thought-provoking insights and ideas. A company which implements Davis’s recommendations at least shows some sensitivity to organizational moral issues. But it might miss the point that moral trouble can also result from a common understanding between managers and engineers. Organizational members sometimes tend to be myopic with regard to safety issues. This paper:

抗体工程研究中几点思维启示和策略

本文以近几年非常活跃的抗体基因工程研究的几个方面为素材,回顾性地阐述了人们在对深邃的自然界认识过程中认识的逐步深化以及科学的创造性思维对研究工作的设计和结局的重大影响,并地未来抗体工程研究方面几个战略性问题提出了商榷性看法和建议。     

Genetic Engineering,Virtue-First Enhancement,and Deification in Neo-Irenaean Theodicy

This article seeks to provide a unified explanation to two profound challenges to Christian belief: the existence of evil and Darwin’s theory of natural selection. It is argued that an understanding of the full implications of our evolutionary past in conjunction with the Irenaean theodicy provides us with the best answer to these challenges. The traditional Irenaean theodicy emphasizes the importance of education for soul building. Soul building can benefit from technologically enhancing the biological superstructure of our humanity. In particular, genetic engineering can enhance human virtue. The biological basis of our moral natures can be improved using genetic technologies, including (possibly) somatic and germline engineering. To plan for virtue-first enhancement—the Genetic Virtue Project, which focuses on genetic improvements to our moral natures—is of paramount importance for the neo-Irenaean theodicy.     

Thirty Years Later: An Oncologist Reflects on Kubler-Ross's Work

As compared with conventional vaccine production systems, plant-made vaccines (PMVs) are said to enjoy a range of advantages including cost of production and ease of storage for distribution in developing countries. In this article, we introduce the science of PMV production, and address ethical issues associated with development and clinical testing of PMVs within three interrelated domains: PMVs as transgenic plants; PMVs as clinical research materials; and PMVs as agents of global health. We present three conclusions: first, while many of the ethical issues raised by PMVs are familiar, PMVs add a new dimension to old issues, and raise some novel issues for ethicists and policy-makers; secondly, it is premature to promise broad applicability of PMVs across the developing world without having demonstrated their feasibility; thirdly, in particular, proponents of PMVs as a solution to global health problems must, as a condition of the ethical conduct of their research, define the commercial feasibility of PMVs for distribution in the developing world.     

Living with Multiple Endocrine Neoplasia Type 1: Decent Care-Insufficient Medical and Genetic Information A Qualitative Study of MEN 1 Patients in a Swedish Hospital

This qualitative study explores how 29 Swedish patients with Multiple Endocrine Neoplasia type 1 (MEN1) experience living with the condition, appraisal of the clinical follow-up program, and surveys their future expectations. The aim of this study is to build knowledge about this patient group in order to provide optimal care. The participants describe physical, psychological, and social limitations in their daily activities and how these limitations influence quality of life. Our findings indicate that a majority of patients have adjusted to their situation, describing themselves as being healthy despite physical symptoms and treatment. The participants received decent care in the clinical follow-up program, - however, greater effort should be put into patient information. These patients might benefit from genetic counseling. Health professionals involved should recognize their potential impact and influence on a patient’s ability to adjust to these circumstances. Antonovsky`s Sense of Coherence theory is used to discuss these findings.     

合成生物学伦理问题研究态势分析

合成生物学以创造新型生物为目标,这一领域的飞速发展在给人类带来巨大福祉的同时,也陆续引发众多伦理问题。利用VOSviewer等科学计量工具对国内外合成生物学伦理领域2000年~2019年近20年的相关研究文献进行量化分析,通过对时间分布、地域分布、关键词共现、研究方向等数据的系统分析,进一步对国内外学者、专家的应用研究成果与伦理思考进行总结概括,并对合成生物学伦理问题的研究趋势提出展望,以图廓清国内外合成生物学伦理问题研究的发展态势。     

Can We Genetically Engineer Virtue and Deification?

In this article we ask: could we speed up the attainment of religious goals such as virtuous living or even deification through genetic engineering? After reviewing current scientific knowledge gained from genetic engineering, it is difficult to answer affirmatively. Because virtuous living is complex and difficult to define, it makes searching for relevant genes difficult. To date, such genes do not appear in the geneticist’s inventory. An additional unknown is the role of free will. Even more important, theologically, is the role of God in leading to our sanctification. This present negative conclusion, however, does not preclude possible future advances in the science of virtue.     

Making the world a better place: Genes and ethics

This paper was presented as part of the 1993 Waynflete Lecture Series onGenes: Science, Law and Ethics, Magdalen College, Oxford University.     

Germ-line gene therapy and the clinical ethos of medical genetics

Although the ability to perform gene therapy in human germ-line cells is still hypothetical, the rate of progress in molecular and cell biology suggests that it will only be a matter of time before reliable clinical techniques will be within reach. Three sets of arguments are commonly advanced against developing those techniques, respectively pointing to the clinical risks, social dangers and better alternatives. In this paper we analyze those arguments from the perspective of the client-centered ethos that traditionally governs practice in medical genetics. This perspective clarifies the merits of these arguments for geneticists, and suggests useful new directions for the professional discussion of germ-line gene therapy. It suggests, for example, that the much discussed prospect of germ-line therapy in human pre-embryos may always be more problematic for medical genetics than adult germ-line interventions, even though the latter faces greater technical difficulties.