Pure optic ataxia and visual hemiagnosia – extending the dual visual hypothesis

Goodale and Milner's two visual system hypothesis is an influential model for the understanding of the primate visual system. Lesions of either the ventral (occipito‐temporal) or the dorsal (occipito‐parietal) stream produce distinct and dissociated syndromes in humans: visual agnosia is typical for ventral damage, whereas optic ataxia (OA) for dorsal damage. We studied the case of a 59‐year‐old left‐handed woman with a circumscribed lesion around the left posterior occipital sulcus, extending to the underlying white matter. Initially, she presented with a central visual field OA, which regressed to an OA to the right visual hemifield during the 3 months observation period. In addition, tachistoscopic experiments showed visual hemiagnosia to the right visual hemifield. In line with the findings of the neuropsychological experiments, the analysis of the structural MR data by means of a trackwise hodologic probabilistic approach revealed damage to the left superior longitudinal fasciculus and to the left inferior longitudinal fasciculus, indicating an impairment of both the dorsal and the ventral stream. The combination of OA and visual hemiagnosia in the same patient has never been previously described. The present case study thus provides further insights for the understanding of visual processing.     

White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis

Most people are left-hemisphere dominant for language. However the neuroanatomy of language lateralization is not fully understood. By combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), we studied whether language lateralization is associated with cerebral white-matter (WM) microstructure. Sixteen healthy, left-handed women aged 20–25 were included in the study. Left-handers were targeted in order to increase the chances of involving subjects with atypical language lateralization. Language lateralization was determined by fMRI using a verbal fluency paradigm. Tract-based spatial statistics analysis of DTI data was applied to test for WM microstructural correlates of language lateralization across the whole brain. Fractional anisotropy and mean diffusivity were used as indicators of WM microstructural organization. Right-hemispheric language dominance was associated with reduced microstructural integrity of the left superior longitudinal fasciculus and left-sided parietal lobe WM. In left-handed women, reduced integrity of the left-sided language related tracts may be closely linked to the development of right hemispheric language dominance. Our results may offer new insights into language lateralization and structure–function relationships in human language system.     

A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference

The present study examined the relationship between hand preference degree and direction, functional language lateralization in Broca’s and Wernicke’s areas, and structural measures of the arcuate fasciculus. Results revealed an effect of degree of hand preference on arcuate fasciculus structure, such that consistently-handed individuals, regardless of the direction of hand preference, demonstrated the most asymmetric arcuate fasciculus, with larger left versus right arcuate, as measured by DTI. Functional language lateralization in Wernicke’s area, measured via fMRI, was related to arcuate fasciculus volume in consistent-left-handers only, and only in people who were not right hemisphere lateralized for language; given the small sample size for this finding, future investigation is warranted. Results suggest handedness degree may be an important variable to investigate in the context of neuroanatomical asymmetries.     

Examining the specific dimensions of distress tolerance that prospectively predict perceived stress

We examined five dimensions of distress tolerance (i.e. uncertainty, ambiguity, frustration, negative emotion, physical discomfort) as prospective predictors of perceived stress. Undergraduate students (N = 135) completed self-report questionnaires over the course of two assessment sessions (T1 and T2). Results of a linear regression in which the five dimensions of distress tolerance and covariates (i.e. T1 perceived stress, duration between T1 and T2) served as predictor variables and T2 perceived stress served as the outcome variable showed that intolerance of uncertainty was the only dimension of distress tolerance to predict T2 perceived stress. To better understand this prospective association, we conducted a post hoc analysis simultaneously regressing two subdimensions of intolerance of uncertainty on T2 perceived stress. The subdimension representing beliefs that “uncertainty has negative behavioral and self-referent implications” significantly predicted T2 perceived stress, while the subdimension indicating that “uncertainty is unfair and spoils everything” did not. Results support a growing body of research suggesting intolerance of uncertainty as a risk factor for a wide variety of maladaptive psychological outcomes. Clinical implications will be discussed.     

Pediatric traumatic brain injury: Language outcomes and their relationship to the arcuate fasciculus

Pediatric traumatic brain injury (TBI) may result in long-lasting language impairments alongside dysarthria, a motor-speech disorder. Whether this co-morbidity is due to the functional links between speech and language networks, or to widespread damage affecting both motor and language tracts, remains unknown.     

The distinctive moral personality of care exemplars

Positive emotion following bereavement was examined in a prospective longitudinal study. Participants lost a spouse (n?=?250) and were interviewed prior to the death, 6 months after the death, and in some cases 18 and 48 months after the death. Early theorists suggested that positive emotion during times of distress may indicate pathology. In contrast, more recent theorists suggest that positive emotion is desirable even during times of distress. In this analysis, positive emotion was associated with desirable outcomes (less depressed mood, more social support received, more social provision to others) and this effect was not diminished among people reporting elevated levels of distress. Also, the simultaneous occurrence of positive emotion and distress was not associated with pre-existing emotional instability. Those experiencing positive emotion reported lower levels of grief, but not qualitatively different grief. The findings suggest that positive emotion tends to be associated with desirable outcomes even among people reporting elevated distress.     

加速追踪设计的方法和应用

加速追踪设计(ALD)是一种选择相邻多个群组同时进行短期追踪研究, 获得在测量上有重叠的多个群组追踪数据, 对多个群组数据进行合并建构一条在时间跨度上较长的发展趋势或增长曲线的方法。ALD结合真追踪和横断设计的特征, 既保持真追踪设计的大部分优点, 克服真追踪研究中由于重测效应和被试缺失导致的问题, 又尝试分离年龄、群组和历史时间效应, 在发展心理研究有重要应用。已有研究探讨ALD的数据分析方法、ALD的有效性及设计特征。未来研究应关注拓展设计条件下ALD的适应性, 探索非线性假设或群组效应显著时的数据分析方法和ALD中缺失数据处理问题。     

不同情境中幼儿情绪表达规则认知发展的追踪研究

用追踪研究方法,对60名幼儿在高兴、惊讶与害怕情境中的情绪表达规则认知两年的发展进行探讨,并考察情绪情境、性别和人际背景对其发展的影响。结果表明：(1)幼儿的情绪表达规则知识、目标和策略水平均随年龄增长显著提升;(2)幼儿在害怕情境中为自我保护而较多使用掩饰策略,在惊讶情境中较多使用掩饰和夸大策略,在高兴情境中综合运用掩饰、弱化和夸大策略;(3)性别和人际背景均对幼儿情绪表达规则认知发展有显著影响。     

Towards a queer dharmology of sex

Lay practitioners of Buddhism, especially lesbian/gay/bisexual/transgender/queer persons, are given little guidance by the traditional Dharmology (Buddhist theology) of sex. The most extensive discussions are the detailed prohibitions in the monastic rule, which focus on the mechanics of sex rather than on love and relationships. What advice there is on sex for lay persons is either vague or over‐determined by its cultural context. Christianity, despite being homophobic and mistrustful of sex, has developed a positive attitude towards sex within heterosexual marriage. An investigation of this suggests a Dharmology of sex as relationship, based on central Buddhist doctrines such as interdependent arising. This Dharmology can be strengthened by queering it with reference to Harry Hay's notion that gay subject–subject consciousness is more compatible with Buddhist non‐duality than the hetero subject–object consciousness. It can be claimed, therefore, that Buddha Nature, and Buddhism itself, is queer.     

发展性阅读障碍与脑异常的因果关系:研究范式及发现

关于阅读障碍神经机制的研究已经有很多,但到目前为止,研究者仍不完全清楚,阅读障碍者脑区的异常,究竟是阅读障碍的原因还是结果。研究者发展出不同的研究范式来探究此问题,包括学龄前研究、双对照组研究、纵向研究等。文中综述了这些研究范式各具的优势、不足和研究结果之间的一致性,并分析了确认因果关系之所以困难的原因。在此基础上,提出如下建议：（1）细致区分阅读障碍的亚类型;（2）以成熟和完善的阅读认知-神经模型为指导;（3）通过不同的研究范式进行交叉印证;（4）综合考虑脑的动态发展变化特点,和基因、环境、经验的作用等多种因素的影响。     

Four simultaneous component models for the analysis of multivariate time series from more than one subject to model intraindividual and interindividual differences

A class of four simultaneous component models for the exploratory analysis of multivariate time series collected from more than one subject simultaneously is discussed. In each of the models, the multivariate time series of each subject is decomposed into a few series of component scores and a loading matrix. The component scores series reveal the latent data structure in the course of time. The interpretation of the components is based on the loading matrix. The simultaneous component models model not only intraindividual variability, but interindividual variability as well. The four models can be ordered hierarchically from weakly to severely constrained, thus allowing for big to small interindividual differences in the model. The use of the models is illustrated by an empirical example.This research has been made possible by funding from the Netherlands Organization of Scientific Research (NWO) to the first author. The authors are obliged to Tom A.B. Snijders, Jos M.F. ten Berge and three anonymous reviewers for comments on an earlier version of this paper, and to Kim Shifren for providing us with her data set, which was collected at Syracuse University.     

Memory Development or the Development of Memory?

For 30 years, the question "What is memory development the development of?" has guided research on children's memory. As theories and research paradigms have evolved over this period, so too has knowledge of the surprising mnemonic competence of young children and of age-related differences in memory performance. Never the less, there are serious limits to current understanding of the development of memory. Indeed, there have been few investigations of changes over time in the memory skills of individual children, and researchers have yet to shed much light on the more difficult question of "What are the forces that propel the development of skilled remembering?" From our perspective, the answer to this question will require movement toward longitudinal research designs that illuminate the mechanisms that bring about developmental change.     

Understanding correlates of change by modeling individual differences in growth

The study of correlates of change is the investigation of systematic individual differences in growth. Our representation of systematic individual differences in growth is built up in two parts: (a) a model for individual growth and, (b) a model for the dependence of parameters in the individual growth models on individual characteristics. First, explicit representations of correlates of change are constructed for various models of individual growth. Second, for the special case of initial status as a correlate of change, properties of collections of growth curves provide new results on the relation between change and initial status. Third, the shortcomings of previous approaches to the assessment of correlates of change are demonstrated. In particular, correlations of residual change measures with exogenous individual characteristics are shown to be poor indicators of systematic individual differences in growth.The research reported here was supported by a grant from The Spencer Foundation to the senior author and by the Study of Stanford and the Schools.     

Causal attributions in clinical subtypes of depression: A longitudinal study of inpatients

The study material comprised inpatients who met DSM-III-R criteria for (a) dysthymia without panic and/or agoraphobia (n=20), (b) major depression without panic and/or agoraphobia (n=26), (c) both major depression and panic with agoraphobia (comorbid patients) (n=17), and (d) panic with agoraphobia without any depressive disorder (n=22). The patients completed the Attributional Style Questionnaire and the Beck Depression Inventory and were assessed on the Comprehensive Psychopathological Rating Scale upon admission to the hospital and at discharge. Some of the self-report scales were also administered at 1-year follow-up. It was assumed that dysthymic patients and patients with both major depression and agoraphobia would exhibit more biased attributions for bad events than purely major depressed and purely agoraphobic patients. However, inconsistent with this hypothesis, obtained group differences could be statistically reduced to differences in depressive symptom level. At each assessment, attributions for bad events correlated significantly with depressive symptom level. Attributional bias tended to decrease during treatment. However, most attribution subscales exhibited moderate stability in terms of correlation across assessments. Attributing bad events to global causes proved to predict later depression.This research was supported by grants from the Halldis and Josef Andresen Legacy.     

Reading problems and depressed mood

Although reading difficulties show well-established overlaps with disruptive behavior disorders in childhood, much less is known about reading-disabled children's vulnerability to emotional difficulties. Using longitudinal data from 6 assessments of boys in the Pittsburgh Youth Study, we found robust links between severe, persistent reading problems and increased risk for depressed mood in a community sample of boys aged 7 and 10 years at initial assessment, though not in those who had already entered their teens. These associations could not be accounted for in terms of selected family risks or comorbid disruptive behaviors; instead, the pattern of the findings pointed to the existence of more direct causal processes whereby reading problems influence younger boys' risk of depressed mood.     

Predicting aggressive patterns in girls and boys: A developmental study

The aim of this multimethod, longitudinal study was to examine similarities and differences in aggressive expression and prediction among school-aged boys and girls. The primary research sample involved 174 children (93 females, 81 males). They were in the fourth grade at the beginning of the study, and the fifth grade at its conclusion. Embedded in the primary sample was a subgroup of 20 children identified as being highly aggressive (ten males, ten females), and a subgroup of 20 matched control children. The research measures included teachers' ratings of aggressive behavior, peer-nominations/reports of prior conflicts, individual interviews/self-ratings, and extensive behavioral observations. Analyses of the concurrent relations among measures pointed to a “public” cluster of measures (including peer-nominations, behaviors, and teacher ratings) and relatively “private” measures (ie, subjects' self-evaluations). In the primary sample, significant developmental trends were detected in the teacher ratings with increasing gender differentiation as children grew older. Few gender differences were observed in the high-aggressive subgroup, but the aggressive and the matched control groups differed on virtually all comparisons. Gender differences in predictability were a function of risk status, with high-aggressive girls showing as much stability as high-aggressive boys.     

A Two-Year Longitudinal Study of Neuropsychological and Cognitive Performance in Relation to Behavioral Problems and Competencies in Elementary School Children

Despite interest in early neuropsychological status as a possible contributor to children's behavioral development, prospective longitudinal investigations of neuropsychological measures in relation to later behavioral outcomes in childhood are few. A 2-year longitudinal study in a nonselected childhood sample is reported. The study tested the influence of early neuropsychological performance (verbal fluency, mental inhibitory control, and visual spatial ability) on later childhood behavioral problems and social competency. Regular education children (n = 235) were assessed at three time points 1 year apart. To control for autocorrelation of outcome measures, Time 1 behavior was partialed while testing the effects of Time 1 neuropsychological scores on Time 3 outcome. To control for autocorrelation of neuropsychological scores, Time 2 scores were partialed while testing the predictive effect of Time 1 scores on Time 3 outcome. Both sets of regression models suggested modest but statistically significant effects for inhibitory control and verbal fluency, but not IQ, reading, or visual spatial ability, on behavioral outcome. Study results are consistent with a modest causal effect of selected neuropsychological skills on later behavioral adjustment. The findings support theories that implicate subtle neuropsychological dysfunction in the development of behavioral problems in childhood.