镜像神经在药物心理渴求中的作用及机制

心理渴求是物质依赖者希望重新感受神经活性药物效应的渴望,其神经机制的早期影像研究,主要集中在前额皮质和奖赏中枢.镜像神经是新近发现的位于动作脑区,能理解、分析所观察动作的目的和性质,并通过内隐模拟,产生直接映射式的情绪和认知的神经.最新的研究发现尼古丁成瘾者在相关线索的刺激下,其镜像神经也能被激活.本研究旨在探索镜像神经参与相关线索下心理渴求形成的机制,为发展更可靠的依赖行为的生物学标记提供另一个重要目标,帮助人们更好地理解药物渴求形成的神经生物学基础与过程.     

计算机支持下协同工作的心理学研究

计算机支持下协同工作（ｃｏｍｐｕｔｅｒｓｕｐｐｏｒｔｅｄｃｏｏｐｅｒａｔｉｖｅｗｏｒｋ,简称ＣＳＣＷ）是计算机科学和认知科学的新兴交叉研究领域,主要研究在高技术支持下的群体协作。ＣＳＣＷ中蕴含着大量的心理学研究问题。心理学家需要更好地理解群体协作的性质以评估新技术是否与群体协作相适应,其研究成果会有助于理解如何构建技术和哪些技术可能成功。本文首先从分析ＣＳＣＷ的领域维度入手,然后讨论与之相关的一些重要的心理学研究问题,最后简要介绍国外在该领域进行的研究工作     

尼古丁依赖对男性吸烟者感知戒烟行为控制的预测：社会支持与抱怨批评的作用

考察尼古丁依赖对男性吸烟者感知戒烟行为控制的预测及他人戒烟社会支持和抱怨批评的调节作用。对326名男性吸烟者进行问卷调查,结果显示：（1）尼古丁依赖显著负向预测感知行为控制;（2）社会支持和抱怨批评共同调节两者关系;在高社会支持且低抱怨批评、高抱怨批评且低社会支持的条件下,尼古丁依赖的预测作用不显著。结果说明,高社会支持在尼古丁依赖削弱感知行为控制过程中起缓冲作用,而高抱怨批评削弱社会支持的缓冲作用。     

尼古丁依赖对男性吸烟者感知戒烟行为控制的预测：社会支持与抱怨批评的作用

考察尼古丁依赖对男性吸烟者感知戒烟行为控制的预测及他人戒烟社会支持和抱怨批评的调节作用。对326名男性吸烟者进行问卷调查,结果显示：（1）尼古丁依赖显著负向预测感知行为控制;（2）社会支持和抱怨批评共同调节两者关系;在高社会支持且低抱怨批评、高抱怨批评且低社会支持的条件下,尼古丁依赖的预测作用不显著。结果说明,高社会支持在尼古丁依赖削弱感知行为控制过程中起缓冲作用,而高抱怨批评削弱社会支持的缓冲作用。     

戒烟治疗中的药物疗法研究进展

停止尼古丁摄入造成的戒断症状是每个戒烟者都要面对的困难。我国的吸烟者很少采用戒烟药物作为辅助,而且国内目前尚无戒烟药物的临床应用研究。本文旨在向国内的医务工作者介绍国外近年来戒烟药物在临床应用的概况,给有戒烟打算的吸烟者提供有效的药物治疗方案。目前国外的研究均肯定了尼古丁替代制剂和盐酸安非他酮缓释片在戒烟治疗中的疗效,且治疗1年后的随访结果显示,这两种药物均能有效提高戒烟率。使用盐酸安非他酮缓释片的效果稍好一些,可能与避免尼古丁替代制剂继续维持戒烟者的尼古丁依赖有关。由盐酸安非他酮缓释片存在不良反应和安全性的问题,在临床应用时多采用两者联用的方法,以求最大程度增加戒烟成功率。     

反社会人格障碍的神经生物学基础及其司法启示

反社会人格障碍(Antisocial Personality Disorder, ASPD)是一种漠视或侵犯他人权益的普遍行为模式, 是与犯罪关联极高的精神障碍。ASPD的形成受基因和环境因素的影响, 表现为神经递质和激素系统的紊乱, 以及自主神经系统活跃程度和大脑结构与功能的异常。上述神经生物学因素可能导致ASPD患者表现出执行控制障碍、情绪功能障碍、无视惩罚信息和奖赏偏好等特点。神经生物学研究的证据为ASPD罪犯的循证矫治、风险评估、定罪量刑等司法实践提供了启示。建议未来从神经生物学角度对ASPD的诊断分类标准、治疗方法和影响因素等方面开展研究。     

国外员工援助计划相关研究述评

员工援助计划（employee assistance programs, EAPs）是组织提供的,旨在帮助员工解决可能影响其工作表现和健康问题的多种策略的整合。在文献研究的基础上,该文系统介绍了员工援助计划的概念,并从起源、发展、内容、测量、执行模式及其与相关因素的关系等方面归纳了当前研究的进展,指出了研究存在的问题与研究的方向     

艺术设计中创造性思维的fMRI研究：一项基于智能CAD的探索

本项工作尝试将人类思维的神经生物学基础研究与人工智能的研究成果相结合, 利用类比生成模型的原理, 开发了一个计算机辅助设计系统“多源类比人脸生成系统”, 并运用此平台开展了fMRI实验, 对人类大脑创造性思维的神经生物学机制进行了探索。实验采用open-ends模式下的“design task”和problem solving模式下的“control task”作为对照, 共采得15名健康成人被试的有效数据。数据结果显示design task与control task相比更为显著地激活了内侧前额叶、额中回、右侧颞上回、前扣带回、双侧海马、楔前叶这些脑区。综合以往研究推测, 内侧前额叶可能更多地与即兴自由创作中对自我信息的表征有关, 颞叶可能与不断产生和输出新颖性的观点有关, 边缘系统则可能主要与创造性活动中的动力驱动作用有关。总的来说, 创造性思维是多个脑区同时参与的高度分布式加工的结果。     

尼古丁对内隐记忆与外显记忆的影响

胆碱是一种与记忆密切相关的物质,以往研究主要探讨不同胆碱类药物对外显记忆的影响,内隐记忆受胆碱影响与外显记忆是否相同仍存在争议。实验1采用词汇判断与词汇再认任务,比较内隐记忆与外显记忆在拟胆碱药物尼古丁的影响下,记忆成绩是否发生变化。结果表明,摄入尼古丁后,内隐与外显记忆成绩都有一定程度的下降,但内隐记忆受影响的程度更大。为进一步探讨尼古丁对两种记忆的影响,实验2分别在编码前与提取前摄入尼古丁,观察其对两种记忆不同阶段的影响,并使用ERP技术观察其中受影响的成分。结果表明,编码前摄入尼古丁使内隐记忆与外显记忆的概念加工都受到影响,而对知觉加工没有影响。提取前摄入尼古丁则对两种记忆的概念加工与知觉加工都产生影响,但是对内隐记忆的影响更大。上述结果表明,拟胆碱物质尼古丁对记忆影响的情况与实验任务较为一致,而与记忆种类关系较小。对两种记忆的影响不同可能主要源于两种记忆采用不同的实验任务导致,两者的生理机制有一定程度的重叠。     

尼古丁作用的辩证思考

尼古丁是一种液态生物碱 ,无色易挥发 ,溶于水 ,并易形成可溶性盐。它作为烟草中的主要毒性物质 ,在吸烟引起的许多疾病中起到了重要作用 ,在医学领域 ,这方面的研究已相当广泛和深入。但近几年来随着对尼古丁药用价值的探讨发现 ,其对许多疾病有缓解和潜在的治疗作用。本文就尼古丁致病和治病效应的两个方面作一综述。1　尼古丁的致病作用1.1　慢性阻塞性疾病 ,动脉粥样硬化等慢性炎症疾病尼古丁促进中性粒细胞 (PMNs)浸润、活化 ,释放炎性介质溶酶体酶、花生四烯酸及活性氧 ,作用于弹性蛋白、胶原蛋白 ,引起损伤。收集大鼠腹腔内PMNs ,…     

Positive reactions to tobacco predict relapse after cessation

Among chronic smokers, individual differences in subjective reactions to smoking may characterize important facets of nicotine dependence that relate to abstinence-induced craving, withdrawal symptom profiles, and risk for relapse. Although the negative reinforcing properties of smoking have achieved prominent positions in models of relapse (Baker, Brandon, & Chassin, 2004), vulnerability to relapse risk may also arise from seeking positive reinforcement from smoking (Shiffman & Kirchner, 2009). In this study, 183 cessation-motivated smokers provided subjective craving, positive and negative reactions to standardized cigarettes following overnight abstinence. Level of craving, negative mood, and positive mood after overnight abstinence were significantly predictive of withdrawal on quit-day. Increased positive reactions to smoking were uniquely predictive of relapse after quitting (Hazard Ratio = 1.22, p < .001). Individual differences in positive reactions to smoking may be important markers of neurobiological systems that promote dependence and interfere with cessation efforts.     

Acute nicotine reinforcement, but not chronic tolerance, predicts withdrawal and relapse after quitting smoking.

Little research has examined the association of tobacco dependence with nicotine tolerance or reinforcement in a clinical sample. Smokers preparing to quit smoking participated in laboratory sessions to assess nicotine tolerance on subjective, cardiovascular, and performance measures and to assess nicotine reinforcement using a choice procedure. Participants were then provided with individual counseling (but no medication), made a quit attempt, and were followed for 1 year to determine clinical outcome, as determined by postquit withdrawal and days to relapse. Nicotine tolerance was unrelated to either withdrawal or relapse. However, acute nicotine reinforcement was significantly related to both greater withdrawal and faster relapse. Results challenge the common assumption that nicotine tolerance is closely related to dependence but suggest that nicotine reinforcement may have theoretical and clinical significance for dependence.     

Assessment of Nicotine Dependence Among Substance Abusing Adolescent Smokers: A Comparison of the DSM-IV Criteria and the Modified Fagerström Tolerance Questionnaire

Nicotine dependence has been found to be a significant factor in adolescent smoking persistence. However, measures of this construct are primarily adult-derived, limiting their utility as bases for characterizing nicotine dependence and formulating youth intervention strategies. This issue is of particular importance among substance abusing youth who have substantially higher rates of cigarette smoking than do adolescents in the general population. The objectives of this preliminary study were to examine the construct validity of the DSM-IV nicotine dependence criteria and the modified Fagerström Tolerance Questionnaire (mFTQ) and to compare the DSM-IV diagnostic criteria for nicotine dependence with the mFTQ in a sample of 67 adolescent smokers in treatment for substance abuse. Results revealed that more participants were classified as nicotine dependent using DSM-IV criteria than by mFTQ scores. Little evidence was found for construct validity of these measures and convergence between the two measures was low. Findings also suggested that the present measures do not capture optimally broad dimensions of adolescent nicotine dependence.     

背景性渴求与事件性渴求:区分心理渴求对尼古丁成瘾的不同作用路径

大量研究发现心理渴求机制的紊乱是尼古丁成瘾的核心机制之一。线索暴露是探索心理渴求与尼古丁成瘾关系的重要研究范式。但最近研究者提出该范式较难区分事件性渴求与背景性渴求,导致无法清楚定位渴求在尼古丁成瘾中扮演的角色。通过对以往文献的回顾,对不同成瘾概念、作用机制和生理基础进行对比分析,认为事件性渴求与背景性渴求两者在维持成瘾行为上的确存在不同的作用路径。未来研究应改进实验范式,分别探讨两种心理渴求与尼古丁成瘾的内在联系,完善心理渴求与尼古丁成瘾的关系模型,为尼古丁成瘾的治疗和干预等方法提供一定的理论依据。     

The Short Nicotine Dependence Syndrome Scale (NDSS-S) in Spanish smokers

We present a brief scale derived from the Nicotine Dependence Syndrome Scale (NDSS). We used a sample of 1.061 daily smokers, which was obtained from five Primary Care Health Centers, a Unit of Alcoholism, and a Smoking Cessation Unit. All smokers were evaluated with the NDSS and the SCID to assess nicotine dependence according to DSM-IV criteria. The results indicate the existence of a general factor of nicotine dependence according to the NDSS. We selected the items with a higher factor loading (>.50), obtaining a short scale of 6 items. With this brief scale, we obtained results similar to those of the total scale in the diverse variables (sociodemographic and smoking) of the study. Scale reliability is satisfactory (a= .79), the correlation between the short and the total scale is very high (r=.95, p<.001) and the short scale discriminates the smokers in terms of cigarette consumption and nicotine dependence, as assessed with the SCID. The operation under the ROC curve is excellent (area under the curve .84). The data indicate the usefulness of this brief scale (NDSS-S) to assess nicotine dependence in smokers.     

The relationship of childhood trauma to nicotine dependence in pregnant smokers

Pregnant women with high levels of nicotine dependence are the least likely to quit smoking spontaneously during pregnancy or to benefit from smoking cessation interventions. In the general population, there is increasing evidence of a relationship between smoking, nicotine dependence, and exposure to childhood trauma. We examined the relationship of childhood trauma to several measures of nicotine dependence and evaluated whether this relationship was mediated by major depressive disorder or depressive symptom severity in pregnant smokers. Moderate to extreme levels of childhood trauma were significantly related to smoking within 5 minutes or less of waking, and to the Behavioral Choice-Melioration, Negative Reinforcement, and Tolerance subscales of the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) scale. The relationships between childhood emotional abuse and the WISDM-68 Total and Negative Reinforcement subscale were partially mediated by depressive symptoms. Results suggest that childhood trauma may be a risk factor underlying nicotine dependence in pregnant smokers. Increased understanding of the relationship of affect regulation to smoking in individuals with childhood trauma histories may aid in the development of more effective treatments of nicotine dependence for this population of smokers.     

Impact of the hormonal milieu on the neurobiology of alcohol dependence and withdrawal

Alcoholism, or alcohol dependence, is a complex disorder with withdrawal symptoms that are often problematic for those trying to recover from their dependence. As researchers attempt to elucidate the neurobiological underpinnings of alcohol dependence and withdrawal, it is becoming clear that numerous factors, including the hormonal environment, impact the manifestations of this disorder. Of particular interest is the observation that women have fewer and less severe withdrawal symptoms than do men even though they tend to suffer greater physiological harm from excessive alcohol consumption. In this article, the authors present an overview of their understanding of how gonadal and stress hormones interact with alcohol, which results in differential neurobiological responses between males and females. Thus far, data generated from representative animal models have shown significant differences between the sexes in behavioral responses and neuroadaptations to chronic alcohol consumption and withdrawal. Accumulating evidence suggests that treatment of alcoholism, including withdrawal, should be tailored to the patient's gender and hormonal status.     

Spanish adaptation of the NDSS (Nicotine Dependence Syndrome Scale) and assessment of nicotine-dependent individuals at primary care health centers in Spain

The availability of adequate instruments for the assessment of nicotine dependence is an important factor that is relevant in the area of tobacco addiction. In this study, we present a Spanish validation of the Nicotine Dependence Syndrome Scale (NDSS) (Shiffman, Waters, & Hickcox, 2004). The sample was composed ofpatients, all daily smokers, who visited their General Practitioner (GP) at five Primary Health Care Centers in different cities of Spain (N = 637). The results indicated adequate reliability for the general factor that assesses nicotine dependence (NDSS-Total) (Cronbach's alpha = .76). Factor analysis confirms the five factors of the original validation: Drive, Continuity, Stereotypy, Priority, and Tolerance. It must be noted that reliability is adequate for the first, and moderate or low for the rest. The NDSS-T and its scales correlate significantly with the Fagerstr?m Test for Nicotine Dependence (FTND), with the nicotine dependence criteria of the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) as assessed through the Structured Clinical Interview for DSM-IV (SCID), with carbon monoxide levels in expired air (CO), and with the number of cigarettes smoked. The ROC curve indicates that the NDSS-T has a score of .79 which is under the curve (.69 for the FTND), thus the prediction of nicotine dependence is adequate. We conclude that this instrument is useful (in terms of its total score NDSS-T) for assessing nicotine dependence for Spanish smokers (in Spain), as has been found in other countries, language groups, and cultures.     

Model-based recursive partitioning of extended redundancy analysis with an application to nicotine dependence among US adults

Extended redundancy analysis (ERA) is used to reduce multiple sets of predictors to a smaller number of components and examine the effects of these components on a response variable. In various social and behavioural studies, auxiliary covariates (e.g., gender, ethnicity) can often lead to heterogeneous subgroups of observations, each of which involves distinctive relationships between predictor and response variables. ERA is currently unable to consider such covariate-dependent heterogeneity to examine whether the model parameters vary across subgroups differentiated by covariates. To address this issue, we combine ERA with model-based recursive partitioning in a single framework. This combined method, MOB-ERA, aims to partition observations into heterogeneous subgroups recursively based on a set of covariates while fitting a specified ERA model to data. Upon the completion of the partitioning procedure, one can easily examine the difference in the estimated ERA parameters across covariate-dependent subgroups. Moreover, it produces a tree diagram that aids in visualizing a hierarchy of partitioning covariates, as well as interpreting their interactions. In the analysis of public data concerning nicotine dependence among US adults, the method uncovered heterogeneous subgroups characterized by several sociodemographic covariates, each of which yielded different directional relationships between three predictor sets and nicotine dependence.