A model of amygdala–hippocampal–prefrontal interaction in fear conditioning and extinction in animals

Empirical research has shown that the amygdala, hippocampus, and ventromedial prefrontal cortex (vmPFC) are involved in fear conditioning. However, the functional contribution of each brain area and the nature of their interactions are not clearly understood. Here, we extend existing neural network models of the functional roles of the hippocampus in classical conditioning to include interactions with the amygdala and prefrontal cortex. We apply the model to fear conditioning, in which animals learn physiological (e.g. heart rate) and behavioral (e.g. freezing) responses to stimuli that have been paired with a highly aversive event (e.g. electrical shock). The key feature of our model is that learning of these conditioned responses in the central nucleus of the amygdala is modulated by two separate processes, one from basolateral amygdala and signaling a positive prediction error, and one from the vmPFC, via the intercalated cells of the amygdala, and signaling a negative prediction error. In addition, we propose that hippocampal input to both vmPFC and basolateral amygdala is essential for contextual modulation of fear acquisition and extinction. The model is sufficient to account for a body of data from various animal fear conditioning paradigms, including acquisition, extinction, reacquisition, and context specificity effects. Consistent with studies on lesioned animals, our model shows that damage to the vmPFC impairs extinction, while damage to the hippocampus impairs extinction in a different context (e.g., a different conditioning chamber from that used in initial training in animal experiments). We also discuss model limitations and predictions, including the effects of number of training trials on fear conditioning.     

Medical explanations and lay conceptions of disease and illness in doctor–patient interaction

Hilary Putnam’s influential analysis of the ‘division of linguistic labour’ has a striking application in the area of doctor–patient interaction: patients typically think of themselves as consumers of technical medical terms in the sense that they normally defer to health professionals’ explanations of meaning. It is at the same time well documented that patients tend to think they are entitled to understand lay health terms like ‘sickness’ and ‘illness’ in ways that do not necessarily correspond to health professionals’ understanding. Drawing on recent philosophical theories of concept possession, the article argues that this disparity between medical and lay vocabulary implies that it is, in an important range of cases, easier for doctors to create a communicative platform of shared concepts by using and explaining special medical expressions than by using common lay expressions. This conclusion is contrasted with the view that doctors and patients typically understand each other when they use lay vocabulary. Obviously, use of expressions like ‘sickness’ or ‘illness’ does not necessarily lead to poor communication, but it is important that doctors have an awareness of how patients interpret such terms.

An exploratory study of linguistic–colour associations across languages in multilingual synaesthetes

In one of the most common forms of synaesthesia, linguistic–colour synaesthesia, colour is induced by stimuli such as numbers, letters, days of the week, and months of the year. It is not clear, however, whether linguistic–colour synaesthesia is determined more by higher level semantic information—that is, word meaning—or by lower level grapheme or phoneme structure. To explore this issue, we tested whether colour is consistently induced by grapheme or phoneme form or word meaning in bilingual and trilingual linguistic–colour synaesthetes. We reasoned that if the induced colour was related to word meaning, rather than to the acoustic or visual properties of the words, then the induced colours would remain consistent across languages. We found that colours were not consistently related to word meaning across languages. Instead, induced colours were more related to form properties of the word across languages, particularly visual structure. However, the type of inducing stimulus influenced specific colour associations. For example, colours to months of the year were more consistent across languages than were colours to numbers or days of the week. Furthermore, the effect of inducing stimuli was also associated with the age of acquisition of additional languages. Our findings are discussed with reference to a critical period in language acquisition on synaesthesia.     

Prognosis in medicine: An analysis of its meaning and rôles

The medical concept of prognosis is analysed into its basic constituents: patient data, medical intervention, outcome, utilities and probabilities; and sources of utility and probability values are discussed. Prognosis cannot be divorced from contemplated medical action, nor from action to be taken by the patient in response to prognostication. Regrettably, the usual decision-theoretic approach ignores this latter aspect. Elicitation of utilities, decision contemplation and prognostic counselling interweave, diagnostics playing a subsidiary role in decision-oriented clinical practice. At times the doctor has grounds for withholding information. As this is known to the patient, prognostic counselling becomes a conflict-prone and rationality-thwarting activity. The meaning of standard phrases such as “prognosis of a disease”, “the prognosis of this patient”, “the prognosis is unknown”, is examined.     

A computerized system for recording and analysis of self-observations of couples’ interaction

This paper describes a method for recording couples’ observations of their communications during an ongoing interaction sequence. The procedure allows the recording and decoding of immediate reactions, while maintaining an ecologically valid observation environment. Responses are encoded on a stereo cassette tape player and are decoded by a PDP-11/10 computer with two Schmitt triggers that count the peaks in the tones. The computer provides analysis of the response value and time. Applications for other research problems in the areas of social and applied clinical psychology are discussed.     

An adventure in scholarship and faith: Reflections on the study centre 1975–1992

CSIC has now had 15 years' experience of Muslim/Christian partnership in an adventure of faith and scholarship. How honest have the partners been able to be with each other, and with the rest of the world? CSIC was a Christian initiative, yet quickly became a co‐operative venture. One of its emergent problems was how to present Christianity intelligibly to Muslims; another the perennial issue of dialogue and mission. Faith and reason clashed predictably among the students, but many outside the institution valued its expertise in their professional responsibilities, and CSIC acquired the credibility to contribute to wide‐ranging socio‐political debates. May the adventure continue, at the expense of academic safety, if necessary.     

Constrained maximization reconsidered — An elaboration and critique of Gauthier's modelling of rational cooperation in a single prisoner's dilemma

Gauthier's argument for constrained maximization, presented inMorals by Agreement, is perfected by taking into account the possibility of accidental exploitation and discussing the limitations on the values of the parameters which measure the translucency of the actors. Gauthier's argument is nevertheless shown to be defective concerning the rationality of constrained maximization as a strategic choice. It can be argued that it applies only to a single actor entering a population of individuals who are themselves not rational actors but simple rule-followers. A proper analysis of the strategic choice situation involving two rational actors who confront each other shows that constrained maximization as the choice of both actors can only result under very demanding assumptions.     

Case–contrast study about parent–infant interaction in a Brazilian sample of siblings of children with autism spectrum disorders

Siblings of children with autism spectrum disorders (ASD) present greater susceptibility to developmental problems, in comparison with siblings of typically developing children. The greater prevalence of mental health disorders among parents of children with ASD increases younger siblings’ vulnerability to emotional problems. The aim of this study is to compare the interaction between carers and babies aged 2 to 26 months (M = 11.7, SD = 6.9) who are siblings of children with ASD (ASD dyads) with the interaction of dyads of siblings of typically developing children (TD dyads). The protocol of Clinical Indicators of Risk for Child Development and the Coding Interactive Behaviour measures were used to evaluate interaction. ASD dyads presented higher scores of constriction in their interaction, P = .024, with babies presenting higher scores of withdrawal behavior, P = .003, and carers presenting higher scores of depressive mood, P = .008, when compared to TD dyads. The ASD dyads have interactive impairments more frequently than do the TD dyads.     

Hindsight bias: An interaction of automatic and motivational factors?

If subjects are asked to recollect a former response after having been informed about the correct response, their recollection tends to approach the correct response. This effect has been termedhindsight bias. We studied hindsight bias in an experiment requiring numerical responses to almanac-type questions for physical quantities. We varied (1) the time at which the correct information was provided, (2) the encoding of the original responses by asking/not asking subjects to give a reason for the respective response, and (3) the motivation to recall correctly. We found that hindsight is less biased if reasons are given and if the correct information is provided at an earlier time. Motivation had only interactive effects: (1) With high motivation to recall correctly, the time the correct information was provided had no influence. (2) With reasons given, the variation of motivation showed no effect. These results rule out purely motivational and purely automatic explanations.     

A model to study orienting responses in zebrafish,and applications towards the emotion–cognition interaction

Animal Cognition - Orienting responses (ORs) are whole-organism reflexes that are elicited by innocuous stimuli, and which decrease in magnitude after stimulus repetition. ORs represent relatively...     

An Examination of Exchange Quality and Work Stressors in Leader–Follower Dyads

This study examined the relationship between quality of leader–member exchange and follower perceptions of work stress. It was proposed that followers in higher quality exchanges were less likely to perceive work stressors than followers in exchanges of lower quality. Data collected from 215 employees of a midsized public university substantially supported this proposition. Quality of leadermember exchange was negatively related to role conflict, role ambiguity, low job scope, lack of career progress, and lack of participation experienced by followers.     

Trends in the creativity literature: An analysis of research in the journal of creative behavior (1967–1989)

Abstract

Many have noted a renewed interest in creativity. However, even with a 40‐year history, little effort has been directed at the study of changes in the field, and no effort has been made to develop a historical perspective of the work being conducted. Which topics have consistently been examined? Which have gone out of favor, and which have shown surges of interest? The present investigation addressed these questions by examining 311 articles, representing a 23‐year span (1967–1989). This span began in 1967 with the founding of the Journal of Creative Behavior. Predictions were based on previous literature reviews and similar studies conducted in other areas of the social sciences. One prediction was that there would be increases in the number of authors per article (women authors in particular) and in the total number of references. Furthermore, empirical articles were expected to be on the rise, as were articles focusing on social and educational issues. The number of articles concerned with personality and related topics were expected to show a decrease. Results generally supported the hypotheses: The number of authors, number of female authors, number of references, and social and educational articles all showed upward trends. However, the number of empirical articles did not increase during the 23‐year period. Overall, the findings suggest that trend‐analytic research is viable and informative. It tells us not only where the field has gone, but also gives hints as to where it may be going.     

Strategic and cognitive differentiation–integration effort in a study of 76 countries

The phenomena of strategic and cognitive differentiation and integration (SD–IE and CD–IE) amongst life history indicators and cognitive abilities as a function of level of latent life history speed have been robustly demonstrated in individual differences samples. Here we examine a cross-national sample (N = 76 nations) with respect to ten aggregate life history indicators (birth rate, infant mortality, skin reflectance, prevalence of STDs, overall life satisfaction, life expectancy, national IQ, cranial capacity, savings rate and crime rate), all of which share substantive common variance stemming from a K-Super factor which accounts for 66.6% of the variance amongst these indicators. All indicators became significantly less strongly correlated with the super factor as the level of K increased indicating the presence of robust SD–IE effects. A ‘cognitive’ factor comprised of the national IQ and cranial capacity variables also exhibited differentiation as a function of increasing levels of K, suggesting the presence of CD–IE also. Consistently with the findings of individual differences studies investigating SD–IE, the degree to which the indicators loaded on the K super-factor positively mediated their sensitivity to the effect.     

Profiles of competence and adaptation in preschoolers as related to the quality of parent–child interaction

In a sample of 107 five-year-olds, cluster analysis was used to identify groups of children with similar profiles of competence and adaptation. A comprehensive set of child characteristics was included in the analysis, together covering the most important aspects of five-year-olds’ development and functioning. Three groups of children emerged, which were labeled Well-adapted/Competent, Underachieving/Internalizing, and Maladapted/Externalizing. Well-adapted/Competent children (59%) were competent and well-adjusted in all domains. The Maladapted/Externalizing children (22%) scored low in almost all domains of competence and functioning, and the Underachieving/Internalizing children (22%) showed a mixed profile of competence and adaptation. The differences in the quality of parent–child interaction that were observed between the groups provide clues as to how the different profiles of competence and adaptation are shaped and maintained in the interactions with parents.     

Mechanisms of motivation–cognition interaction: challenges and opportunities

Recent years have seen a rejuvenation of interest in studies of motivation–cognition interactions arising from many different areas of psychology and neuroscience. The present issue of Cognitive, Affective, & Behavioral Neuroscience provides a sampling of some of the latest research from a number of these different areas. In this introductory article, we provide an overview of the current state of the field, in terms of key research developments and candidate neural mechanisms receiving focused investigation as potential sources of motivation–cognition interaction. However, our primary goal is conceptual: to highlight the distinct perspectives taken by different research areas, in terms of how motivation is defined, the relevant dimensions and dissociations that are emphasized, and the theoretical questions being targeted. Together, these distinctions present both challenges and opportunities for efforts aiming toward a more unified and cross-disciplinary approach. We identify a set of pressing research questions calling for this sort of cross-disciplinary approach, with the explicit goal of encouraging integrative and collaborative investigations directed toward them.     

Formation and analysis of amorphous and nanocrystalline phases in Al–Cu–Mg alloy under friction stir processing

Homogeneous amorphous and nanocrystalline phases formed in the nugget zone of a friction stir-processed Al–Cu–Mg alloy have been studied. X-ray diffraction analysis indicated a diffuse scattering peak with characteristics of an amorphous phase existed in the range 15°–29°. Further, TEM analysis proved the existence of an amorphous structure. Friction stir processing provides special physical conditions, such as high temperature, high hydrostatic pressure and large shear stress, which could induce the amorphization of the alloy.     

An increase of intelligence in China 1986–2012

The Flynn effect has been widely researched in Western and European nations, while it has been comparatively understudied in Asian countries. This study examines possible Flynn effects in China from 1985 to 86 and to 2011–12. Results are reported for an IQ increase among 12 year olds on the Full Scale IQ WISC-R (Wechsler Intelligence Scale for Children-Revised) of 6.19 IQ points, a gain on the Performance IQ of 6.55 IQ points, and a gain on the Verbal IQ of 1.91 IQ points.     

Reciprocal involvement in adolescent dating aggression: An Italian–Spanish study

This study aimed to: (1) analyse the association of different patterns of reciprocal involvement in dating aggression (reciprocal psychological and physical aggression; reciprocal psychological aggression; non-aggressive individuals) with different qualities of romantic relationship; and (2) compare results in two European countries, Italy and Spain. Participants were 304 adolescents (141 Italy, 163 Spain) with a current dating relationship. Results in both countries showed that adolescents involved in reciprocal psychological and physical aggression are more likely to have higher levels of couple conflict and power imbalance as compared to the reciprocal psychological aggressive group and to the non-aggressive individuals. Besides, adolescents involved in reciprocal psychological aggression are more likely to have lower levels of support as compared to the non-aggressive individuals. Discussion is focused on different patterns of reciprocal involvement differentiated in relation to level of aggression, conflict and power imbalance.