Contrasting effects of motor and visual spatial learning tasks on dendritic arborization and spine density in rats

Rats were trained in four different learning tasks including the Morris-water task, a T-maze delayed nonmatch-to-sample task, a skilled unilateral reaching task, and a skilled bilateral string-pulling task. At the end of training the brains were harvested and stained using a Golgi-Cox procedure. Learning the spatial navigation task produced increased dendritic length and branching as well as decreased spine density in layer III pyramidal cells in occipital cortex. Learning the T-maze task increased dendritic branching in layer III medial but not orbital frontal cortex pyramidal cells and increased spine density in both regions. The motor learning tasks produced increased dendritic length and branching in layer V pyramidal cells in the forelimb cortex in the hemisphere contralateral to the trained limb in the unilateral skilled reaching task and in both limbs in the bilateral skilled pulling task. There were no changes in spine density in layer V in the motor tasks, but there was a decrease in spine density in layer III in the unilateral reaching task. Spatial and motor learning thus produce different patterns of change in layer III cortical pyramidal neurons. Furthermore, changes in spine density and dendritic length and branching are not tightly correlated and can increase and/or decrease independently of one another in learning tasks.     

A further analysis of time bisection behavior in children with and without reference memory: the similarity and the partition task

Experiment 1 compared the temporal performance of 5-year-olds, 8-year-olds and adults in a bisection task with and without referent durations (similarity vs. partition). The results showed that temporal sensitivity was lower in the partition than in the similarity condition in children, whereas it was similar in these two conditions in the adults. In addition, the 5-year-olds produced a higher bisection point value in the partition than in the similarity task. Experiment 2, which examined changes in bisection performance over the trial blocks in the partition task, revealed that the 5-year-olds' bisection performance improved over the trial blocks, whereas the performance of the older participants did not. Further analyses revealed a greater variability in the establishment of the duration criterion in young children.     

Successive independence of multiple-schedule component performances

In three experiments, pigeons' responses were reinforced on two keys in each component of a series of multiple-schedule conditions. In each series, concurrent variable-interval schedules were constant in one component and were varied over conditions in the other component. In the first experiment both components arranged the same, constant total number of reinforcers, in the second the two components arranged constant but different totals, and in the third experiment the total was varied in one component and remained constant in the other. Relative reinforcer rate during the varied component was manipulated over conditions in all three experiments. In all these experiments, response and time allocation in the constant component were invariant when reinforcer ratios varied in the other component, demonstrating independence of behavior allocation in a multiple-schedule component from the relative reinforcer rate for the same alternatives in another component. In the two experiments which maintained constant reinforcer totals in components, sensitivity to reinforcement in the multiple schedules was the same as that in the concurrent schedules arranged during the varied component, with multiple-schedule bias in the experiment in which the totals were unequal.     

Delta-sleep inducing peptide (DSIP) and ACTH (4-10) analogue influence fos-induction in the limbic structures of the rat brain under emotional stress

The effects of the ACTH (4-10) analogue, ACTH (4-7)-Pro-Gly-Pro, and delta-sleep inducing peptide (DSIP) on the induction of Fos immunoreactivity in the hypothalamic parvocellular paraventricular nucleus (pPVN) and limbic brain regions were studied in Wistar rats with high (resistant) or low (predisposed) resistance to emotional stress, predicted from differences in their open-field behaviour. Fos-immunoreactive (Fos-IR) cells were counted in brain sections automatically with a computer-based image analyser. Under basal conditions, Fos-IR cell numbers were greater in the pPVN in the predisposed rats, but were lower than in the resistant rats in the basolateral amygdala and medial and lateral septum. Intraperitoneal DSIP injection (30 μg/kg) increased basal Fos-IR cell number in the pPVN and lateral septum in resistant rats, with no effects in predisposed rats. ACTH (4-10) analogue (50 μg/kg)increased Fos expression in the pPVN in both resistant and predisposed rats, with essentially no effects in the basolateral amygdala or medial and lateral septum. Emotional stress (60 min restraint and intermittent subcutaneous electrical shocks) increased Fos expression in the pPVN and medial and lateral septum similarly in predisposed and resistant rats, but in the basolateral amygdala in only the predisposed rats. Intraperitoneal DSIP injection reduced the increases in Fos-IR cell number after emotional stress, particularly in predisposed rats. In predisposed rats DSIP decreased the number of Fos-IR cells in the pPVN and the medial and lateral septum, with no change in the basolateral amygdala. In resistant rats, DSIP decreased Fos expression only in the lateral septum. ACTH (4-10) analogue injection inhibited stress-induced Fos expression in the pPVN and the medial septum, but only in predisposed rats. The experiments indicate that DSIP and ACTH (4-10) analogue reduce pPVN and limbic neurone responses to emotional stress in the rats predisposed to emotional stress; the effects on Fos expression may play a role in the biological activities of these peptides.     

Maze navigation by honeybees: learning path regularity

We investigated the ability of honeybees to learn mazes of four types: constant-turn mazes, in which the appropriate turn is always in the same direction in each decision chamber; zig-zag mazes, in which the appropriate turn is alternately left and right in successive decision chambers; irregular mazes, in which there is no readily apparent pattern to the turns; and variable irregular mazes, in which the bees were trained to learn several irregular mazes simultaneously. The bees were able to learn to navigate all four types of maze. Performance was best in the constant-turn mazes, somewhat poorer in the zig-zag mazes, poorer still in the irregular mazes, and poorest in the variable irregular mazes. These results demonstrate that bees do not navigate such mazes simply by memorizing the entire sequence of appropriate turns. Rather, performance in the various configurations depends on the existence of regularity in the structure of the maze and on the ease with which this regularity is recognized and learned.     

Strategies for visual word recognition and orthographical depth: a multilingual comparison

We investigated the psychological reality of the concept of orthographical depth and its influence on visual word recognition by examining naming performance in Hebrew, English, and Serbo-Croatian. We ran three sets of experiments in which we used native speakers and identical experimental methods in each language. Experiment 1 revealed that the lexical status of the stimulus (high-frequency words, low-frequency words, and nonwords) significantly affected naming in Hebrew (the deepest of the three orthographies). This effect was only moderate in English and nonsignificant in Serbo-Croatian (the shallowest of the three orthographies). Moreover, only in Hebrew did lexical status have similar effects on naming and lexical decision performance. Experiment 2 revealed that semantic priming effects in naming were larger in Hebrew than in English and completely absent in Serbo-Croatian. Experiment 3 revealed that a large proportion of nonlexical tokens (nonwords) in the stimulus list affects naming words in Hebrew and in English, but not in Serbo-Croatian. These results were interpreted as strong support for the orthographical depth hypothesis and suggest, in general, that in shallow orthographies phonology is generated directly from print, whereas in deep orthographies phonology is derived from the internal lexicon.     

Sustained behavioral contrast in children

Children were exposed to a multiple schedule involving equal variable-interval schedules in each of two components and a multiple schedule involving a variable-interval schedule in one component and an extinction schedule in the other. Response rates were equal in both components when each involved a variable-interval schedule. Response rates differed in the two components of the multiple variable-interval extinction schedule. Response rates were higher in the variable-interval schedule when the accompanying schedule was extinction than when it was variable interval. The increase in response rate in the variable-interval component, simultaneous with the decrease in response rate in the extinction component, illustrated sustained behavioral contrast, and was the first evidence of this phenomenon in children.     

《易》象与《诗》象:论《周易》的类艺术表现方式

文章从符号学角度,通过《诗》《易》比较,论述了《周易》的类艺术特征。在构成符号的综合性上,在篇章的结构、句式词语的使用上,在物象选择与深层意蕴上,《易》和《诗》具有异质同构的关系。后世艺术作品中出现的同类意象,其原型可溯到《诗》,更可求诸《易》。     

A local-rate-of-response and interresponse-time analysis of behavioral contrast

Three pigeons were exposed to a two-component multiple schedule in which a variable-interval 3-min schedule was always in effect in one component. The schedule in the other component was either variable-interval 3-min or extinction in alternate blocks of sessions. When the schedule was changed from multiple variable-interval 3-min variable-interval 3-min to multiple variable-interval 3-min extinction in the second and fourth phases of the experiment, overall response rates in the unchanged variable-interval 3-min component increased in two pigeons. Response rate declined when the schedule was changed to multiple variable-interval 3-min variable-interval 3-min again. Correlated with increases in overall response rate in the unchanged component were increases in local response rates at the beginning of the unchanged component and immediately after food presentation. Local rates 40 sec after food presentation did not increase greatly in the presence of the multiple variable-interval 3-min extinction schedule. An interresponse time analysis of three local rate samples showed small increases in the relative frequency of short-duration interresponse times at the beginning of the unchanged component and immediately after food presentation. Neither the postreinforcement pause nor the latency to the first response in the unchanged component changed systematically.     

The putative role of free radicals in the loss of neuronal functioning in senescence

One of the hallmarks of the aging process is a loss of sensitivity in central neuronal receptors to agonist stimulation. This appears to be especially true in central (hippocampal, striatal) muscarinic cholinergic systems and in the striatal dopamine systems. For these two systems, any decline in their sensitivity can be of extreme importance in determining the behavioral capabilities of the organism. Decrements in the striatal dopamine system may be reflected as motor behavioral deficits, while the central cholinergic systems play a major role in the processing of memory through the activation of muscarinic receptors (mAChR). Declines in the function of these receptors appear to be at least partially responsible for the marked deterioration of cognitive function in normal aging and, more notably, in Alzheimer’s disease (AD). Previous work has indicated only minimal success in improving performance in tasks that assess memory in senescent animals or humans with pharmacological agents which enhance cholinergic functioning. The present review describes research that indicates that two of the factors involved in this decline in receptor sensitivity include: (a) decreased receptor concentrations and (b) age-related decrements in signal transduction pathways. Studies are reviewed that indicate that the oxidative neural damage that occurs via kainic acid or ionizing radiation parallel those seen in aging. It is suggested that the common mechanism that may exist among all of the age-, disease-, excitatory amino acid- or radiation-induced deficits in neuronal transmission may involve free-radical-mediated alterations in membrane integrity through lipid peroxidation.     

老年甲状腺结节的诊治经验

介绍笔者及科室老年甲状腺结节的诊治经验,对2003年1月至2009年12月期间共收治的144例年龄大于60岁的老年甲状腺结节患者进行分析和总结。老年甲状腺结节以多发为主;压迫症状、异物和不适感、继发性甲状腺功能亢进是老年甲状腺结节患者主要的手术指证;术中发现喉返神经和甲状旁腺有脂肪沉着;病理方面良性结节的钙化率较高;患者术后切口水肿比较明显;暂时性低钙血症的发生率较高;虽然术前麻醉ASA评分较低,但术后心肺并发症的发生率并未上升。老年甲状腺结节患者以全麻为宜,最好采用双甲近全切除术,这不仅可避免术后复发和再次手术率,更可减少甲状腺素制剂的用量,减少药物副作用。     

The effect of UCS intensity in classical and avoidance GSR conditioning

This study compared GSR avoidance and yoked-control conditioning procedures. Classical conditioning at two UCS intensities was followed by extinction and, two months later, by an avoidance session. Matching of Ss was based on GSR responsiveness and classical conditioning in the first session. The strong UCS led to more rapid reduction in CR latency (due to an increase in number of Ss responding) in the first session, and there was a tendency for maximum CR magnitude to occur in fewer trials with the strong UCS. No UCS-intensity difference in level of responding to the CS or UCS was found in the first session. A greater amount of spontaneous recovery in the second session was found in the strong UCS group. The avoidance and yoked control groups did not differ in CR magnitudes, latencies, or frequencies, nor in UCR magnitudes in the second session. They did differ significantly in the rate of decline in intertriai responses, the decline being more rapid in the avoidance condition.     

What is the nature of increased Stroop interference in schizophrenia?

In comparison to controls, patients with schizophrenia classically display (1) an overall slowing in response times (RTs) and (2) a disproportionate slowing in RTs in the conflict condition of the Stroop color/word interference task. These two effects appear repeatedly in the card version of the Stroop task but were not replicated in a number of studies using a computer item-by-item version of the task. The present study was aimed at understanding the exact nature of the increased interference classically found in the performance of patients with schizophrenia in the card version of the Stroop task. We used a computer trial-by-trial version in which we investigated the effects of two major methodological differences between the two versions: (1) blocked (card version) versus mixed (computer version) presentation of the neutral, congruent and conflict conditions and (2) presence (card version) versus absence (computer version) of distractors in the spatial surrounding of the target. We found an overall slowing in performance and a disproportionate slowing in the conflict condition for patients with schizophrenia but only when the target was surrounded by distractors (in Experiments 2 and 3). The data are discussed in terms of a deficit in selective attention and inhibitory processes in schizophrenia.     

Stimulus context and duration discrimination

The ability of human observers to discriminate duration was assessed in two types of tasks: (1) pulse tasks, in which the observer compared the duration of two brief increments in an ongoing sinusoid, and (2) gap tasks, in which the observer compared the duration of two brief interruptions in an ongoing sinusoid. Performance in these tasks was assessed in three different contexts: noise alone, noise plus continuous sinusoids, and noise plus continuous sinusoids chosen to induce a pitch segregation effect. Performance in the pulse task was independent of the changes in context; however, performance in the gap task changed as a function of context condition. There was a large decrement in the observers’ ability to discriminate duration when the stimulus ensemble induced the pitch segregation effect. The results are discussed in terms of the relationship between duration discrimination and stimulus variations which do not carry duration information.     

Visual mental imagery and visual perception: Structural equivalence revealed by scanning processes

The research reported in the present article investigates whether information is represented the same way in both visual mental imagery and the early phases of visual perception. In Experiment 1, the same participants scanned over patterns of dots in a mental image (with images based on a just-seen pattern), during perception, and in an iconic image. The time to scan increasing distances increased at comparable rates in the three tasks. However, in Experiment 2, when mental images were created from information stored in long-term memory, participants scanned more slowly in the mental image condition. Nevertheless, the rates of scanning in the perceptual tasks were highly correlated with the rates of scanning in the imagery tasks in both experiments. The results provide evidence that mental images and perceived stimuli are represented similarly and can be processed in the same way.     

一种混合型前瞻记忆的干扰效应的神经机制

采用3（任务类型）×2（时段）被试内实验设计,对比一种混合型前瞻记忆（MPM）和基于事件的前瞻记忆（EBPM）在不同时段对进行中任务的干扰效应的神经机制。结果表明,在目标出现的时段,MPM对进行中任务有干扰效应,额区电极最活跃,额区电压最高,而在非目标时段MPM无干扰效应,但刺激出现后200-300ms额区电极较活跃。说明前瞻记忆任务在大脑中可能处于较高的激活状态,额叶灵活地调配意识的不同状态在前瞻记忆加工中参与的程度和时段。     

Religious Context and Prosociality: An Experimental Study from Valparaíso,Chile

Are people more prosocial in a religious context? We addressed this question through an experiment. We randomly placed participants in the control group in a neutral location (a lecture hall), and we placed participants in the experimental group in a religious location (a chapel). The participants then took part in a one‐shot three‐person public goods game, which measured participants’ degree of cooperativeness. The results showed that participants in the experimental group cooperated significantly more than did participants in the control group. Furthermore, participants’ beliefs about other participants’ cooperativeness were more positive in the experimental group than they were in the control group. Improved expectations of others partially explained the enhanced cooperation in the religious context. We found no main or interaction effect of self‐reported religiosity in the experiment.     

材料模式与认知负荷对小学生类比学习的影响

探讨学习材料不同模式和学习过程不同的认知负荷对小学生类比推理学习迁移的影响.包括两个分实验.实验1探讨学习材料的不同组织模式对小学生类比推理学习迁移的影响,两组小学生分别学习模式化与非模式化的材料,然后完成迁移程度远近不同的四类测题.结果表明,非模式化条件下完成远迁移题目的成绩显著优于模式化条件下的成绩.实验2探讨小学生在不同认知负荷条件下类比推理学习的迁移效果,两组小学生分别在高认知负荷与低认知负荷情况下学习类比推理的材料,然后完成上述四类测题.结果表明,高认知负荷条件下完成远迁移题目的成绩显著优于低认知负荷条件下的成绩.本实验结果表明,对于小学生类比推理的学习来说,非模式化、高负荷的学习更有利于促进迁移,支持了积极反应理论.     

长时记忆中文本目标信息的激活机制

选取138名大学生被试,采用移动窗口实时阅读技术和探测技术,探讨文本理解过程中长时记忆的目标信息激活的机制。实验1探讨在中文条件下目标焦点是否也启动长时记忆中目标信息的整合。结果表明在目标实现的条件下,目标句1可以作为目标启动句,激活进入长时记忆中的目标信息。实验2和3探讨长时记忆中目标信息的激活是自然实现的还是需要目标愈合信号启动激活,实验结果表明长时记忆中目标信息的激活需要目标愈合信号的启动。该研究结果总的表明:阅读过程长时记忆中目标信息的激活不需要与当前阅读信息发生共振,目标愈合情境是影响长时记忆目标信息通达的关键因素。     

高中文理分科及学生认知方式对阅读理解影响的实验研究

以高中二年级学生为被试,探讨文理分科、不同认知方式的学生对不同体裁文章及对文章不同信息加工层次的学习效果的影响。结果表明,（1）文理分科、学生认知方式对学生阅读成绩的影响不显著;（2）从总体上看,学生对不同体裁的文章学习效果不同,对说明文的学习明显优于对散文的学习;在文章不同信息的加工层次上,学生对细节的记忆优于对结构的把握;（3）对于不同体裁的文章,学生在信息加工层次上存在差异,对散文的细节记忆好于对结构的把握,对说明文的结构把握好于对细节的记忆。