A method for obtaining single cell responses in the optic tract of self-respiring fish

This paper describes a preparation for recording action potentials from the central nervous system of an intact self-respiring fish. The cervical spinal cord of the anesthetized fish was lesioned to minimize body movements, and the brain was exposed by cutting a hole in the dorsal skull. A clamp was attached to the rostral edge of this hole to eliminate motion of the skull. The fish in this preparation can control its own respiration and thus maintain an essentially normal respiratory state. This is a significant improvement over previous preparations, as respiratory state has been shown to be an important determinant of central nervous system function.     

Pain,suffering, and anxiety in animals and humans

We attempt to bring the concepts of pain, suffering, and anxiety into sufficient focus to make them serviceable for empirical investigation. The common-sense view that many animals experience these phenomena is supported by empirical and philosophical arguments. We conclude, first, that pain, suffering, and anxiety are different conceptually and as phenomena, and should not be conflated. Second, suffering can be the result — or perhaps take the form — of a variety of states including pain, anxiety, fear, and boredom. Third, pain and nociception are not equivalent and should be carefully distinguished. Fourth, nociception can explain the behavior of insects and perhaps other invertebrates (except possibly the cephalopods). Fifth, a behavioral inhibition system associated with anxiety in humans seems to be present in mammals and most or all other vertebrates. Based on neurochemical and behavioral evidence, it seems parsimonious to claim that these animals are capable of experiencing anxious states.     

Positive evidence for Eysenck’s arousal hypothesis: A combined EEG and MRI study with multiple measurement occasions

Eysenck’s arousal hypothesis suggests that introverts have greater cortical activity than extraverts. This prediction was tested in several studies that used the electroencephalogram (EEG) alpha activity to index cortical arousal, but empirical findings are inconsistent. Possibly, external factors of the measurement situation or static factors such as skull thickness may act as nuisance variables on alpha activity and thus mitigate the relation between arousal and extraversion. The aim of the present study was to test the arousal hypothesis with a focus on these methodological issues. Resting EEG was acquired on several occasions of measurement, skull thickness was quantified with anatomical magnetic resonance imaging (MRI), and extraversion was assessed by questionnaire. There was a positive association between alpha activity and extraversion, which was neither affected by external factors nor by skull thickness. This finding is in line with the arousal hypothesis and suggests that external or static factors do not contribute to the inconsistency of empirical findings.     

Sex,skull length,breed, and age predict how dogs look at faces of humans and conspecifics

The gaze of other dogs and humans is informative for dogs, but it has not been explored which factors predict face-directed attention. We used image presentations of unfamiliar human and dog heads, facing the observer (portrait) or facing away (profile), and measured looking time responses. We expected dog portraits to be aversive, human portraits to attract interest, and tested dogs of different sex, skull length and breed function, which in previous work had predicted human-directed attention. Dog portraits attracted longer looking times than human profiles. Mesocephalic dogs looked at portraits longer than at profiles, independent of the species in the image. Overall, brachycephalic dogs and dogs of unspecified breed function (such as mixed breeds) displayed the longest looking times. Among the latter, females observed the images for longer than males, which is in line with human findings on sex differences in processing faces. In a subsequent experiment, we tested whether dog portraits functioned as threatening stimuli. We hypothesized that dogs will avoid food rewards or approach them more slowly in the presence of a dog portrait, but found no effect of image type. In general, older dogs took longer to approach food placed in front of the images and mesocephalic dogs were faster than dogs of other skull length types. The results suggest that short-headed dogs are more attentive to faces, while sex and breed function predict looking times through complex interactions.     

Value of small cystic supratentorial PEG changes

Small solitary or multiple cystic lesions were found in the hemispheres of 3.6% of all patients suffering from cerebrovascular disorders, seizures, system degeneration or skull or brain injuries who were examined by PEG. Such lesions were especially frequent in patients in their forties to sixties. The absence of corresponding changes in the results of electroencephalographic, scintillation scanning and angiographic examination makes PEG an indispensable tool for prognosis in such cases.     

负压封闭引流技术在慢性创面处理中的实践与认识

自古至今,慢性创面的治疗是困扰人们的一大问题,在不断探索中,有学者提出负压吸引理论,并付诸实践,在应用中认识到负压封闭引流技术（vacuum sealing drainage,VSD）的作用机制及优缺点,并对其改进,以有效治疗慢性创面。纵观其出现、挫折、成熟和完善的发展历程,与其他客观事物一样,VSD经历了“实践-认识...     

The Datafication of Learning: Data Technologies as Reflection Issue in the System of Education

Like other parts of the social system, education is becoming an information-driven venture: data technologies pervade all levels of the system. This datafication of education seems to take place alongside a general turn to learning that Gert Biesta has called learnification: a progressively singular focus on the manipulable features of individual learning in education. Given rapidly rising levels of datafication, it seems timely to take up Luhmann and Schorr’s contention that education entails a technology deficit and discuss datafication as reflection issue in the system of education. Against their argument that human learning is not amenable to a technology, I develop the counter-argument that data technologies are replacing human learning outright with data at the level of organisation. Data thus present a concretely digital form of what Raf Vanderstraeten has called education as an ersatz order. In a data-driven form of organising education, human dimensions of learning become secondary to a systemic dimension: making learning visible as data and so susceptible to databased manipulation. The text treats school-wide positive behaviour support interventions as an evidence-based exemplar of this trend towards datafication in the system of education.     

Nietzsche Contra Darwin

Nietzsche attributes 'will power' to all living things, but this seems in sharp conflict with other positions important to him-and implausible besides. The doctrine smacks of both metaphysics and anthropomorphizing, which he elsewhere derides. Will to power seems to be an intentional end-directedness, involving cognitive or representational powers he is rightly loath to attribute to all organisms, and tends to downplay even in persons. This paper argues that we find a stronger reading of will to power-both more plausible and more consistent with Nietzsche's other views-by developing his affinities with Darwinism. By seeing will to power as an 'internal revision'to Darwinism, opposing the latter's stress (as Nietzsche thinks) on 'survival', but assenting to its uses of natural selection, we can ground or naturalize that notion, congenially to Nietzsche and to us.     

Introduction: Special Issue on Positive Psychology and Adult Development

An adult seems to articulate surprisingly similar meaning themes and similar processes about relationships in several widely disparate domains of behavior, domains of both non-pathological and pathological types. Whether the person is consciously describing early relationships with parental figures, unconsciously acting them out in current relationships, experiencing relationships with God or the Transcendent, or acting on the basis of relational delusions during psychotic episodes, his or his experienced relational reality seems to be filtered through a single, coherent, personally unique spiritual, existential, and epistemological relational lens. Conflicts may involve other relational meanings, but may be conflicts because of the existence of that dominant lens. Two parts of that dominant lens system, specifically the part relating the person’s concept of God to the other parts of the system and the part relating the specifics of psychotic breaks and spiritual emergence to other parts of the system, are seldom discussed. Both understanding the person’s dominant relational lens and the implications of that person’s using the lens to see reality, and sharing that knowledge with the individual (if he or he has stabilized to some degree) can help the troubled or disoriented individual. That person can gradually give a more adaptive meaning to consistent distortions in the many areas of meaning and behavior attached to relationships, and even to very skewed behavior such as hallucinations and delusions during psychotic breaks. Distortions during experiences of spiritual emergence also can be made clearer to the disturbed client if the therapist has a better understanding of the person’s overall coherent relational meaning system and its implications, and can translate the language of that system into spiritually transformative terms. A case is summarized and discussed as an example of these ideas. Then, two theories are described. A useful theory of human-felt connection and a cognitive developmental theory of Postformal Complex Thought have been developed by the author and described in earlier publications. These two theories help make sense of the multiple but coherent themes, cognitive dimensions of theme genesis and change, and the nature of the relational lenses used. Suggestions about interventions in the person’s system of coherently distorted relational themes, suggestions based on the two theories, are discussed. The recommendation is made that all therapists become fluent in the languages of, and especially the connections among, all of the relational areas named in the title of this paper that are part of the coherent relational theme.     

The oedipal wound in two stories by Kafka: The Metamorphosis and A Country Doctor

Kafka read Freud and was interested in psychoanalysis but believed there was no ‘cure’ for what was essentially the problem of living. As always with creative artists, the writer is his own psychoanalyst, and the actual process of writing is his means of self-revelation. The aim of this paper is to consider, in relation to two stories (The Metamorphosis and A Country Doctor), Kafka’s use of this background oedipal conflict with his father or received values (the ‘law’) as a springboard for the type of wound that results in creative writing. The wound for him became a kind of personal myth, and was also associated with other painful stimuli, including his tuberculosis and his troubled love affairs, but above all with his identity as a writer. The writing process and the ‘faith-value’ it demands is an underlying metaphor behind these narratives of Kafka’s ‘dream-like inner life’. There are parallels here with Bion’s psychoanalytic philosophy of ‘suffering’ and ‘psyche-lodgement’.     

Coherent Themes: Individuals’ Relationships with God,Their Early Childhood Experiences,Their Bonds with Significant Others,and Their Relational Delusions During Psychotic Episodes All Have Similar Holistic,Existential, and Relational Themes

An adult seems to articulate surprisingly similar meaning themes and similar processes about relationships in several widely disparate domains of behavior, domains of both non-pathological and pathological types. Whether the person is consciously describing early relationships with parental figures, unconsciously acting them out in current relationships, experiencing relationships with God or the Transcendent, or acting on the basis of relational delusions during psychotic episodes, his or his experienced relational reality seems to be filtered through a single, coherent, personally unique spiritual, existential, and epistemological relational lens. Conflicts may involve other relational meanings, but may be conflicts because of the existence of that dominant lens. Two parts of that dominant lens system, specifically the part relating the person’s concept of God to the other parts of the system and the part relating the specifics of psychotic breaks and spiritual emergence to other parts of the system, are seldom discussed. Both understanding the person’s dominant relational lens and the implications of that person’s using the lens to see reality, and sharing that knowledge with the individual (if he or he has stabilized to some degree) can help the troubled or disoriented individual. That person can gradually give a more adaptive meaning to consistent distortions in the many areas of meaning and behavior attached to relationships, and even to very skewed behavior such as hallucinations and delusions during psychotic breaks. Distortions during experiences of spiritual emergence also can be made clearer to the disturbed client if the therapist has a better understanding of the person’s overall coherent relational meaning system and its implications, and can translate the language of that system into spiritually transformative terms. A case is summarized and discussed as an example of these ideas. Then, two theories are described. A useful theory of human-felt connection and a cognitive developmental theory of Postformal Complex Thought have been developed by the author and described in earlier publications. These two theories help make sense of the multiple but coherent themes, cognitive dimensions of theme genesis and change, and the nature of the relational lenses used. Suggestions about interventions in the person’s system of coherently distorted relational themes, suggestions based on the two theories, are discussed. The recommendation is made that all therapists become fluent in the languages of, and especially the connections among, all of the relational areas named in the title of this paper that are part of the coherent relational theme.     

The cholinergic neurotransmitter system in human memory and dementia: A review

The present paper reviews three types of evidence implicating the role of acetylcholine in human memory and dementia: (1) neuropathological evidence that the cholinergic transmitter system is depleted in Alzheimer-type dementia; (2) psychopharmacological studies that have employed “cholinergic blockade” as a model of cholinergic depletion; and (3) clinical studies of cholinergic “replacement” therapy in Alzheimer-type dementia. The evidence that the cholinergic system is depleted in Alzheimer-type dementia has been complemented by the finding that cholinergic blockade in healthy subjects causes a substantial learning (or “acquisition”) deficit in episodic memory. The overall results of studies of replacement therapy have generally been disappointing, but a few have reported benefits in recall and recognition tests. The role of the cholinergic system in many aspects of memory remains to be elucidated; but it seems unlikely that cholinergic depletion accounts for all aspects of the memory disorder in Alzheimer-type dementia, and possibly the depletions of other neurotransmitters also contribute to the memory impairment.     

Action, verbal response and spatial reasoning

Studies have shown that perception of distance, orientation and size can be dissociated from action tasks. The action system seems to possess more veridical, unbiased information than the perceptual/verbal system. The current study examines the nature of the distinction between action and verbal responses in a spatial reasoning task. Participants imagined themselves facing different orientations and either pointed to where other objects would be, or verbally reported their egocentric directions (e.g., "50 degrees to my left"). When using pointing responses, RT and error increased as a function of the angular disparity between the imagined heading and their actual heading. However, when using verbal responses, performance was not affected by angular disparity, suggesting that participants knew the direction of the targets from the imagined perspective but could not point to them directly. The verbal and action systems have fundamentally different information or processes rather than quantitatively different ones.     

Sadistic fantasies modified by aversive conditioning and substitution: a case study

A case study involving unpleasant electric shocks as the consequence of sadistic fantasies seems to have successfully helped to suppress or extinguish them while incompatible “normal” sex fantasies were strengthened. The results are seen as analogous to other studies using extinction with aversive stimuli.     

Minds as Connoting Systems: Logic and the Language of Thought

The principal aim of this essay is to discuss some logical features of the so-called Classical model of cognitive architecture as it is advocated by J. Fodor and Z. Pylyshyn in their much discussed article 'Connectionism and Cognitive Architecture: A Critical Analysis'. It is pointed out that their structural assumptions have consequences of a logical kind which call into question the view that the Classical architecture (in their sense) can be employed to model human cognition. It seems that the consequences have escaped Fodor and Pylyshyn's notice, or else they have failed to appreciate them, since some of their claims evidently conflict with them. It is also investigated whether the human mind can be characterized as being logical in some weaker sense of logic. Furthermore, it is argued that J. H. Fetzer's view that it is a semiotic system is more realistic than the Classical model, but the distinction he suggests between human cognition and other kinds may be problematic.     

The weight of time: affordances for an integrated magnitude system

In five experiments we explored the effects of weight on time in different action contexts to test the hypothesis that an integrated magnitude system is tuned to affordances. Larger magnitudes generally seem longer; however, Lu and colleagues (2009) found that if numbers were presented as weights in a range heavy enough to affect lifting, the "larger seems longer" effect was enhanced, but it was eliminated with weights too light to affect lifting. Experiments 1 and 2 revealed that actually lifting kilogram and gram weights had effects parallel to symbolized weights, suggesting that Lu et al.'s task implicitly evoked a lifting context. Experiments 3 and 4 showed that weights too heavy (e.g., tons) or too light to be discriminated by lifting, but relevant to other affordances (e.g., grams of a toxin) had effects on time as large or larger than for kilograms. Experiment 5 showed that the effect for grams in a toxicology context did not generalize to the lifting task of Experiment 2. Weight appears to integrate with other magnitudes when it is relevant to meaningful actions, including but not limited to lifting.     

THE ‘EXTENDEDNESS’ OF SCIENTIFIC EVIDENCE

In recent years, the idea has been gaining ground that our traditional conceptions of knowledge and cognition are unduly limiting, in that they privilege what goes on inside the ‘skin and skull’ (Clark 1997: 82) of an individual reasoner. Instead, it has been argued, knowledge and cognition need to be understood as embodied (involving both mind and body), situated (being dependent on the complex interplay between the individual and its environment), and extended (that is, continuous with, rather than separate from, the world ‘outside’). Whether these various interrelations and dependencies are ‘merely’ causal, or are in a more fundamental sense constitutive of knowledge and cognition, is as much a matter of controversy as the degree to which they pose a challenge to ‘traditional’ conceptions of cognition, knowledge and the mind. In this paper we argue that when the idea of ‘extendedness’ is applied to a core concept in epistemology and the philosophy of science—namely, scientific evidence—things appear to be on a much surer footing. The evidential status of data gathered through extended processes—including its utility as justification or warrant—do not seem to be weakened by virtue of being extended, but instead are often strengthened because of it. Indeed, it is often precisely by virtue of this extendedness that scientific evidence grounds knowledge claims, which individuals may subsequently ascribe to themselves. The functional equivalence between machine‐based gathering, filtering, and processing of data and human interpretation and assessment is the crucial factor in deciding whether evidence has been gathered, rather than the distinction between intra‐ and extracranial processes or individual and social processes (or combinations thereof). To prioritize biological processes here, and to assert the superiority of human cognitive capacities seems both arbitrary and unwarranted with respect to gathering evidence, and ultimately would lead to an unattractive skepticism about many of the methods used in science to gather evidence. In other words, conceiving of scientific evidence as ‘impersonal’ (or at least not necessarily personal) not only better captures the character of evidence‐gathering in practice, but also makes sense of a large amount of evidence‐gathering that ‘personal’ accounts fail to either acknowledge or accurately describe. Whilst we suggest it is likely that all internally‐distributed evidence‐gathering processes are merely contingently internal processes, a significant number of externally‐distributed evidence‐gathering processes are necessarily externally‐distributed. Some evidence can only be gathered by extended epistemic agents.     

A fixed rehearsal capacity interpretation of limits on absolute identification performance

The information transmitted in absolute identification quickly reaches its upper limit as the number of (one-dimensional) signals, and their range, is increased. Several explanations have been given of this phenomenon, but all are ad hoc in one way or another. Here we present a ‘memory’ or ‘rehearsal’ interpretation. The basic (psychological) representation of each signal in an absolute identification experiment is assumed to be quite accurate, and independent of the other stimuli used in the experiment. However, the identification of the stimulus presented on a particular trial is relative to a ‘frame’ (usually the range of stimuli in that experiment) that the subject must ‘rehearse’ using a fixed capacity rehearsal system. In special cases, this model reduces to earlier suggestions, but its general motivation seems somewhat less ad hoc than that of earlier ideas, and it is also easily applied to the absolute identification of multivariate signals and to magnitude estimation.     

Do Expectations Have Time Span?

If it is possible to think that human life is temporal as a whole, and we can make sense of Wittgenstein’s claim that the psychological phenomena called ‘dispositions’ do not have genuine temporal duration on the basis of a distinction between dispositions and other mental processes, we need a compelling account of how time applies to these dispositions. I undertake this here by examining the concept of expectation, a disposition with a clear nexus to time by the temporal point at which the expectation is satisfied. However, it seems that we cannot always identify the beginning of an expectation, and in a few cases, its end. If so, the reduction of expectations to neural events or accompanying feelings which spread over time in the usual way seems a hard enterprise, because these processes, much as other physical processes, have a definite and largely measurable time span. Only at a higher level, that is, as part of human life, expectation can be said to be temporal.     

Healing the wounds and the wounds of healing: a journey of the spirit

This article is a reflective narrative about the death of a parent told from the perspective of her daughter. It is an experience-based account. This shared journey of mother and child links the familiar realm of the conscious and known self to a realm that is not known in the same way and is not merely the self. It is as if one end is in the midst of life's struggles and crises and the other in another realm; yet the whole works together as a single force. In this way the idea is introduced that the very challenges and trauma of life can be a wound that is a healing of wounds, in so far as it prompts recognition of the realm that is out of sight, though the wound certainly is real enough.