Controlling behavior experiments with BASIC on 6502-based microcomputers

A combination of high-level BASIC and transparent machine language routines forms an inexpensive (about $800), powerful, and easy-to-use microcomputer system for behavior research, based on the AIM-65. The interrupt-driven machine language routines keep track of real time, poll inputs, and are not typically modified for different experiments. Expandable machine language listings that support eight input lines and eight output lines on the AIM-65 are presented. The user-written BASIC program controls experiments and records data. BASIC programs for simple reinforcement schedules are used as examples. The software is readily transferred to other 6602-based microcomputers with BASIC.     

A simple system for displaying alphanumeric characters on an oscilloscope using an AIM-65 microcomputer

A simple system for displaying alphanumeric characters on an oscilloscope screen is described. It may be useful for those applications in which only a few chaxacters should be shown, but within small time limitations. The system, using an AIM-65 microcomputer, is capable of exposure durations below 100 microsec/character. Possibilities of speeding up the system and designing characters are indicated.     

Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory

Evidence suggests that plasticity of the amygdalar and hippocampal GABAergic system is critical for fear memory formation. In this study we investigated in wild-type and genetically manipulated mice the role of the activity-dependent 65-kDa isozyme of glutamic acid decarboxylase (GAD65) in the consolidation and generalization of conditioned fear. First, we demonstrate a transient reduction of GAD65 gene expression in the dorsal hippocampus (6 h post training) and in the basolateral complex of the amygdala (24 h post training) during distinct phases of fear memory consolidation. Second, we show that targeted ablation of the GAD65 gene in Gad65(-/-) mice results in a pronounced context-independent, intramodal generalization of auditory fear memory during long-term (24 h or 14 d) but not short-term (30 min) memory retrieval. The temporal specificity of both gene regulation and memory deficits in Gad65 mutant mice suggests that GAD65-mediated GABA synthesis is critical for the consolidation of stimulus-specific fear memory. This function appears to involve a modulation of neural activity patterns in the amygdalo-hippocampal pathway as indicated by a reduction in theta frequency synchronization between the amygdala and hippocampus of Gad65(-/-) mice during the expression of generalized fear memory.     

Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome

Spatial working memory and the ability of a cholinesterase inhibitor to enhance memory were assessed at 4, 10, and 16 months of ages in control and Ts65Dn mice, a partial trisomy model of Down syndrome, with possibly significant relationships to Alzheimer's disease as well. In addition, ACh release during memory testing was measured in samples collected from the hippocampus using in vivo microdialysis at 4, 10, and 22-25 months of age. When tested on a four-arm spontaneous alternation task, the Ts65Dn mice exhibited impaired memory scores at both 4 and 10 months. At 16 months, control performance had declined toward that of the Ts65Dn mice and the difference in scores across genotypes was not significant. Physostigmine (50 microg/kg) fully reversed memory deficits in the Ts65Dn mice in the 4-month-old group but not in older mice. Ts65Dn and control mice exhibited comparable baseline levels of ACh release at all ages tested; these levels did not decline significantly across age in either genotype. ACh release increased significantly during alternation testing only in the young Ts65Dn and control mice. However, the increase in ACh release during alternation testing was significantly greater in control than Ts65Dn mice at this age. The controls exhibited a significant age-related decline in the testing-related increase in ACh release. With only a small increase during testing in young Ts65Dn mice, the age-related decline in responsiveness of ACh release to testing was not significant in these mice. Overall, these results suggest that diminished responsiveness of ACh release in the hippocampus to behavioral testing may contribute memory impairments in Ts65Dn mice.     

A dimensional analysis of claustrophobia

The present study investigated whether situational and cognitive dimensions of claustrophobia exist. To this end, the Claustrophobia Situations Questionnaire (CSQ) and the Claustrophobia General Cognitions Questionnaire (CGCQ) were developed and exploratory factor analyses were performed on these scales. Two-factor solutions for both the anxiety and the avoidance ratings on the CSQ were obtained, accounting for 40.1% and 34.2% of the variance, respectively. Two subscales were created from the two-factor solution of the anxiety section of the CSQ: (1) Fear of Entrapment and (2) Fear of Physical Confinement. Two subscales were also created from the two-factor solution of the avoidance section of the CSQ: (1) Avoidance of Crowds and (2) Avoidance of Physical Confinement. A three-factor solution was obtained for the CGCQ, accounting for 54.4% of the variance, from which the following three subscales were created: (1) Fear of Loss of Control, (2) Fear of Suffocation, and (3) Fear of Inability to Escape. Cronbach alphas for all subscales ranged from .84 to .94. Exploratory correlational analyses were conducted between the situational and the cognitive dimensions.     

Saccadic eye movements: what do they tell us about aging cognition?

Although the relationship between age-related cognitive decline and saccadic eye movement (SEM) deficits has been outlined, specific cognitive alterations underlying age-related changes in saccadic performance remain unclear. This study attempted to better understand the nature of aging effects on SEMs. We compared SEMs in younger and older adults in prosaccade (PS) and antisaccade (AS) tasks under gap, step, and overlap conditions. We also examined relationships between these performances and several neuropsychological scores. Twenty-eight younger adults (YA), 24 older adults under 65 years (OA_<65) and 24 over 65 years (OA_>65) of age completed a neuropsychological evaluation, PS and AS tasks. Our results showed that latencies, AS cost, time to correct AS errors, and uncorrected AS, increased with aging. YA showed higher overlap effects than OA_>65 and OA_<65. Importantly, correlations and regressions revealed close relationships not only between latencies and processing speed measures but also between the AS cost and the inhibition process measures. Correct saccades and the time to correct AS errors were closely related to the inhibition process and cognitive flexibility measures. These findings suggest that the progressive age-related decline of processing speed and executive attention are associated with, and can be highlighted though SEMs in PS and AS tasks.     

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 μM NMDA for 3 min and 50 μM DHPG for 5 min, respectively. We found that Ts65Dn mice display exaggerated NMDA-induced, but not mGluR-induced, LTD in the CA1 region of the hippocampus compared with euploid control animals. In addition, this abnormal level of LTD can be pharmacologically rescued by the NMDA receptor antagonist memantine.     

The politics of situating knowledge: An exercise in social epistemology

This essay forges links between Popperians and feminists by considering the connections between Donna Haraway's situated knowledge and Karl R. Popper's situational logic. It is concerned with the political commitments behind methodological issues, with the degree to which there can be a Popperian contribution to the feminist vision of a successor science, and with ways of dealing with, while not resolving, the political differences between socialist feminists and libertarian Popperians.     

Buyers Versus Sellers: How They Differ in Their Responses to Framed Outcomes

Consumers’ reactions to a difference in price can depend on how it is framed. If buyers interpret paying $60 rather than $65 as getting a $5 discount, then they are likely to consider paying $60 to be a gain and paying $65 to be a nongain. Alternatively, if they interpret having to pay $65 rather than $60 as incurring a $5 penalty, then they may consider paying $60 to be a nonloss and paying $65 to be a loss. Similarly, sellers can also experience gains, nongains, nonlosses, and losses. This article suggests that buyers are prevention focused and consequently place a greater emphasis on loss‐related frames, whereas sellers are promotion focused and place a greater emphasis on gain‐related frames. Therefore, for equivalent positive outcomes, buyers feel better about nonlosses, but sellers feel better about gains. For equivalent negative outcomes, buyers feel worse about losses, but sellers feel worse about nongains. These effects, however, disappear when there is little motivation to process information about the monetary transaction.     

ANOVA and ANCOVA of pre- and post-test,ordinal data

With random assignment to treatments and standard assumptions, either a one-way ANOVA of post-test scores or a two-way, repeated measures ANOVA of pre- and post-test scores provides a legitimate test of the equal treatment effect null hypothesis for latent variable . In an ANCOVA for pre- and post-test variablesX andY which are ordinal measures of and , respectively, random assignment and standard assumptions ensure the legitimacy of inferences about the equality of treatment effects on latent variable . Sample estimates of adjustedY treatment means are ordinal estimators of adjusted post-test means on latent variable .     

The Growing Use of Firearms by Suicidal Older Women, 1979–1992: A Research Note

Suicide among older women (65 +) has received very little attention despite increasing numbers of suicides in this population. An examination of national mortality data from the National Center for Health Statistics for the years 1979 through 1992 shows an increasing trend in rates of suicide among older women and a declining trend among women under 65. Over the 14-year period, firearms replaced poisoning as the most prevalent method of suicide by women 65 and over. The results seem consistent with the assertion that the availability, familiarity, and cultural acceptability of firearms may play a role in the choice of suicide method among older women. Although violent death and the use of firearms are generally associated with males in our society, the trends reported here indicate that greater attention to firearm suicides among older women is warranted.     

Differential regulation of glutamic acid decarboxylase gene expression after extinction of a recent memory vs. intermediate memory

Extinction reduces fear to stimuli that were once associated with an aversive event by no longer coupling the stimulus with the aversive event. Extinction learning is supported by a network comprising the amygdala, hippocampus, and prefrontal cortex. Previous studies implicate a critical role of GABA in extinction learning, specifically the GAD65 isoform of the GABA synthesizing enzyme glutamic acid decarboxylase (GAD). However, a detailed analysis of changes in gene expression of GAD in the subregions comprising the extinction network has not been undertaken. Here, we report changes in gene expression of the GAD65 and GAD67 isoforms of GAD, as measured by relative quantitative real-time RT-PCR, in subregions of the amygdala, hippocampus, and prefrontal cortex 24-26 h after extinction of a recent (1-d) or intermediate (14-d) fear memory. Our results show that extinction of a recent memory induces a down-regulation of Gad65 gene expression in the hippocampus (CA1, dentate gyrus) and an up-regulation of Gad67 gene expression in the infralimbic cortex. Extinguishing an intermediate memory increased Gad65 gene expression in the central amygdala. These results indicate a differential regulation of Gad gene expression after extinction of a recent memory vs. intermediate memory.     

Effects on responding of mixed and multiple schedules of signalled and unsignalled response-dependent electric-shock delivery

Responding in two rats was maintained under mixed and multiple variable-interval 35-sec variable-interval 35-sec food delivery schedules. Similar rates and patterns of responding occurred in each component of the two schedules. Mixed and multiple variable-interval 65-sec variable-interval 65-sec schedules of response-dependent shock delivery were super-imposed on the mixed and multiple baseline food schedules, respectively. In one component, a 5-sec stimulus was presented on the average of once every 65 sec. Offset of the stimulus arranged that the next response would produce shock. In the other component, no stimulus was presented during the 5-sec period. The mixed schedule of signalled and unsignalled dependent shock delivery yielded similar degrees of response suppression in each component, but the multiple schedule of shock delivery revealed differential degrees of response suppression. Considerably more suppression occurred in the component not associated with the preshock stimulus, thus implicating the discriminative functions of the correlated stimulus.     

Attributions of Responsibility for Memory Problems in Older and Younger Adults

This study investigated older and younger persons' responsibility attributions for the cause of and solution to a memory problem and, for comparison, a weight problem. Traditional college-age students (n = 116) and persons over 65 years of age (n = 98) read a vignette describing either a 25-year-old or 65-year-old who had a memory or weight problem. Results indicated that both the age of the help-seeker and problem type affected attributions. Specifically, the 65-year-old was perceived to be less responsible than the 25-year-old for the cause of and solution to a memory problem. In addition, help-seekers with a memory problem were held less responsible for causing and solving their problem than were help-seekers with a weight problem.     

Real Metaphysics

Book Information Real Metaphysics. Real Metaphysics Hallvard Lillehammer and Gonzalo Rodriguez-Pereyra, eds., London : Routledge, 2003, VIII + 248, £65 (cloth), £19.99 (paper) Edited by Hallvard Lillehammer; and Gonzalo Rodriguez-Pereyra. Routledge. London. Pp. VIII + 248. £65 (cloth:), £19.99 (paper:),     

Who Is I?

Whilst it may seem strange to ask to whom I refers, we show that there are occasionswhen it is not always obvious. In demonstratingthis we challenge Kaplan's assumptionthat the utterer, agent and referent of I arealways the same person.We begin by presenting what weregard to be the received view about indexicalreference popularized by David Kaplan in hisinfluential 1972 Demonstratives before goingon, in section 2, to discuss Sidelle'sanswering machine paradox which may be thoughtto threaten this view, and his deferredutterance method of resolving this puzzle. Insection 3 we introduce a novel version of theanswering machine paradox which suggests that,in certain cases, Kaplan's identification ofutterer, agent and referent of I breaks down.In the fourth section we go on to consider arecent revision of Kaplan's picture by Predelliwhich appeals to the intentions of the utterer,before arguing that this picture is committedto unacceptable consequences and, therefore,should be avoided if possible. Finally, insection 5, we present a new revision ofKaplan's account which retains much of thespirit of his original proposal whilst offeringa intuitively acceptable way to explain all ofthe apparently problematic data. In doing so,we also show how this picture is able toexplain the scenario which motivated Predelli'saccount without appealing to speakerintentions.     

The rise and decline of prospective memory performance across the lifespan

In the present study, the trajectory of prospective memory across the lifespan was investigated in a total of 200 participants from five age groups (4- to 6-year-old children, 13- to 14-year-old adolescents, 19- to 26-year-old adults, 55- to 65-year-old adults, and 65- to 75-year-old adults). In an event-based prospective memory task the prospective and the retrospective components were assessed separately. For the prospective component, the results showed better performance for adolescents and young adults than for children and 65- to 75-year-old adults. In addition, participants belonging to the latter group were more likely to forget the retrospective component after having noticed the prospective memory targets. Overall, these results indicate that across the lifespan prospective memory performance follows a similar inverted u-shape function as is well known for retrospective episodic memory.     

The rise and decline of prospective memory performance across the lifespan

In the present study, the trajectory of prospective memory across the lifespan was investigated in a total of 200 participants from five age groups (4- to 6-year-old children, 13- to 14-year-old adolescents, 19- to 26-year-old adults, 55- to 65-year-old adults, and 65- to 75-year-old adults). In an event-based prospective memory task the prospective and the retrospective components were assessed separately. For the prospective component, the results showed better performance for adolescents and young adults than for children and 65- to 75-year-old adults. In addition, participants belonging to the latter group were more likely to forget the retrospective component after having noticed the prospective memory targets. Overall, these results indicate that across the lifespan prospective memory performance follows a similar inverted u-shape function as is well known for retrospective episodic memory.