Language development after unilateral brain injury.

This longitudinal study describes the growth of syntactic abilities and vocabulary size in nine children with unilateral antepartum or perinatal brain injury. Five children with left hemisphere damage (LHD) and four with right hemisphere damage (RHD), ages 15 to 48 months, were evaluated on three or more occasions. Language samples generated from parent-child interaction were transcribed, coded, and analyzed using the Child Language Data Exchange System. Individual growth trajectories were constructed by graphing three dependent variables--MLU, scores on the Index of Productive Syntax (IPSYN), and number of different words--as a function of the child's age. One subject remained in a prelinguistic stage throughout the study. Simple linear functions best described the growth of MLU, IPSYN scores, and vocabulary in the other eight children. The slopes of the individual growth trajectories, the graphic representations of rates of progress, were comparable in the eight children. Seven children showed developmental delays in initial word use and five in the onset of multiword utterances. However, by age 24 months, four children with LHD and two children with RHD had syntactic capabilities comparable to those of children without brain injuries. The developmental patterns suggested that both cerebral hemispheres may play critical roles in the very earliest stages of language acquisition. Some unilateral lesions caused little discernible effect on language outcome in the toddler-preschool years after the initial developmental delays.     

Language experience changes subsequent learning

What are the effects of experience on subsequent learning? We explored the effects of language-specific word order knowledge on the acquisition of sequential conditional information. Korean and English adults were engaged in a sequence learning task involving three different sets of stimuli: auditory linguistic (nonsense syllables), visual non-linguistic (nonsense shapes), and auditory non-linguistic (pure tones). The forward and backward probabilities between adjacent elements generated two equally probable and orthogonal perceptual parses of the elements, such that any significant preference at test must be due to either general cognitive biases, or prior language-induced biases. We found that language modulated parsing preferences with the linguistic stimuli only. Intriguingly, these preferences are congruent with the dominant word order patterns of each language, as corroborated by corpus analyses, and are driven by probabilistic preferences. Furthermore, although the Korean individuals had received extensive formal explicit training in English and lived in an English-speaking environment, they exhibited statistical learning biases congruent with their native language. Our findings suggest that mechanisms of statistical sequential learning are implicated in language across the lifespan, and experience with language may affect cognitive processes and later learning.     

Language after hemispherectomy

We studied the spoken language of 49 children who had undergone hemispherectomy as part of the UCLA Pediatric Epilepsy Surgery Research Program and analyzed, among a number of clinical factors, the relation between acquired vs developmental pathology and spoken language outcomes. In this paper we will briefly review the results of our study and attempt to explain (1) why "the early" is not always better, (2) why so many right hemispherectomies fail to develop language, and (3) why some left hemispherectomized children develop remarkably good language despite removal of the "language" hemisphere. This account will rest on the proposed model of brain maturation and progressive lateralization.     

Language functioning after bilateral prefrontal leukotomy

Three groups of patients with orbital frontal lesions secondary to leukotomy were compared to psychiatric and normal control groups on a series of tasks involving language. The results indicated that chronic orbital frontal lesions, at least in the patients in this study, do not affect language as defined by the tasks used in the study. The frontal lobes, when implicated in language, appear to require dorsal-lateral or medial cortical involvement.     

巴别塔之前与之后——语言哲学中的语言-哲学关系

巴别塔之前与之后的人类语言状态的关系,可以称作单数的语言与各个具体的民族语言关系。如果语言与世界观之间存在一种内在的联系,甚至语言就是世界观,那么意识形态之差异的问题,最终可以归结为语言差异的问题,那么各个民族语言就应是决定一个民族的世界观,即民族的心智和文化特性的东西,而人类共同的语法结构就应体现出人类的共同世界观,即人类本性,它是决定人之为人的东西。但“世界观”在这里并不一定是指关于世界的思考内容,而首先并且主要是指关于世界的思考方式。     

Physiological changes after biofeedback and relaxation training for multiple-pain tension-headache patients

This paper is concerned with the psychophysiology of "muscle-contraction" headaches in a group of Compensation patients suffering from multiple pain problems in addition to headaches. A total of 55 of these patients were divided into 4 groups which received frontalis EMG biofeedback, relaxation training, combined biofeedback-relaxation training, or no treatment. Differences were observed among the 3 experimental treatments and the control group with respect to headache changes, but there were no differences among groups with respect to the changes observed in four underlying physiological responses as a function of time or practice. While the subjects who showed the largest changes in headache characteristics were those who exhibited the largest decreases in frontalis EMG, these were also the subjects whose initial frontalis EMG levels were the highest. It is concluded that, in keeping with a growing literature, the link between frontalis EMG and "muscle-contraction" headaches is a tenuous one and that the changes brought about in headache symptomatology through biofeedback or relaxation training are most likely attributable to a generalization of feelings of mastery over the environment or of self-efficacy brought about in the subjects through apparent success at the task.     

Spoken Language Outcomes after Hemispherectomy: Factoring in Etiology

We analyzed postsurgery linguistic outcomes of 43 hemispherectomy patients operated on at UCLA. We rated spoken language (Spoken Language Rank, SLR) on a scale from 0 (no language) to 6 (mature grammar) and examined the effects of side of resection/damage, age at surgery/seizure onset, seizure control postsurgery, and etiology on language development. Etiology was defined as developmental (cortical dysplasia and prenatal stroke) and acquired pathology (Rasmussen's encephalitis and postnatal stroke). We found that clinical variables were predictive of language outcomes only when they were considered within distinct etiology groups. Specifically, children with developmental etiologies had lower SLRs than those with acquired pathologies (p =.0006); age factors correlated positively with higher SLRs only for children with acquired etiologies (p =.0006); right-sided resections led to higher SLRs only for the acquired group (p =.0008); and postsurgery seizure control correlated positively with SLR only for those with developmental etiologies (p =.0047). We argue that the variables considered are not independent predictors of spoken language outcome posthemispherectomy but should be viewed instead as characteristics of etiology.     

Attention,Memory, and Language after Pediatric Ischemic Stroke

A previous study evaluating receptive language after unilateral brain damage in childhood hypothesized lateralized attention and memory deficits without direct measurement. Our study directly measured attention, memory, and language in order to evaluate empirically the severity and laterality of sequelae. The performances of 11 individuals with a unilateral ischemic-lesion (7 right and 4 left hemisphere) were compared to controls matched on age, sex, and socioeconomic status. Results suggest subtle but persistent deficits in verbal memory, functional memory, and speed of processing after a lesion to either hemisphere. Lesions sustained before two years of age were associated with the lowest IQ scores. Our findings provide support for a configural representation of language that can to some extent compensate for inefficient or damaged components (Bates, 1994), and the middle-ground lateralization position (Thal et al., 1991) that asserts initial hemispheric specialization with the potential for reorganization.     

双语者语言转换中非目标语言的加工机制

语言转换是指双语者由所掌握的一种语言转换到另一种语言的现象, 这一现象近些年来引起了研究者的广泛关注。针对语言转换中双语者在从心理词典中顺利提取所需要的语言(称之为目标语言)时如何加工在当前任务中不使用的那种语言(称之为非目标语言), 研究者进行了大量研究。仔细分析这些研究, 可以看出这些研究主要围绕着3个核心问题: (1)语言转换中双语者使用目标语言时非目标语言是否激活; (2)若非目标语言激活, 这种激活发生在何种层面(概念层面还是词汇层面); (3)激活的非目标语言会对目标语言产生什么样的影响。以此为基础, 本文从语言产生转换和语言理解转换两大领域对相关研究进行了总结和梳理, 最后对未来的语言转换研究进行了展望。     

Language supports for children's understanding of numerical fractions: cross-national comparisons.

This study examined Croatian, Korean, and U.S. children's knowledge of numerical fractions prior to school instruction. The research is part of an ongoing project examining the influence of language characteristics on mathematical thinking and performance. The part-whole quantitative relation denoted by numerical fractions may be easier to understand in East Asian languages like Korean. In these languages, the concept of fractional parts is embedded in the mathematics terms used for fractions. The results from this study suggest that the Korean vocabulary of fractions may influence the meaning 6- to 7-year-old children ascribe to numerical fractions and that this results in children being able to associate numerical fractions with corresponding pictorial representations prior to formal instruction.     

Spatial localization in children after changes in position

Five experiments investigated the young child's ability to retrieve a target after a change in the position of the child or the target. In Experiments I–IV 2- to 4-year-old children were rotated 90, 180, 270, or 360° about a stationary square table containing four identical hiding locations at each of the cardinal locations. The children tested performed this task significantly better than chance, but their errors reflected either their response biases in the absence of any information as to the location of the target, or the repetition of a response which had been successful in retrieving the target prior to the change in position. When the children were forced to respond rapidly, these errors increased significantly. In Experiment V a table top was rotated 90, 180, 270, or 360° in front of 3- to 10-year-old children. There were two cue situations. The child saw the rotation, or the child had to infer the rotation. Young children made errors of the types observed in Experiments I–IV. The ability to inhibit these errors increased with age. By 7 years of age performance was virtually perfect when the child could observe the change in position of the hidden object. The ability to infer the positional change developed more slowly and was good but not perfect at 10 years of age.     

Language after temporal or frontal lobe surgery in children with epilepsy

The purpose of this study was to compare language function in children undergoing temporal or frontal lobe surgery to control intractable epilepsy. Language measures (expressive vocabulary, receptive vocabulary, comprehension, reading, spelling, phonemic fluency, and category fluency) were administered to 9 children with frontal lobe epilepsy (mean age: 10.8 +/- 2.7 years) and 10 children with temporal lobe epilepsy (11.5 +/- 2.6 years). The results indicate that no differences exist, in language function, before and after surgery between children with frontal and temporal lobe epilepsy (all p > or = .05). Children with left hemisphere lesions had significantly lower scores than those with right on category fluency and comprehension, but laterality effects were not seen on the other measures. In both groups, language function was not significantly affected by surgery.     

Developmental changes in the linguistic brain after puberty

The development of reading skills is a complex and very long-lasting process. In an influential study Booth et al. demonstrated age-related changes in the activation of a network of left hemisphere regions, including the inferior frontal area, the superior temporal gyrus, and the angular gyrus. Interestingly, they found that the angular gyrus, which is involved in the mapping between phonological and orthographic representation, is automatically activated in adults during visual orthographic tasks not requiring this operation.     

A method for analyzing changes in response efficiency.

Although experimental effects typically are evaluated by summarizing levels of responding across time (e.g., calculating the mean levels of problem behavior during 10‐min sessions), these data summaries may obscure important mechanisms that may be responsible for changes in responding. A case study is reported to illustrate alternative methods of data analysis when decreasing trends in responding may be due to increases in response efficiency.     

Historical changes in cigarette smoking and smoking-related beliefs after 2 decades in a midwestern community.

Rates of cigarette smoking and smoking-related beliefs in 1980 and 2001 among 7th-11th graders in a midwestern community were compared. Smoking was less prevalent in 2001 than in 1980, with the greatest declines in experimental smoking and a smaller drop in regular smoking. Beliefs about smoking generally became more negative. Adolescents (particularly nonsmokers) viewed smoking as more addictive and as having more negative social consequences in 2001 than in 1980 and had more negative attitudes toward smoking in 2001. These results were replicated among parent-child pairs in which parents were measured when they were adolescents between 1980 and 1983 and their children were measured in 2001. These beliefs and attitudes partially mediated the effects of time on smoking.     

Brain Organization of Language after Early Unilateral Lesion: A PET Study

Neuropsychological studies suggest that good long-term language outcome is possible following extensive early left-hemisphere damage. We explored the brain organization for language in children with early unilateral lesion, using [¹⁵O]-water PET. In 12 patients with left lesion (LL) and 9 patients with right lesion (RL), cerebral blood flow changes during listening to sentences and repetition were studied. A rightward shift of language activations in the LL group was found in perisylvian areas and multiple other, mostly temporo-parietal, regions. The hypothesis of intrahemispheric reorganization in the LL group found only limited support. The number of activated regions was overall greater in the RL group. Unexpected findings included a stronger subcortical and cerebellar language involvement in the RL group. We suggest that (a) early left lesion is associated with enhanced language participation of the right hemisphere in and beyond the classical language areas, and (b) postlesional effects are in part additive (recruitment of noncanonical areas), in part subtractive (functional depression in areas normally involved in language).