PTEN、p53和BAG-1在三阴乳腺癌中的表达及意义

为了研究PTEN、p53和BAG-1在三阴乳腺癌中的表达情况及临床病理意义,并讨论三者之间的关系.采用免疫组织化学SP法检测89例三阴乳腺癌中PTEN、p53、BAG-1的表达,其阳性表达率分别为44.9％、47.2％、73.0％,三者的表达均与患者的病理组织学分级、淋巴结转移情况有关(P＜0.05).PTEN的表达与p53、BAG-1表达呈负相关;BAG-1与p53的表达呈正相关,提示三者在三阴乳腺癌中的表达存在一定关联性,临床上联合检测三者可能为TNBC预后评估、患者的个体化治疗提供一定的参考.     

血尿酸水平与脑梗死及其各指标的相关性分析

研究血尿酸(UA)与脑梗死发病与预后的相关性.本试验选择2008年5月至2009年3月中国医科大学附属一院神经内科就诊的脑梗死患者为病例组,同期中国医科大学附属一院门诊体检者70例为对照组,均进行血尿酸(SUA)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、空腹血糖(FBG)、纤维蛋白原(Fg)及C反应蛋白(hs-CRP)及血压的测定.比较病例组与对照组的相关指标的变化,并比较高尿酸与非高尿酸组的梗死例数与严重程度、生化指标等的变化.脑梗死组SUA水平明显高于对照组(P＜0.05);HUA组的患病率也显著高于非HUA组(P＜0.05);大梗死灶组UA值高于小梗死灶组(P＜0.05),中梗死灶组UA值高于小梗死灶组(P＜0.05).重度损伤组UA值大于轻度组(P＜0.05);中度损伤组UA值大于轻度组(P＜0.05).HUA组的SBP、DBP、TC、TG、LDL-C、FBG及hs-CRP各值高于非HUA组,HDL-CD低于非HUA,差异有统计学意义(P＜0.05).     

血清CCL11水平对结肠癌患者预后的影响

探讨CC修饰趋化因子11(CCL11)在结肠癌(CRC)患者血清中的表达情况及临床意义。分别采用qRT-PCR和ELISA法检测100例术前CRC及30例健康志愿者血清样本中CCL11mRNA及蛋白的表达,分析血清CCL11蛋白表达与患者临床特征及预后间的相关性。CCL11在CRC患者血清中高表达(P0.05),并与肿瘤淋巴结转移及高TNM分期呈显著正相关(P0.05);血清CCL11蛋白高表达的患者3年生存率低于CCL11蛋白表达阴性患者(P0.05)。CCL11在CRC患者血清中表达上调,血清高水平CCL11蛋白表达与肿瘤恶性临床病理特征及不良预后有关。     

PTEN、p53和BAG-1在三阴乳腺癌中的表达及意义

为了研究PTEN、p53和BAG-1在三阴乳腺癌中的表达情况及临床病理意义,并讨论三者之间的关系.采用免疫组织化学SP法检测89例三阴乳腺癌中PTEN、p53、BAG-1的表达,其阳性表达率分别为44.9％、47.2％、73.0％,三者的表达均与患者的病理组织学分级、淋巴结转移情况有关（P＜0.05）.PTEN的表达与p53、BAG-1表达呈负相关;BAG-1与p53的表达呈正相关,提示三者在三阴乳腺癌中的表达存在一定关联性,临床上联合检测三者可能为TNBC预后评估、患者的个体化治疗提供一定的参考.     

乳腺微乳头状癌的临床病理特征分析

回顾性分析乳腺浸润性微乳头状癌(IMPC)的临床病理特征.选取河北医科大学第四医院乳腺中心手术切除并经病理证实的女性原发性乳腺癌共3 383例,筛选出符合IMPC为实验组,同期乳腺浸润性导管癌(IDC)为对照组.结果显示,本组IMPC 167例,占同期乳腺癌4.94％,年龄29岁～80岁,中位年龄54岁.淋巴结转移者共135例,占80.8％,淋巴结转移数目≥4个共105例,占62.9％,HER2阳性率58.7％,与IDC组相比差异均有统计学意义(P＜0.05).IMPC为一种少见类型的浸润性乳腺癌,具有淋巴管侵袭性强、淋巴结转移率高的生物学行为.应与其他类型肿瘤进行鉴别,明确诊断.     

妊娠相关血浆蛋白A对短暂性脑缺血发作预后的预测价值

探讨妊娠相关血浆蛋白A(PAPP-A)对短暂性脑缺血发作(TIA)预后的预测价值.检测88例TIA患者血清PAPP-A水平,出院半年随访动脉硬化性血栓事件的发生情况.结果TIA患者PAPP-A浓度为4.75(1.67～7.13)mIU/L.预后不良组PAPP-A浓度高于预后良好组(5.31mIU/L vs.2.61mIU/L,P＜0.05),PAPP-A浓度为TIA预后独立危险因素,OR值为3.88(P＜0.05).因此,血清PAPP-A浓度对TIA患者预后有预测作用.     

脑钠肽和内皮素在慢性阻塞性肺疾病的应用研究

探讨脑钠肽、内皮素测定在慢性阻塞性肺疾病(COPD)患者肺动脉高压、病情严重程度及近期预后评估的意义.观察60例COPD急性加重期患者,60例经治疗转为稳定期的患者,以30例健康者作对照.COPD急性加重期患者根据肺动脉压力分为肺动脉高压组(A组)30例、肺动脉压力正常组(B组)30例,根据病情分为轻度组21例、中度组23例、重度组16例.用免疫分析法测定血浆脑钠肽、内皮素浓度.结果COPD急性加重期组脑钠肽、内皮素浓度明显升高,稳定期组明显下降(P＜0.001),但仍高于健康对照组(P＜0.001);A组明显高于B组(P＜0.05);重度组高于中度组(P＜0.05),中度组高于轻度组(P＜0.05).说明脑钠肽、内皮素浓度可反映COPD患者肺动脉压力情况及病情严重程度,有利于其疗效及近期预后评估.     

食管鳞癌患者高血小板血症与预后关系分析

探讨食管鳞癌患者高血小板血症与临床病理特征及预后的关系,回顾性分析340例食管鳞癌患者术前血小板计数,结果显示高血小板血症与肿瘤长度、分化程度、肿瘤分期及淋巴转移密切相关(P<0.05),而与性别、年龄及肿瘤位置无关(P>0.05);高血小板血症者的生存率明显低于血小板计数正常者(P<0.001);并且高血小板血症是影响食管鳞癌患者预后的独立因素.因此高血小板血症与食管鳞癌的进展及不良预后有关.     

HMGA1及MMP2在非小细胞肺癌中的表达、临床意义

采用免疫组织化学方法检测高迁移率族蛋白1(HMGA 1)及基质金属蛋白酶2(MMP2)在非小细胞肺癌(NSCLC)中的表达.结果显示在NSCLC中HMGA1及MM P2的阳性表达率(57.1％、63.5％)显著高于正常肺组织,其阳性表达与性别、年龄无关(P＞0.05),与肺癌分化程度、TNM分期和有无淋巴结转移密切相关(P＜0 05).因此临床上,联合检测HMGA 1及MM P2蛋白对NSCLC的诊断及判断其预后可能具有一定的参考价值.     

血清HBsAg阳性肾小球肾炎的临床与病理分析

分析血清HBsAg阳性肾炎患者发生乙型肝炎病毒相关性肾炎(HBV-GN)的相关因素。根据肾组织中是否检测到HBsAg和/或HBcAg将研究对象分为两组:HBV-GN组(30例)和乙型肝炎病毒合并肾炎(HBV-CG)组(26例),分析两组之间临床资料及病理特点。HBV-GN患者血清HBeAg的阳性率明显高于HBV-CG组(P0.05),且HBV-GN组表现为大三阳[HBsAg(+)HBeAg(+)HBcAb(+)]的病例数明显多于HBV-CG组(21例vs.10例,P0.05);HBV-GN组肾脏病理表现为微小病变肾病的病例数显著低于HBV-CG组(1例vs.7例,P0.05)。HBV感染及病毒高复制状态与HBV-GN密切相关。     

Seeing and hearing and space and space and time

A previous experiment had shown spatial location to be judged in terms of the framework provided by the modality in which stimuli were presented. In the present study, digits were either auditorally or visually presented, and in either form the three digits appeared successivly to the left, in the center, and to the right of the S. The digit which occurred temporally in the middle of the sequence was never central from the spatial viewpoint. The S was asked to indicate which digit was the middle one. Ss were blind, deaf, or normal. The deaf and two control groups saw visual displays, and the blind and their controls heard auditory displays. The former groups predominantly chose the spatially middle digit and the latter groups the temporally middle. It was concluded that modality of presentation was the trigger which switched in the coding dimension of time or space.     

Law and Gospel,and Youth and Family Ministry

Abstract : If “faith comes through hearing” the word of God comprised in law and gospel, how do the imperatives that characterize ‘Youth and Family Ministry’ make such hearing possible? Here, literature delineating ‘Youth and Family Ministry’ is analyzed in light of its biblical foundations. The primary lens implemented in this analysis is the law/gospel hermeneutic advocated by Martin Luther and other reformers.     

Extremes of self-esteem and narcissism and the experience and expression of anger and aggression

This study examined the level of self-esteem and narcissism as personality variables involved in the disposition to experience and express anger. Three hundred thirty-eight subjects were sampled across two higher education centres and one student teaching programme in the United Kingdom. It was reasoned that individuals with both high self-esteem and narcissism would report especially high tendencies to experience and express anger and aggression and that those with high self-esteem and low narcissism would report the lowest. These predictions were influenced by theories that emphasise the role of threats to high self-esteem in the production of aggression and violence. Results indicate that groups defined by their extreme scores on self-esteem and narcissism scales produced levels of anger expression in the predicted direction. The importance of considering extreme levels of self-esteem and narcissism (in conjunction with other factors) in an analysis of anger is discussed with reference to currently influential theories in the field. Aggr. Behav. 24:421–438, 1998. © 1998 Wiley-Liss, Inc.     

Bob and Carol and Tess and Ali

Conflicting religious experiences in different traditions do not necessarily defeat the rationality of conflicting beliefs sustained by those experiences in those traditions. The circularity that protects religious beliefs from such mutual defeat is not vicious. Moreover, the lack of ‘epistemological humility’ exhibited by such believers poses no threat to world peace. In fact, a campaign for compulsory humility would itself constitute a much greater threat.     

Yin and Yang,and the Hot and the Cold

Yin and Yang are important concepts in ancient Chinese philosophy.Western scholars have become more familiar with these two concepts recently,but for a long time almost no one considered comparing them with their own tradition such as the ancient Greek philosophy,and especially with the ideas of the Hot and the Cold in Presocratic philosophy.In this paper,I make an attempt to do exactly that,and especially make a detailed comparison between the thoughts of two ancient thinkers:Laozi and Anaximander.I discuss the thought of Yin and Yang in Laozi-who was the earliest philosopher making use of the concepts Yin and Yang-to express his cosmological thought in ancient Chinese philosophy.Comparatively,I discuss the ideas of the Hot and the Cold in Anaximander,the earlier among Presocratic philosophers referring to the Hot and the Cold as fundamental concepts used to establish his cosmological system.Through this comparison,I indicate that the similarity between ancient Chinese and Western traditions is far more significant than what people are used to imagining.     

Perversion and infancy and adolescence

Abstract

Studying the works of Freud and Lacan, the authors carried out research on perversion in childhood. Their work covered the perverse polymorphism of infantile sexuality and the perception of the anatomic difference between the sexes that leads the child to create sexual theories and fantasies. The phallic mother and the fetish are viewed as imaginary solutions directly related to the Oedipus and castration complexes. In perversion, a particular position is taken in relation to the Oedipus complex: a serious flaw occurs in the symbolization of the law, and the mechanisms of denial and disavowal take form. Sexuality requires a second “logical time,” separated from infancy by the latency period, in order to confirm (in action) that a fixed position of jouissance (enjoyment) has actually been established. This can only happen in a period after adolescent enhancement. The distinction between perverse traces and a perverse structure is made, taking into account the fact that, in the case of child analysis, the analyst should free the child from the family fantasy and help him/her to build his/her own fantasy.

Campos Santoro V. et al. Perversion und Kindheit und Adoleszenz.

Im Studium der Arbeiten von Freud und Lacan haben die Autoren Forschung über Perversion in der Kindheit gemacht. Die Studien behandeln den perversen Polymorphismus der infantilen Sexualität und die Wahrnehmung des anatomischen Unterschiedes zwischen den Geschlechtern, welche das Kind dazu führt, Sexual-Theorien und Phatasien zu schaffen.

Die phallische Mutter und der Fetisch werden als imaginäre Lösungen angesehen, die sich direkt auf den Ödipus- und Kastrations-Komplex beziehen. Bei der Perversion wird eine besondere Position in Bezug auf den Ödipus angenommen; ein ernsthafter Mangel tritt bei der Symbolisierung des Rechts auf; die Mechanismen der Verneinung und der Verleugnung bilden sich. Sexualität erfordert eine zweite “logische Zeit”, von der Kindheit durch die Latenz Periode getrennt, um (in der Handlung) zu bestätigen, daß eine fixierte Position der jouissance (Vergnügung) sich tatsächlich etabliert hat. Das kann sich nur in einer Periode nach der adoleszenten Verstärkung ereignen.

Es wird die Unterscheidung zwischen perversen Spuren und einer perversen Struktur gemacht, in Rechnung stellend, daß im Fall der Kinder-Analyse der Analytiker das Kind von der Familien-Phantasie befreien sollte und ihm/ihr helfen sollte, seine/ihre Phantasie auszubilden.

Campos Santoro V. Perversión e infancia y adolescencia.

Estudiando los trabajos de Freud y Lacan, los autores han investigado la perversión en la niñez. Los estudios cubren la sexualidad infantil perversa polimorfa y la percepción de la diferencia anatómica entre los sexos, que llevan al niño a crear teorías sexuales y fantasías.

La madre fálica y el fetiche son vistos como soluciones imaginarias relacionadas directamente con el complejo de Edipo y de castración. La perversión, toma una posición particular en relación al Edipo; un fallo importante tiene lugar en la simbolización de la ley; los mecanismos de negación y repudio toman forma. La sexualidad requiere un segundo “tiempo lógico” separado de la infancia por el periodo de latencia, para confirmar (en acto) que una posición fija de jouissance (goce) se ha establecido. Esto solo puede ocurrir en un periodo posterior a la intensificación adolescente.

La distinción entre las huellas perversas y la estructura perversa se ha hecho, teniendo en cuenta que, en el caso del análisis de niños, el analista debe librar al niño de la fantasía familiar y ayudar a el/ella a construir su propia fantasía.     

Human Dignity and the Ethics and Aesthetics of Pain and Suffering

Inasmuch as unmitigated pain and suffering areoften thought to rob human beings of theirdignity, physicians and other care providersincur a special duty to relieve pain andsuffering when they encounter it. When pain andsuffering cannot be controlled it is sometimesthought that human dignity is compromised.Death, it is sometimes argued, would bepreferred to a life without dignity.Reasoning such as this trades on certainpreconceptions of the nature of pain andsuffering, and of their relationships todignity. The purpose of this paper is to laybare these preconceptions. The duties torelieve pain and suffering are clearly mattersof moral obligation, as is the duty to respondappropriately to the dignity of other persons.However, it is argued that our understanding ofthe phenomena of pain and suffering and theirrelationships to human dignity will be expandedwhen we explore the aesthetic dimensions ofthese various concepts. On the view presentedhere the life worth living is both morally goodand aesthetically beautiful. Appropriate``suffering with' another can help to maintainand restore the dignity of the relationshipsinvolved, even as it preserves and enhances thedignity of patient and caregiver alike.     

Lmx and Job Tension: Linear and Non-Linear Effects and Affectivity

We examined whether linear or non-linear LMX–job tension relationships existed, and if these effects were consistent across levels of negative (NA) and positive (PA) affect. Results indicated that NA and PA moderated the non-linear LMX–job tension relationship. Specifically, the LMX–job tension association was best depicted by an inverted-U form for high NAs. Tension was highest when LMX was moderate and lowest when LMX was either low or high. Tension increased minimally for low NAs across levels of LMX. For high PAs, the relationship was linear and inverse. Conversely, a U-shaped form best represented the LMX–job tension relationship for low PAs. Implications, strengths and limitations, and directions for future research are discussed.     

Religiosity and Secular and Ascetic Deviance

According to the antiascetic hypothesis, religiosity should be strongly related to behaviors that violate ascetic standards (getting drunk and using marijuana), but only weakly related to behaviors that violate social standards (violence and stealing). Using the second wave of the National Study of Youth and Religion, I tested the antiascetic hypothesis using a question about the most important basis for deciding what is morally right or wrong. Contrary to the antiascetic hypothesis, individuals who believe that God's law is the most important for deciding what is morally right or wrong, compared to those who believe that society is the most important, are not less likely to get drunk or use marijuana. Furthermore, for getting drunk and marijuana use, differences in behavior are not the result of different ethical standards (ascetic or social), but rather differences in the willingness to uphold those standards (is it OK to break moral rules).