Neuroendocrine mechanisms involved in the physiological effects caused by skin-to-skin contact – With a particular focus on the oxytocinergic system

The positive clinical effects caused by skin-to-skin contact immediately after birth or after repeated skin-to-skin contact of premature infants (kangaroo care) or fullterm infants are well documented in the literature. However, information regarding the physiological mechanisms mediating these effects are surprisingly scarce and incomplete. In this article the oxytocinergic system and the cutaneous sensory pathways by which the oxytocinergic system is activated in response to skin-to-skin contact are presented in more detail. In addition, we discuss how the effects of skin-to-skin treatment can be attributed to different aspects of the effect spectrum of the oxytocinergic or calm and connection system.The structure of the oxytocinergic system, comprising the peripheral (circulating, hormonal) and the central (neurotransmitter) components, as well as, the pathways and mechanisms by which these functions are coordinated are described. Also the various effects induced by the oxytocinergic system (the calm and connection system) are reviewed.The sensory pathways, which include visual, auditory, olfactory and tactile stimuli, given and received by both mother and newborn and which activate the oxytocinergic system in response to skin-to-skin contact, are reviewed. A special emphasis is placed on the role of cutaneous sensory nerves and their activation by touch, light pressure and in particular warmth. The important role of the rise and the pulsatility of maternal temperature in mediating the positive effects of skin-to-skin contact in the newborn is highlighted. The concept of maternal giving of warmth and its possible link to the experience of trust and safety in the newborn is discussed from an evolutionary perspective.The effects induced by skin-to-skin contact can be attributed to the different functions of the oxytocinergic system. Ameliorated social interaction (e.g., more tactile and auditory interaction, more sensitive and synchronous interaction between mother and baby, the baby’s crawling behavior) are expressions of oxytocin’s ability to stimulate social interaction. The decreased levels of fear and stress are expressions of oxytocin’s ability to reduce the activity of the amygdala and of the stress system, e.g. the activity in the HPA-axis and the sympathetic nervous system. Increased HRV, increased activity in endocrine system of the gastrointestinal tract as well as stimulation of growth and maturation are examples of oxytocin’s ability to stimulate the activity of the parasympathetic nervous system and other peripheral and central mechanisms related to restoration and growth.The propensity of different types of treatment with skin-to-skin contact to induce long-term effects is also highlighted. We propose that the sustained effects caused by skin-to-skin contact are induced by an enduring shift in the balance between the oxytocinergic system (the calm and connection system) and the stress system (fight flight reaction) in favor of the oxytocinergic system. This shift leads to a sustained decrease in the HPA-axis and the sympathetic nervous system probably involving alpha 2-adrenoceptors.It is of clinical importance to be aware of the mechanisms by which skin-to-skin contact induces short and longterm positive effects in parents and newborns. If ward routines are adapted to ascertain a maximal stimulation of these mechanisms, the function of the oxytocinergic system will be optimized, which will be linked to a better clinical outcome for parents and newborns.     

Neural and Pavlovian influences on immunity

The traditional view that the nervous and immune systems are functionally independent (aside from general stress effects and autoimmune disorders of the nervous system) is being challenged by a new view that the nervous system regulates the activity of the immune system. If this is true, it should be possible to change the activity of the immune system by means of Pavlovian conditioning, just as it is possible to condition other physiological events influenced by the autonomic nervous system or neuroendocrine substances. Evidence for autonomic and neuroendocrine modulation of immune activity is briefly reviewed; and, the various studies reporting conditioned immune effects, the physiological mechanisms most likely involved, and their possible significance are discussed.     

Instrumentation designed to simulate the effects of prisms used in studies of visual rearrangement

A system is described which simulates some of the visual rearrangements and changes in sensorimotor relations that occur when experimental subjects move their eyes while looking through a contact lens with a prism attached. The simulated system is more convenient than a system based on the use of a contact lens, and it is based on measures of eye movement that are important in research on the perceptual effects of visual rearrangement. The effects that occur are reviewed in this paper. We also show in detail how the artificial system, which has an eye movement monitor interfaced with a computer and display, simulates the former effects. The data show that experimental subjects who experience visual rearrangement by simulated means manifest the same kind of perceptual adaptation produced in studies in which visual rearrangement is generated by means of a prism mounted on a contact lens.     

Order effects in sequential measurements of non-commuting psychological observables

Sequential measurements of non-commuting observables produce order effects that are well-known in quantum physics. But their conceptual basis, a significant measurement interaction, is relevant for far more general situations. We argue that non-commutativity is ubiquitous in psychology where almost every interaction with a mental system changes that system in an uncontrollable fashion. Psychological order effects for sequential measurements are therefore to be expected as a rule. In this paper we focus on the theoretical basis of such effects. We classify several families of order effects theoretically, relate them to psychological observations, and predict effects yet to be discovered empirically. We assess the complexity, related to the predictive power, of particular (Hilbert space) models of order effects and discuss possible limitations of such models.     

Effect of system-related work interruptions in computer-assisted text processing: a field study]

To validate laboratory research findings on the stress inducing effects of system response time in human-computer interaction, a field study was performed at the central typing office of a bank. Simultaneous subject-oriented and object-oriented measures (questionnaires) of working properties were taken with a relatively high sampling rate over several days in addition to the ordinary business activities. In summary, the negative effects of system response times could also be observed in the real work setting, but were modified by subjective and situational factors which had not been considered in laboratory research yet. The users also avoided situations of temporal uncertainty by adapting their working style to the system. Therefore it is concluded, that the effects of system response time should be interpreted by the concept of user acceptance and not by temporal uncertainty.     

恶性肿瘤皮肤表现

恶性肿瘤皮肤表现可分为肿瘤直接效应与间接效应。直接效应是指恶性肿瘤或其转移灶生长影响周围器官或组织正常功能;间接效应是指恶性肿瘤或其转移灶经复杂生物学效应影响远处器官或组织正常功能,也称为副肿瘤性皮肤病。恶性肿瘤皮肤表现发病率根据原发肿瘤而束同,可能是患者潜在肿瘤首发临床表现,并且与肿瘤复发转移相关。     

Varieties of relaxation methods and their unique effects

This paper reviews literature on specific effects of various relaxation methods, and of differences between varieties of two widely-used (and widely modified) methods: progressive relaxation and autogenic training. There is considerable evidence for modality-specific effects. Muscularly-oriented methods have the greatest effects on the musculoskeletal system, autonomically-oriented methods on the autonomic nervous system, etc. Modified methods of Jacobson's progressive relaxation technique have a greater cognitive and less muscular focus than Jacobson's original method, and Norris and Fahrion's autogenic feedback training de-emphasizes hypnotic components of autogenic training compared with Schultz and Luthe's original method. Hypotheses are presented regarding differential effects of these modifications on clinical outcome, on their appeal and usefulness to individuals with various personality profiles, and on possible negative side effects.     

New systems: new behaviour?

Traditional methods of speed reduction such as traffic calming and enforcement tend to have only local effects. A global speed reducing measure, Intelligent Speed Adaptation (ISA) which restricts drivers to the posted speed limit is being considered as an alternative. This paper reports a driving simulator study that evaluated the effects of such a system on driver behaviour. Measures of safety were taken when drivers drove with and without an ISA system, in addition to subjective measures of workload and acceptability. A number of changes in behaviour were noted, whereby drivers were more inclined to engage in riskier behaviour when the ISA system was operational. These changes were accompanied by reductions in maximum speeds, particularly in low speed limit areas and at speed limit transition points. It is suggested that the combinatory effects of these changes in behaviour have to be considered within the context of total network safety.     

The behavioral immune system: Current concerns and future directions

The behavioral immune system is a motivational system that helps minimize infection risk by changing cognition, affect, and behavior in ways that promote pathogen avoidance. In the current paper, we review foundational concepts of the behavioral immune system and provide a brief summary of recent social psychological research on this topic. Next, we highlight current conceptual and empirical limitations of this work and delineate important questions that have the potential to drive major advances in the field. These questions include predicting the ontological development of the behavioral immune system, specifying the relationship between this system and the physiological immune system, and distinguishing conditions that elicit direct effects of situational pathogen threats versus effects that occur only in interaction with dispositional disease concerns. This discussion highlights significant challenges and underexplored topics to be addressed by the next generation of behavioral immune system research.     

Neurobiology of prenatal cocaine exposure effect on developing monoamine systems

Cocaine and crack belong to a broad category of agents that act primarily as central nervous system stimulants at the level of the monoaminergic neurotransmitter system (dopamine, norepinephrine, and serotonin). These neurotransmitters are involved in the regulation of a number of basic psychological functions including attention and arousal and play a crucial role in the defining of brain structure and neuronal formation. This paper outlines what is currently known about the direct effects of cocaine on the mature and developing central nervous system. Three general points are reviewed: (1) Cocaine has differing effects on structural and functional brain development throughout gestation (e.g., there is not a single, all or none effect); (2) No one area of the brain is singularly affected. Areas related by the monoaminergic system are differentially influenced and affecting one area may result in a functional change in another; and (3) Because substantial brain growth, synaptic formation, and remodeling occur in the first months after birth, ongoing postnatal exposure to cocaine also carries risk for direct effects on brain function. Understanding the developmental neurobiological effects of cocaine provides data to guide studies in infants and young children of how prenatal cocaine exposure may contribute to specific, biologically based areas of neurological vulnerability that will be expressed behaviorally and developmentally in the first 3 to 5 years of life.     

Psychoneuroimmunology

Psychoneuroimmunology is the study of the relationships among behavioral, neural and endocrine, and immune processes. Bidirectional pathways connect the brain and the immune system and provide the foundation for neural, endocrine, and behavioral effects on immunity. Examples of such effects are conditioned and stress-induced changes in immune function and in susceptibility to immunologically mediated diseases. These data indicate that researchers should no longer study the immune system as if it functioned independently of other systems in the body. Changes in immune function are hypothesized to mediate the effects of psychological factors on the development of some diseases, and research strategies for studying the clinical significance of behaviorally induced changes in immune function are suggested.     

Contrast adaptation implies two spatiotemporal channels but three adapting processes

The contrast gain control model of adaptation predicts that the effects of contrast adaptation correlate with contrast sensitivity. This article reports that the effects of high contrast spatiotemporal adaptors are maximum when adapting around 19 Hz, which is a factor of two or more greater than the peak in contrast sensitivity. To explain the discrepancy, the predictions made by parallel versus cascaded models of spatiotemporal processing are compared. It is demonstrated that a parallel two-temporal channel model, in which the adaptive attenuation of a channel is proportional to its response, cannot explain the effects of adaptation on threshold contrast but that a cascaded model can. The cascaded model suggests that the visual system temporally encodes spatiotemporal signals via an adaptive transient encoding process that lies in cascade with an adaptable two-temporal channel system of sustained versus transient processes.     

抑郁和焦虑与心血管疾病

抑郁焦虑与心血管疾病的关系最能体现身与心两者相互影响、不可分割的特点。但临床上,心血管疾病患者抑郁焦虑的诊疗率不足1％。这说明现有的诊疗理念和方式没有将心血管疾病和精神障碍联系起来,给患者全面全程的干预和管理。这样的缺陷不仅增加患者的痛苦和功能障碍,也增加心血管疾病的发病率和病死率,还增加患者及社会的医疗负担。本文结合临床经验,从心身一体的诊疗理念,谈谈抑郁焦虑与心血管疾病。     

The role of correlated factors in factor analysis

The fundamental factor theorem is developed in matrix form for the case of correlated factors. The properties of the correlated factor system are discussed, and some effects of sampling error considered. The psychological meaning of correlated factors is discussed, and several mechanisms by which general factors may operate in the factorial system are indicated.     

打坐健身机制新探

打坐是一种席地端坐时将两腿交叉相压并调息入静的锻炼方式。打坐行为历史悠久,具有良好的健身作用,近年还发现对心脑血管疾病有一定治疗康复作用。但在中国由于打坐经常被认为属于宗教修炼而被普通大众忽视。本文将打坐与宗教分离开来,通过现代医学理论从调整呼吸、入静、远程缺血预适应保护等对神经系统、内脏功能（肺、消化系统、心血管系统及淋巴循环功能）的影响方面探讨了打坐的健身机制,为进一步研究并向大众推广这种安全有效的健身方法提供一管之见。特别是对心血管系统的保护作用值得进一步研究利用。     

Priming across modalities and priming across category levels: extending the domain of preserved function in amnesia

Amnesia is considered to reflect the effects of damage to a specific brain system required for elaboration, consolidation, and conscious recollection. The study of amnesia is therefore a useful approach for establishing dissociations of function and for understanding the normal organization of memory functions. Amnesic patients and two control groups were tested in two studies of priming. In the first experiment, as measured by a word completion test, all groups exhibited significant priming effects that were greater within a modality than across modalities. The amnesic patients exhibited normal priming effects both within and across modalities, despite severe impairment in recall. In the second experiment, all groups exhibited significant and equivalent priming of category exemplars when category labels were presented and subjects were asked to produce the first exemplars that came to mind. The results extend the domain in which preserved priming effects can be observed in amnesia and they suggest that features of priming observed in normal subjects describe a capacity that is independent of the brain system damaged in amnesia.     

Widening the temporal window: processing support in the treatment of aphasic language production

Investigations of language processing in aphasia have increasingly implicated performance factors such as slowed activation and/or rapid decay of linguistic information. This approach is supported by studies utilizing a communication system (SentenceShaper) which functions as a "processing prosthesis." The system may reduce the impact of processing limitations by allowing repeated refreshing of working memory and by increasing the opportunity for aphasic subjects to monitor their own speech. Some aphasic subjects are able to produce markedly more structured speech on the system than they are able to produce spontaneously, and periods of largely independent home use of SentenceShaper have been linked to treatment effects, that is, to gains in speech produced without the use of the system. The purpose of the current study was to follow up on these studies with a new group of subjects. A second goal was to determine whether repeated, unassisted elicitations of the same narratives at baseline would give rise to practice effects, which could undermine claims for the efficacy of the system.     

信息的充分性和情绪性对推理的影响：时间压力的调节作用

主要探讨推理中信息相关因素对分析系统与启发式系统的影响。通过两个实验考察信息的充分性和情绪性对突发事件情境下推理的影响。实验1任务无时间压力,结果发现：信息充分性对推理的影响显著,表现为信息越充分,被试推理的逻辑指数越高,更多使用了分析系统;且信息充分时,接受积极信息的被试的信念指数显著增高。实验2任务有时间压力,结果发现：信息的情绪性对推理的影响显著,表现为接受积极信息的被试推理的逻辑指数显著大于接受消极信息组,更多使用了分析系统。两个实验结果表明,信息的充分性主要通过分析系统对推理产生影响,而信息的情绪性可通过双系统影响推理过程,即积极信息在推理时间充裕时促进启发式系统,但在有时间压力下促进分析系统。     

A multifactor-system dynamics theory of emotion

In multifactor individuality theory, emotion is treated as the product of the interaction of the cognitive and affective systems, where the cognitive system is defined as a multidimensional, hierarchical system that transforms information in order to detect environmental invariants, and the affective system is defined as a multidimensional hierarchical system that transforms information into arousal states. The highest order dimensions of the cognitive system are conceptual, perceptual, and symbolizing; the highest order dimensions of the affective system are emotional independence, introversion — extroversion, and emotional stability. The concept of arousal provides a key to understanding the complex interactions between cognition and affect. It is hypothesized that specifiable subsets of cognitive and affective dimensions conform to either the facilitative or decremental effects of arousal, and that the Yerkes-Dodson inverted-U function is a composite of both effects. An explanation for the differentiation of distinct emotional states is also presented. Essentially, emotions are differentiated by different weightings of the affective and cognitive dimensions. A theoretical framework for studying the temporal sequencing of phases of emotional behavior is presented as well.This research was supported by grant number S76-0908-RI, awarded to Joseph R. Royce by the Canada Council. Stephen R. Diamond is a research associate on the Individuality Project supported by the grant. We are grateful to Arnold Powell for assistance with the layout of Figure 7.     

The role of orthography in speech production revisited

The language production system of literate adults comprises an orthographic system (used during written language production) and a phonological system (used during spoken language production). Recent psycholinguistic research has investigated possible influences of the orthographic system on the phonological system. This research has produced contrastive results, with some studies showing effects of orthography in the course of normal speech production while others failing to show such effects. In this article, we review the available evidence and consider possible explanations for the discrepancy. We then report two form-preparation experiments which aimed at testing for the effects of orthography in spoken word-production. Our results provide clear evidence that the orthographic properties of the words do not influence their spoken production in picture naming. We discuss this finding in relation to psycholinguistic and neuropsychological investigations of the relationship between written and spoken word-production.