不同时程应激对大鼠行为、免疫和交感神经系统反应的影响

研究旨在研究不同时程情绪应激诱导的大鼠行为、免疫和神经内分泌反应的动态变化及其相互关系。实验采用一种在程序性饮水的固定时间点不确定性给予大鼠空瓶刺激诱发其情绪反应的应激模式,测定不同时程（14,21和28天）应激对大鼠行为、交感神经系统反应、体液免疫功能及体重增长的影响。结果表明,情绪应激导致大鼠攻击行为显著增加,且在整个应激过程中情绪应激组大鼠的攻击行为都被稳定地诱导;不同时程的情绪应激均导致大鼠特异性抗OVA抗体水平明显降低,且降低的程度类似;在情绪应激的第14天和28天应激组大鼠血中去甲肾上腺素水平明显高于对照组,但后者升高的水平明显低于前者。此外,14天应激明显抑制大鼠的体重增长,但随着应激时程的延长,体重增长逐渐恢复。这些结果表明,随着应激时程的延长,大鼠行为、免疫和神经内分泌反应的适应性改变存在时程差异,有助于进一步了解应激诱发的各种反应间的复杂关系     

早期应激对情绪调节的影响及其神经机制

在个体生命早期遭遇的长期或重大的应激经历会显著增加个体罹患抑郁、焦虑等心理疾患的风险, 而情绪调节能力的损伤是引发这些心理疾患的重要因素之一。以人类为对象的行为实验和调查研究表明, 早期应激不仅会影响日常生活中情绪调节策略的使用, 还会对情绪调节能力造成影响, 其影响方向可能与早期应激的严重程度有关。目前, 大部分研究表明严重的早期应激会损伤情绪调节能力, 但中度的早期应激也可能提高情绪调节能力。更为整合性的研究表明情绪调节能力中介了早期应激和各类疾患之间的关系。进一步, 我们从神经层面上阐述了早期应激对情绪调节相关脑区和神经环路的影响。未来研究应当注意控制无关变量, 进一步探究不同早期应激对于情绪调节的影响。     

中枢肥大细胞在脑功能和行为调节中的作用

已知肥大细胞作为免疫细胞在过敏反应和炎性疾病中发挥重要作用。肥大细胞在中枢亦有表达, 但对其作用了解不足。新近的研究发现中枢肥大细胞在脑功能和行为调节中发挥重要的内源性平衡作用。一方面, 中枢肥大细胞在维持相关脑区发育, 正常神经活动, 以及动机, 情绪和认知等多种行为中发挥保护性作用, 各种应激条件诱导的中枢肥大细胞表达和活动改变参与脑和行为的适应性反应过程。另一方面, 中枢肥大细胞过度激活或者过度抑制都可导致脑功能和行为异常, 并参与某些免疫相关心身疾病的病理过程。体外神经解剖学和功能学研究证据提示中枢肥大细胞与神经系统间存在结构性和功能性相互作用网络。肥大细胞和神经组织间通过形成类似突触的结构性联系直接影响相邻细胞的活动。肥大细胞还可以通过脱颗粒释放多种生物活性介质调节神经活动, 同时表达多种受体接受脑内免疫性和神经性分子调节。但是目前对于中枢肥大细胞-神经系统相互作用的认识主要基于体外研究, 其在脑内相互作用方式及其与特定脑区功能和行为表型的关系所知甚少, 开展相关研究可以为认识脑与行为的神经免疫调节机制提供新的视角。     

辩证地探讨精神应激与冠心病的关系

冠心病是严重威胁人们生命和影响生活质量的一种心身疾病,精神应激不仅是不可忽略的重要危险因素之一,而且是一种致病因素.但是精神应激不一定都会引起冠心病,这其中有个体的基因素质和心理素质的作用.它的中介机制主要有脂肪途径和非脂途径.     

应激影响创造力的神经生理机制

人类的很多创造性活动都在一定程度的应激状态下完成,探讨应激与创造力之间的关系成为当前的一个研究焦点。本文从神经内分泌的新视角,梳理了多巴胺、去甲肾上腺素与创造力之间的关系,以及二者在应激影响创造性认知加工过程中的内在神经调节机制,力图揭示应激如何通过神经递质调节大脑神经反应进而对创造力产生影响。未来研究应该综合运用多模态手段,继续探索HPA轴在应激影响创造力中的中介作用机制,并从神经内分泌系统动态平衡机制的视角构建神经科学分子水平-脑网络-行为的综合框架。     

重视心身疾病同治

心理因素导致的躯体疾病称为心身疾病(psychosomaticdisorder),而心身医学(psvchosomaticmedicine)是研究生物学、心理学和社会学等因素影响人类健康和疾病发生发展过程中相互关系的多学科交界的边缘医学。现代社会随着科技进步和经济增长,在生活、学习和工作中,人们普遍出现快节奏、压力和竞争带来的各种情绪的产生,本来是作为人对环境的适应性应激,如果这种应激变得过分强烈而持久,则可以通过主管情绪的网状结构、边缘系统影响到下丘脑和垂体的神经体液中枢,并通过植物神经的过度反应而产生多系统的躯体症状。国内外许多神经生理学家通过…     

不同应激范式对大鼠行为和脑神经颗粒素含量的影响

为探讨慢性情绪应激、生理应激对大鼠旷场行为和脑神经颗粒素（Neurogranin,NG）含量的不同作用,以及NG含量变化与应激性行为效应之间的相互关系。分别以不确定性空瓶刺激和饮水剥夺,建立情绪应激和生理应激动物模型。将40只雄性SD大鼠随机分为情绪应激组（ES）、生理应激组（PS）、定时饮水组（C1）和正常对照组（C2）（n=10）。以旷场行为任务来评定大鼠应激后的行为变化,Western blotting方法测定海马和前脑皮层中的NG含量。结果表明：应激后四组大鼠海马的NG含量差异无显著性;ES组前脑皮层的NG含量低于C2组,差异具有显著性,p<0.01;PS组的前脑皮层NG含量也下降,但与C2组相比差异无显著性; 应激后ES组、PS组修饰行为多于C2组,差异具有显著性,分别为p<0.01,p<0.05;前脑皮层NG含量与修饰行为之间的相关达显著水平。提示慢性情绪和生理应激均能导致前脑皮层NG含量下降,修饰行为增加,情绪应激作用更显著。修饰行为可能是反映情绪状态的较敏感行为指标,前脑皮层NG水平可能是预测情绪应激所致焦虑或抑郁行为的较敏感生物学指标。     

强迫性冷水游泳应激对大鼠行为和海马神经颗粒素的影响

为考察应激对海马神经颗粒素含量和磷酸化水平的影响,以及神经颗粒素是否涉及应激所致行为效应的脑机制,采用强迫性冷水游泳应激模型,选取40只Sprague-Dawley大鼠,随机分为应激组、装置对照组和正常对照组1和正常对照组2。以旷场试验法测定应激前后大鼠行为的变化,以Western blotting技术测定大鼠海马区域神经颗粒素的总含量和磷酸化水平,并分析两者之间的相互关系。结果表明：应激组动物活动增加,表现出焦虑行为;而海马区域神经颗粒素含量降低,与对照组相比差异具有显著性;且多项行为指标的变化与海马神经颗粒素含量的改变呈显著相关。这些结果提示神经颗粒素有可能在应激所致焦虑行为中起作用,可作为预测应激所致焦虑行为的较为敏感的指标之一。慢性应激过程中海马区域没有发现神经颗粒素的磷酸化反应。     

情绪应激对不同脑区c-fos表达的影响

利用电击信号和空瓶刺激两种情绪应激体液免疫调节作用动物模型,以c-fos原癌基因为探针,观察情绪应激后2个小时,大鼠全脑的c—fos原癌基因表达情况,探讨情绪应激对不同脑区c—fos表达的影响。结果表明,电击信号和空瓶刺激两种情绪应激源均能引起某些脑区或核团的c—fos蛋白表达明显增加,包括额皮质、扣带皮质、杏仁内侧核、前连合核、下丘脑背内侧核弥散部、弓状核、孤束核。结果提示,这些脑区或核团是情绪应激主要激活的中枢部位。     

急性心理性应激诱发的神经内分泌反应及其影响因素

急性心理性应激源分别通过下丘脑-脑垂体-肾上腺轴(hypothalamus–pituitary–adrenal axis,HPAA)和交感神经-肾上腺髓质轴(sympathetic-adrenal medulla axis)诱发神经内分泌反应。唾液皮质醇被认为是检测急性心理性应激所诱发的HPA轴反应的稳定指标。以特里尔社会应激测试(Trier Social Stress Test,TSST)及其变式作为应激源, 以HPA轴的反应作为应激指标, 影响个体在急性心理性应激情境中发生特异性神经内分泌反应的因素主要包括人口统计学、环境和应激频率三大方面, 未来应加强急性心理性应激所诱发的神经内分泌反应的纵向研究。     

Status der psychosomatischen Forschung im deutschsprachigen Bereich

Psychosomatic medicine aims at exploring the relationships between biological, psychological and social factors in onset, maintenance and treatment of psychosomatic disorders. The present article describes current topics and methodological approaches in the field of psychosomatic research. A bibliometric analysis of two German journals in 2009 and 2010 was conducted, yielding 43 articles dealing with different aspects of psychosomatic medicine: chronic illness, somatoform disorders and pain, trauma-related disorders, borderline personality disorder and attention deficit hyperactivity disorder. The results show that psychosomatic research covers a variety of topics with different research designs. However, there is still a paucity of controlled studies in the field.     

Associations between Stress,Psychosomatic Complaints,and Parental Criticism among Affluent Adolescent Girls

A growing body of research has shown that adolescent girls in the context of affluence face a series of unique pressures that may increase social-emotional problems. Little research, however, has examined associations between perceived stress and psychosomatic complaints among privileged youth. In the present study, we investigated the relationships between stress, psychosomatic complaints, and parental criticism in a sample of preadolescent and adolescent girls (n?=?218) from selective, private schools. Using OLS regression analyses, cross-sectional and longitudinal associations were evident between perceived stress and psychosomatic complaints, with increases in stress associated with increases in psychosomatic problems. Parental criticism was also examined as a predictor of girls’ psychosomatic complaints and stress levels. Results indicated that parental criticism was significantly and positively associated with psychosomatic problems in cross-sectional models and that perceived stress levels mediated this association. Additional analyses demonstrated that the relationship between psychosomatic complaints and stress may be bidirectional. Taken together, results from this exploratory study suggest that girls in the context of affluence may also experience psychosomatic complaints, in addition to social-emotional problems.     

Post traumatic stress disorders

A clinical overview of the Post-Traumatic Stress Disorders (PTSD) is presented emphasizing altered qualities of experience and behavior. A schema of human psychological responses to stressful life events is reviewed as an introduction to the extensive development of concepts of pathological stress response syndromes: Post-Traumatic Stress Disorders; post-traumatic stress disorder, chronic type; delayed Post-Traumatic Stress Disorder. An illustrative case history is presented. The potential development of PTSD in individuals experiencing less than overwhelming stressors is conceptualized.     

慢性疼痛与抑郁的心身医学整合观

生物医疗观对慢性疼痛患者的诊疗作用较差。慢性疼痛常因为心理应激、个性、行为和疾病状况而复杂化,增加了患者诊疗的难度。患者常因情感症状、生活压力,而失去信心,陷入无助地痛苦选择冲突中。应用一种系统的跨学科方法重建和保持医生的共情和患者的积极心理,采用疾病状态、生活经历、个性特征和行为模式的四种心身整合观点,综合评估抑郁和慢性疼痛患者。设计综合诊疗方案评定的痛苦作用,在方案制定的过程中认识到这四个观点彼此不同,相互补充,全面阐释影响患者痛苦的生物、心理和社会的多种原因。心身整合观点为设计合理的治疗方案提供了方法,提高了医生成功治疗慢性疼痛患者的可行性。     

The moderating effects of gender on the associations between multidimensional hostility and psychosomatic symptoms: a Chinese case

The purpose of this study was to examine the effects of gender on the relationship between multidimensional hostility and psychosomatic symptoms in Chinese culture. The participants in this study were 398 Chinese college students (40% female) recruited from Taiwan. Four dimensions of multidimensional hostility-hostility cognition, hostility affect, expressive hostility behavior, and suppressive hostility behavior-were measured by the Chinese Hostility Inventory. After controlling for the effects of depression and anxiety, the results of path analysis revealed that the multidimensional hostility predicted psychosomatic symptoms directly, and predicted psychosomatic symptoms indirectly through negative health behavior. Furthermore, gender moderated the relationships between multidimensional hostility and health outcomes. Expressive hostility exacerbated psychosomatic symptom in females but buffered it in males, while affective hostility exacerbated psychosomatic symptoms in males. Additionally, suppressive hostility behavior was correlated to psychosomatic symptoms indirectly through negative health behavior in females. Moreover, expressive hostility was correlated to psychosomatic symptoms indirectly through negative health behavior more in males than in females.     

心理异常中“一般心理问题“的判别标准与临床表现

心理异常是相对于心理健康而言的。心理异常不仅是指心理障碍、心理疾病以及心身障碍和心身疾病,而且也包括一般心理问题。人们通常认为的所谓“心理障碍”以及心理辅导和心理咨询中常见的心理异常,大量的还是指一般心理问题。本文就一般心理问题的判别标准以及各种主要一般心理问题的临床表现与鉴别诊断作了有益的探索,为心理辅导和心理咨询工作提供了心理学依据。     

Early childhood predictors of boys’ antisocial and violent behavior in early adulthood

Research on early childhood predictors of violent behaviors in early adulthood is limited. The current study investigated whether individual, family, and community risk factors from 18 to 42 months of age were predictive of violent criminal arrests during late adolescence and early adulthood using a sample of 310 low-income male participants living in an urban community. In addition, differences in trajectories of overt conduct problems (CP), hyperactivity/attention problems (HAP), and co-occurring patterns of CP and HAP from age 1½ to 10 years were investigated in regard to their relationship to violent and nonviolent behaviors, depression, and anxiety at age 20. Results of multivariate analyses indicated that early childhood family income, home environment, emotion regulation, oppositional behavior, and minority status were all significant in distinguishing violent offending boys from those with no criminal records. In addition, trajectories of early childhood CP, but not attention deficit hyperactivity disorder, were significantly related to self-reports of violent behavior, depressive symptoms, and anxiety symptoms. Implications for the prevention of early childhood risk factors associated with adolescent and adult violent behavior for males are discussed.     

The animating body: psychoid substance as a mutual experience of psychosomatic disorder

Starting from Jung's hypothesis of 'the psychoid', the author suggests that the concept can be extended and understood as a dynamic, relational and interpersonal experience-especially in regressed analytic relations. The author then defines his use of the term 'animating body' as having to do with primitive animal imagery and with psychosomatic symptoms stemming from disturbed pre-verbal and pre-whole-object stages of development. A case of a borderline patient is presented, whose projective identifications into the analyst infected him with her psychosomatic disorder, with her internalized Oedipal confusion and necessarily induced a mutually similar animal dream symbolism. If these embodied countertransference experiences (of desperate merging and sickening identification) can be lived through (tolerated and survived), thought through and interpreted, then they can actually become enlivening and lead to a therapeutic psychosomatic co-ordination.     

Ambulant oder stationär?

A central issue in psychosomatic-psychotherapeutic consultations is whether to recommend outpatient or inpatient psychotherapy. In a prospective field study at a psychosomatic outpatient unit sociodemographic and clinical variables were compared for patients for whom outpatient treatment (N = 129) or inpatient treatment (N = 112) had been recommended. The assessments of the therapeutic alliance were made by the referring therapist and the therapist who conducted the therapy. The main findings were: The decision about what type of treatment to recommend was based mainly on the type and severity of the disorder, including the patient's functional level and personality structure. There was no difference between the patient groups in how the referring therapists assessed the initial therapeutic alliance, but there was a difference in how the treating therapists did, the relationship to the inpatients being rated significantly less favorably. The importance of the different treatment settings in interaction with the severity of the disorder is discussed. The initial therapeutic alliance in the consultation did not enable a prognosis about the therapeutic alliance during therapy.     

Mobbing at work and the development of post-traumatic stress disorders

Abstract

Psychosocial research on mobbing is currently being carried out in a number of countries, mainly in Europe. Mobbing is defined as an extreme social stressor at workplaces. In this article, its serious mental and psychosomatic health consequences are demonstrated and discussed. A factor analysis of symptom statistics collected through answers from a study representative of the entire Swedish workforce showed post-traumatic stress disorder (PTSD) as the plausible diagnosis. In addition, 64 patients subjected to mobbing at their work places are diagnosed with the co-operation of a rehabilitation clinic specializing in the treatment of chrome PTSD. The statistical analysis of these 64 diagnoses shows a severe degree of PTSD, with mental effects fully comparable with PTSD from war or prison camp experiences.