The New Biology and its Impact in Biomedical Strategies Against HIV/AIDS

Abstract. The sequencing of the human genome and the initiation of the structural genomics projects have ushered in a new age of biology that involves multi‐lab, high‐cost projects with broad task‐oriented goals rather than the more conventional hypothesis‐driven approach of the past. The new biology has led to the development of new sets of tools for the scientist to use in the quest to solve mysteries of human disease, biomolecular structure‐function relationships, and other burning biological questions. Nevertheless, the impact of the new biology on the field of AIDS investigation has been minimal, predominantly because many of the tools in the HIV field of study were developed before the full advance of the new biology was felt in the biomedical community. Many of the high‐cost megaprojects that involve large technological advances and are marketed as projects of promise to the biomedical community are not likely to significantly impact the field of HIV/AIDS research and cannot serve as a substitute for direct funding to the HIV/AIDS scientists working for vaccine development, an understanding of mechanisms of disease causation, and new tools for therapeutic intervention.     

Analogical reasoning as a tool of epidemiological investigation

Few, if any, scientific inquiries are conducted against a background of complete knowledge, a background in which inquirers are in possession of the full facts that relate to a particular question or issue. More often than not, scientists are compelled to conduct their deliberations in contexts of epistemic uncertainty, in which partial knowledge or even a total absence of knowledge characterise inquiry. Nowhere is this epistemic uncertainty more evident, or indeed more successfully controlled, than in the branch of scientific inquiry called epidemiology. In this paper, I examine how epidemiologists overcome the unique challenges to inquiry that are posed by epistemic uncertainty. In specific terms, I contend that epidemiologists employ analogical reasoning strategies in an attempt to advance their inquiries in situations that are epistemically uncertain. The context for my claims will be the early inquiries that were conducted into the emergence of HIV/AIDS in the United States. I argue that early scientific work in relation to HIV/AIDS was directly premised upon epidemiological investigations in which analogical reasoning with hepatitis B had featured significantly. I conclude that epidemiological investigations of AIDS exemplify the capacity of analogical reasoning to advance inquiry under conditions of epistemic uncertainty. To this extent, analogical reasoning should be a concern both to those who address practical problems of uncertainty management and to those who pursue theoretical debates within argumentation studies and epistemology.     

The Institute on Human Values in Medicine: Its Role and Influence in the Conception and Evolution of Bioethics

For ten years, 1971–1981, the Institute onHuman Values in Medicine (IHVM) played a keyrole in the development of Bioethics as afield. We have written this history andanalysis to bring to new generations ofBioethicists information about the developmentof their field within both the humanitiesdisciplines and the health professions. Thepioneers in medical humanities and ethics cametogether with medical professionals in thedecade of the 1960s. By the 1980s Bioethics wasa fully recognized discipline. We show the rolethat IHVM programs played in defining thefield, training faculty and helping schools todevelop programs. We review the beginnings ofthe IHVM in the crucible of social andtechnological change that led to theestablishment of the IHVM's parentorganization, the Society for Health and HumanValues. We then turn to the IHVM programsthrough which Faculty members receivedfellowships to explore new crossovers betweenthe humanities and the health professions. Wehave not only described the Fellows Program asit existed in 1973–1980, but have completed asurvey of the fellows a quarter of a centuryafter they held their fellowships. We describeother IHVM programs designed to facilitate theinitiation and development of new humanitiesprograms, to explore conceptual issues betweenmedicine and five humanities fields, to conductissue driven or educational method conferencesand to advance humanities programs intograduate education through the Directors ofMedical Education.     

Local and normative rationality of science: The ‘content of discovery’ rehabilitated

The recent turn to the context of discovery and other postmodernist developments in the philosophy of science have undermined the idea of a universal rationality of science. This parallels the fate of the classical dream of a logic of discovery. Still, justificational questions have remained as a distinct perspective, though comprising both consequential and generative justification — an insight delayed by certain confusions about the (original) context distinction. An examination of one particular heuristic strategy shows its local rationality; even as an efficient procedure of hypothesis generation, it carries probative weight. It will be explored in which respects such a strategy can be normative or contain normative elements.Parts of this paper were published, in summary fashion, in Kirschenmann (1989).     

Using the Theory of Gender and Power to Examine Experiences of Partner Violence,Sexual Negotiation,and Risk of HIV/AIDS Among Economically Disadvantaged Women in Southern India

This article uses the Theory of Gender and Power to examine women's vulnerability to HIV/AIDS in order to: understand the vulnerability of female sex workers/poor women due to poverty and lack of educational resources; explore women's vulnerability in the context of client/partner violence, alcohol use, male partner's high-risk behaviors, and women's lack of control in their intimate relationships; and explore the role of traditional heterosexual gender norms in the outcomes of sexual negotiation. Ethnographic data were collected from 32 women and 38 men in India as part of an ongoing National Institute of Mental Health study. Results highlighted women's vulnerability to HIV/AIDS stemming from partner violence, alcohol use, poverty, dangers of sex work environments, and tacit acceptance of cultural/gender norms.     

COLLECTIVE RELIGIO‐SCIENTIFIC DISCUSSIONS ON ISLAM AND HIV/AIDS: I. BIOMEDICAL SCIENTISTS

During the 1990s, biomedical scientists and Muslim religious scholars collaborated to construe Islamic responses for the ethical questions raised by the AIDS pandemic. This is the first of a two‐part study examining this collective legal reasoning (ijtihād jamā‘ī). The main thesis is that the role of the biomedical scientists is not limited to presenting scientific information. They engaged in the human rights discourse pertinent to people living with HIV/AIDS, gave an account of the preventive strategy adopted by the World Health Organization, and offered an (Islamic) virtue‐based preventive model. Finally, these scientists tried to draft a number of Islamic legal rulings (a?kām), usually seen in Islamic jurisprudence as the exclusive business of Muslim religious scholars. This multilayered role played by the scientists reflects intriguing developments in the Islamic religio‐ethical discourse in general and in the field of Islamic jurisprudence in particular.     

Coping,psychological adjustment,and complementary and alternative medicine use in persons living with hiv and aids

Abstract

Many HIV-positive individuals dissatisfied with allopathic approaches to disease management have turned to complementary and alternative medicines (CAM). Although people use CAM for a variety of reasons (e.g., symptom management, holistic approach towards healthcare, improved immunity), the psychological benefits that these treatments may have are still not fully understood. The present study was designed to further previous research that demonstrated relationships between CAM use, stress appraisals, and coping behaviors. HIV-positive individuals (N= 127) completed measures assessing stress appraisals, coping, psychological adjustment, satisfaction with life, and immune functioning. After controlling for ethnicity and sexual orientation, stress appraisals and coping behaviors were found to be related to CAM use. Further, curvilinear relationships between CAM use and adjustment emerged, suggesting that some CAM use may be adaptive. Self-reported immune measures were unrelated to CAM use. In all, it appears that CAM use may be a complex form of coping that assists individuals in adjusting to a life-threatening illness. The implications of these findings with respect to adherence to highly active antiretroviral therapies (HAART) are also discussed.     

TOWARD A NEW RELATION BETWEEN HUMANITY AND NATURE: RECONSTRUCTING T'IEN-JEN-HO-I

Abstract. The traditional Chinese idea of t'ien-jen-ho-i (Heaven and humanity in union) implies that humanity has to live in harmony with nature. As science and technology progress, however, the idea appears increasingly outmoded, and it becomes fashionable to talk about overcoming nature. Ironically, though, the further science reaches the more clearly are its limitations exposed. The exploitation of nature not only endangers many life forms on earth but threatens the very existence of the human species. I propose that a reconstruction of the traditional Chinese idea of T'ien-jen-ho-i will help us envisage a new and salutary relation between humanity and nature.     

FAITH,SCIENCE, AND NONRELIGIOUS IDENTITY FORMATION AMONG MALE KENYAN YOUTH

The faith and science dialogue has received scholarly attention in the recent past. Within the African landscape at large, the underlying assumption has been that Africans are religious. However, there has been a rising cohort of Africans who are increasingly identified as nonreligious or atheist or agnostic. This research presents a qualitative analysis of the sociocultural factors that affect or influence these minority identities within a pluralistic African context, exploring their emergence and diversities within the African context, with a specific focus on 20 male Kenyan youth who are identified as nonreligious. This research utilized purposive sampling within nonreligious groups and networks. Second, this research aims at exploring how nonreligious identities are constructed, particularly given the concomitant issues surrounding emerging adulthood and new media. This builds up on the theories around youth and identity formation, while foregrounding science and belief as a central theme of study.     

The Epic of Evolution as a Framework for Human Orientation in Life

This article sketches what is required of a world picture (religious or nonreligious) that is intended to provide orientation in the world for ongoing human life today. How do we move from conceptions and theories prominent in the modern sciences—such as cosmic and biological evolution—to an overall picture or cosmology which can orient us for the effective address of today's deepest human problems? A biohistoricalconception of the human is proposed in answer to this question.     

A Draft for Unifying Controversies in Philosophy of Science

The basic (negative and positive) methodological maxims of three currents of philosophy of science (logical empiricism, falsificationism, and postpositivism) are formulated. Many of these maxims (stratagems) are controversial, e.g., the stance about the nonsense of metaphysics, and that of its indispensability. The restricted validity of these maxims allows for their unification. Within the framework of most of them there may be a relationship of (synchronic, or diachronic) subordination of the contradicting desiderata. In this vein ten stratagems are formulated. This revised version was published online in August 2006 with corrections to the Cover Date.     

Discrimination of sea-bird sounds vs. garden-bird songs: Do Scottish and German-Saxon infants show the same preferential looking behaviour as adults?

Birdsong and human speech share some genetic origins (Haesler, Rochefort, Georgi, Licznerski, Osten, & Scharff, 2007 Haesler, S., Rochefort, C., Georgi, B., Licznerski, P., Osten, P. and Scharff, C. 2007. Incomplete and inaccurate vocal imitation after knockdown of FoxP2 in songbird basal ganglia nucleus area X. PLOS Biology, 5: e312–e321.  [Google Scholar]; Vargha-Khadem, Gadian, Copp, & Mishkin, 2005 Vargha-Khadem, F., Gadian, D. G., Copp, A. and Mishkin, M. 2005. FoxP2 and the neuroanatomy of speech and language. Nature Review of Neuroscience, 6: 131–138. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]). In two studies (N = 67 infants and N = 28 adults) in Scotland (UK) and Saxony (Germany), perceptual discrimination of innate, repetitive, lower frequency sea-bird sounds vs. learned, melodic, higher frequency garden-bird songs was tested in infants in their first year as well as in adults, using the conditioned head-turn procedure (CHTP; e.g., Jusczyk, Friederici, Wessels, Svernkerud, & Jusczyk, 1993 Jusczyk, P. W. and Krumhansl, C. L. 1993. Pitch and rhythmic patterns affecting infants' sensitivity to musical phrase structure. Journal of Experimental Psychology: Human Perception and Performance, 19: 627–640.  [Google Scholar]). Infants and adults reliably distinguished between the two types of sounds. Independently of environment, infants paid more attention to sea-bird sounds than to garden-bird songs, while adults showed the reverse preference. Further analysis revealed additional insights into the underlying processes.     

“Intrinsically” or just “Instrumentally” Valuable? On Structural Types of Values of Scientific Knowledge

Debates about scientific (though rarely about otherforms of) knowledge, research policies or academic trainingoften involve a controversy about whether scientificknowledge possesses just “instrumental” value or also “intrinsic” value. Questioning this common simpleopposition, I scrutinize the issues involved in terms of agreater variety of structural types of values attributableto (scientific) knowledge. (Intermittently, I address thepuzzling habit of attributing “intrinsic” value to quitedifferent things, e.g. also to nature, in environmentalethics.) After some remarks on relevant broader philosophicaldebates about scientific knowledge, I pave a path throughthe (terminological) thicket of structural types of values. Our initial simple opposition is shown to conflate thedistinctions intrinsic/extrinsic and instrumental (or justuseful)/final. Next, I consider the value(s) of knowledgeand knowing in general and their possible value components(like the values of truth and justifiedness). After havingdiscussed the types of value of everyday knowledge,especially its functional and constitutive value (notionsintroduced earlier), I argue that these can or should alsobe attributed to scientific knowledge, thus departing fromboth objectivist and sociological views of science. One could say that I offer a certain defense of theintrinsic value of scientific knowing (and the inherentvalue of scientific knowledge) and some importantdifferentiations of its “instrumental values”. I alsocaution (in relation with my puzzle) against drawing hastymoral conclusions. This revised version was published online in August 2006 with corrections to the Cover Date.