The Critical Role of Cholinergic Basal Forebrain Neurons in Morphological Change and Memory Encoding: A Hypothesis

It has been known for a long time that cholinergic basal forebrain neurons which project to the cerebral cortex play a role in learning and memory. Behavioral studies following lesions, for example, repeatedly have suggested multiple learning-related roles for these neurons. Apart from behavioral studies, cholinergic neurons have been shown to possess extraordinarily plastic axons. This plasticity has not been related comprehensively to mnemonic devises, even though morphological changes in the CNS are prime candidates for the neural engram. In this paper, I propose a hypothesis that relates these two characteristics of cholinergic neurons. This hypothesis is that plastic cholinergic axon terminals induce structural reorganization in their targets during memory storage. Possible intracellular mechanisms are examined, whereby acetylcholine release in the cerebral cortex could cause postsynaptic structural changes. Finally, the characteristics of the overall cholinergic–cholinoceptive cell “engram” are elaborated with particular attention paid to the encoding of the stimulus properties along with the context and meaning of the stimulus.     

A thematic coding system for the intimacy motive

A new thematic (TAT) measure of intimacy motivation was developed and cross-validated in four separate arousal studies using three different college populations. A brief sketch of the derived thematic scoring system for intimacy motivation was presented. The goal state of the intimacy motive was defined as experiencing a warm, close, and communicative exchange with another person. In a college sample, subjects scoring high on the intimacy motive were rated by friends and acquaintances as significantly more “warm,” “natural,” “sincere,” “loving,” and “appreciative” and less “dominant,” “outspoken,” and “self-centered” than subjects scoring lower. The results were discussed in terms of the theories of Sullivan on the need for interpersonal intimacy, Maslow on growth motivation and “B-love,” Bakan on communion, and Buber on the I-Thou relation. Differences between the new coding system and the need for Affiliation (n Aff) system for scoring imaginative productions were also suggested.     

Direct perception in the intersubjective context

This paper, in opposition to the standard theories of social cognition found in psychology and cognitive science, defends the idea that direct perception plays an important role in social cognition. The two dominant theories, theory theory (TT) and simulation theory (ST), both posit something more than a perceptual element as necessary for our ability to understand others, i.e., to “mindread” or “mentalize.” In contrast, certain phenomenological approaches depend heavily on the concept of perception and the idea that we have a direct perceptual grasp of the other person’s intentions, feelings, etc. This paper explains precisely what the notion of direct perception means, offers evidence from developmental studies, and proposes a non-simulationist interpretation of the neuroscience of mirror systems.     

The Value of the Virtues

Direct theories of the virtues maintain that an explanation of why some virtuous trait counts as valuable should ultimately appeal to the value of its characteristic motive or aim. In this paper I argue that, if we take the idea of a direct approach to virtue theory seriously, we should favour a view according to which virtue involves knowledge. I raise problems for recent “agent-based” and “end-based” versions of the direct approach, show how my account proves preferable to these, and defend it against a number of objections.     

The myth of open concepts: Meehl’s analysis of construct meaning versus black box essentialism

Two views of theoretical concepts in psychology are compared. Meehl’s “open concept” account holds that theoretical concepts are implicitly defined by theories but that empirical criteria can be changed over time (e.g., added or dropped, weightings changed, exchanged for theoretical reductions). This account confuses concepts and theories, does not reflect how diagnostic concepts actually work in medicine and psychology, leads to theory incommensurability, and is unclear about when concepts are the same or different. I propose that an alternative “black box essentialist” account of theoretical concepts, drawn from recent philosophical work on natural kind concepts, better explains how we manage to refer to the same construct even as our theories and criteria change. One implication is that Meehl is incorrect to claim that a reason for psychology’s lack of progress is that its concepts are inherently different from those in the hard sciences.     

Tomboyism or Lesbianism? Beyond Sex/Gender/Sexual Conflation

To illuminate questions of sex/gender/sexual conflation the researcher focused on the relationship between reported tomboyism and lesbianism. Narratives of childhood and adolescence were collected from 32 women who were grouped into four gender/sexual status combinations: “lesbian/bisexual butch,” “straight butch,” “lesbian/bisexual femme,” and “straight femme.” The effects of participants’ sexual and gendered statuses on their retrospective accounts of two aspects of tomboyism—“choosing masculinity” and “rejecting femininity”—were examined. Chi square and qualitative analyses suggest that stage in the life cycle, gender, and sexual status influence distinct mergings and separations of sex, gender, and sexuality in women’s retrospective reports. The researcher concludes that attention to sex, gender, and sexuality as both distinct and connected clarifies the relationship between tomboyism and lesbianism.Part of this paper was presented at the Annual Meeting of the American Sociological Association in Atlanta, Georgia in 2003. Interview data for this study were originally collected for an unpublished dissertation (Carr, 2002).     

Voice Onset Time in Ataxic Dysarthria

In eight patients with a purely ataxic syndrome due to cerebellar atrophy the voice onset time (VOT) of word-initial stop consonants was measured at the acoustic signal. The subjects had been asked to produce sentence utterances including either one of the German minimal pair cognates “Daten” (/datn/, “data”) and “Taten” (/tatn/, “deeds”). In addition, a master tape comprising the target words from patients and controls in randomized order was played to six listeners for perceptual evaluation. Two major findings emerged. First, the cerebellar subjects presented with a reduced categorical distinction of the VOT of voiced and unvoiced stop consonants. Second, the patients' target words with initial unvoiced plosive gave rise to a significantly increased number of misassignments at perceptual evaluation. To some extent comparable VOT disruptions have been noted in apraxia of speech and basal ganglia disorders. Thus, different pathomechanisms might result in similar VOT abnormalities.     

“Consistency” and “contradiction” in the development of gender role characteristics

There is currently an increasing amount of theoretical and empirical work arguing that stereotyped sex role behavior is maladaptive in our culture and that “androgyny” or “sex role transcendence” is a preferred mode of being. The latter, however, seems to require individual inconsistency and self-contradiction in behaviors and attitudes (since the individual is both active and passive, both independent and dependent, etc.). Theories of cognitive consistency maintain that individuals avoid self-contradiction and inconsistency, and therefore that androgyny runs counter to important motivational principles. This article examines this issue in some detail, and concludes that theories of cognitive dissonance and consistency reflect particular socio-cultural conditions rather than universal motivation principles. There is nothing inherently uncomfortable or “inconsistent” about androgyny and sex role transcendence.     

Does intermodal equivalence exist between heteromodal stimulus dimensions or between stimulus values on those dimensions?

In a same--different judgement task with successively presented signals, subjects matched dots in different vertical positions and tones of different frequencies intramodally and intermodally. The first and second stimuli of trials in each of the four modality conditions were drawn from a set consisting of two, three or five alternatives. In all intermodal set size conditions, the dimensions of pitch and vertical position were related by the same equivalence rule. While intramodal performance improvement depended only on the total number of practice trials at matching on the relevant dimensions, intermodal performance improvement appeared to be related to the number of trials practice with each heteromodal stimulus pairing in a particular set. After performance had approached asymptotic level neither intramodal nor intermodal matching reaction time depended on set size. Mean “same” reaction time was less than mean “different” reaction time, and this difference was greater for intermodal matching than for intramodal matching. The results indicated that intermodal equivalence exists between discrete stimulus values on heteromodal dimensions rather than between the dimensons themselves.     

Hierarchical structure in perceptual representation

A theoretical framework for perceptual representation is presented which proposes that information is coded in hierarchical networks of nonverbal propositions. The hierarchical structure of the representations implies selective organization: Some subsets of a figure will be encoded as integral, structural units of that figure, while others will not. A context-sensitive metric for the “goodness” of a part within a figure is developed, corresponding to the probability that the subset will be encoded as a structural unit. Converging evidence supporting this position is presented from four different tasks using simple, straight-line figures. The tasks studied are (a) dividing figures into “natural” parts, (b) rating the “goodness” of parts within figures, (c) timed verification of parts within figures, and (d) timed mental synthesis of spatially separated parts into unitary figures. The results are discussed in terms of the proposed theory of representation, the processes that operate on those representations, and the general implications of the data for perceptual theories.     

A Brain of Her Own: A Neural Correlate of Song Assessment in a Female Songbird

The song control region in the avian forebrain is a series of discrete, interconnected nuclei mediating song learning and production. It has been studied in males or in species where both sexes sing. Little is known about the neural correlates of song perception in nonsinging females, often the intended recipients of song. We studied cowbirds (Molothrus ater), a species in which only males sing but in which females discriminate between males on the basis of song. We focused on nucleus lMAN because it has been implicated in early song acquisition, a stage relevant to both sexes to choose among competing acoustic models. We found that volume of lMAN was monomorphic in cowbirds. Moreover, the volume and neuronal number of female lMAN were positively correlated with selectivity of copulatory responding. The results provide strong evidence of nonsinging female's use of “song” control nuclei for song perception without the possibility of song production.     

The pitch of “real” and “rhetorical” questions directed by a father to his daughter: A longitudinal case study

A longitudinal study of a father and his daughter examined pitch-variation of “real” and “rhetorical” questions. Although the father asked “real” and “rhetorical” questions from the start of the recordings, he did not distinguish them through differential pitch height until the baby was 15 months old.     

Heart rate variability and respiratory concomitants of visual and nonvisual “imagery” and cognitive style

Attention to visual and nonvisual imagery, elicited by an imagery questionnaire, was studied using both within and between subjects analyses of cardiac and respiratory parameters. Visual imagery was accompanied by more regular interbeat heart rate (HR) and shorter, more stable respiratory cycles than nonvisual imagery. “Visually-oriented” thinkers (visualizers), identified by a word association test, manifested less overall variability in HR than “verbally-oriented” thinkers (verbalizers), as well as less variable HR and respiratory period during visual imagery. Visual and nonvisual imagery differed in HR variability for verbalizers and in respiration period for visualizers. The results are discussed in terms of the concepts of attention deployment, “mental load”, cerebral asymmetry, and stylistic personality differences in cognitive functioning.     

The K-factor: Individual differences in life history strategy

Until recently, variations in life history strategy were studied exclusively at the species level. Although this domain of study has been extended to examine systematic differences in life history strategy among various human ethnic groupings, more recent evolutionary theories of human development and related behavioral genetic work imply substantial within-group individual variation in life history strategy. We constructed a latent variable model identifying a single common factor, denoted as K, which underlies a variety of otherwise disparate life history parameters. This “K-Factor” loaded 0.36 on childhood attachment to the biological father, −0.36 on childhood attachment to any non-biological father figure, 0.38 on adult romantic partner attachment, −0.51 on mating effort, −0.58 on Machiavellianism, and −0.41 on risk propensity. The bivariate correlations of the K-factor with higher-order personality factors were statistically significant, −0.24 with “Big Neuroticism” and −0.67 with “Big Psychoticism”, and approached significance, correlating 0.12, with “Big Extraversion”. The K-factor appears to be an underappreciated individual difference variable of major importance to human development.     

The EEG and intelligence: An appraisal of methods and theories

Formerly, attempts were made to discover some relationship between intelligence differences and measures of “spontaneous” EEG activity. More recently the focus of interest has shifted to a putative relationship between intelligence differences and differences in EEG responses evoked by sensory stimulation. This article identifies serious conceptual and methodological problems of the EEG-intelligence literature which render some EEG-intelligence theories untenable. It is concluded that the “cerebral arousability” theory of EEG-intelligence relations is the only one that can account for the physical, neurological and psychological facts while addressing the main issues that have dominated the whole field of intelligence research for the past 100 years.     

Powerful perceivers, powerless objects: Flexibility of powerholders’ social attention

We argue that the effect of power on social attention is a function of flexible, instrumental information processing that allows the high power perceiver to attain situation specific goals using whatever means are available, including attention. Study 1 assigned powerful participants to more “people-centered” or more “product-centered” goals, and found that people-centered powerholders better individuated low-power targets. Study 2 examined responses by both high- and low-power organization members, and found powerful judges more responsive to organizational goals in setting priorities and using information about the organization than powerless judges. Together, these results suggest that powerholders use social attention, like other resources, in order to advance their ability to fulfill organizational goals.     

A reexamination of body build stereotypes

Using semantic differential and discriminant analysis techniques, the study sought to determine (a) the existence of body build stereotypes, (b) the extent of identification with these stereotypes, and (c) the effect of identification upon the child's self-evaluation. The subjects were 406 children in Grades four to eight from a midwestern community. All subjects were white and had predominantly middle-class backgrounds. Subjects completed the Piers-Harris Children's Self Concept Scale, semantic differential ratings of the Global self-concept, and the body build concepts of “SKINNY GIRL,” “FAT GIRL,” “SKINNY BOY,” and “FAT BOY,” and the situationally specific self-concepts of “MYSELF IN THE CLASSROOM,” “MYSELF AT LUNCH/RECESS,” and “MYSELF WHEN LOOKING IN A MIRROR,” Measures of weight and height were obtained using a standard weighing scale and wall chart. Fat child and skinny child stereotypes were found to be invariant across age and sex groups and did not appear to be gender specific. Actual fatness was found to be generally related to identification with the body build stereotypes, but not strongly so. Low self-esteem was a concomitant of identification with the fat child stereotype. The majority of children identified with the average child in all settings.     

Motivationally neutral stimulation of the nucleus basalis induces specific behavioral memory

The cholinergic system has been implicated in learning and memory. The nucleus basalis (NB) provides acetylcholine (ACh) to the cerebral cortex. Pairing a tone with NB stimulation (NBstm) to alter cortical state induces both associative specific tuning plasticity in the primary auditory cortex (A1) and associative specific auditory behavioral memory. NB-induced memory has major features of natural memory that is induced by pairing a tone with motivational reinforcers, e.g., food or shock, suggesting that the cholinergic system may be a “final common pathway” whose activation promotes memory storage. Alternatively, NB stimulation might itself be motivationally significant, either rewarding or punishing. To investigate these alternatives, adult male rats (n = 7) first formed a specific NB-induced memory (CS = 8.0 kHz, 2.0 s paired with NBstm, ISI = 1.8 s, 200 trials), validated by post-training (24 h) frequency generalization gradients (1–15 kHz) of respiration interruption that were specific to the CS frequency. Thereafter, they received the same level of NBstm that had induced memory, while confined to one quadrant of an arena, and later tested for place-preference, i.e., avoidance or seeking of the quadrant of NBstm. This NBstm group exhibited neither preference for nor against the stimulated quadrant, compared to sham-operated subjects (n = 7). The findings indicate that specific associative memory can be induced by direct activation of the NB without detectable motivational effects of NB stimulation. These results are concordant with a memory-promoting role for the nucleus basalis that places it “downstream” of motivational systems, which activate it to initiate the storage of the current state of its cholinergic targets.     

Locus of control and the perception of freedom in an agent of reinforcement

Internals and externals observed a staged videotape presentation that portrayed a “teacher” and a “learner” engaging in a 20-item anagrams task. For externals, any variability (10, 50, and 90% schedule) in the reinforcing behavior of the “teacher” (agent of reinforcement) resulted in significantly greater perceived freedom than when no variability (0 and 100% schedule) occurred in behavior. For internals, perceived freedom was a negative linear function of the amount of reinforcement administered. Internals indicated that they could influence the behavior of the “teacher” in all reinforcement conditions, whereas externals indicated that they could influence only the “teachers” in the variable reinforcement conditions. It was concluded that greater freedom is attributed to a person whose behavior is perceived as congruent with the person's inner disposition.