Crime and amnesia: A review

The present article reviews amnesia for criminal offenses. It discusses the organic disorders most likely to be implicated, and the nature and differentiation of psychogenic amnesia. With the exception of alcohol and drug intoxication, organic dysfunction is a rare (though important) cause of amnesia for crime. Likewise, fugue states may occasionally be triggered by an offence, but are a very rare cause of the amnesia claimed by offenders. Amnesia is most commonly seen in homicide cases, in which it is claimed by 25% to 45% of offenders, but it occurs also in other types of violent crime, and occasionally in nonviolent crime. It arises in states of extreme emotional arousal, in alcoholic intoxication, and in states of florid psychosis; and it is also associated with depressed mood. Various methods have been advocated for the differentiation of genuine amnesia from deliberate simulation: this distinction can be difficult, but it is noticeable that many amnesic subjects either have reported the crime themselves or have made no attempt to conceal it. The nature of the deficit in this type of amnesia, and its implications for assessment, are also discussed.     

Functional Thought Experiments

The literature on thought experiments has been mainly concernedwith thought experiments that are directed at a theory, be it in aconstructive or a destructive manner. This has led somephilosophers to argue that all thought experiments can beformulated as arguments. The aim of this paper is to drawattention to a type of thought experiment that is not directed ata theory, but fulfills a specific function within a theory. Suchthought experiments are referred to as functional thoughtexperiments, and they are routinely used in applied statistics. An example is given from frequentist statistics, where a thoughtexperiment is required to establish the probability space. It isconcluded that (a) not all thought experiments can be formulated asarguments, and (b) the role of thought experiments is more generaland more important to scientific reasoning than has previouslybeen recognized.     

Genetics and educational psychology

Background: Molecular genetics, one of the most energetic and exciting areas of science, is slowly but surely coming to educational psychology. Aims: We review recent molecular genetic research on learning disabilities as a sign of things to come in educational psychology. We also consider some misconceptions about genetics that have slowed the acceptance of genetics in educational psychology. Samples: Diverse samples of children with learning disabilities have been studied, primarily in the UK and the USA. Methods: Linkage analysis can detect genes that have large effects on learning disabilities. Association analysis can detect genes of much smaller effect size, which is important because common disorders such as learning disabilities are likely to be influenced by many genes as well as by many environmental factors. Results: For reading disability, replicated linkages have been identified on chromosomes 6, 15 and 18. A gene responsible for a rare type of language impairment has recently been identified. For common language impairment, linkages on chromosomes 16 and 19 have recently been reported. More than 200 genetic disorders, most extremely rare, include mental retardation among their symptoms, and chromosomal abnormalities are a major cause of mental retardation. Conclusions: Although finding specific genes associated with learning disabilities is unlikely to have much of a direct application for teachers in the classroom, such findings will have far‐reaching implications for diagnosis, treatment and prevention of learning disabilities and for research in educational psychology. Educational psychology has been slower to accept evidence for the importance of genetics than other areas of psychology in part because of misconceptions about what it means to say that genetics is important for common complex disorders such as learning disabilities.     

Parental Alienation Syndrome (PAS) in the Netherlands

In the Netherlands, about 20% of children do not have any contact with their non-resident parent after parental divorce. There are often many reasons underlying the broken contact, but one might well be the process of parental alienation, when the child denigrates and excludes the non-resident parent. This article presents the results of two studies conducted among divorce experts and divorced, non-resident parents. A total of 138 respondents co-operated in our studies. Of the respondents, 58% thought PAS either does not, or rarely occurs in the Netherlands, and 42% thought it does occur. The extent of parental alienation was classified as mild (33%) or moderate (9%). From our factor analysis, it became clear that Gardner's classification of eight separate symptoms of parental alienation was not evident in our research data. We were able to distinguish four separate aspects: two of them concerning alienation due to the resident parent and two concerning alienation due to the child. Our results underpin the importance of mediation, since it seemed that parental alienation syndrome (PAS) occurred significantly more often when decisions with relation to the children were not taken together by the parents but were determined in court. We consider that compulsory mediation and better communication during divorce would prevent many cases of PAS.     

“You Have to Sit and Explain it All,and Explain Yourself.” Mothers’ Experiences of Support Services for Their Offspring with a Rare Genetic Intellectual Disability Syndrome

The experiences of mothers of adult offspring with Angelman, Cornelia de Lange, or Cri du Chat syndrome have not been previously explored in research. The current study focuses on experiences with social and medical services and the impact the rareness of an adult offspring’s syndrome has on the experiences of mothers. Eight mothers of adults with Angelman, Cornelia de Lange, or Cri du Chat syndrome were interviewed. Thematic Content Analysis was used to interpret the interviews. Four themes emerged from the analysis: (i) The rarity of their offspring’s syndrome, (ii) Uneven medical and social care service provision, (iii) The inertia of social care services, and (iv) Mothers as advocates. Mothers felt that the rareness of their offspring’s syndrome did not affect experiences with social care services, but did affect access to medical services and some aspects of day-to-day living. Accessing appropriate social care services was reported to be a lengthy and complex process. These data may help inform care service providers about how best to support adults with rare genetic syndromes and their families.     

Cerebrospinal fluid findings in chronic cerebral-organic psychiatric axis syndrome

Retrospective examinations of liquors from 136 children with a chronic brain-organic psychic axis syndrome following brain damage during infancy yielded pathological findings in 75.7% of the cases. These included changes in total protein content, slight increases in cell counts and the occurrence of monocytic forms of stimulus, but rarely changes in the pattern produced by electrophoresis of the liquor. Combinations of these pathological findings are rare, so that it is not possible to elaborate a typical liquor syndrome for this group of patients.     

A case of thalamic aphasia with postmortem verification

This study discusses a case of aphasia after dominant thalamic lesion, a hemorrhagic infarction. Unlike other such cases, both repeated standardized assessment and postmortem verification were available. The patient was assessed at 3 weeks and again at 9 weeks postonset. The aphasia demonstrated the syndrome common to dominant thalamic hemorrhage: fluent but paraphasic output sometimes deteriorating to jargon, comprehension less impaired than this type of output usually indicates, and the least impairment in repetition. As sometimes reported in previous cases, semantic paraphasias were more common than phonemic paraphasias. The lesion was located in the dorsal aspect of the lateral nucleus, but it extended into the pulvinar, including the anterior superior lateral aspect which has been implicated in language by previous studies. Thus, data from this case are consistent with an involvement of the dominant pulvinar in language and suggest that this role involves the semantic aspects of language.     

The use of genomic microarrays to study chromosomal abnormalities in mental retardation

Mental retardation affects 2 to 3% of the US population. It is defined by broad criteria, including significantly subaverage intelligence, onset by age 18, and impaired function in a group of adaptive skills. A myriad of genetic and environmental causes have been described, but for approximately half of individuals diagnosed with mental retardation the molecular basis remains unknown. Genomic microarrays, also called array comparative genomic hybridization (array CGH), represent one of several novel technologies that allow the detection of chromosomal abnormalities, such as microdeletions and microduplications, in a rapid, high throughput fashion from genomic DNA samples. In one early application of this technology, genomic microarrays have been used to characterize the extent of chromosomal changes in a group of patients diagnosed with one particular type of disorder that causes mental retardation, such as deletion 1p36 syndrome. In another application, DNA samples from individuals with idiopathic mental retardation have been assayed to scan the entire genome in attempts to identify chromosomal changes. Genomic microarrays offer both a genome-wide perspective of chromosomal aberrations as well as higher resolution (to the level of approximately one megabase) compared to alternative available technologies.     

医学中的哲学：临床思维

良好的临床思维不仅是医生正确诊治疾病的基础,也是医务人员高素质的体现。本文从哲学的角度,通过大量的临床案例,讨论了临床思维的重要性、,临床思维失误的常见原因、以及如何培养良好的,临床思维。要提高自身的人文素质和思维水平,必须意识到学习辨证唯物主义哲学的重要性,并自觉应用到临床实践中。     

Mosaic trisomy 20 and mitigation in capital crimes sentencing: A review and case report

Trisomy 20 is a genetic abnormality in which individuals have an extra copy of chromosome 20. Complete trisomy 20 is rare and believed to be incompatible with life. A mosaic form of trisomy 20, in which only some cells or tissues contain the extra chromosome, is a relatively commonly encountered chromosomal abnormality found during prenatal testing, and c. 90% result in a normal phenotype. However, despite the absence of a consistent phenotype, certain findings have been reported across multiple cases of mosaic trisomy 20. These include an array of morphological findings, developmental delays, and learning disabilities. Beyond physical manifestations, a wide range of developmental and learning delays have also been reported. In this work, we provide an overview of the trisomy 20 literature and a case report of a young adult male with mosaic trisomy 20 who committed homicide. His developmental and life history, eventual diagnosis of mosaic trisomy 20, similarities and differences in his condition compared with prior research findings, and potentially new phenotypic findings associated with trisomy 20 that he manifested (childhood visual hallucinations, self‐injury, polydactyly) are presented. Additionally, the potential role of this genetic diagnosis in his neuropsychiatric history and its successful application as a mitigating factor at his capital sentencing trial are described. We did not identify other similar cases during our search of major scientific and legal databases. As a backdrop, the use of genetics in criminal trials is on the rise, and courts are increasingly likely to accept behavioral genetics evidence; therefore, it is crucial that the legal system is well acquainted with the opportunities and limitations of these approaches.     

‘Hate the sin but not the sinner’: forgiveness and condemnation

Abstract

Forgiveness is traditionally thought of as the forswearing of resentment. Resentment has been argued to be a moral emotion, tightly interrelated with moral protest against a wrongdoing. This has lead to forgiveness being thought of as the forgetting or condoning of wrongdoing. I will argue for a concept of forgiveness that is ‘uncompromising’ for it does not involve giving up one’s judgements about the wrongdoing. I will argue that resentment should be understood as a type of reactive attitude, and that this means that it is not necessarily connected with moral protest. I will show that forgiveness is better understood as the overcoming of reactive attitudes (which includes resentment, but also indignation, anger, and other similar emotions). This will allow for forgiveness to be compatible with maintaining condemnation of wrongdoing.     

Consummated mother-son incest in latency: a case report of an adult analysis

Reported cases of mother-son incest are very rare in the psychoanalytic literature; the fact of such incest, however, may not be so rare as has generally been believed. A detailed case report of the analysis of an adult with a history of severe physical, sexual, and verbal abuse, including consummated incest with his mother during latency, is considered in the context of other reported studies. The author raises some issues of resistance and countertransference that may influence the reporting, treatment, and perhaps even recognition of cases of mother-son incest.     

Commanding Intentions and Prize-Winning Decisions

It is widely held that any justifying reason for making a decision must also be a justifying reason for doing what one thereby decides to do. Desires to win decision prizes, such as the one that figures in Kavka’s toxin puzzle, might be thought to be exceptions to this principle, but the principle has been defended in the face of such examples. Similarly, it has been argued that a command to intend cannot give one a justifying reason to intend as commanded. Here it is argued that ordinary agents in ordinary cases can have justifying reasons for deciding that are not and will not be justifying reasons for doing what, in making those decisions, they come to intend to do. The paper concludes with some brief observations on the functions of decision-making.     

The vascular cerebellopontile angle syndrome]

A cerebellopontine angle tumor cannot be reliably diagnosed from a classical clinicotopographic cerebellopontine angle syndrome. There is also a vascular cerebellopontine angle syndrome which is not too rare an occurrence. In some cases of tumorigenesis, where there is no papilledema and no characteristic increase in total liqour protein, it is not possible to make a clear decision between tumorous growth and vascular syndrome. The extension of the internal auditory meatus cannot be considered to be a symptom clearly indicating the presence of a tumor.     

Visuospatial Neglect: The Ultimate Deconstruction?

Unilateral visuospatial neglect is now widely acknowledged to be a highly heterogeneous condition: The overt manifestations of visual neglect can vary as a function of task, spatial domain, and mode of response (at least). Double dissociations (sometimes of the strong form) have already been reported between most of the components of what was originally thought to be a relatively stable construct within the visual modality. Nonetheless, throughout successive fractionations of neglect, reported cases of bidirectional task-specific neglect after unilateral brain damage are rare. We now report two such cases. After right hemisphere stroke, the first patient reliably showed severe left neglect on cancellation but right neglect on line bisection. After left hemisphere stroke, the second case showed right neglect on cancellation but left neglect on line bisection. Extensive investigation of case 1 confirmed our previous conjecture that the crucial distinction between these tasks lies in the presence or the absence of an overt target. In contrast to cancellation, line bisection demands the internal computation of the location of the “target” (the midpoint), followed by executing a motor response toward the precise location of that “imaginary” midpoint. The relative attentional and premotor contributions of the intact and damaged hemispheres to these forms of bidirectional neglect are also assessed.     

More than off-task: Increased freely-moving thought in ADHD

Off-task thought has been found to occur at high rates and is related to impairment in ADHD. However, off-task thought is heterogenous and it remains unclear which specific dimensions of off-task thought are more prevalent in this disorder. It is therefore important to dissociate different aspects of off-task thought in order to better understand the mechanisms underlying impairment. The current study focused on the dimension of constrained (focused) to freely moving off-task thought. Self-report and neurophysiological measures during a computerized attention tasks provided convergent evidence that individuals with ADHD not only have more off-task thought than those without, but also engaged in a greater proportion of freely moving off-task thought than non-ADHD controls. Overall, this work demonstrated differences in both the quantity and type of off-task thought in adults with ADHD. It provides novel insight into both the phenomenology of off-task thought, as well as potential mechanisms underlying impairment in ADHD.     

Higher-order activity beyond the word level: cortical dynamics of simple transitive sentence comprehension

Slow electrophysiological effects, which fluctuate throughout the course of a sentence, independent of transient responses to individual words, have been reported. However, this type of activity has scarcely been studied, and with only limited use of electrophysiological information, so that the brain areas in which these variations originate have not been clearly identified. To improve this state of affairs, a principal component analysis and a modern source analysis algorithm (LORETA) were applied to the slow activity underlying transitive sentence reading. Four components explained 97.3% of the variance. Of key interest was a slow variation that occurred throughout the entire sentence but peaked with the appearance of the verb. The main solution for this component was localized in prefrontal and temporal regions presumably involved in semantic sentence processing. This constitutes empirical evidence for cortical activity--related to semantic processes thought to be involved in thematic role assignment--developing throughout the sentence but presenting a conspicuous maximum with the appearance of the verb. This finding also highlights the central role of verb information in the understanding of transitive sentences.     

Late Onset First Episode Psychosis Emerging as Delusional Misidentification of Familiar Sacred Places During a Holy Pilgrimage: A Case Report and Literature Review

Background

The delusional misidentification syndromes (DMS) include a myriad of discrete but related syndromes, which have wide spectrum anomalies of familiarity. Several misidentification syndromes have been described in the psychiatric literature, the most common of these delusions are: the Capgras syndrome; the Fregoli syndrome; the syndrome of inter-metamorphosis; reduplicative paramnesia; and environmental reduplication.

Case Presentation

The reported case highlights the emergence of late onset first episode psychosis in a Middle Eastern 65-year-old female who has no previous psychiatric history. The nature of psychosis was mainly delusions of misidentification and persecution.

Discussion

DMS are relatively rare and occur predominantly in association with schizophrenia and affective psychosis. Between 25 and 40% are associated with organic conditions such as dementia, head injuries, brain tumors, and epilepsy. Only three cases of misidentification of sacred places have been reported previously in the literature. This case report is the first to present a DMS, emerging as a late onset first episode psychosis during the sacred journey of Hajj.

Clinical Implications

The reported case highlights the importance of early recognition and treatment of mental health conditions that may appear de novo during the Hajj sacred journey. Readily available psychiatric resources, psychotropic medications, and psycho-education may be pivotal in ensuring mental well-being of pilgrims, which is fundamental to maintain the mental capacity required for completing these journeys.

     

Late capitalism and postmodernism: Educational problems and possibilities

This work analyzes certain aspects of postmodernist thought in terms of the challenges it presents to the secular, radical democratic project to which the author subscribes. It is argued that much of postmodernist thought has been effective in attacking foundationalism, as well as supporting marginalized persons and ideas, but holds little promise with regard to building an integrative democratic community. Postmodernist radicalism has not usually been directed against capitalist power; therefore, it is not clear how this form of radicalism can be useful to a project that is predicated upon the incompatibilities between capitalism and bona fide democracy.     

The eyes have it!: an fMRI investigation

For the past several years it has been thought that cues, such as eye direction, can trigger reflexive shifts in attention because of their biological relevance and their specialized neural architecture. However, very recently, reported that other stimuli, such as arrows, trigger reflexive shifts in attention in a manner that is behaviourally identical to those triggered by eyes. Nevertheless these authors speculated that reflexive orienting to gaze direction may be subserved by a neural system-the superior temporal sulcus (STS)-that is specialized for processing eyes. The present study presents fMRI data that provide direct and compelling empirical support to this proposal. Subjects were presented with fixation stimuli that, based on instruction, could be perceived as eyes or as another type of directional cue. Both produced equivalent shifts in reflexive attention, replicating Ristic et al. However, the neural systems subserving the two forms of orienting were not equivalent-with the STS being engaged exceptionally when the fixation stimulus was perceived as eyes.