载体介导P53基因在肿瘤治疗中的应用

P53肿瘤抑制基因参与细胞周期调控,在防止癌变过程中起着重要作用,用不同的载体如:脂质体、腺病毒载体、腺相关病毒载体、纳米载体等转入不同细胞,均可产生抑制肿瘤生长,到目前为止,所以这些载体均存在一些缺陷。     

关于抑癌基因P53认识过程的反思

关于抑癌基因ｐ５３认识过程的反思第四军医大学博士生（７１００３２）胡敏导师王文亮今天,抑癌基因已为全世界生命科学工作者所瞩目。７０年代末期至８０年代,科学家相继报道,在人的基因组中存在有原癌基因,即每一个体均有罹有癌症的可能,曾多少引起不同程度的恐慌...     

心理干预在膀胱肿瘤治疗方案中的应用

在临床工作中诊疗膀胱肿瘤时应重视患者的心理状态和精神活动,采取针对性的干预措施,对其躯体疾病的治疗和术后生存质量的提高,有积极的促进作用及良好的辅助治疗效果。本文主要阐述了膀胱肿瘤患者心理因素对膀胱肿瘤的诊疗效果的影响机制,并就如何制定心理干预措施给出了建议。     

体外循环在气管内肿瘤治疗中的应用与思考

近年来体外循环技术已经不仅仅用于心脏手术,还广泛应用于非心脏手术。应用体外循环技术切除气管内肿瘤比常规气管插管全身麻醉扩大了手术适应征,但是也附加了相应的手术并发症。临床医生应有系统的观点,以循证医学模式为指导,坚持以人为本,个性化地将这项技术应用于患者。     

消融术在甲状腺肿瘤治疗中的争议

近年来甲状腺结节的发病率呈现增高趋势,但是只有10%左右的甲状腺结节为甲状腺癌,如何治疗如此多的良性甲状腺结节是一个巨大的挑战。传统手术方式效果好,但是会在颈部留有疤痕,且有术后甲状腺功能减退的可能,不易被良性甲状腺结节患者接受。最近消融疗法让良性甲状腺结节患者多了一个选择,但消融术在国内应用时间较短,其适应证和安全性尚有争议,本文就消融术在甲状腺肿瘤中的应用做一述评。     

正确对待胸腔镜在肿瘤手术中的应用

以胸腔镜为代表的微创胸外科迅速发展并取得了良好的临床效果.胸腔镜手术治疗肺癌和食管癌存在较大争议,全盘否定或盲目应用都会影响胸外科的发展.胸腔镜肺癌、食管癌切除术都有其适应证,对医生提出了更高的技术要求.     

正确对待胸腔镜在肿瘤手术中的应用

以胸腔镜为代表的微创胸外科迅速发展并取得了良好的临床效果。胸腔镜手术治疗肺癌和食管癌存在较大争议,全盘否定或盲目应用都会影响胸外科的发展。胸腔镜肺癌、食管癌切除术都有其适应证,对医生提出了更高的技术要求。     

超声联合微泡剂介导的肿瘤靶向治疗研究进展

包被气体的微泡剂作为超声造影剂不仅显著提高了临床超声显像诊断能力,而且其作为一种新型药物载体的靶向治疗作用正逐步被揭示。携带基因或药物的超声微泡剂介导肿瘤靶向治疗已经成为超声研究领域中的研究热点。这种微泡剂在超声能量作用下因空化效应导致自身破裂并定向释放所携带的药物或者基因,使特定肿瘤组织或细胞部位浓度大大提高,从而起...     

The P600 in Implicit Artificial Grammar Learning

The suitability of the artificial grammar learning (AGL) paradigm to capture relevant aspects of the acquisition of linguistic structures has been empirically tested in a number of EEG studies. Some have shown a syntax‐related P600 component, but it has not been ruled out that the AGL P600 effect is a response to surface features (e.g., subsequence familiarity) rather than the underlying syntax structure. Therefore, in this study, we controlled for the surface characteristics of the test sequences (associative chunk strength) and recorded the EEG before (baseline preference classification) and after (preference and grammaticality classification) exposure to a grammar. After exposure, a typical, centroparietal P600 effect was elicited by grammatical violations and not by unfamiliar subsequences, suggesting that the AGL P600 effect signals a response to structural irregularities. Moreover, preference and grammaticality classification showed a qualitatively similar ERP profile, strengthening the idea that the implicit structural mere‐exposure paradigm in combination with preference classification is a suitable alternative to the traditional grammaticality classification test.     

The program of the psychometric society 53rd annual meeting

The program of the psychometric society 53rd annual meeting     

The P & p illusion

Identical letters can appear to differ in size and shape depending on whether they are interpreted as uppercase or lowercase. The effect is most dramatic with the letter p. Examination of subjects’ estimates of the magnitude of the effect for different stimuli suggests that two factors are involved in the illusion. One factor depends only on whether a letter is interpreted as uppercase or lowercase. Thisfactor can be manipulated by changes in the size or case ofthe surrounding letters. The second factor, which depends on the possibility of interpreting a vertical line alternatively as an ascender or a descender(as in p or y), seems to involve a change in the perceived size of the letters’ loops.     

Contents of Volume 53

Volume Contents

Contents of Volume 53