C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects

Cortisol affects the acute-phase response, but it is unknown whether C-reactive protein (CRP), an acute-phase reactant, also affects hypothalamus?pituitary?adrenal axis activity. In the present study, associations were explored between CRP haplotypes with plasma CRP concentrations and basal salivary cortisol level. We included 266 physically healthy Caucasian subjects (103 females and 163 males) aged between 18 and 65 years of whom 94 had a psychiatric disorder in a genetic association study. Six tag single-nucleotide polymorphisms capturing the common genetic variation of the CRP gene were genotyped (i.e. rs2808628, rs2808630, rs1205, rs1800947, rs1417938, and rs3091244) to yield common CRP haplotypes. Plasma CRP concentrations, the salivary cortisol awakening response (CAR) (0, 30, 45, and 60?min after awakening), and the diurnal cortisol decline (11:00, 15:00, 19:00, and 23:00 h) were assessed for 2 days. rs2808628, rs1205, rs1417938, and rs3091244 showed expected associations not only with CRP concentrations, but also with salivary cortisol levels during the CAR. Five well-characterized CRP haplotypes were arranged in ascending order according to increasing CRP levels. There was an inverse linear association between CRP haplotypes and cortisol levels during the CAR, but no association with the diurnal cortisol decline. Hence, genetic variants in the CRP gene that are associated with lifetime plasma CRP levels were also associated with salivary cortisol levels after awakening, in basal, non-inflammatory conditions.     

A comparison of auditory monitoring performance in blind subjects with that of sighted subjects in light and dark

Two experiments were performed in which blind Ss, sighted Ss working in the dark, and sighted Ss working in the light were compared as to their efficiency on an auditory watchkeeping task. Absolute and differential auditory thresholds were measured in both experiments, and in the second experiment the groups also underwent a signal detection session under alerted conditions. There was some inconsistency as to relative performance of the sighted groups, but in both experiments the blind Ss were superior on the auditory watchkeeping task as to signals detected and effective sensitivity (d’). 1 This difference was not attributable to a difference in auditory sensitivity or to a criterion adopted for     

Studies of implicit prototype extraction in patients with mild cognitive impairment and early Alzheimer's disease

Studies of incidental category learning support the hypothesis of an implicit prototype-extraction system that is distinct from explicit memory (Smith, 2008). In those studies, patients with explicit-memory impairments due to damage to the medial-temporal lobe performed normally in implicit categorization tasks (Bozoki, Grossman, & Smith, 2006; Knowlton & Squire, 1993). However, alternative interpretations are that (a) even people with impairments to a single memory system have sufficient resources to succeed on the particular categorization tasks that have been tested (Nosofsky & Zaki, 1998; Zaki & Nosofsky, 2001) and (b) working memory can be used at time of test to learn the categories (Palmeri & Flanery, 1999). In the present experiments, patients with amnestic mild cognitive impairment or early Alzheimer's disease were tested in prototype-extraction tasks to examine these possibilities. In a categorization task involving discrete-feature stimuli, the majority of subjects relied on memories for exceedingly few features, even when the task structure strongly encouraged reliance on broad-based prototypes. In a dot-pattern categorization task, even the memory-impaired patients were able to use working memory at time of test to extract the category structure (at least for the stimulus set used in past work). We argue that the results weaken the past case made in favor of a separate system of implicit prototype extraction.     

The effect of somaesthetic and acoustic stimuli on the threshold of fusion of paired light flashes in human subjects

The threshold of fusion of paired flashes of light was measured by determining the largest interval between two flashes of light at which they were reported as one and not as two flashes. When a weak electric shock to the skin was presented at the same time as the first flash, the threshold was increased compared to the threshold measured when the flashes were unaccompanied by a shock. As the interval between shock and first flash was increased up to 600 millisec, the effect diminished. A similar pattern of results was obtained using a click, instead of a shock as the additional stimulus. The effect on the two-flash threshold of varying click intensity was also studied. No retroactive effects of the shock on the two-flash threshold were observed.     

Executive functioning in older adults with mild cognitive impairment: MCI has effects on planning, but not on inhibition

In this study, we compared executive functioning in 32 mild cognitive impairment (MCI) individuals with that of normally aging controls. Cognitive planning tests (Trail Making, Porteus Maze Test, verbal fluency tests) show a group difference favoring the normal controls, but tests for inhibition of prepotent responses (no-go accuracy, two measures of the Stroop effect, and negative priming) failed to uncover a significant group difference. The results indicate that there is no general executive control function impairment in MCI; rather, the deficits found are compatible with the hypothesis that MCI is an accelerated form of normal aging.     

Large variations of global functioning over five years in treated patients with personality traits and disorders

The aim of this study was to examine the long-term course of global functioning in patients with personality disorders (PD) and investigate predictors of variation. The Global Assessment of Functioning (GAF) was repeated over five years in 352 patients with PDs of varying severity, all treated in psychotherapeutic day hospitals. Growth models were used for statistical analysis. Large variations in the long-term course of global functioning were evident in this clinical sample. At five-year follow-up, 46% reached a GAF-score above 60 with a mean GAF-score of 71. Their linear change-rate over the five years was estimated to be 4.4 GAF points per year. The average five-year GAF-score for the remaining subgroup (54%) was 50 and their linear yearly change-rate was 0.8 GAF points. Greater relief of symptom distress and interpersonal problems was typical of patients with functional improvement. The number of avoidant PD criteria was associated with slower functional change.     

An examination of an enhancing effect of music on attentional abilities in older persons with mild cognitive impairment

While the effect of listening to music on cognitive abilities is highly debated, studies reporting an enhancing effect of music in elderly populations appear to be more consistent. In this study, the effects of listening to music on attention in groups of cognitively normal older adults and those with mild cognitive impairment were considered. Participants were exposed to both a music and silence condition, and after each condition performed Digit Span and Coding tasks which require attention for maximal performance. The hypothesis that listening to music, compared to a silence condition, enhances performance was not supported for either group. Various explanations for these findings are considered.     

Interocular suppression in normal and amblyopic subjects: The effect of unilateral attenuation with neutral density filters

In normal subjects, binocular rivalry suppression takes time to build up (Wolfe, 1986a). The time courses of interocular suppression are different and heterogeneous in amblyopic subjects (de Belsunce & Sireteanu, 1991). In the present study, we found that, in normal observers, progressive reduction of one eye’s stimulus luminance with neutral density filters produces time courses similar to those of amblyopic subjects. Conversely, in amblyopes, attenuation of the dominant eye’s stimulus produces time courses similar to those of normal observers. Under conditions of balancing of the two eyes, amblyopes experience alternating suppression, similarly to binocular rivalry of normals.     

A guilt gradient in the illegal use of parking spaces reserved for people with disabilities: field observations over five years.

Three parking spaces clearly designated as reserved for people with disabilities were observed from 8:00 AM until 9:00 PM on Monday through Saturday of the second or third week in November for five consecutive years. During the seven weeks of observation, 962 drivers parked illegally in those three reserved spaces. Informal observations and previous research suggested that illegal parkers would be more likely to park in the least conspicuous parking spaces, and, as predicted, a significant monotonic relationship was found. Thus, the data generally agree with the prediction that illegal parkers in spaces reserved for people with disabilities are less likely to park in the more conspicuous parking spaces and are more likely to park in the least conspicuous parking spaces, suggesting a guilt gradient in this illegal parking.     

The effect of concordance in the treatment of clients with dental anxiety.

This study followed from an earlier case study in which an agoraphobic client was treated daily for a period of four weeks by in vivo exposure. Ratings of his perceived anxiety responses in the behavioural, cognitive, and physiological systems were monitored throughout treatment. Concordance between these ratings was associated with positive outcome. This study was an attempt to replicate some of these findings. A group programme involving four sessions in which clients were taught anxiety management skills, exposed in imagination to situations relating, to dentistry, and given homework assignments was carried out with clients presenting with disproportionate dental anxiety. The subjects were obtained by means of local newspaper and radio advertisements and randomly assigned to a massed or spaced treatment condition. It was predicted that the massed condition involving shorter intersession intervals would be superior at producing habituation and concordance than the spaced condition. The results failed to show differences between the massed and spaced treatment condition with regard to concordance and outcome. However, it was confirmed, once more, that concordance between the three modes of anxiety responding was positively related to outcome.     

Waxing and waning in concert: dynamic comorbidity of conduct disorder with other disruptive and emotional problems over 7 years among clinic-referred boys

Six waves of structured diagnostic assessments were conducted of 168 clinic-referred 7- to 12-year-olds, over 7 years. Wave-to-wave changes in the number of conduct disorder (CD) behaviors were paralleled by correlated changes in the numbers of symptoms of oppositional defiant disorder (ODD), attention-deficit/hyperactivity disorder (ADHD), depression, and anxiety. In addition, CD in Wave 1 predicted levels of ODD, ADHD, depression, and anxiety in later waves when initial levels of those symptoms were controlled, but only ODD in Wave 1 predicted CD in later waves when initial CD levels were controlled. These findings indicate a striking degree of dynamic comorbidity between CD and other types of psychopathology and provide an initial empirical framework for needed developmental models of comorbidity.     

Personality characteristics of women with alcohol addiction: A Rorschach study of women in an early treatment programme

This study identifies personality characteristics in a group of Swedish women (N=60) attending their first treatment for alcohol problems.The treatment programme specifically addressed women in an early phase of their drinking career, and was called "Early Treatment of Women with Alcohol Addiction" (EWA). Rorschach personality profiles of the 60 women differed significantly in almost all investigated aspects in a psychopathological direction from norms reported by Exner for a reference group of female non-patients. The findings are consistent with the assumption that, although the EWA women were socially well-functioning and fairly early in their drinking career, they nevertheless reveal serious underlying psychopathology. Clinical implications of the findings are discussed.     

Fluid intelligence is independently associated with all-cause mortality over 17 years in an elderly community sample: An investigation of potential mechanisms

The long-term relationship between lower intelligence and mortality risk in later life is well established, even when controlling for a range of health and sociodemographic measures. However, there is some evidence for differential effects in various domains of cognitive performance. Specifically, tests of fluid intelligence may have a stronger association with mortality than do tests of crystallized intelligence. The present study examines the relationship between intelligence and mortality in a sample of 896 Australian community-dwelling males and females, aged 70–97 at recruitment and followed for up to 17 years. There were 687 deaths during the follow-up period. Cox proportional hazard regression models examined whether the relationship between intelligence and mortality might be mediated by socioeconomic status, by health behaviors, by health status, or a combination of these. Higher fluid intelligence — as measured by the Symbol–Letter Modalities Test — was strongly associated with lower mortality rates (Hazard ratio = 0.80; 95% confidence interval = 0.72–0.88), even after accounting for any combination of potential mediators and confounders. A significant association between crystallized intelligence, as measured by the National Adult Reading Test, and mortality (HR = 0.89; 95% CI = 0.80–0.99) was attenuated by the inclusion of socioeconomic, health status measures, and health behavior measures and when deaths from the first four years of the study were excluded. The findings show little support for the hypothesized mechanisms of the intelligence–mortality relationship.     

Perseveration of the partial reinforcement effect in extinction with rats over two phases of extinction and two stages of continuous reinforcement

One group of 10 male albino rats was given partial reinforcement while the other 10 rats received continuous reinforcement in a straight alley. Subjects then experienced five consecutive stages of Extinction 1, Continuous Reinforcement 1, Extinction 2, Continuous Reinforcement 2, and finally, Extinction 3. Analysis showed the partial reinforcement effect in extinction was sustained over two stages of extinction and two stages of continuous reinforcement, since subjects receiving partial reinforcement ran faster than rats given continuous reinforcement throughout all three of the extinction periods. The results seem to support those of Amsel's (1967) and Cabpaldi's (1967) theoretical formulations of the partial reinforcement effect in extinction.     

Laterality, attention and rate effects in the auditory temporal discrimination of chronic schizophrenics: The effect of treatment with chlorpromazine

Schizophrenic patients, non-psychotic patients and healthy subjects were required to detect longer target tones from a sequence of short tones presented to either ear. The rate of stimulus presentation and the frequency of switches between the ears were varied. The schizophrenic patients were examined for four weeks while on standard clinical doses of chlorpromazine, for four weeks while on placebo, and for four weeks following reinstatement of medication. Lateral asymmetries in the performance of the schizophrenics were found to diminish in proportion to both the duration and the dosage of medication. The results are consistent with the hypothesis that chlorpromazine causes an improvement of left hemisphere performance relative to the right. The performance of the schizophrenics, relative to that of comparison subjects, deteriorated as the rate of stimulus presentation increased, supporting the hypothesis that schizophrenics have particular difficulties in response selection or organization.