Variability in fundamental frequency during speech in prodromal and incipient Parkinson's disease: a longitudinal case study

Nearly two centuries ago, first observed that a particular pattern of speech changes occur in patients with idiopathic Parkinson's disease (PD). Numerous studies have documented these changes using a wide variety of acoustic measures, and yet few studies have attempted to quantify any such changes longitudinally, through the early course of the disease. Moreover, no attempt has been made to determine if speech changes are evident during the prodromal period, prior to the onset of clinically noticeable symptoms. This case-control pilot study is a first attempt to determine if changes in fundamental frequency variability during speech, an acoustic measure known to be affected later in the course of the disease, are evident during the prodromal period. A retrospective analysis of videotape footage recorded and made available by a leading national television news service. Videotape samples were obtained for a single individual (and a well-matched control subject) over an 11-year period of this individual's life (7 years prior to diagnosis of PD, and 3 years post-diagnosis). Results suggest that changes in F0 variability can be detected as early as 5 years prior to diagnosis (consistent with findings from other laboratories that have relied on cross-sectional study approaches). This pilot study supports the utility of such a design approach, and these results warrant continued effort to better understand the onset of PD and sensitivity of measurement of voice acoustical changes during the prodromal period.     

Rapid Cycling

Rapid cycling is not a distinct disorder, but is a particularly severe form of bipolar disease. One in six patients with bipolar disease seen by psychiatrists either as an outpatient or as an inpatient suffers from four or more episodes per year. If at least four episodes occur within one year, this high-frequency phase is called ?rapid cycling“ (RC). Treatment for bipolar disorder with RC usually includes trialling mood stabilizers, such as lithium, anticonvulsants, and modern antipsychotics.In four out of five RC patients, treatment improves disease progression; however, some patients exhibit RC for many years.Specific studies have raised the suspicion that administering antidepressive therapy could facilitate an unfavorable course of bipolar affective disorder. The present case demonstrates disease progression and treatment attempts in a patient with distinct RC progression.     

预防为主——防止禽流感的决策

对传染病的处理,根据几千年历史的共视,近半个世纪的科学进步,传染病的变迁,特别是今年突发传染病的暴发;以及传染病本身的三个特点即病原、传播途径及易感者等,预防为主应该是首要决策。目前引起全球震惊的禽流感,由于病原易变,同时野禽感染导致污染源不好控制,病禽感染人的病死率竟高达50%。从病原、病源及治疗方面都很棘手,未知数不少,治疗缺少现成的经验。因此防禽流感、人流感及治疗方面均要掌握预防为主的决策主体,无病有防,有病早发现,早治疗,既防播散又防加重病情,还要防止不合理施治造成不良反应及二重感染。     

The Effect of Genetic Counseling for Adult Offspring of Patients with Type 2 Diabetes on Attitudes Toward Diabetes and its Heredity: A Randomized Controlled Trial

The aim of this study is to investigate the effect of diabetes genetic counseling on attitudes toward diabetes and its heredity in relatives of type 2 diabetes patients. This study was an unmasked, randomized controlled trial at a medical check-up center in Japan. Subjects in this study are healthy adults between 30 and 60 years of age who have a family history of type 2 diabetes in their first degree relatives. Participants in the intervention group received a brief genetic counseling session for approximately 10 min. Genetic counseling was structured based on the Health Belief Model. Both intervention and control groups received a booklet for general diabetes prevention. Risk perception and recognition of diabetes, and attitude towards its prevention were measured at baseline, 1 week and 1 year after genetic counseling. Participants who received genetic counseling showed significantly higher recognition about their sense of control over diabetes onset than control group both at 1 week and 1 year after the session. On the other hand, anxiety about diabetes did not change significantly. The findings show that genetic counseling for diabetes at a medical check center helped adults with diabetes family history understand they are able to exert control over the onset of their disease through lifestyle modification.     

元代疫灾述论

元代疫灾严重程度难以想象,为害甚重。据史实考察可以发现：元代疫灾虽是由自然界的破坏力及人与人之间社会关系失调共同作用而引发的,但作用主体是有变化的,且时段划分比较明显。疫灾的时间分布密集,空间分布也较为平衡。元政府在防疫方面也有许多积极举措。     

Universal newborn screening and adverse medical outcomes: a historical note

Universal newborn screening programs for metabolic disorders are typically described as a triumph of medicine and public policy in the US over the last 50 years. Advances in science and technology, including the Human Genome Project, offer the opportunity to expand universal newborn screening programs to include many additional metabolic and genetic conditions. Although the benefits of such screening programs appear to outweigh their costs, some critics have claimed that historical examples of inadvertent harm ensuing from false-positive screening results and subsequent inappropriate medical treatment should make us wary of expanding universal newborn screening. In this essay, we report the results of a review of the published literature to assess whether the extension of screening from at risk populations to all newborns led to substantial morbidity and mortality from misguided medical treatment. We provide a historical overview of universal newborn screening programs in the United States, and then focus on six early NBS programs: congenital hypothyroidism, phenylketonuria, congenital adrenal hyperplasia, galactosemia, sickle cell disease, and maple syrup urine disease. Our comprehensive search of published sources did not reveal a widespread problem of harm ensuing from medical treatment of children with false positive screening test results.     

Observations about Family Interaction and the Effect of Therapy: Interviews with Families Eight Years after the Onset of Schizophrenia

This study focused on the development of and changes in the interaction within a family after the onset of schizophrenia in a family member. Special attention is given to the possible effects of various treatments on the interaction. Our method was a circular interview of all family members in a joint session 8 years after the onset of schizophrenia. We observed that changes in family interaction usually had taken place during the first year of the illness. Thereafter, family conditions and interactions seem to have remained relatively unchanged. On the other hand, in addition to actual family-centered therapy, all other treatment modes--individual therapy, medication, hospitalization--seemed to have acted as systemic interventions on the family level. Our observation that family interactions and models of therapy often had a surprisingly strong resemblance led us to consider the idea of their coevolution over the years and the possible significance of this. This article aims at calling the reader's attention to the manifold influences that the onset of schizophrenia and its various treatments seem to have had on family system.     

Bridging History and Social Psychology: What, How and Why

This special issue aims to bridge history and social psychology by bringing together historians and social psychologists in an exercise of reading and learning from each other??s work. This interdisciplinary exercise is not only timely but of great importance for both disciplines. Social psychologists can benefit from engaging with historical sources by being able to contextualise their findings and enrich their theoretical models. It is not only that all social and psychological phenomena have a history but this history is very much part of present-day and future developments. On the other hand historians can enhance their analysis of historical sources by drawing upon the conceptual tools developed in social psychology. They can ??test?? these tools and contribute to their validation and enrichment from completely different perspectives. Most important, as contributions to this special issue amply demonstrate, psychology??s ??historical turn?? has the potential to shed a new light on striking, yet underexplored, similarities between contemporary public spheres and their pre-modern counterparts. This issue thereby calls into question the dichotomy between traditional and de-traditionalized societies??a distinction that lies at the heart of many social psychology accounts of the world we live in. The present editorial will introduce and consider this act of bridging history and social psychology by focusing on three main questions: What is the bridge made of? How can the two disciplines be bridged? and Why we cross this interdisciplinary bridge? In the end a reflection on the future of this collaboration will be offered.     

Frank–Read sources and the yield of anisotropic cubic crystals

Frank–Read sources are among the most important mechanisms of dislocation multiplication, and their operation signals the onset of yield in crystals. We show that the critical stress required to initiate dislocation production falls dramatically at high-elastic anisotropy, irrespective of the mean shear modulus. We hence predict the yield stress of crystals to fall dramatically as their anisotropy increases. This behaviour is consistent with the severe plastic softening observed in α-iron and ferritic steels as the α ? γ martensitic phase transition is approached, a temperature regime of crucial importance for structural steels designed for use in future nuclear applications.     

Latent growth curve analyses of accelerating decline in cognitive abilities in late adulthood

Latent growth models were applied to data from the Swedish Adoption/Twin Study of Aging to discover if the rate of change in cognitive performance increased from middle age to later adulthood. The sample included 590 participants aged 44 to 88 years at first measurement. Data were gathered at 2 follow-up occasions at intervals of 3 years. Cognitive ability was assessed through 11 tests that tapped crystallized, fluid, memory, and spatial abilities and perceptual speed. Results indicated stability for measures of crystallized ability, linear age changes for many cognitive abilities, and a significant acceleration in linear decline after age 65 for measures with a large speed component. Gender differences were found only in mean level, not in rate of decline.     

Why Are You Betraying Your Class?

Abstract: Social justice concerns us on two counts: One, what is social justice? Two, given that we know the answer to one, then the question is: how can social justice be implemented? Answering the first question requires hitting the right balance between two values: liberty and equality. My concern here, however, is with the second question, the question of implementation rather than with what social justice consists of. I assume that the right balance between liberty and equality is somehow a given. To implement the structural changes that a just society requires calls for a historical agent that can bring about such changes. The working class was a good candidate to be such a historical agent. The working class was suitable for this historical task because it was the class that had the most to gain from a just society and it was a very large class of people. The working class was singled out for this task not for being a particularly virtuous class but by being the class that had the most to gain from a change in the status quo. But the working class is rapidly disappearing; in the developed countries, it has shrunk considerably. Thus, the implementation of social justice is now left without an effective historical agent to carry it through.     

Juvenile onset Huntington's disease--clinical and research perspectives

Huntington's disease (HD) is an inherited neurodegenerative disorder. The mutation which causes the disease is an expansion in the number of repetitions of three nucleotides, C, A, and G in exon 1 of the huntingtin gene. The gene normally has 15 to 30 repeats and an expansion to 40 or more is associated with HD. HD usually has a mid-life onset, but a juvenile form, defined by onset of symptoms before the age of 21 years, is present in about 7% of HD cases. Juvenile HD is characterized by (1) transmission from an HD affected father, (2) an unusually large repeat size, usually of 60 or more units, and (3) unique clinical features, including rigidity and seizure disorder. Although juvenile onset is associated with a more severe neuropathological involvement, the neuropathological characteristics of juvenile HD are similar to those seen in the adult form in that the striatum bears the brunt of the illness. Clumps of protein, termed inclusion bodies, which stain positive for huntingtin and ubiquitin, are found primarily in the nucleus but also in the cytoplasm and axons in HD neurons. Research suggests that these inclusion bodies sequester a deleterious protein fragment and prolong cell life during the degenerative process of the disease.     

Longitudinal analysis of adolescent girls' aspirations at school and perceptions of popularity

The purpose of this longitudinal study was to examine changes in adolescent girls' aspirations at school and perceptions of popularity as they matured, and to determine if there were any differences between participants and nonparticipants on interschool teams. One hundred forty girls completed a questionnaire each year for five years from Grades 6 to 10 (ages 11 to 15), answering the following questions: What would you most like to do at school? Which of the following make you most popular among your friends? and How many interschool teams have you been on? For aspirations at school the overwhelming first choice of the total sample was making good grades; participants ranked being good at sports second; nonparticipants ranked being popular second. For the total sample, being popular increased slightly in importance, while sports decreased slightly over the five years. As for perceptions of popularity, grades were most important in Grades 6 and 10, while looks were ranked first during junior high school. Interschool participants ranked grades and sports first or second, while nonparticipants chose looks as most important for achieving popularity.     

Psychosocial Factors and HIV Prevention for Gay,Bisexual, and Other Men Who Have Sex with Men

We are more than 30 years into the HIV epidemic, and, although we have made many important scientific advances, there remains much to understand and implement to prevent new infections. The science of HIV prevention, although interdisciplinary, has relied heavily on psychological theories and research methods to address many key questions. In this paper, we briefly review some historical and epidemiologic considerations about the U.S. HIV epidemic and then present some key psychological concepts from HIV prevention. We make the case for continuing to focus efforts on gay, bisexual, and other men who have sex with men, who represent the sociocultural group with the highest incidence and prevalence of HIV in the domestic epidemic. We present a summary of the research support for, and limitations of, the three major psychosocial models that predict HIV risk behaviors – the information–motivation–behavioral skills model, the minority stress model, and the syndemics framework. We discuss the use of these models in the development and testing of HIV prevention interventions and end by highlighting a few novel research areas, including bio‐behavioral approaches.     

FOCUS: European Views on Complexity,Recursion, and Planetary Ethics Preface to the FOCUS Section

Global geographical patterns of repressive, painful, traumatic, and violent patrist behaviors and social institutions, which thwart materal‐infant and male‐female bonds, were correlated and developed through a systematic analysis of anthropological data on 1170 subsistence‐level cultures. When the behavior data were mapped, the hyperarid desert belt encompassing North Africa, the Near East, and Central Asia, which I call Saharasia, was found to possess the greatest areal extent of the most extreme patrist behaviors and social institutions on Earth. Regions farthest removed from Saharasia, in Oceania and the New World, were found to possess the most extreme matrist behaviors, which support and protect maternal‐infant and male‐female bonds. A systematic review of archaeological and historical materials suggests that patrism first developed in Saharasia after c.4000 BCE, the time of a major ecological transition from relatively wet grassland‐forest conditions to arid desert conditions. Settlement and migration patterns of patrist peoples were traced, from their earliest homelands in Saharasia, to explain the later appearance of patrism in regions outside of Saharasia. Prior to the onset of dry conditions in Saharasia, evidence for matrism is widespread, but evidence for patrism is generally nonexistent. It is argued that matrism constitutes the earliest, original, and innate form of human behavior and social organization, while patrism, perpetuated by trauma‐inducing social institutions, first developed among Homo Sapiens in Saharasia, under the pressures of severe desertification, famine, and forced migrations.     

Can hearing puter activate pupil? Phonological competition and the processing of reduced spoken words in spontaneous conversations

In listeners' daily communicative exchanges, they most often hear casual speech, in which words are often produced with fewer segments, rather than the careful speech used in most psycholinguistic experiments. Three experiments examined phonological competition during the recognition of reduced forms such as [pjut?r] for computer using a target-absent variant of the visual world paradigm. Listeners' eye movements were tracked upon hearing canonical and reduced forms as they looked at displays of four printed words. One of the words was phonologically similar to the canonical pronunciation of the target word, one word was similar to the reduced pronunciation, and two words served as unrelated distractors. When spoken targets were presented in isolation (Experiment 1) and in sentential contexts (Experiment 2), competition was modulated as a function of the target word form. When reduced targets were presented in sentential contexts, listeners were probabilistically more likely to first fixate reduced-form competitors before shifting their eye gaze to canonical-form competitors. Experiment 3, in which the original /p/ from [pjut?r] was replaced with a “real” onset /p/, showed an effect of cross-splicing in the late time window. We conjecture that these results fit best with the notion that speech reductions initially activate competitors that are similar to the phonological surface form of the reduction, but that listeners nevertheless can exploit fine phonetic detail to reconstruct strongly reduced forms to their canonical counterparts.     

Narcissism in the modern world

Narcissism has been around since the time of Ovid more than 2000?years ago and the concept has long been a source of study, intrigue, fascination and literature both within and beyond the psychoanalytic community. While Narcissistic Personality Disorder remains a severe and fairly rare clinically diagnosed condition, sub-clinical narcissism or narcissistic traits have reached epidemic proportions with serious consequences. Ever increasing levels of greed, self-obsession, superficial relationships, arrogance and vanity are everywhere apparent and not making us any happier, with common mental health problems on the increase, especially among the young. Seemingly irreversible alterations to family life, technological development – including social media, attitudes to death and dying and celebrity worship, all feature in the rise of our narcissistic society and are interconnected trends. Group greed and grandiosity, as in the world of banking, have led to wide-scale corruption and cover-ups leaving us vulnerable and unable to place our trust in many organisations. Perhaps most sinister of all is our attitude to the planet that supports us, as we play a part in the destruction of much of the environment and many of the species that share the earth with us. Looking at the literature of narcissism, the aim of this paper is to consider ways in which cultural changes have brought about this huge rise in both individual and group egotism. We are seeing many more clients high on the narcissistic spectrum but consideration will be given to the narcissism of the therapist and the impact of the therapist’s narcissism on the client. We live in difficult times and cannot step outside our culture but there are ways of countering our narcissism and helping our clients to do the same. Having compassion for one’s self and recognising how ordinary we really are make for a good start.     

Christlicher und Philosophischer Glaube

This article consists of two parts: first, a methodological part and secondly, a historical example. The aim is to discuss the understanding of the theological study of church history in comparison to historical study in general. This is done through the example of two influential Danish scholars on Luther from the 20^th Century. Secondly the article gives an introduction to the Danish reformer Hans Tausen in order to point to two things: an example of the method presented in the first part and an area of research in progress. Strangely enough, Hans Tausen has not been subject to profound scholarly investigation for many years, even though he is one of the most important persons in Danish Reformation history.     

Evidence for a sensitive period in the effects of early life stress on hippocampal volume

Exposure to stress has been causally linked to changes in hippocampal volume (HV). Given that the hippocampus undergoes rapid changes in the first years of life, stressful experiences during this period may be particularly important in understanding individual differences in the development of the hippocampus. One hundred seventy‐eight early adolescents (ages 9–13 years; 43% male) were interviewed regarding exposure to and age of onset of experiences of stress; the severity of each stressful event was rated by an objective panel. All participants underwent structural magnetic resonance imaging, from which HVs were automatically segmented. Without considering the age of onset for stressful experiences, there was a small but statistically significant negative association of stress severity with bilateral HV. When considering the age of onset, there was a moderate and significant negative association between stress severity during early childhood (through 5 years of age) and HV; there was no association between stress severity during later childhood (age 6 years and older) and HV. We provide evidence of a sensitive period through 5 years of age for the effects of life stress on HV in adolescence. It will be important in future research to elucidate how reduced HV stemming from early life stress may contribute to stress‐related health outcomes.     

21世纪新发传染病--非典型肺炎

传染性非典型肺炎 (SARS)是全球人类健康非常严重的威胁 ,是由一种新病毒———SARS冠状病毒引起的新发传染病。具有全球大流行的潜在可能。面对一种新发传染病做好宣传教育工作 ,动员全社会参与尤为重要 ,信息发布要选择合适的途径、合适的对象、合适的信息和合适的时间。即使暴发过去了 ,详细的流行病学及环境调查分析 ,会丰富我们的认识 ,并可防止疫情的蔓延和再次暴发。控制新发传染病不是局部问题 ,是超越地域及政府界限的 ,需要全球支持 ,国际合作与协调 ,共同努力把疾病控制在萌芽之中。