Linking major depression and the neural substrates of associative processing

It has been proposed that mood correlates with the breadth of associative thinking. Here we set this hypothesis to the test in healthy and depressed individuals. Generating contextual associations engages a network of cortical regions including the parahippocampal cortex (PHC), retrosplenial complex, and medial prefrontal cortex. The link between mood, associative processing, and its underlying cortical infrastructure provides a promising avenue for elucidating the mechanisms underlying the cognitive impairments in major depressive disorder (MDD). The participants included 15 nonmedicated individuals with acute major depressive episodes and 15 healthy matched controls. In an fMRI experiment, participants viewed images of objects that were either strongly or weakly associated with a specific context (e.g., a beach chair vs. a water bottle) while rating the commonality of each object. Analyses were performed to examine the brain activation and structural differences between the groups. Consistent with our hypothesis, controls showed greater activation of the contextual associations network than did depressed participants. In addition, PHC structural volume was correlated with ruminative tendencies, and the volumes of the hippocampal subfields were significantly smaller in depressed participants. Surprisingly, depressed participants showed increased activity in the entorhinal cortex (ERC), as compared with controls. We integrated these findings within a mechanistic account linking mood and associative thinking and suggest directions for the future.     

Self-schemas and risk for depression: a prospective study

The role of depressive self-schemas in vulnerability to depression was explored in a longitudinal design. Five groups of subjects hypothesized to be at differential risk for depression according to a schema model were identified: depressed schematic, depressed nonschematic, nondepressed schematic, nondepressed nonschematic, and a psychopathology control. They were followed regularly for 4 months with self-report and clinical interview measures of depression. There was no evidence of risk for depression associated with schema status apart from initial mood and no interaction of life stress events and schemas. In a second experiment with the same subjects, it was shown that depressive self-schemas do not exert an ongoing, active influence on everyday information processing; instead current mood affected information processing. Remitted depressed persons resembled nondepressed rather than depressed ones. The results support Kuiper and colleagues' distinction between concomitant and vulnerability schemas, and help to clarify differences between cognitions that are symptoms or correlates of depression and those that may play a causal role under certain conditions.     

When the ends outweigh the means: mood and level of identification in depression

Research in healthy controls has found that mood influences cognitive processing via level of action identification: happy moods are associated with global and abstract processing; sad moods are associated with local and concrete processing. However, this pattern seems inconsistent with the high level of abstract processing observed in depressed patients, leading Watkins (2008, 2010) to hypothesise that the association between mood and level of goal/action identification is impaired in depression. We tested this hypothesis by measuring level of identification on the Behavioural Identification Form after happy and sad mood inductions in never-depressed controls and currently depressed patients. Participants used increasingly concrete action identifications as they became sadder and less happy, but this effect was moderated by depression status. Consistent with Watkins' (2008) hypothesis, increases in sad mood and decreases in happiness were associated with shifts towards the use of more concrete action identifications in never-depressed individuals, but not in depressed patients. These findings suggest that the putatively adaptive association between mood and level of identification is impaired in major depression.     

When the ends outweigh the means: Mood and level of identification in depression

Research in healthy controls has found that mood influences cognitive processing via level of action identification: happy moods are associated with global and abstract processing; sad moods are associated with local and concrete processing. However, this pattern seems inconsistent with the high level of abstract processing observed in depressed patients, leading Watkins (2008, 2010) to hypothesise that the association between mood and level of goal/action identification is impaired in depression. We tested this hypothesis by measuring level of identification on the Behavioural Identification Form after happy and sad mood inductions in never-depressed controls and currently depressed patients. Participants used increasingly concrete action identifications as they became sadder and less happy, but this effect was moderated by depression status. Consistent with Watkins' (2008) hypothesis, increases in sad mood and decreases in happiness were associated with shifts towards the use of more concrete action identifications in never-depressed individuals, but not in depressed patients. These findings suggest that the putatively adaptive association between mood and level of identification is impaired in major depression.     

Moderators of Mood-congruent Encoding and Judgement: Evidence that Elated and Depressed Moods Implicate Distinct Processes

An experiment investigated the contributions of elaborative processes to mood-congruent encoding (MCE) and judgement (MCJ) of trait adjectives that referred to the self and two others. Evidence from multiple sources (recall, judgement, decision latency) supported the main hypotheses: Elated mood produces MCE/MCJ through elaborative processes that implicate mood-congruent self-schemata; depressed mood produces MCE/MCJ through elaborative, but nonschematically based, processing of self-referent material; and, elated mood produces MCJ (but not MCE) of positive material that referred to the experimenter through simplified or heuristic (rather than elaborative) processing. The hypothesis that elated mood produces MCE/ MCJ through elaborative, but nonschematically based, processing of friendreferent material did not receive support; instead, the results suggested that mood-congruent schemata about the friend also contributed to both the encoding and judgement effects of elated mood.     

Recalling positive self-defining memories in depression: The impact of processing mode

Recalling positive memories is a powerful and effective way to improve mood. However, unlike never-depressed individuals, those with current or past depression do not benefit emotionally from positive memory recall. To examine whether rumination is involved in this difficulty, 80 participants (26 currently depressed, 29 recovered depressed, and 25 never depressed) were instructed to recall a positive self-defining memory while in a sad mood. They were then instructed to think about their memory, adopting either an abstract or concrete processing mode. Never-depressed and recovered depressed participants experienced improved mood after memory recall, regardless of processing mode. However, for depressed individuals neither an abstract nor a concrete processing mode produced emotional benefit. These findings suggest that a complex relationship exists among processing mode, memory type, and depressive status, and indicate that the way in which individuals process positive emotional material may have important consequences for treatment.     

Depression,restraint and eating behavior

Contrary to the belief that weight loss is a principal symptom of depression, several recent studies have suggested that certain people gain rather than lose weight when depressed. The present experiment concerned the effects of experimentally induced mood states on the eating behavior of high- and low-restraint persons. Sixty-eight female undergraduates were randomly assigned to one of three groups each designed to induce a different mood state (depressed, neutral or elated), and were classified as high or low restraint based on their responses to a questionnaire. During the mood induction procedure subjects were provided with the opportunity to eat. High-restraint persons induced into a depressed mood ate significantly more than high-restraint persons induced into neutral or elated moods, and more than low-restraint persons induced into a depressed mood. This effect was most prominent among subjects who scored high on the weight-fluctuation factor of the restraint scale. There was no evidence that this effect occurred among subjects who scored high on the concern for dieting factor. The role of emotional arousal on the self-control over eating behavior of high weight-fluctuation persons, and the implications of these findings for the evaluation of depression were discussed.     

Rationales in children’s causal learning from others’ actions

Shown commensurate actions and information by an adult, preschoolers’ causal learning was influenced by the pedagogical context in which these actions occurred. Four-year-olds who were provided with a reason for an experimenter’s action relevant to learning causal structure showed more accurate causal learning than children exposed to the same action and data accompanied by an inappropriate rationale or accompanied by no explanatory information. These results suggest that children’s accurate causal learning is influenced by contextual factors that specify the instructional value of others’ actions.     

Autobiographical memory characteristics in depression vulnerability: formerly depressed individuals recall less vivid positive memories

The differential activation hypothesis (DAH; Teasdale, 1988) proposes that individuals who are vulnerable to depression can be distinguished from non-vulnerable individuals by the degree to which negative thoughts and maladaptive cognitive processes are activated during sad mood. While retrieval of negative autobiographical memories is noted as one such process, the model does not articulate a role for deficits in recalling positive memories. Two studies were conducted to compare the autobiographical memory characteristics of never-depressed and formerly depressed individuals following a sad mood induction. In Study 1, features of negative memories of never-depressed and formerly depressed individuals did not differ, either in neutral or sad mood. For positive memories, groups did not differ in neutral mood, but following a sad mood induction, formerly depressed individuals rated their positive memories as less vivid than their never-depressed counterparts. Study 2 examined positive autobiographical memory features more comprehensively and replicated the finding that in a sad mood formerly depressed individuals recalled less vivid positive memories than never-depressed controls. These findings suggest that the phenomenological features of positive memories could represent an important factor in depressive vulnerability, and, more broadly, that depression may be associated with a deficit in the processing of positive material.     

Effects of contextual questions on experimentally induced dysphoria

In a replication and extension of Watkins, Teasdale, and Williams (2003), a scrambled sentences paradigm was used to test whether prompting contextual processing of negative cognitive primes would limit the activation of dysphoric mood. Participants were divided into two groups and, after a dysphoric mood induction procedure, were asked to unscramble sentences that either did or did not emphasise the contextual aspects of moods. Consistent with Watkins et al., participants’ despondency decreased significantly more in the contextual group than in the neutral group. This effect could not be accounted for by variations in the way sentences were unscrambled.     

Contextual mood priming following left and right hemisphere damage

This research examined the influence of mood-congruent and mood-incongruent contexts on recognizing affective prosody after brain damage. Predictions stemmed from an associative network theory of learning and memory. Thirty-three male subjects, 11 each in right hemisphere damaged (RHD), left hemisphere damaged (LHD), and normal control groups judged moods from the prosody of semantically neutral phrases. In one task, the prosodic stimulus phrases were judged in isolation. In another task, the phrases were preceded by short paragraphs which were either congruent or incongruent in emotional tone with the prosodic stimuli. These paragraphs were designed to prime specific mood choices. As anticipated, LHD subjects' prosodic mood recognition was more accurate when given congruent rather than incongruent affective contexts. Congruent contexts facilitated, and incongruent contexts disrupted, their prosodic mood judgments to the same extent as normals. RHD subjects showed a partial context decrement. They were less accurate than normal or LHD subjects in the congruent condition, and were unaffected by incongruent contexts. When given congruent biasing paragraphs, however, RHD subjects did experience facilitation on a par with that found for the other groups, indicating spared sensitivity to certain contextual factors. The distinction between automatic and effortful processes is offered as a potential explanation for the RHD group's pattern of performance.     

Autobiographical memory characteristics in depression vulnerability: Formerly depressed individuals recall less vivid positive memories

The differential activation hypothesis (DAH; Teasdale, 1988) proposes that individuals who are vulnerable to depression can be distinguished from non-vulnerable individuals by the degree to which negative thoughts and maladaptive cognitive processes are activated during sad mood. While retrieval of negative autobiographical memories is noted as one such process, the model does not articulate a role for deficits in recalling positive memories. Two studies were conducted to compare the autobiographical memory characteristics of never-depressed and formerly depressed individuals following a sad mood induction. In Study 1, features of negative memories of never-depressed and formerly depressed individuals did not differ, either in neutral or sad mood. For positive memories, groups did not differ in neutral mood, but following a sad mood induction, formerly depressed individuals rated their positive memories as less vivid than their never-depressed counterparts. Study 2 examined positive autobiographical memory features more comprehensively and replicated the finding that in a sad mood formerly depressed individuals recalled less vivid positive memories than never-depressed controls. These findings suggest that the phenomenological features of positive memories could represent an important factor in depressive vulnerability, and, more broadly, that depression may be associated with a deficit in the processing of positive material.     

Using scissors to bisect a line: A perception–action dissociation in complex tool use

Previous research has shown that unilateral visual neglect is improved when patients are required to actively grasp an object at its center, rather than only pointing to its center. A similar dissociation between pointing and grasping responses has been reported for pseudoneglect, a spatial bias toward the left side of space that is normally exhibited by healthy participants. Among other theories, the two-visual-streams hypothesis has been offered as an explanation for these dissociations. According to this hypothesis, highly practiced actions that are performed under easily available visual input (e.g., grasping an object) are controlled by the dorsal stream and can resist perceptual judgment biases. We investigated whether, in pseudoneglect, dissociations between perceptual judgments and motor–manipulative responses occur when participants have to respond with complex tools that are highly practiced but that have been shown to rely on both ventral- and dorsal-stream processing. In a standard line bisection task, participants had to either mark the center of a line with a pencil or cut the line in two halves using a pair of scissors. The results indicated the typical leftward bias (pseudoneglect) in the pencil task, whereas performance was much more accurate in the scissors task. These results show that actions featuring complex tool use can resist perceptual judgment biases, and the findings are discussed with reference to existing accounts of perception–action dissociations.     

Mood repair and processing mode in depression

Recalling positive autobiographical memories is a powerful emotion regulation strategy that can be used to repair low mood and alleviate negative affect. Unlike healthy individuals, those with current or past depression do not experience an improvement in mood as a consequence of recalling positive memories. We tested whether differences in processing mode might account for this impairment. Following mood induction procedures designed to ensure equivalence of mood state, depressed (n = 35) and recovered depressed (n = 33) participants were instructed to recall a positive memory and focus on it while adopting either an abstract or a concrete mode of processing. Participants in the abstract processing condition experienced no change in mood, while those in the concrete processing condition showed improved mood after memory recall. This research illustrates that the process by which positive autobiographical memories are recalled is important in determining their emotional impact and suggests that psychological interventions for depression may be improved by explicitly targeting processing mode.     

Contextual questions prevent mood primes from maintaining experimentally induced dysphoria

We investigated the effects of questions designed to increase a wider awareness of the context in which moods occur on mood-maintaining primes in induced dysphoria. These questions were incorporated, with the primes (negative Velten mood induction statements) into a scrambled sentence task. In Study 1, contextual questions produced a significantly greater reduction in despondency compared to control questions. Study 2 replicated this finding and also demonstrated that contextual questions reduced corrugator EMG response to repeated despondency-inducing statements. The results indicate that contextual questions can prevent negative primes from maintaining depressed mood, consistent with Brewin's (1989) suggestion that one mechanism of psychotherapy is reducing the activation of situationally accessible negative representations.     

Exploring the relation between visual mental imagery and affect in the daily life of previously depressed and never depressed individuals

Previously depressed individuals experience disturbances in affect. Affective disturbances may be related to visual mental imagery, given that imagery-based processing of emotional stimuli causes stronger affective responses than verbal processing in experimental laboratory studies. However, the role of imagery-based processing in everyday life is unknown. This study assessed mental imagery in the daily life of previously and never depressed individuals. Higher levels of visual mental imagery was hypothesised to be associated with more affective reactivity to both negatively and positively valenced mental representations.

This study was the first to explore mental imagery in daily life using experience sampling methodology. Previously depressed (n?=?10) and matched never depressed (n?=?11) individuals participated in this study. Momentary affect and imagery-based processing were assessed using the “Imagine your mood” smartphone application. Participants recorded on average 136 momentary reports over a period of 8 weeks.

The expected association between visual mental imagery and affective reactivity was not found. Unexpectedly, in both previously and never depressed individuals, higher levels of imagery-based processing of mental representations in daily life were significantly associated with better momentary mood and more positive affect, regardless of valence.

The causality of effects remains to be examined in future studies.     

A Cross‐National Comparison of Suicide Attempts,Drug Use,and Depressed Mood Among Dominican Youth

We compared suicide attempts, depressed mood, and drug use of 1,710 Dominican public high school students in New York City (NYC) and 9,573 in the Dominican Republic (DR) in 2009. Compared to DR Dominicans, NYC Dominicans were more likely to have reported lifetime marijuana use (27.6% vs. 1.5%), lifetime inhalant use (11.0% vs. 7.6%), lifetime other drug use (9.9% vs. 3.0%), depressed mood (31.3% vs. 27.2%), and suicide attempt (13.8% vs. 8.8%). The results of this study supported the hypothesis that substantial increases in illicit drug use, especially cocaine, heroin, ecstasy, and methamphetamines, among NYC Dominican youth account for their increased risk for suicide attempts compared to their DR Dominican counterparts. It also identified suicide attempts as a public health problem among NYC Dominicans, the largest NYC Latino immigrant population.     

Effects of responses to depression on the remediation of depressive affect

The effects of different types of responses to a depressed mood on the duration and severity of the mood were examined. On the basis of Nolen-Hoeksema's (1987) response styles theory of depression, it was hypothesized that distracting, active responses would be more effective in alleviating a depressed mood than would ruminative, passive responses. A depressed mood was induced in 35 male and 34 female Ss, and subjects were randomly assigned to engage in 1 of 4 types of responses: an active task that distracted them from their mood; a passive, distracting task; an active task designed to lead to ruminations about their mood; or a passive, ruminative task. As predicted, the greatest remediation of depressed mood was found in Ss in the distracting-active response condition, followed in order by the distracting-passive, ruminative-active, and ruminative-passive response conditions. Degree of rumination had a greater impact on remediation of depressive affect than level of activity, with greater rumination leading to lesser remediation of depressive affect. In addition, the effects of the response tasks were limited to depressed mood. The implications of these results for interventions with depressed persons are discussed.     

Self-focused attention, coping responses, and distressed mood in everyday life

Several questions concerning the relation between self-focused attention and depressed mood were examined: (a) Does the association involve global negative affect, rather than sadness per se? (b) is self-focus associated with specific negative affects other than sadness? and (c) does the association occur at the between-subjects or within-subject level? Also hypothesized was that self-focus is associated with coping responses that may perpetuate negative mood. In an idiographic/nomothetic design, 40 male community residents completed daily reports for 30 days. Results suggest that self-focus is linked with global negative mood as well as specific negative affects other than sadness and that the association occurs on a between-persons, rather than a day-to-day within-person, basis. In addition, highly self-focused men reported using passive and ruminative coping styles, which in turn were associated with distressed affect.     

心境对未来事件发生概率判断的影响

本研究采用短影片人为诱发心境的方法,用正性和负性两种情绪事件作为刺激材料,在控制人格变量的前提下,探讨了大学生在不同心境下对未来事件发生概率的判断中是否存在心境一致性效应。结果表明：（1）愉悦心境会增加做出积极判断的倾向,悲伤心境会增加做出消极判断的倾向;（2）无论是在愉悦心境还是在悲伤心境中,被试在对未来事件发生概率的判断上不存在性别差异。结果支持心境对未来事件发生概率判断有所影响,即诱发的心境与未来事件的效价存在一致性效应。