Maze-running and thigmotaxis in mice: Applicability of models across the sexes

Both male (n = 244) and female (n = 223) Swiss albino mice displayed a U-shaped pattern of thigmotaxis (wall-seeking) in a circular open-field (OF) before and after a daily maze-running. A significant increase of mice's tendency to occupy the inner partitions of the OF after the maze trial on the last three out of five days of training was observed. When factor analyzed, the variables indicating the wall-seeking behaviour of both sexes were divided into two factors interpreted as "spontaneous" in conjunction with the first three to four maze trials and as "learning-related thigmotactic behaviour" during the subsequent trials in the course of the learning process.     

Mice selectively bred for open-field thigmotaxis: life span and stability of the selection trait

In 2 experiments, the authors examined 69 mice selectively bred for high or low levels of open-field (OF) thigmotactic behavior (high open-field thigmotaxis [HOFT] and low open-field thigmotaxis [LOFT], respectively). They found that the strains differed in defecation during the 60-min exposure to the OF. Furthermore, the strains differed with regard to their life spans: The more thigmotactic HOFT mice lived longer than the LOFT mice. The strains were not differentiated by food intake or excretion. The strain difference in thigmotaxis was not age dependent, and it persisted in the home-cage condition as well. Neither the location (center or wall) of the starting point nor the shape (circular or square) of the OF arena affected the difference in wall-seeking behavior between the two strains. The authors concluded that the difference in thigmotaxis (or emotionality) between the HOFT and LOFT mice is a stable and robust feature of these animals.     

Prepartum and postpartum open-field behavior and maternal responsiveness in mice bidirectionally selected for open-field thigmotaxis

The authors examined pre- and postpartum open-field (OF) behavior and maternal responsiveness in mice that they bidirectionally selected for OF thigmotaxis. The authors tested 40 female mice under 3 conditions: prepartum OF, postpartum OF, and a pup retrieval test. In both OF conditions, the high OF thigmotaxis (HOFT) mice were more thigmotactic but explored and reared less than the low OF thigmotaxis (LOFT) mice, indicating that the HOFT mice were more emotional. In the postpartum condition, the HOFT mothers also defecated more and ambulated less than the LOFT mothers. The increase in grooming after parturition was more conspicuous among the LOFT mothers than among the HOFT mothers. The LOFT mothers were also more attracted to their pups in the OF, but the retrieval test did not show any substantial line differences. The results suggested that the line difference in emotionality was more pronounced during lactation than during pregnancy, although parturition exerted no effect on thigmotaxis.     

Preoperative operant circling training facilitates recovery following unilateral substantia nigra lesion in rats.

This study was undertaken to examine (1) whether pre- and/or postoperative training, using water reinforcement, to turn in circles (rotation) affects the behavioral symptoms induced by unilateral 6-hydroxydopamine (6-OHDA)-induced DA denervation of the rat substantia nigra (SN); (2) whether there was any influence of this training on the temporal pattern of recovery; and (3) whether the rotational training influences turning induced by systemic injection of dopaminergic drugs. In the first experiment, rats were trained either ipsi- or contraversive (TI or TO) to the side to be damaged 11 days before and 23 days after lesion, and tested in an open field for rotational behavior following systemic administration of apomorphine and amphetamine. In the second experiment rats were trained only before the lesion was made and tested in the open field for spontaneous circling and thigmotactic behavior. The results of the first experiment indicated maintenance of the training performance after the lesion. At the 14th day after the lesion, the ipsiversive trained group showed a higher contraversive circling frequency after apomorphine injection in relation to the contralateral trained group. In the second experiment, rats trained only before the surgery, showed asymmetrical spontaneous circling in the trained direction before and 14 days after surgery, indicating, in a drug free condition, that training direction can be restored after unilateral SN lesions, even to the contralateral body side. Moreover, thigmotactic behavior indicated a lack of habituation in an open field in unilateral lesion rats.(ABSTRACT TRUNCATED AT 250 WORDS)     

Mice selectively bred for an open field activity increase after maze learning

A unidirectional selective breeding experiment performed over six generations resulted in a line of mice (S6), which differed from the maintained unselected Swiss albino strain, called normal (N) strain, in the following respects: S6 mice increased their open field activity after maze learning significantly more than N mice. S6 mice ambulated more and exhibited more thigmotactic behaviour in a circular open field than N mice. S6 mice were superior than N mice in regard to maze learning capacity. Finally, S6 mice were interpreted as significantly less emotional according to their defecation, more responsive to novelty according to their urine pattern and more aggressive than N mice.     

An evaluation of group therapy for adolescents using social skills training

The present study investigated the hypothesis that social skills training is more effective in increasing socially acceptable behaviour in adolescents than is a generalized or non-specific form of group therapy. Forty-two subjects were selected to participate in the study from among adolescents referred for group therapy at two youth guidance clinics in Brisbane, Australia. The 23 males and 19 females were randomly assigned to one of three treatment conditions: a social skills training group, a non-specific therapy group and a waiting-list-for-therapy (control) condition. All subjects were assessed before and after treatment on five measures of social skills. Subjects in the social skills training group showed significant improvements on three of these measures while the non-specific therapy and waiting-list control groups showed no specific changes on any of the measures.     

A comparison of the effects of child management and planned activities training in five parenting environments

This study compared the effects of two procedures designd to enhance the extratraining effects of behavioral parents training. Twenty parents of oppositianal children were randomly assign to either a child manangment training condition or a combined child management plus planned activity condition. A further 10 nonproblem children and their parents serve as a social validation group. Observation of both parents and children behavior were conducted in each of five home observation setting (breakfirst time, kindy (kindergarten) or school exit, a structured playtime, bathtime, and bedtime). Both training procedures result in change in both child oppositional and parents oversive behaviosr in all observation settings. In addition, desire positive parents behaviour also improve in all setting. Treatment effect were maintained in all setting at 3-month follow up. Composition between oppositional children following treatment and children in the social validation group showed that they each displayed similarly low lavels of oppositional behaviour in all settings. The inplecation of the results for faciliating generalised changes in behavioral parent training are discusssd.This study was supported by a grant from the National Health and Medical Research Council (NHMRC324 82 579049). We wish to thank all families, therapists, and observers who participated in the project.     

German students’ current choice of profession in the field of psychotherapy

The psychoanalytic societies in Germany as in many other countries are concerned by a decline in the number of candidates for full psychoanalytic training. While this situation is partly attributable to changes both in society and in educational and healthcare systems, it is questionable whether psychoanalytic training institutions have yet found adequate responses to it. Under the banner of ‘evidence‐based treatment’, behaviour therapy has come to be widely disseminated, with major implications for the teaching of different psychotherapy paradigms at universities. To investigate the determinants of this trend in the specific German situation, a large‐scale, multi‐method exploratory study supported by IPA's DPPT programme was undertaken, focusing on the reasons given by a population (N = 679) of German psychology, medical, and education students for embarking on training in psychoanalysis or behaviour therapy. The results suggest that behaviour therapy is more compatible with the prevailing scientific understanding and with current societal and cultural trends, owing in part to inadequacies or bias in university teaching of the various paradigms of psychotherapy. While most of the psychology students expressed a preference for behavioural training, the psychotherapy option proved less attractive for their counterparts in the fields of medicine and education. Semi‐standardized qualitative interviews were used to gain a deeper understanding of the students’ decisions for or against training in a specific paradigm, and led to the identification of seven decision‐making prototypes. Possible reasons for the students’ decisions are discussed, and concrete proposals and recommendations are presented.     

The Effects on Interpersonal Verbal Behaviour of Varying Participant Role in Initial Dyadic Conversations

Abstract

Approaches to social skills assessment and training have generally failed to view behaviour in context or consider the contingencies of particular acts. The Verbal Interaction Analysis System (VIAS) measures the frequency of particular sequences of verbal behaviour that feature in the speech of both participants in a dyadic exchange. Data are presented to illustrate the use of the VIAS and demonstrate that it is responsive to manipulated changes of role by participants. In addition they support the initial assumptions of the VIAS whereby active contributors to the maintenance of a conversation are judged as more competent. In particular, independent ratings of global interpersonal behaviour were negatively correlated with verbal behaviour that discouraged topic maintenance. These findings are interpreted as supporting the hypothesis that competence in interpersonal interactions is substantially determined by the effects that one participant's verbal utterances have on those of the other participant and vice versa. Furthermore, support is also given to the view that it is unproductive to consider the verbal behaviour of one person outside the context of the interaction with the other person in a dyadic exchange. Discussion is mainly concerned with the need to adapt assessment measures and training procedures to take account of the current findings.     

Phosphorylation state of CREB in the rat hippocampus: a molecular switch between spatial novelty and spatial familiarity?

The activation of cAMP response element-binding protein (CREB) after a learning experience is a common feature in the formation of several associative memories. We recently demonstrated that the increase in the hippocampal phosphorylated CREB (pCREB) levels 1 h after a short exploration of an open field (OF) was associated to detection of spatial novelty and was not related to the memory formation of habituation in this non-associative learning paradigm. Moreover, after a long training of three OF sessions, hippocampal pCREB levels were below to that observed in control rats. The present results show that such decrease does not correlate with memory retrieval or improvement in long-term memory of habituation. Instead, it is associated with the familiarity to the arena. Our experiments revealed that the relevant variable to induce CREB deactivation was the prolonged exploration of the arena (30 min). A 15 min OF exploration was ineffective. Furthermore, the last 5 min period of a prolonged exploration was crucial to change CREB phosphorylation state: when exploration took place in a novel arena the level of pCREB increased; in contrast, when it was performed in the familiar OF, pCREB levels decreased. Taken as a whole, our results suggest that CREB phosphorylation state in the hippocampus switches in response to exposure to a novel or to a familiar spatial environment.     

The influence of action video game playing on eye movement behaviour during visual search in abstract,in-game and natural scenes

Action game playing has been associated with several improvements in visual attention tasks. However, it is not clear how such changes might influence the way we overtly select information from our visual world (i.e. eye movements). We examined whether action-video-game training changed eye movement behaviour in a series of visual search tasks including conjunctive search (relatively abstracted from natural behaviour), game-related search, and more naturalistic scene search. Forty nongamers were trained in either an action first-person shooter game or a card game (control) for 10 hours. As a further control, we recorded eye movements of 20 experienced action gamers on the same tasks. The results did not show any change in duration of fixations or saccade amplitude either from before to after the training or between all nongamers (pretraining) and experienced action gamers. However, we observed a change in search strategy, reflected by a reduction in the vertical distribution of fixations for the game-related search task in the action-game-trained group. This might suggest learning the likely distribution of targets. In other words, game training only skilled participants to search game images for targets important to the game, with no indication of transfer to the more natural scene search. Taken together, these results suggest no modification in overt allocation of attention. Either the skills that can be trained with action gaming are not powerful enough to influence information selection through eye movements, or action-game-learned skills are not used when deciding where to move the eyes.     

The impact of training in sexual counselling for drugs workers upon HIV related risk behaviours and attitudes among injecting drug users

Forty-five drug-using clients attending two drug services at a London hospital were interviewed before and after a training programme on sexual counselling delivered to staff working at the two units. Following staff training, clients reported increased interaction during counselling with staff on sexual issues. Results indicated that drug use and injecting behaviours were unaflected by the stag training and that changes in sexual behaviour were modest. Attitudinal changes were more substantial with more positive attitudes emerging to limiting the number of sexual partners and towards the use of condoms. The value of observed attitudinal changes and the importance of decision-making processes of clients for harm minimization are discussed     

Amnestic effect of intrahippocampal AM251, a CB1-selective blocker, in the inhibitory avoidance, but not in the open field habituation task, in rats

CB1 is the most abundant metabotropic receptor of the brain, being found in areas classically involved in learning and memory and present at higher density at presynaptic terminals. Different sets of evidence support the idea that endogenous ligands (endocannabinoids) to the CB1 receptors act as modulators of neurotransmission. In hippocampus, endocannabinoids seem to act as retrograde messengers mediating down-regulation of GABA release. Previous reports have described a cognitive impairment effect of cannabinoid agonists, or facilitation by antagonists. The scope of the present study is to investigate the effect of intrahippocampal administration of the CB1-selective antagonist, AM251, in two behavioral tasks. One hundred and twelve male Wistar rats with bilateral cannulae implanted in the CA1 region of the dorsal hippocampus were trained in a step-down inhibitory avoidance task (IA, footshock, 0.5 mA) or an open field habituation task (OF). Immediately, after training, animals received an infusion of 0.55, 5.5, and 55.5 ng/side of AM251 (Tocris), or its vehicle (DMSO/saline), via these cannulae. Our results show that AM251 disrupted memory consolidation of the IA task, but not the OF task, an effect that seems to be purely mnemonic since the drug showed no motor performance effects. Only the intermediate dose (5.5 ng/side) of AM251 was effective in IA and the absence of effect with the larger dose may be the consequence of non-specific binding. The fact that OF was not affected raises the possibility that this endogenous system requires some degree of aversiveness to be recruited. We propose that increased levels of endogenous cannabinoids in the hippocampus, following a training session, contribute to facilitate memory consolidation, a process that may have been disrupted with AM251.     

Behaviorism Och Marxism - Ett Omaka Par

Six moderately retarded 1 adults with undesirable behaviours such as noncompliance and physical aggression were taught more appropriate responses with a social learning package. Training consisted of seven daily "report card" measures checked plus (did not occcur) or minus (did occur) for each target behaviour. Instructions and feedback were provided after every training session by staff as was praise for appropriate behaviour. Short periods of social isolation were used after daily training when a minus was reported in any training period that day. During treatment, 21 of 22 target behaviours decreased in frequency. Seven months after treatment, 20 target behaviours were still well below baseline levels.     

The effects of two methods of training and sequencing on structuring and relationship skills of family therapists

Abstract

This study was an attempt to evaluate two methods of training family therapists (n = 26). Specifically, this research evaluated the relative effectiveness of observation-feedback (OF) and skill-based (SB) training methods, as well as OF-SB and SB-OF sequences of training on the acquisition of structuring and relationship skills. The only significant finding was that the OF-SB sequence resulted in significant gains in the acquisition of relationship skills. Implications are discussed for the training of family therapists.     

Cognitive changes associated with social skills training

Changes in locus of control and self-esteem during social skills training and at 6 month follow-up were investigated. Forty-four adolescent, male offenders were randomly assigned to a social skills training, attention-placebo, or no-treatment control procedure. The results showed that pre- to post-training increases in self-esteem were produced for both the social skills training and attention-placebo control groups, but not for the no-treatment control group. These increases did not continue during the follow-up phase; the social skills training group, which showed the greatest improvement during training, displayed a decrease in self- esteem during follow-up.The locus of control measures showed a statistically significant shift towards internality for the social skills training group during training, which was not found for the attention-placebo and no-treatment controls. During the follow-up phase, all three groups showed a statistically significant shift towards externality, suggesting a tendency for boys to view their behaviour and consequences as being under the control of chance factors or powerful others, during institutionalization. This effect was partly reversed during training for the social skills training group, but the effect was not long lasting. It seems therefore that social skills training is effective in producing an increase in self-esteem and a shift towards internal locus of control. These changes are, however, of short duration and the self-esteem shift may be the result of increased staff contact or other non-specific therapy factors.     

Resistance to extinction following habituation to behaviourally disruptive novel stimuli

Three experiments tested the prediction, derived from generalized frustration theory (Amsel, 1972), that habituation to behaviourally disruptive stimuli increases resistance to extinction in the runway. In each experiment, rats received initial consistent reinforcement (CRF) training and then either continued CRF (Groups C), partial reinforcement (PRF) training (Groups P), or CRF accompanied by presentations of a novel tactile, tone, or obstacle stimulus (Groups D) in Experiments 1-3, respectively. PRF increased resistance to extinction whether non-reinforcement disrupted behaviour (Experiment 1) or not (Experiments 2 and 3). The tactile and obstacle stimuli very substantially disrupted behaviour, and the tone produced a modest disruption of behaviour. All subjects habituated to the disruptive effects of these stimuli, but Group D was not more resistant to extinction than Group C in any experiment. The results suggest that non-reinforcement has unique stimulus properties, a consequence of which is that habituation to other sources of disruptive stimulation does not promote responding to non-reinforcement in extinction.     

Integrating theory and practice in counsellor training

A training programme for counsellors, based on the principle that counselling is a behavioural skill, is described. The programme aimed to improve client-centred skills, though the methods used could also be applied to other approaches to counselling. The pre- and post-course measures of skill were based on (a) a 45-minute recorded interview with a client, and (b) recorded responses to simulated clients, using a language laboratory. During the programme the skills were practised, with feedback on progress, using a behaviour category language. This enabled trainees to become more sensitively aware of others, to become aware of the discrepancies between their intentions and their actions, and to monitor their own progress in learning the skills. Striking changes were observed between the pre- and post-course measures. The results are discussed in relation to counselling training.     

The impact of dialectical behaviour therapy training on therapists in Singapore: A mixed-methods study

Background

While dialectical behaviour therapy (DBT) has much empirical support for treating borderline personality disorder (BPD) and other conditions, little research has examined the dissemination of DBT in Southeast Asia.

Aims

This study evaluated training outcomes following a 5-day intensive DBT training programme in a group of psychologists in Singapore, who were in the process of implementing DBT as part of the training's objectives.

Methodology

A mixed-methods design was employed. Fourteen psychologists from a public psychiatric hospital in Singapore were recruited. Seven self-selected into DBT training, and the remaining were matched controls who were not attending the training programme. The latter served as a nonrandomised control group. Prior to and 3 months after training, all participants completed measures of stigma towards BPD patients, burnout and therapeutic alliance. DBT training participants additionally attended a focus group discussion assessing their experiences and challenges implementing DBT in Singapore's context.

Findings

Quantitative analyses using mixed ANOVA showed that, compared with controls, DBT-trained participants demonstrated significantly greater increases in acceptance towards BPD patients. No between-group differences were found on changes in burnout or therapy alliance with patients. Analyses of qualitative data using thematic analysis revealed that DBT training impacted the way participants conceptualised and delivered therapy for BPD patients, and highlighted several challenges in implementing DBT in the local hospital context.

Conclusion

The findings demonstrate the potential of DBT training in improving clinicians' attitudes towards BPD patients and support a need for policymakers to prepare organisations for DBT implementation to ensure programme sustainability.