A humanistic psychology for the new millennium

In this article, it is contended that for the past century psychology has not lived up to its mandate as a trusted guide for the establishment of a well-functioning society. Ten responsibilities of an enlightened psychology for the new millennium that are based on humanistic values are discussed.     

Psychopharmacology of depression in the next millennium

Over the last half of the 20th century, there have been a series of psychopharmacologic strategies for treatment of depression. As we approach the next century, new therapies in varying stages of American release are being developed. This review will focus on information available for the following proposed antidepressants: 1) reboxetine, a norepinephrine selective reuptake inhibitor; 2) milnacipran, a combined serotonin/norepinephrine reuptake inhibitor; 3) a new enantiomer of fluoxetine, a selective serotonin reuptake inhibitor; 4) duloxetine, another combined serotonin/norepinephrine reuptake inhibitor; 5) sunepitron, a combined 5-HT1A agonist and a2 antagonist; and 6) MK-869, a substance P inhibitor. Finally, other possible developing directions will be reviewed, including corticotropin-releasing factor.     

Mental lexicon research in the new millennium

This article presents an overview of current research on the mental lexicon, as it is represented by articles in the spring 2002 Special Issue of Brain and Language. We examine current findings in terms of language, task, and population effects associated with how words are presented and processed in the mind. We discuss how such mental representations may be linked to neurological instantiations and address the issue of ecological validity in the field. These discussions are organized in order to both provide an overview of the issues and to enable the reader to locate specific articles that bear on these issues. Finally, we present an organizational framework for the characterization of mental lexicon research within which challenges for advancement are isolated.     

Pharmacotherapy of paraphilias in the next millennium

Paraphilias are psychiatric disorders of abnormal sexual behavior whose prevalence has markedly increased during the last decade. Treatment modalities currently used fall into three categories: surgical castration, psychotherapy, and pharmacotherapy. The pharmacological interventions consist of antiandrogens that either completely reduce testosterone secretion and/or antagonize the action of testosterone at the level of the receptor, and psychotropic drugs, namely antidepressants. Cyproterone and medroxyprogesterone acetates are the two antiandrogens more commonly used. They are only effective in relatively high doses, but have a substantial number of severe side effects which has considerably limited their use. Psychotropic drugs may be effective solely in men with a definite obsessive-compulsive disorder component. Because of the erratic results and lack of permanent eradication of the paraphilic manifestations their use in paraphilias is highly controversial. Long-acting gonadotropin-releasing hormone (GnRH) agonist analogues are the most potent antiandrogens, and selectively abolish testosterone secretion in a totally reversible fashion. They are administered parenterally once every 1 to 3 months, and have the fewest side effects. Long-acting GnRH analogues, together with psychotherapy, are highly effective in controlling selected paraphilias (pedophilia, exhibitionism, and voyeurism), and are the most promising mode of therapy in the next millennium. There is an urgent need for good methodological research; carefully designed double-blind controlled studies with a large number of subjects in order to validate or not the use of the various pharmacotherapies.     

Neuroscience and psychopharmacology into the next millennium

The end of the millennium provides an opportunity to review some of the common practices that were present in psychopharmacology during the 20th century. The author focuses on two approaches that have dominated research and guided the clinical application of psychopharmacologic therapeutics: the unitary clinically-based and single-lesion perspectives. The author expands upon these older formulations of neuropsychiatric disease pathogenesis and describes how the approach to psychopharmacologic research and therapeutics has changed in light of advances in the basic neurosciences. Relevant recent advances in the basic neurosciences that shed light on the pathophysiology of neuropsychiatric disease states and that guide psychopharmacologic practices are described. The use of atypical antipsychotic agents to treat schizophrenia is given as one example of the clinical applications of the approach to psychopharmacology in the next century.     

Thoughts on the eve of the millennium

Spiritually hungry is how I would characterize our society in this last part of the twentieth century in the United States. Jung's statement that the world is hanging by a slender thread, and that only consciousness can save it, seems appropriate here.     

Career management: The issue of the millennium

Abstract

The last decade has seen immense changes in the business environment. The globalization of business, its deregulation and the consequent opening up of new markets, the advances in information technology, and the growth of consumerism have all added to the competitive pressures which commercial organizations face (Hamel & Prahalad, 1994). At the same time, changes in social attitudes, especially regarding societal institutions such as government, education, and health, have increased the pressures on the public sector to provide value for taxpayers' money.