Loss of Financial Capacity in Alzheimer's Disease: The Role of Working Memory

Recent research has demonstrated that loss of financial capacity is a common consequence of Alzheimer's disease (AD). While progressive cognitive decline is a defining feature of AD, the relationship between such decline and loss of financial capacity in AD remains unclear. Working memory may be strongly associated with financial abilities, as many financial tasks require temporary storage and manipulation of numerical and other data. The present study examined the relationship between financial capacity and working memory in AD patients. Participants included 20 AD patients and 23 cognitively intact older controls. Working memory was conceptualized using Baddeley and colleagues' model, which posits that the three components of the working memory system are the visuospatial sketchpad, phonological loop, and central executive system. The present study examined only the latter two components of working memory. Each participant was administered the Financial Capacity Instrument (FCI), an instrument that directly assesses eight domains of financial activity, and the WAIS-III Working Memory subtests (Digit Span, Arithmetic, Letter–Number Sequencing). AD patients as a group performed significantly below controls on the FCI Total Score and on each of the eight FCI domains and working memory subtests. Within the AD group, measures of the central executive component of working memory (WAIS-III Digits Backward, Arithmetic, and Letter-Number Sequencing tests) showed strong correlations with the FCI domains of basic monetary skills, checkbook management, bank statement management, and bill payment and FCI total score, while a measure of the phonological loop component of working memory (WAIS-III Digits Forward) was not significantly correlated with any FCI domains or with the FCI total score. The results suggest that the multiple domains of financial capacity are primarily correlated with the central executive component of working memory.     

Neurocognitive Contributions to Motor Skill Learning: The Role of Working Memory

ABSTRACT

Researchers have begun to delineate the precise nature and neural correlates of the cognitive processes that contribute to motor skill learning. The authors review recent work from their laboratory designed to further understand the neurocognitive mechanisms of skill acquisition. The authors have demonstrated an important role for spatial working memory in 2 different types of motor skill learning, sensorimotor adaptation and motor sequence learning. They have shown that individual differences in spatial working memory capacity predict the rate of motor learning for sensorimotor adaptation and motor sequence learning, and have also reported neural overlap between a spatial working memory task and the early, but not late, stages of adaptation, particularly in the right dorsolateral prefrontal cortex and bilateral inferior parietal lobules. The authors propose that spatial working memory is relied on for processing motor error information to update motor control for subsequent actions. Further, they suggest that working memory is relied on during learning new action sequences for chunking individual action elements together.     

The Role of Working Memory and Divided Attention in Metaphor Interpretation

Although several types of figurative language exist, neuropsychological tests of non-literal language have focused on proverbs. Metaphors in the form X is (a) Y (e.g., The body’s immunological response is a battle against disease.) place a lower demand on language skills and are more easily manipulated for novelty than proverbs. Forty healthy participants completed the Metaphor Interpretation Test (developed by the authors). The task includes 20 items chosen from a list of metaphors that were rated on several scales (e.g. imagery, aptness) in a study by Katz et al. (Metaphor Symb Act 3(4):191–214, 1988). Participants were asked to rate the familiarity and provide an explanation of each metaphor. A scoring system was developed to categorize answers into: abstract complete (AC), abstract partial (AP), concrete (CT), and other/unrelated (OT) types. Participants also completed short-term memory and divided attention tests. Overall, participants produced 56 % AC, 25.38 % AP, 7.88 % CT, and 10.88 % OT responses. It was found that a measure of verbal short-term memory span was the best predictor of performance on this task (adjusted \(R^{2}= .369\) ). It appears that short-term memory span, not working memory or divided attention, contributes most to providing abstract responses in explaining metaphors. This is in line with the idea that when one accesses the semantic network associated with a novel metaphor, one must hold this information in mind long enough to search for and link similar cognitive networks.     

工作记忆子成分在听觉障碍儿童心算过程中的作用

采用2×2×3的混合实验设计,比较听力正常儿童和听觉障碍儿童在心算作业上的差异,考察了工作记忆子成分在听觉障碍儿童心算过程中的作用。结果表明,与听力正常儿童相比,听觉障碍儿童在高存储负载水平下的心算成绩显著降低,说明语音回路负责心算过程中的存储成分;而且听觉障碍儿童在对中央执行能力有高需求的实验条件下的作业水平并不比正常听力儿童差,说明他们的中央执行能力并没有受到损失。     

Role of Verbal Working Memory in Complex Skill Acquisition

Although research has shown that general cognitive ability is related to performance during the initial stage of skill acquisition, empirical evidence is needed to increase understanding of the primary abilities responsible for the relation. We propose that verbal working memory is related to initial skill acquisition performance based on cognitive activities people enact when learning complex skills. After completing a general cognitive ability measure and a test of verbal working memory, 120 undergraduate students performed a complex computer simulation. The working memory test accounted for a meaningful amount of performance variance after statistically controlling for the general cognitive ability measure. These data suggest that tasks depending heavily on the activation of multiple knowledge structures may be understood in terms of individual differences in working memory.     

工作记忆在简单指数乘法等式判断中的作用

选择大学二年级数学系的学生作为被试,要求他们完成控制条件、语音任务、手动任务和随机间隔决策任务条件下的简单指数乘法等式判断任务,实验结果表明：（1）三种次级任务在真假等式判断的反应时上的干扰效应非常显著;（2）三种次级任务显著增加了假等式判断的错误率,但没有显著增加真等式判断的错误率。这说明,语音环路、视空间模板和反应选择成分参与简单指数乘法等式判断,而且真假等式判断具有不同的注意资源需求。     

学龄儿童工作记忆结构的验证研究

该研究目标是验证儿童工作记忆是否符合Baddeley提出的由中央执行、情景缓冲区、语音环路及视觉空间模板构成的四成分模型。211名6~9岁小学生完成9个工作记忆任务,这些任务分别测量工作记忆四个子成分的功能。验证性因素分析表明,四因素模型比三因素模型和单因素模型更好地拟合数据。在小学阶段儿童工作记忆不是一个单一的结构,已经分化为四个子成分构成的记忆系统。     

From Incubation to Insight: Working Memory and the Role of the Cerebellum

An experiment involving 90 students in the 1st, 3rd, and 5th grades investigated how visual examples and grade (our surrogate for age) affected variability in a drawing task. The task involved using circles as the main element in a set of drawings. There were two examples: One was simple and single (a smiley face inside a circle); the other, complex and dual (a fishbowl extending outside a circle and a bicycle using two circles). There were significant effects of both example and grade on variability. Between-grades, 3rd and 5th graders were more variable than 1st graders with the complex (but not the simple) set of examples. Within-grades, 3rd and 5th graders were more variable with the complex (compared to the simple) set of examples. First graders' variability levels did not change with examples. The discussion focuses on how examples have and should be used to increase variability in drawings of both younger and older children.     

Auditory List Memory in Rhesus Monkeys

Auditory memory of 2 rhesus monkeys was tested in a serial probe recognition task. Lists of four environmental or natural sounds were followed by a retention interval and a test. The test matched one of the list items on half of the trials. The retention interval was varied across sessions. Six experiments showed similar results and changes in the serial position function. At short retention intervals, there was good memory for first list items (primacy effect) and poor memory for last list items. At intermediate retention intervals, memory improved for last list items (recency effect). At long retention intervals (20 s and 30 s), the recency effect was strong, and the primacy effect had dissipated. These auditory primacy and recency effects and their changes with retention interval were opposite to those for visual memory. Implications for processes and mechanisms of memory are discussed.     

视觉工作记忆中基于客体的存储机制：来自ERPs的证据

该研究以简单形状和颜色构成的客体为材料,采用延迟匹配范式,通过记录事件相关电位,以反映工作记忆表征与知觉输入间冲突的N270为指标,就视觉工作记忆中的客体存储机制进行了探讨。结果发现,无关维度特征变化与目标维度特征变化均可诱发N270。该结果表明,视觉工作记忆对客体目标特征进行存储时,无关特征亦自动得到选择加工,支持基于客体的存储说。     

Small Change Makes a Big Splash: The Role of Working Self-Concept in the Effects of Stereotype Threat on Memory

Assuming that the principle of an active-self account holds true in real life, priming certain constructs could selectively activate a working self-concept, which in turn guides behavior. The current study involved two experiments that examined the relationships between stereotypic identity, working self-concept, and memory performance in older adults. Specifically, Study 1 tested whether a stereotype threat can affect older adults' working self-concept and memory performance. A modified Stroop color naming task and a separate recognition task showed that a stereotype threat prime altered the activation of the working self-concept and deteriorated the older adults' memory performance. Additionally, the working self-concept mediated the effect of stereotype threat on memory performance. Accordingly, we designed Study 2 to assess whether priming different identities can alter the working self-concept of the elderly and buffer the stereotype threat effect on memory performance. The results not only were the same as Study 1 but also revealed that activating multiple identities could mitigate the stereotype threat. These results support an active-self account and the efficacy of stereotype threat intervention. This intervention strategy may be able to be used in real situations to help the elderly alleviate stereotype threats and memory impairment.     

客体运动速度的视觉工作记忆容量

自Luck等人的研究以来,诸多研究者对客体信息在视觉工作记忆中的表征与存储问题进行了探讨。现有研究主要采用呈现于静态场景的客体作为刺激材料,而不涉及对客体运动特征信息的短时存储。本研究结合多客体追踪范式和视觉工作记忆的变化觉察范式,通过比较检测项全部呈现方式与单检测项呈现方式条件下,客体运动速度的视觉工作记忆绩效,探讨了多个客体的运动速度信息在工作记忆中的存储方式和容量问题。结果表明,在工作记忆中能够存储约3仑独立客体的运动速度信息。     

Interference in Visual Working Memory

This paper uses the theoretical distinction that has recently developed between the passive visual store and the active spatial rehearsal mechanism of the visuo-spatial component of working memory (VSSP). It examines the circumstances under which visual fields gain functional access to the passive visual store and seeks to cast light on the circumstances under which irrelevant visual fields interfere with concurrent visual processing. Experiment 1 contrasts a dynamic visual noise field with a static noise field and shows that the static field, in contrast to the dynamic noise field, causes no interference when presented concurrently with a visual task. Experiment 2 investigates the reason for this contrast and concludes that the static field is susceptible to decay and so fails to cause interference. Experiment 3 investigates further the circumstances under which dynamic visual noise causes interference and shows that manipulation of the number of changes within the noise field is also of importance in causing interference. The results allow further consideration of the characteristics of the VSSP.     

Inattentive Behavior in Boys with ADHD during Classroom Instruction: the Mediating Role of Working Memory Processes

Children with ADHD exhibit clinically impairing inattentive behavior during classroom instruction and in other cognitively demanding contexts. However, there have been surprisingly few attempts to validate anecdotal parent/teacher reports of intact sustained attention during ‘preferred’ activities such as watching movies. The current investigation addresses this omission, and provides an initial test of how ADHD-related working memory deficits contribute to inattentive behavior during classroom instruction. Boys ages 8–12 (M = 9.62, SD = 1.22) with ADHD (n = 32) and typically developing boys (TD; n = 30) completed a counterbalanced series of working memory tests and watched two videos on separate assessment days: an analogue math instructional video, and a non-instructional video selected to match the content and cognitive demands of parent/teacher-described ‘preferred’ activities. Objective, reliable observations of attentive behavior revealed no between-group differences during the non-instructional video (d = ?0.02), and attentive behavior during the non-instructional video was unrelated to all working memory variables (r = ?0.11 to 0.19, ns). In contrast, the ADHD group showed disproportionate attentive behavior decrements during analogue classroom instruction (d = ?0.71). Bias-corrected, bootstrapped, serial mediation revealed that 59% of this between-group difference was attributable to ADHD-related impairments in central executive working memory, both directly (ER = 41%) and indirectly via its role in coordinating phonological short-term memory (ER = 15%). Between-group attentive behavior differences were no longer detectable after accounting for ADHD-related working memory impairments (d = ?0.29, ns). Results confirm anecdotal reports of intact sustained attention during activities that place minimal demands on working memory, and indicate that ADHD children’s inattention during analogue classroom instruction is related, in large part, to their underdeveloped working memory abilities.     

工作记忆对类比推理的影响

该实验采用2(类比推理类型)×6(组别)双因素实验设计来探讨工作记忆与类比推理之间的关系,尤其关注工作记忆的各个子成分对类比推理的影响。控制组的被试只需完成类比推理测验,而实验组的被试是在双任务的条件下进行实验。结果表明,工作记忆是影响类比推理的一个重要因素。在图形类比推理中,主要有视空间模板中的空间成分,语音回路中的发音成分以及中央执行器的参与;在言语类比推理中,则是视空间模板中的空间成分起主要作用。     

小学生的工作记忆资源分配策略

以连环数运算的问题解决为实验材料,以小学三到六年级175名学生为被试,对小学生工作记忆资源的分配策略进行了考察。结果发现:小学生工作记忆资源的分配策略有多种,策略具有多样性;外部策略的正确性高于内部策略和内外部结合策略;使用不同策略解决问题的反应时差异显著;高年级学生比低年级学生更倾向于选择效率较高的策略。