Right amygdalar and temporofrontal activation during autobiographic, but not during fictitious memory retrieval

What distinguishes the recall of real-life experiences from that of self-created, fictitious emotionally laden information? Both kinds of information belong to the episodic memory system. Autobiographic memories constitute that part of the episodic memory system that is composed of significant life episodes, primarily of the distant past. Functional imaging was used to study the neural networks engaged in retrieving autobiographic and fictitious information of closely similar content. The principally activated brain regions overlapped considerably and constituted temporal and inferior prefrontal regions plus the cerebellum. Selective activations of the right amygdala and the right ventral prefrontal cortex (at the level of the uncinate fascicle interconnnecting prefrontal and temporopolar areas) were found when subtracting fictitious from autobiographic retrieval. Furthermore, distinct foci in the left temporal lobe were engaged. These data demonstrate that autobiographic memory retrieval uses (at least in non-brain damaged individuals) a network of right hemispheric ventral prefrontal and temporopolar regions and left hemispheric lateral temporal regions. It is concluded that it is the experiential character, its special emotional infiltration and its arousal which distinguishes memory of real-life from that of fictitious episodes. Consequently, our results point to the engagement of a bi-hemispheric network in which the right temporo-prefrontal hemisphere is likely to be responsible for the affective/arousal side of information retrieval and the left-hemispheric temporal gyrus for its engram-like representation. Portions of the neural activation found during retrieval might, however, reflect re-encoding processes as well.     

Autobiographical memory and the self in time: brain lesion effects, functional neuroanatomy, and lifespan development

Autobiographical remembering reflects an advanced state of consciousness that mediates awareness of the self as continuous across time. In naturalistic autobiographical memory, self-aware recollection of temporally and spatially specific episodes and generic factual information (both public and personal) operate in tandem. Evidence from both laboratory and real-life studies, however, suggests that these two processes can be dissociated. This paper reviews aging, lesion, and functional neuroimaging research on the anatomical substrates of autobiographical memory processes using a new measure, the Autobiographical Interview, and prospective collection of autobiographical material. Results indicate that autobiographical recollection is mediated by a distributed fronto-temporo-parietal system, with the anteromedial prefrontal cortex positioned to integrate sensory information with self-specific information. The emergence of autobiographical recollection at around age four coincides with the timing of prefrontal regressive cortical and progressive white matter changes that may support the development of this high-level capacity.     

The association between risky decision making and attention-deficit/hyperactivity disorder symptoms: A preregistered assessment of need for cognition as underlying mechanism

Attention-Deficit/Hyperactivity Disorder (ADHD) is related to suboptimal decision making in experimental tasks and to real-life risk-taking behavior (RTB) such as substance abuse and unsafe traffic conduct. In this preregistered study, we tested whether these associations are mediated by need for cognition—the extent to which one tends towards, and enjoys, analytical thought. In a large sample of young adults (N = 463, M_age = 19.7 years), we tested whether need for cognition mediated the association between self-reported ADHD symptoms on the one hand and decision-making strategy complexity on an experimental gambling task and self-reported real-life RTB on the other hand. Preregistered confirmatory analyses indicated first that ADHD symptoms were positively associated with real-life RTB, but the association was not mediated by need for cognition. Second, ADHD symptoms were not related to decision-making strategy complexity, and need for cognition was not a significant mediator. Explorative analyses revealed that (a) need for cognition was associated with higher decision-making accuracy and slower reaction time; (b) need for cognition was related to inattentive but not to hyperactive/impulsive ADHD symptoms; (c) need for cognition was associated with health-related RTB but not interpersonal RTB; and (4) only the association between inattention and health-related RTB was mediated by need for cognition. We conclude that need for cognition is not a mediator in the association between ADHD symptoms and RTB. Additionally, we conclude that neither ADHD symptoms nor need for cognition predict decision-making strategy complexity. Implications for both future research and clinical practice are discussed.     

The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning

Converging evidence from human lesion, animal lesion, and human functional neuroimaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning.     

Delayed response, preoperative overtraining, and prefrontal lesions in the rat

An earlier study in this laboratory found that preoperative overtraining improved retention of a delayed alternation task after prefrontal lesions in the rat. In this study, however, it was found that preoperative overtraining did not improve performance of the rat in a delayed response task following prefrontal lesions. These results support the hypothesis that preoperative overtraining can improve postoperative performance only when postoperative recovery is ordinarily present, as it is with delayed alternation. but not with delayed response, in the prefrontal rat. This suggests that effects of preoperative overtraining and postoperative recovery may be mediated by similar mechanisms. It further suggests that a shift of function, which seems to account for postoperative recovery, may occur in some parts of the normal adult brain as a result of overtraining.     

Experiences in virtual reality entail different processes of retrieval as opposed to conventional laboratory settings: A study on human memory

Current Psychology - Recently, it has been claimed that real-life, autobiographical events are processed differently compared to conventional laboratory events. Virtual reality might bridge the gap...     

Effect of regulating anger and sadness on decision-making

The aim of the current study was to investigate the effects of reappraisal, acceptance, and rumination for regulating anger and sadness on decision-making. Participants (N = 165) were asked to recall two autobiographical events in which they felt intense anger and sadness, respectively. Participants were then instructed to reappraise, accept, ruminate, or not use any strategies to regulate their feelings of anger and sadness. Following this manipulation, risk aversion, and decision-making strategies were measured using a computer-based measure of risk-taking and a simulated real-life decision-making task. Participants who were instructed to reappraise their emotions showed the least anger and sadness, the most adaptive decision-making strategies, but the least risk aversion as compared to the participants in the other conditions. These findings suggest that emotion regulation strategies of negative affective states have an immediate effect on decision-making and risk-taking behaviors.     

社会排斥影响跨期决策的心理机制探讨

社会排斥广泛存在于社会生活中, 并对人们的认知、情感、行为等诸多方面产生严重的消极影响。它会损害个体的认知功能, 导致个体不能进行理性的判断和决策。研究发现被排斥的个体在风险决策时倾向于风险寻求。跨期决策和风险决策都与人类的生存和发展息息相关, 但目前并不清楚社会排斥是否以及如何影响跨期决策。因此, 本研究拟从跨期决策的评估和选择两个阶段展开研究, 揭示社会排斥对其的作用机制。并在此基础上, 运用tDCS技术激活社会排斥的调节脑区, 以改善被排斥个体的跨期决策能力。研究结果将揭示人际情境因素与决策者个人因素对跨期决策的联合作用机制, 帮助被排斥者提高跨期决策能力, 提高被排斥者的个人成就和生活质量。     

Is gaze behaviour in a laboratory context similar to that in real-life? A study in bicyclists

Numerous laboratory-based studies recorded eye movements in participants with varying expertise when watching video projections in the lab. Although research in the lab offers the advantage of internal validity, reliability and ethical considerations, ecological validity is often questionable. Therefore the current study compared visual search in 13 adult cyclists, when cycling a real bicycle path and while watching a film clip of the same road. Dwell time towards five Areas of Interest (AOIs) is analysed. Dwell time (%) in the lab and real-life was comparable only for the low quality bicycle path. Both in real-life and the lab, gaze is predominantly driven towards the road. Since gaze behaviour in the lab and real-life tends to be comparable with increasing task-complexity (road quality), it is concluded that under certain task constraints laboratory experiments making use of video clips might provide valuable information regarding gaze behaviour in real-life.     

The legal self: executive processes and legal theory

When laws or legal principles mention mental states such as intentions to form a contract, knowledge of risk, or purposely causing a death, what parts of the brain are they speaking about? We argue here that these principles are tacitly directed at our prefrontal executive processes. Our current best theories of consciousness portray it as a workspace in which executive processes operate, but what is important to the law is what is done with the workspace content rather than the content itself. This makes executive processes more important to the law than consciousness, since they are responsible for channelling conscious decision-making into intentions and actions, or inhibiting action. We provide a summary of the current state of our knowledge about executive processes, which consists primarily of information about which portions of the prefrontal lobes perform which executive processes. Then we describe several examples in which legal principles can be understood as tacitly singling out executive processes, including principles regarding defendants' intentions or plans to commit crimes and their awareness that certain facts are the case (for instance, that a gun is loaded), as well as excusatory principles which result in lesser responsibility for those who are juveniles, mentally ill, sleepwalking, hypnotized, or who suffer from psychopathy.     

Value, pleasure and choice in the ventral prefrontal cortex

Rapid advances have recently been made in understanding how value-based decision-making processes are implemented in the brain. We integrate neuroeconomic and computational approaches with evidence on the neural correlates of value and experienced pleasure to describe how systems for valuation and decision-making are organized in the prefrontal cortex of humans and other primates. We show that the orbitofrontal and ventromedial prefrontal (VMPFC) cortices compute expected value, reward outcome and experienced pleasure for different stimuli on a common value scale. Attractor networks in VMPFC area 10 then implement categorical decision processes that transform value signals into a choice between the values, thereby guiding action. This synthesis of findings across fields provides a unifying perspective for the study of decision-making processes in the brain.     

爱荷华博弈任务(IGT)与决策的认知神经机制

爱荷华博弈任务(IGT)是一项检查情感性决策机制的常用实验范式。据此, Damasio等人提出了躯体标记假设(SMH)解释情绪影响决策的神经生理机制。近期, 大量研究在IGT究竟是模糊决策还是风险决策、与情绪和认知的关系、与工作记忆和陈述性记忆的关系以及IGT的神经网络与分子遗传机制等方面积累了丰富资料。结果显示, IGT加工的早期由模糊决策主导, 情绪性躯体信号对引导决策选项的偏好可能起关键作用, 后期则倾向是一种风险决策, 认知评价和预期对选项偏向逐渐占优势; IGT与工作记忆的加工成分有相互重叠, 也需陈述性记忆的参与; IGT的加工不仅依赖于杏仁核、腹内侧前额皮层、眶额皮层等组成的情绪脑网络的活动, 还与背外侧前额皮层、海马、腹侧纹状体、岛叶皮层、辅助运动前区、扣带回皮层等许多脑区的活动有关; COMT和5-HTT的基因多态性会调节IGT相关的决策加工。总之, IGT是一项需要多重神经系统协同活动的决策加工任务, 且模糊与风险决策可能具有不同的遗传基础。     

主观价值计算与整合的神经机制及其影响因素

决策在人类社会发展的历程中扮演着非常重要的作用,而对其神经机制的探讨才不过几十年的时间。基于价值的决策理论,强调人们首先计算和表征事物的价值,随后比较和决策。在人脑中负责主观价值计算的神经基础有腹内侧前额叶皮层、眶额皮层以及其他脑区,而负责价值整合的脑区有腹内侧前额叶皮层、眶额皮层、背外侧前额叶皮层等。其中时间和风险的价值计算有着相同的神经基础,并且人脑可以将不同属性以及成本进行整合形成主观价值,按照曲线交互作用范式进行。通过自我控制、注意和认知调节等方法,同样可以调制人们的主观价值大小。未来需要继续强调模式分析、个体差异、老龄化和基因对价值计算的影响。     

Using Insights from Applied Moral Psychology to Promote Ethical Behavior Among Engineering Students and Professional Engineers

In this essay I discuss a novel engineering ethics class that has the potential to significantly decrease the likelihood that students (and professionals) will inadvertently or unintentionally act unethically in the future. This class is different from standard engineering ethics classes in that it focuses on the issue of why people act unethically and how students (and professionals) can avoid a variety of hurdles to ethical behavior. I do not deny that it is important for students to develop cogent moral reasoning and ethical decision-making as taught in traditional college-level ethics classes, but as an educator, I aim to help students apply moral reasoning in specific, real-life situations so they are able to make ethical decisions and act ethically in their academic careers and after they graduate. Research in moral psychology provides evidence that many seemingly irrelevant situational factors affect the moral judgment of most moral agents and frequently lead agents to unintentionally or inadvertently act wrongly. I argue that, in addition to teaching college students moral reasoning and ethical decision-making, it is important to: 1. Teach students about psychological and situational factors that affect people’s ethical judgments/behaviors in the sometimes stressful, emotion-laden environment of the workplace; 2. Guide students to engage in critical reflection about the sorts of situations they personally might find ethically challenging before they encounter those situations; and 3. Provide students with strategies to help them avoid future unethical behavior when they encounter these situations in school and in the workplace.     

Social anxiety modulates visual exploration in real life – but not in the laboratory

In clinical reports, individuals high on social anxiety are often described to avoid gaze at other people, whereas several experimental studies employing images of persons yielded conflicting results. Here, we show that gaze avoidance crucially depends on the possibility of social interactions. We examined gaze behaviour in individuals with varying degrees of social anxiety in real-life and in a second group of participants using a closely matched laboratory condition. In the real-life situation, individuals with a higher degree of social anxiety had a reduced bias to look at near persons compared to individuals with a lower degree of social anxiety, while gaze behaviour in the laboratory group was not modulated by social anxiety. This effect was specific to social attention since there was no corresponding effect regarding fixations on objects. The presence of anxiety effects in real-life but not in the laboratory condition, where participants do not expect to be evaluated by gazed-at conspecifics, points to critical deficits of current laboratory research paradigms in eliciting authentic social attentional mechanisms, possibly leading to spurious results.     

自我损耗促进冲动决策：来自行为和ERPs的证据

该研究以自我控制资源模型为理论框架, 采用行为实验和ERPs技术考察自我损耗对冲动决策的影响。实验1采用Stroop任务操纵自我控制资源并采用延迟折扣任务考察被试的决策冲动性, 实验2采用同样的实验任务并同时采用ERPs技术记录高、低自我损耗者在随后决策任务中的脑电成分。行为结果发现, 在控制心境、特质自我控制水平以及风险偏好等无关变量后, 高损耗者比低损耗者在延迟折扣任务上的折扣程度更大。ERPs结果发现, 不论延迟金额大小, 高损耗者在左侧额区诱发的N1波幅显著小于低损耗者; 高损耗者在右半球诱发的P2波幅显著大于低损耗者。研究表明, 自我损耗抑制决策早期左侧额区的激活水平, 个体因而无法识别冲突以及抵制即时满足的诱惑, 这促使他们采用直觉启发式进行决策, 最终导致冲动决策的产生。     

Instructional cues modify performance on the Iowa Gambling Task

The current study investigated whether acute alcohol intoxication produces impaired decision-making on tasks assessing ventromedial prefrontal (VMF) cortex functioning and impulsive responding. Participants completed the Iowa Gambling Task (IGT), a decision-making test targeting the VMF, and the Newman Perseveration Task (NT), a measure of impulsivity. Personality measures of impulsivity were assessed using the Barratt Impulsiveness Scale (BIS). To encourage natural responding on both tasks, participants were falsely informed that the study was examining the effects of alcohol on memory; the impulsivity tasks were presented as 'distractor' tasks. Advantageous performance on the IGT was related to specific instructional cues as well as to knowledge about the experimental purpose. Performance of intoxicated and sober participants did not differ. A subsequent study in which the true purpose of the experiment was revealed confirmed that alcohol does not affect IGT performance. Most importantly, the instruction-sensitivity of the IGT emphasizes the importance of salient cues for decision-making.     

基于预期理论的风险决策的神经机制

预期理论基于对期望效用理论的批判与发展,提出了价值函数与权重函数,对以往风险决策研究中所发现的现象进行了很好的预测与解释。预期理论的核心概念包括参照依赖、损失规避与权重函数。基于预期理论的一些决策偏差包括框架效应、禀赋效应和默认偏差也部分揭示了与人们风险决策有关的脑区。近年来,通过采用功能性核磁共振等脑成像手段对预期理论的一些核心成分进行的研究表明,涉及到人们风险决策的脑区主要有前额叶、纹状体、脑岛与杏仁核。未来的研究可以从预期理论的产生根源、个体发展以及遗传基因等角度进行进一步的探讨。     

Incidental learning of real-world regularities

The large literature on incidental learning relies almost exclusively on laboratory experiments. Whenever researchers have attempted to demonstrate incidental learning of real-world regularities, they have typically failed to show learning. For example, it is well established that people do not learn regularities in everyday objects, such as the left-right orientation of faces on coins, despite a very large exposure to them. In this report, we examine this apparent contradiction. We argue that most studies exploring real-life incidental learning use tests that are not as sensitive to low-confidence information as those traditionally used in laboratory tasks. Using more sensitive measures, we show that it is possible to learn regularities from British and Japanese cultural life as a direct result of exposure to these regularities. Further, confidence measures suggest that although the information may be acquired incidentally, it can be expressed with and without concomitant awareness of that knowledge.     

Assessing coping flexibility in real-life and laboratory settings: a multimethod approach

This research sought to formulate a theoretically based conceptualization of coping flexibility and to adopt a multimethod approach in assessing this construct. A self-report daily measure and an experiment were designed geared to theoretical and empirical grounds. The new daily measure was used in Study 1 to examine coping flexibility in a life transition. Findings showed individual differences in patterns of coping flexibility across different real-life stressful events. In Study 2, coping flexibility was examined in both real-life and laboratory settings. Results replicated those of Study 1 and further revealed consistency between the self-report and the experiment data. Study 3 extended previous studies by adopting a longitudinal design over a 3-month time span. Participants' flexibility in coping with laboratory tasks was found to predict how flexible they would be in handling real-life stressful events.