Revisiting the effects of Parkinson's disease and frontal lobe lesions on task switching: The role of rule reconfiguration

This study investigated the hypothesis that rule reconfiguration in task switching can isolate aspects of intact and impaired control at different stages of Parkinson's disease (PD) by comparing switches between concrete naming rules pertaining to stimulus selection, to switches between abstract rules which allocate categorization responses to these stimuli. Based on previous findings, it was hypothesized that attentional switches, where task set competition emerges at the stimulus but not response set level, highlights striatal dopaminergic function. Conversely, increasing the degree of task set competition to encompass reconfiguration of response set when switching between abstract rules, represents a condition which engages the prefrontal cortex (PFC) and renders this manipulation sensitive to frontal damage. To this end, we investigated task switching with concrete and abstract rules in unilaterally (Hoehn & Yahr stage I) and bilaterally (Hoehn & Yahr stage II) affected PD patients, as well as striatally intact frontal lesion patients. As predicted, frontal lesion patients demonstrated switching deficits only with abstract categorization rules, where switching engendered complete task set reconfiguration and a new response, as did stage II PD patients with presumed frontal cortical pathology. Replicating previous findings, stage I PD patients with relatively circumscribed striatal pathology demonstrated no such impairment. Disease severity also impacted on attentional switching indexed by naming rules, since medicated stage II but not stage I patients demonstrated switching deficits emerging from stimulus set reconfiguration, suggesting that the ameliorative efficacy of dopaminergic medication is inversely related to the severity of the striatal deficit. These findings illustrate that the nature of the rules that are switched, and its implication in terms of reconfiguring different task set elements, highlights different neural characters of cognitive flexibility. These manipulations may help decipher the differential effects of progressive neurodegeneration on parkinsonian cognition, and provide a framework in which to conceptualize the contributions of cortical and subcortical regions to cognitive control.     

“热”执行对注意缺陷多动障碍和阅读障碍儿童言语工作记忆的影响

ADHD儿童在与背外侧前额叶(DLPFC)相关的"冷"执行功能上的缺陷已大量证实,但在与眼眶和中前额叶皮层(OMPFC)相关的"热"执行功能上,ADHD儿童是否存在缺陷则未可知。与儿童赌博任务实验范式(该任务中"热"启动对"冷"执行起到抑制作用)不同,本研究考察趣味言语N-back任务是否对ADHD和阅读障碍儿童的成绩有促进作用。枯燥N-back任务考察的是言语工作记忆的纯认知特征,而趣味任务则卷入了"热"执行对"冷"执行的影响。结果表明,在枯燥任务上,ADHD和阅读障碍儿童的成绩均明显低于正常儿童,二者之间差异不显著,在趣味任务成绩上,ADHD儿童与正常儿童的成绩没有显著差异,而阅读障碍儿童成绩落后于正常控制组和ADHD组,在成绩变化的趋势上,ADHD儿童在趣味任务上成绩明显提高,而阅读障碍儿童则无明显改善。结果说明ADHD和阅读障碍儿童的言语工作记忆均存在明显的缺陷,但是机制不同,"热"执行对提高ADHD的言语工作记忆有明显的促进作用,ADHD的"冷"执行缺陷能够通过"热"执行的调节得到改善。     

Cross-modal working memory binding and learning of visual-phonological associations in children with reading difficulties

Reading decoding requires the association of a visual input (the printed word) with a verbal output (the spoken word), and the learning of visual-phonological associations via repeated exposure occurs both explicitly (by instruction and training) and implicitly (by exposure to written material). However, a general ability to implicitly learn visual-phonological associations (or cross-modal bindings) in children with reading difficulties (RD) has not been deeply explored. The present paper examined this issue in two studies comparing groups of children with RD with matched groups of control children in a working memory binding task involving sequences of variable combinations of nonsense shapes and nonwords (odd trials), as well as fixed combinations (even trials). Stimuli presentation was followed by a recognition test in which the nonwords were given one at a time and the children were required to mouse click on their respective shapes. In Study 1, fixed bindings were presented in random sequences across even trials, and the recognition test presented the nonwords at random. In Study 2, fixed bindings were presented in the same order across even trials, and the recognition test presented the nonwords following the same sequence order. In both studies, a consistent and strong learning effect of fixed bindings was observed for the control groups, with significantly better performance than the groups with RD. Such results suggest that poor cross-modal binding learning is associated with reading difficulties. Implications for the study and treatment of dyslexia are discussed.     

Rapid automatized naming in children referred for evaluation of heterogeneous learning problems: how specific are naming speed deficits to reading disability?

Because the Rapid Automatized Naming (RAN) test reliably predicts reading skill, it is typically viewed as a diagnostic indicator of risk for reading disability (RD). Since most of the work on naming speed has been undertaken within the framework of reading research, however, the extent to which poor RAN is specifically associated with RD or with learning impairment (LI) in general is uncertain. We tested the hypothesis that slow naming speed is specific to RD. Participants were 188 children (ages 7 to 11) referred for evaluation of learning problems. Receiver operating characteristic (ROC) analysis was used to evaluate the utility of the RAN task for classifying children in diagnostic groups. RAN was an excellent tool for detecting risk for learning problems in general, but it was much less effective at distinguishing LI children with and without RD from each other.     

Perception of speech and nonspeech stimuli by children with and without reading disability and attention deficit hyperactivity disorder

The auditory temporal deficit hypothesis predicts that children with reading disability (RD) will exhibit deficits in the perception of speech and nonspeech acoustic stimuli in discrimination and temporal ordering tasks when the interstimulus interval (ISI) is short. Initial studies testing this hypothesis did not account for the potential presence of attention deficit hyperactivity disorder (ADHD). Temporal order judgment and discrimination tasks were administered to children with (1) RD/no-ADHD (n=38), (2) ADHD (n=29), (3) RD and ADHD (RD/ADHD; n=32), and (4) no impairment (NI; n=43). Contrary to predictions, children with RD showed no specific sensitivity to ISI and performed worse relative to children without RD on speech but not nonspeech tasks. Relationships between perceptual tasks and phonological processing measures were stronger and more consistent for speech than nonspeech stimuli. These results were independent of the presence of ADHD and suggest that children with RD have a deficit in phoneme perception that correlates with reading and phonological processing ability. (c) 2002 Elsevier Science (USA).     

RD,ADHD, and their comorbidity from a dual route perspective

In order to achieve further insight into the comorbidity of reading disorder (RD) and attention deficit/hyperactivity disorder (ADHD), lexical processing and rapid naming were studied in RD and ADHD. The Dual Route Cascaded model postulates that lexical processing contains two parallel processes: lexical route processing and sublexical route processing. An orthographic decision task and a phonological decision task were used to measure lexical and sublexical route processing, respectively. In addition, a rapid naming task was used to compare 27 children with RD, 18 children with ADHD, 20 children with ADHD+RD, and 29 controls. RD and ADHD shared impairments in accuracy of orthographic and phonological decision making as well as in rapid naming, which suggest that RD and ADHD may be overlapping disorders that share deficits in both lexical route and sublexical route processing. RD was dissociated from ADHD by being slower in both orthographical and phonological decision making that indicates unique deficits in RD on lexical and sublexical speed.     

前摄抑制对儿童注意缺陷多动障碍(ADHD)和阅读障碍的言语工作记忆的影响

ADHD和阅读障碍儿童在言语工作记忆上的缺陷得到了大量研究的证实,但是二者机制并不相同,前摄抑制对工作记忆容量产生了不利的影响,主要影响的也是中央执行功能。研究将最近探测任务和n-back任务相结合,直接比较被试在最近负探测和非最近负探测条件下记忆成绩的差异,以考察前摄抑制对两种障碍言语工作记忆的影响,被试是60名障碍儿童(阅读障碍和ADHD)和17名正常儿童,年龄均在7至12岁之间。结果发现,受前摄抑制的影响,正常被试和障碍被试成绩均明显下降,具体而言,ADHD和ADHD伴随阅读障碍组成绩大幅下滑(26.44%,28.44%),程度明显高于正常儿童和阅读障碍儿童(14.62%,15.84%),后两者差异并不明显,这说明前摄抑制是影响工作记忆容量的重要因素,并且ADHD儿童更加容易受到前摄抑制的影响,这是导致其工作记忆成绩缺损的重要原因,而阅读障碍儿童能够像正常儿童一样,在一定程度上处理前摄抑制,ADHD和阅读障碍组在言语工作记忆缺损机制上存在差异。     

RD, ADHD, and their comorbidity from a dual route perspective

In order to achieve further insight into the comorbidity of reading disorder (RD) and attention deficit/hyperactivity disorder (ADHD), lexical processing and rapid naming were studied in RD and ADHD. The Dual Route Cascaded model postulates that lexical processing contains two parallel processes: lexical route processing and sublexical route processing. An orthographic decision task and a phonological decision task were used to measure lexical and sublexical route processing, respectively. In addition, a rapid naming task was used to compare 27 children with RD, 18 children with ADHD, 20 children with ADHD+RD, and 29 controls. RD and ADHD shared impairments in accuracy of orthographic and phonological decision making as well as in rapid naming, which suggest that RD and ADHD may be overlapping disorders that share deficits in both lexical route and sublexical route processing. RD was dissociated from ADHD by being slower in both orthographical and phonological decision making that indicates unique deficits in RD on lexical and sublexical speed.     

The effects of concurrent task interference on category learning: evidence for multiple category learning systems

Participants learned simple and complex category structures under typical single-task conditions and when performing a simultaneous numerical Stroop task. In the simple categorization tasks, each set of contrasting categories was separated by a unidimensional explicit rule, whereas the complex tasks required integrating information from three stimulus dimensions and resulted in implicit rules that were difficult to verbalize. The concurrent Stroop task dramatically impaired learning of the simple explicit rules, but did not significantly delay learning of the complex implicit rules. These results support the hypothesis that category learning is mediated by multiple learning systems.     

Development of relational learning: Effects of instruction and delay of transfer

Preschool children were trained on a color relevant oddity problem by one of three methods: increased salience of the oddity relationship, instruction on the solution rule, or a combination of increased salience and rule instruction. The youngest Ss solved the training problem when the solution rule was provided but not under the salience procedure. The two older groups solved in all conditions and errors decreased with age. The generality of the solution was determined by performance on a form relevant transfer task. The youngest Ss made fewer errors on the transfer problem following rule instruction training than following training in the combined procedure. The intermediate age group made fewer errors when the transfer task was administered one week after training than one minute after training. The transfer problem was easily solved by the oldest Ss and performance was independent of training procedure and amount of delay. These results were interpreted as reflecting developmental differences in relational concept learning.     

Paired associate learning in reading-disabled children: evidence for a rule-learning deficiency

Two experiments examined whether normal and disabled readers differed in the utilization of rules in a paired associate learning task. Experiment 1 required children to learn symbol-word associates. Children were assigned to one of three conditions: nonrule, consistent rule, or inconsistent rule. When present, the rule was based on semantic opposites. Subjects benefited from having the rule, but disabled readers showed less improvement across four test blocks than both chronological age (CA) controls and reading age (RA) controls, particularly in the inconsistent condition. Experiment 2 required subjects to learn symbol-symbol associations in one of three conditions: nonrule, consistent rule, or inconsistent rule. When present, the rule specified the locations of a subsidiary figure in each symbol according to the pattern top-right, bottom-left. Disabled and normal readers did not differ in the nonrule condition where reliance on visual memory would be an effective strategy. Normal readers were superior to disabled readers in both rule conditions. In addition, disabled readers in the inconsistent rule condition were less able than normal readers to apply the rule in a generalization task where memory demands were reduced. Results supported the hypothesis that disabled readers have greater difficulty than normal readers inducing and/or using rules, particularly when they are inconsistent. It is suggested that difficulties in acquiring or using complex and inconsistent rules may be one important source of problems learning spelling-sound correspondence rules, which in English are complex and inconsistent.     

Language Abilities in Children with Attention Deficit Hyperactivity Disorder, Reading Disabilities, and Normal Controls

Research has demonstrated a high prevalence of language impairments (LI) and reading disabilities (RD) in children with attention deficit hyperactivity disorder (ADHD). Since RD is also associated with LI, it is unclear whether the language impairments are specific to ADHD or associated with comorbid RD. The language abilities of ADHD children with and without RD were investigated in a task requiring recall of a lengthy narrative, and in tests assessing knowledge of the semantic aspects of language. The study was conducted with 50 boys—14 ADHD, 14 ADHD + RD, 8 RD, and 14 normal controls, aged 7 to 11. Children with ADHD (ADHD-only, ADHD + RD) exhibited difficulties in organizing and monitoring their story retelling. Children with RD (RD-only, ADHD + RD) demonstrated deficits in receptive and expressive semantic language abilities on the language processing tests. The comorbid group (ADHD + RD) exhibited the deficits of both ADHD and RD children. The deficiencies of ADHD children are consistent with higher-order executive function deficits while the deficits of RD children are consistent with deficits in the basic semantics of language processing.     

Memory Functioning in Children with Reading Disabilities and/or Attention Deficit/Hyperactivity Disorder: A Clinical Investigation of their Working Memory and Long-Term Memory Functioning

We examined memory functioning in children with reading disabilities (RD), Attention deficit/hyperactivity disorder (ADHD), and RD/ADHD using a clinic sample with a clinical instrument: the Children's Memory Scale, enhancing its generalizability. Participants included 23 children with RD, 30 with ADHD, 30 with RD/ADHD, and 30 controls. Children with RD presented with reduced verbal short-term memory (STM) but intact visual STM, central executive (CE), and long-term memory (LTM) functioning. Their deficit in STM appeared specific to tasks requiring phonetic coding of material. Children with ADHD displayed intact CE and LTM functioning but reduced visual-spatial STM, especially when off stimulant medication. Children with RD/ADHD had deficits consistent with both disorders.     

Social cognition is not reducible to theory of mind: When children use deontic rules to predict the behaviour of others

The objective of this paper is to discuss whether children have a capacity for deontic reasoning that is irreducible to mentalizing. The results of two experiments point to the existence of such non‐mentalistic understanding and prediction of the behaviour of others. In Study 1, young children (3‐ and 4‐year‐olds) were told different versions of classic false‐belief tasks, some of which were modified by the introduction of a rule or a regularity. When the task (a standard change of location task) included a rule, the performance of 3‐year‐olds, who fail traditional false‐belief tasks, significantly improved. In Study 2, 3‐year‐olds proved to be able to infer a rule from a social situation and to use it in order to predict the behaviour of a character involved in a modified version of the false‐belief task. These studies suggest that rules play a central role in the social cognition of young children and that deontic reasoning might not necessarily involve mind reading.     

Basic level and superordinate level categorization by autistic, mentally retarded, and normal children

Three experiments designed to test autistic children's nonverbal and verbal categorization abilities are reported in this paper. In the first two experiments, 14 autistic children were compared to 14 retarded and 14 normal children matched on verbal mental age. Their ability to categorize pictures from basic level categories and from biological and artifactual superordinate level categories was assessed using a matching-to-sample procedure. The three groups of subjects were similar in their performance. Basic level categorization was easier than more abstract categorization, and for all three groups, prototypicality played a role in categorizing superordinate level concepts; that is, children in all three groups made more errors categorizing peripheral examples. In the third experiment, a subgroup of 7 autistic children showed evidence that their lexicons were well organized and that they appreciated the meaning relationships among words at the superordinate level. These findings suggest that autistic children do not suffer a specific cognitive deficit in the ability to categorize and form abstract concepts, as has been previously suggested in the literature.     

Basic number processing in children with specific learning disorders: Comorbidity of reading and mathematics disorders

As well as being the hallmark of mathematics disorders, deficits in number processing have also been reported for individuals with reading disorders. The aim of the present study was to investigate separately the components of numerical processing affected in reading and mathematical disorders within the framework of the Triple Code Model. Children with reading disorders (RD), mathematics disorders (MD), comorbid deficits (RD + MD), and typically developing children (TD) were tested on verbal, visual-verbal, and nonverbal number tasks. As expected, children with MD were impaired across a broad range of numerical tasks. In contrast, children with RD were impaired in (visual-)verbal number tasks but showed age-appropriate performance in nonverbal number skills, suggesting their impairments were domain specific and related to their reading difficulties. The comorbid group showed an additive profile of the impairments of the two single-deficit groups. Performance in speeded verbal number tasks was related to rapid automatized naming, a measure of visual-verbal access in the RD but not in the MD group. The results indicate that deficits in number skills are due to different underlying cognitive deficits in children with RD compared to children with MD: a phonological deficit in RD and a deficit in processing numerosities in MD.     

Concrete problems in the abstract deontic selection task - and how to solve them

The abstract deontic selection task was introduced by Cheng and Holyoak with the aim of demonstrating that people possess abstract reasoning schemas for processing deontic rules about what an individual must, must not, may, or need not do. Solving this task requires people to detect possible rule violators. The average solution rate across several studies, while being substantially higher than that with abstract nondeontic tasks, did not reach the level obtained with concrete deontic tasks. A task analysis based on the deontic principles by Beller uncovers several problems with the formulation of the original task. They concern the presentation of the deontic rule as well as the instructions (focusing on rule following) and result in a specific selection behaviour. Three experiments replicate the difficulties with the original task and show that task performance increases when the formulation problems are resolved. The best performance was obtained with a task that combined a genuine violation detection instruction with a genuine permission rule. Interestingly, permissions are weak deontic rules that, if taken literally, cannot be violated in a deontic sense. Therefore, people must interpret these rules as implying a strong deontic constraint (i.e., a ban), which then constitutes the basis for solving the task. The results provide novel insights into the interpretation of deontic rules and into the role that these content-specific, but abstract, tasks can play for the study of reasoning processes.     

Learning and transfer of category knowledge in an indirect categorization task

Knowledge representations acquired during category learning experiments are ‘tuned’ to the task goal. A useful paradigm to study category representations is indirect category learning. In the present article, we propose a new indirect categorization task called the “same”–“different” categorization task. The same–different categorization task is a regular same–different task, but the question asked to the participants is about the stimulus category membership instead of stimulus identity. Experiment 1 explores the possibility of indirectly learning rule-based and information-integration category structures using the new paradigm. The results suggest that there is little learning about the category structures resulting from an indirect categorization task unless the categories can be separated by a one-dimensional rule. Experiment 2 explores whether a category representation learned indirectly can be used in a direct classification task (and vice versa). The results suggest that previous categorical knowledge acquired during a direct classification task can be expressed in the same–different categorization task only when the categories can be separated by a rule that is easily verbalized. Implications of these results for categorization research are discussed.     

Reading Difficulties in Low-SES Children: A Study of Cognitive Profiles

Reading difficulties of children growing up in poverty contexts have not received as much attention as those of children from middle-income families. This paper analyzes the reading-related cognitive profiles of Argentine, Spanish-speaking, low-SES children with reading difficulties (RD), by comparing them with chronological age- (CA) and reading age- (RA) matched children from the same socioeconomic background. Ninety children (30 in each group) participated in the study. Testing included reading, spelling, verbal memory, phonological sensitivity, rapid naming, letter knowledge, and vocabulary measures. Results showed that children from the RD group performed significantly worse than their same-age peers. These findings would suggest the presence of a cognitive vulnerability in children with reading difficulties. Interestingly, when compared with children from the RA-matched control group, children in the RD group only obtained significantly lower scores in phoneme segmentation and letter-sound recognition tasks. Cognitive profiles of low-income children growing in poverty differ from cognitive profiles described for middle-income children with dyslexia. Given that teaching of letter sounds is not included in Argentina’s mandatory curriculum, it is possible that letter-sound teaching constitutes an environmental factor that interacts with other risk factors to produce reading difficulties in poverty contexts.     

Continuous executive function disruption interferes with application of an information integration categorization strategy

Category learning is often characterized as being supported by two separate learning systems. A verbal system learns rule-defined (RD) categories that can be described using a verbal rule and relies on executive functions (EFs) to learn via hypothesis testing. A nonverbal system learns non-rule-defined (NRD) categories that cannot be described by a verbal rule and uses automatic, procedural learning. The verbal system is dominant in that adults tend to use it during initial learning but may switch to the nonverbal system when the verbal system is unsuccessful. The nonverbal system has traditionally been thought to operate independently of EFs, but recent studies suggest that EFs may play a role in the nonverbal system—specifically, to facilitate the transition away from the verbal system. Accordingly, continuously interfering with EFs during the categorization process, so that EFs are never fully available to facilitate the transition, may be more detrimental to the nonverbal system than is temporary EF interference. Participants learned an NRD or an RD category while EFs were untaxed, taxed temporarily, or taxed continuously. When EFs were continuously taxed during NRD categorization, participants were less likely to use a nonverbal categorization strategy than when EFs were temporarily taxed, suggesting that when EFs were unavailable, the transition to the nonverbal system was hindered. For the verbal system, temporary and continuous interference had similar effects on categorization performance and on strategy use, illustrating that EFs play an important but different role in each of the category-learning systems.