音乐训练对大脑前注意加工的影响

前注意加工(pre-attentive processing)是发生在注意之前不依赖于意识的一种认知过程, 它反映了大脑对刺激的无意识的、自动的加工。失匹配负波(mismatch negativity, MMN)是研究前注意加工最常用的指标。MMN波幅降低已成为精神分裂症、抑郁症等精神类疾病的重要临床指征。MMN的研究范式主要包括经典oddball范式和多特征范式等。音乐训练对于人脑结构和功能有重要的影响, 对于增加灰质体积、改善注意记忆功能都有着显著的功效。音乐训练对MMN也有显著影响, 并表现在由各类声音特征构建的范式上。未来研究应进一步比较东西方音乐对MMN的影响, 探索更具生态化效度的研究范式, 揭示音乐训练对老年人MMN的影响及机制。     

视觉工作记忆负载对偏差干扰调控的ERP研究

采用事件相关电位技术（ERPs）,对听视跨通道不同工作记忆负载下偏差干扰效应的加工机制进行研究。当视觉线索50%时,比较有无工作记忆负载条件下偏差干扰效应,分析偏差刺激与标准刺激诱发的差异波,结果发现：（1）存在工作记忆负载和偏差干扰效应;（2）有无工作记忆负载下差异波均出现明显的N1/MMN成分、NP3和RON成分;（3）差异波中N1/MMN成分的平均波幅和潜伏期均没有差异,NP3成分的平均波幅下降;RON成分在平均波幅上没有差异,潜伏期上有工作记忆负载下显著小于无工作记忆负载。研究表明视觉工作记忆负载对偏差干扰调控过程的神经机制并不会因为无关信息与相关信息间冲突竞争增强而改变。     

失匹配负波研究的主要争论与动向

失匹配负波(MMN)是小概率刺激ERP减大概率刺激ERP的差异负波,可由Oddball范式和多特征选择范式获得。近年研究发现MMN不仅存在于听觉通道,还存在于其他通道,且其波幅可反映自动加工,潜伏期则可反映控制加工。MMN可能反映与错误负波ERN相同或相似的加工过程,MMN反映社会认知加工的观点还需进一步研究。未来研究需整合高时间和空间精度技术,从行为和认知神经科学多层面来开展复杂社会刺激的研究,以便阐明MMN可能反映社会认知加工的性质,并在此基础上增强对MMN与ERN的比较研究。     

汉语语调早期加工的脑机制

采用ERP方法, 结合LORETA源定位分析技术, 考察了汉语语调早期自动加工的脑机制。结果发现： (1)对于附着在二声调汉字后的语调, 无论以单字词的形式, 还是以句子的形式呈现, 都没有诱发MMN; (2)当过滤掉实验刺激的言语信息后, 词音高和句子音高条件均诱发了MMN, 且这两个条件下的MMN波幅差异不显著; (3)LORETA分析发现, 句子音高条件在右半球顶叶的多个区域存在显著激活。该结果拓展了以往的研究结论, 为声学假设提供了证据。     

快速阅读训练对基于视觉定向搜索的注意力影响：ERP研究

以视觉搜索任务为检测作业,运用事件相关电位（ERPs）技术,考察快速阅读训练对神经系统注意功能的影响。进行视觉定位搜索测试,被试后测ERP成分P200在电极点F3的波幅较前测显著减小,但P130在电极点P7的潜伏期显著长于前测,N200在电极点P7的波幅较前测显著增大;进行视觉顺序搜索测试,被试后测ERP成分P130在电极点P7的潜伏期显著长于前测,N120在电极点P7的波幅显著大于前测;对于相同的视觉搜索任务,被试后测的反应时和作答率均优于前测,且被试进行顺序搜索时的作答率前后测差异具有显著性。结果表明,经过快速阅读训练,被试的前额叶功能和外源性注意功能可能得到了激活和扩大。     

听觉失匹配负波反映自动加工──感觉道间选择性注意时的新证据

为考察听觉失匹配负波是否反映自动加工,实验改进了视觉和听觉刺激同时呈现的感觉道间选择性注意实验模式,更好地控制了非注意听觉条件。结果发现,在注意与非注意听觉条件下,听觉偏离刺激均诱发出失匹配负波;注意听觉刺激时１４０－１８０ｍｓ的偏离相关负波与非注意时该时程负波的平均波幅之间无显著差异,而注意时１８０－２２０ｍｓ的偏离相关负波的平均波幅大于非注意时同一时程之负波;非注意听觉时失匹配负波的平均波幅和峰潜伏期不受视觉道任务难度的影响,该结果为听觉失匹配负波反映自动加工的观点提供了进一步证据。     

人脑加工自我参照任务的时空特点:来自ERP的证据

以自我参照加工任务为范式,实验采用事件相关电位(ERP)技术,探讨了自我参照加工中符合判断和不符合判断加工的时间进程和大脑神经机制。结果发现,自我参照加工在时间上可以概括分为三个阶段:注意分配阶段N1(80~150 ms)波幅出现自我参照结果的差异;语义整合阶段N2(250~450 ms)波幅和潜伏期出现自我参照结果的差异;评价判断阶段P3(450~700 ms)波幅和潜伏期出现自我参照结果的差异。从我们选择的大脑兴趣区激活水平上分析发现,自我信息在大脑中的激活似乎是一个由右及左,由后及前再及后的动态变化过程。研究结果丰富了自我参照加工的已有结果,并且对未来研究具有一定的启示意义。     

学习困难的ERP研究

事件相关脑电位（Event—related potentials,ERPs）是研究心理学和认知神经科学的重要技术手段,将该技术用于学习困难的脑机制的研究,有助于发现学习困难的神经机制。研究表明,学习困难者的P300波幅较小,潜伏期较长。学习困难者的MMN波幅比控制组小,在信息的自动加工方面存在缺陷。在单词命名任务中,学习困难者的N400较小,而且不同类型学习困难者的波幅和潜伏期存在明显差异。     

高感觉寻求者对危险意义声音的自动加工优势：N1、P2和MMN的证据

Zuckerman关于感觉寻求特质的唤醒理论认为,高感觉寻求者为提高其大脑唤醒,会不惜以冒险方式来寻求高强度、变化、新异和复杂的刺激经验。既往研究已经证实了高感觉寻求者对高强度的、变化的和新奇的刺激材料的认知加工偏向,但尚缺乏来自复杂的和具有危险意义刺激材料的研究证据。我们运用反转Oddball实验范式,以听觉N1、P2和MMN（Mismatch negativity）为ERPs指标,系统比较了高、低感觉寻求者对危险意义声音的自动唤醒、注意偏向和特征探测这三个方面的认知加工差异。结果发现,高感觉寻求者的N1、P2和MMN波幅均显著大于低感觉寻求者。结果表明,高感觉寻求者对危险意义声音产生了更高的唤醒水平、注意偏向和特征探测自动加工优势,这些优势可能是其偏于冒险行为的认知神经机制。     

攻击性儿童的P300事件相关电位研究

运用听觉P300任务对攻击性儿童(17人,其中16名男孩,1名女孩)与对照组的正常儿童( 人数与性别分布同攻击组)的事件相关电位(ERP)进行比较,发现攻击性儿童P30 0的潜伏期较长,波幅尤其是额部波幅较小,表明攻击性个体存在认知加工缺陷,特别是选择性注意与调控机能缺陷.研究结果同时表明P300可以作为鉴别攻击性个体的一个可靠指标.     

Chronic drinking, binge drinking, and drunk driving II

Data from the Rhode Island Behavioral Risk Factor Survey on self-reported alcohol consumption and drunk driving were examined. Driving while intoxicated was significantly associated with both binge drinking and chronic drinking, but the measures of drinking were not significantly associated.     

Attitudes,knowledge, and use of alcohol in university students

This paper investigated attitudes towards alcohol, knowledge of alcohol, parents drinking behaviour, reasons for drinking and television viewing habits varied in relation to actual drinking behaviour. A sample of 106 University students completed a questionnaire which enabled their classification as non, light, medium and heavy drinkers on the basis of their self-reported consumption levels. Results revealed 9% to be non-drinkers, 22% to be light, 38% to be moderate and 31% to be heavy. They also showed that alcohol drinking habits differed significantly with age, sex, smoking habits and in particular with parents drinking habits. Alcohol drinking habits also differed significantly with knowledge of alcohol, heavier drinkers being found to have a better overall knowledge, but reasons for drinking and attitudes towards drinking did not show any overall difference between the drinking habit categories. Finally, there was no indication that television viewing independently contributed to alcohol beliefs, knowledge, attitudes or habits. The results are discussed in terms of future research implications.     

Relationship between egocentrism, alcohol consumption and reasons given for drinking

University students, 86 men and 141 women, completed a questionnaire from which their level of egocentrism, amount of alcohol consumed, and number of reasons for drinking could be estimated. Analysis supported earlier findings that men consume significantly more alcohol than do women. Both men and women who were rated as having high egocentrism scores gave significantly more reasons for drinking than did the women scoring low on egocentrism. Also, there was a significant correlation between egocentrism and reasons for drinking but not between egocentrism and amount consumed. The correlation was higher between the number of reasons given for drinking and the amount of alcohol consumed. Since men scoring high on egocentrism report the highest consumption, while high-scoring women report the lowest consumption, it is concluded that egocentrism plays an indirect role in the consumption of alcohol and the role it plays is different for men and women.     

An experimental analysis of aversive imagery versus electrical aversive conditioning in the treatment of chronic alcoholics

A series of three experiments is described comparing an aversive imagery and an electrical escape conditioning procedure in the treatment of chronic alcoholics. Treatment effects were objectively measured by recording subjects' alcohol consumption in a semi-naturalistic laboratory setting. In contrast to conventional group outcome studies, the use of single-subject methodology provided a fine-grained analysis of individual response patterns. The aversive imagery and escape conditioning methods did not differ from each other, and were relatively ineffective in suppressing alcohol intake. In contrast, a punishment procedure in which shock was contingent on drinking did effectively suppress drinking. The data suggest that alcoholics can control their drinking by self-administered shock. The implications for the analysis and treatment of alcoholics are discussed.     

Perceptions of Postdrinking Female Sexuality: Effects of Gender,Beverage Choice,and Drink Payment1

To examine the postulate that the drinking woman is viewed differently than her nondrinking counterpart, two experiments were conducted. In Study 1, 174 subjects completed an alcohol expectancy questionnaire that was modified to assess expected alcohol effects on another person: young man or young woman. The woman was perceived as being more sexual after drinking than was the man. These perceptions were also influenced by expected alcohol dosage, subjects' gender, and drinking experience. In Study 2, 176 subjects read a vignette depicting a woman having drinks with a man. To manipulate the stimulus woman's consumption and the drink payment arrangement, 8 versions of the vignette were employed: The woman was described as drinking cola or alcohol (beer, wine or whiskey) and as paying for her own drinks or allowing the man to “pick up the tab”. Subjects rated the drinking woman as significantly more aggressive, impaired, sexually available, and as significantly more likely to engage in foreplay and intercourse. Perceptions of her sexual disinhibition and likelihood of sex play were significantly enhanced if the man bought the drinks. Compared to their own perceptions of her, subjects estimated that her date would see her as significantly more disinhibited and socially skilled and as less impaired. The alcohol-drinking woman was also seen as less attractive than her cola-drinking counterpart. Practical implications regarding stereotypes about cross-gender drinking situations and theoretical implications regarding alcohol expectancy research are discussed.     

Adolescents'' alcohol use related to perceived norms

A questionnaire survey was carried out among 898 Norwegian adolescents age twelve to twenty. The study focused on the relation between adolescents' alcohol use on one side and estimated drinking norms (peers' drinking) together with attributed opinion norms (parents' and friends' acceptance of adolescents' alcohol use) on the other. On average, 5% of students in 7th, 8th, and 9th grade reported weekly alcohol use. They overestimated the number of fellow students using alcohol every week seven-fold. Students' estimates were significantly related to self-reported alcohol use. Even in high-school (10th, 11th and 12th grade) where 29% reported weekly alcohol use, students overestimated number of weekly drinkers among friends and fellow students by two-fold. Contrary to the results from a previous study conducted in Norway, in this study opinions attributed to both friends and parents about adolescents' alcohol use were significantly related to the students' own alcohol use. Estimated behavior norms and attributed opinion norms explained 46% of the observed variance in students' self-reported frequency of drinking. In a health promotion context, these results point to the importance of correcting student misconceptions about how often friends and fellow students drink alcohol.     

Relations of parental status with alcohol use patterns and attitudes about underage drinking

In a sample of 143 adults from a population of households in Idaho, significant differences in patterns of alcohol use and attitudes about underage drinking were related to parental status. Nonparents reported drinking alcohol more frequently than parents. Parents were significantly more likely than nonparents to report that it is never acceptable for minors to drink alcohol, that minors should not be allowed to drink alcohol at parties with no parents present, and that "sting" operations by police are warranted. Surprisingly, nonparents were significantly more likely than parents to report stores and bars are not careful enough about selling alcohol to minors.     

Contingent reinforcement of lowered blood-alcohol levels in an outpatient chronic alcoholic

Recently. the proposition that alcohol abuse is an operant behavior and thus functionally related to its consequences has been investigated under experimental conditions. In controlled laboratory settings, in which inpatient chronic alcoholics are allowed access to alcoholic beverages, alcohol consumption has been markedly altered via operant strategies. Monetary rewards (Cohen et al., 1971), the opportunity to participate in an enriched environment (Cohen et al., 1971). and visits to a girlfriend (Bigelow et al., 1973) have been used as reinforcers for decreased drinking.Other investigators (Sulzer, 1965; Miller, 1972: Hunt and Azrin, 1973) have successfully applied similar contingency management techniques to alcoholics in the natural environment. However, failure to control for the influence of extraneous therapeutic variables (e.g., attention-placebo factors, job counseling) together with reliance on self-report measures of drinking behavior seriously limit the conclusiveness of these results. Objective assessment is particularly essential with operant techniques since consequent events must be systematically scheduled upon the occurrence or non-occurrence of drinking. Documentation of drinking in the natural environment is a difficult task since the alcoholic frequently consumes alcohol when he is alone. In lieu of direct observation, blood alcohol concentrations are an obvious means of objective assessment. Such data are most conveniently obtained via breath tests similar to the ones that law enforcement officers utilize to identify intoxicated motorists.The purpose of the present study was to investigate the influence of reinforcement contingencies on lowering blood alcohol concentrations obtained in an alcoholic's natural environment.     

Feeling Controlled and Drinking Motives Among College Students: Contingent Self-Esteem as a Mediator

This article presents an examination of college student drinking motives from a self-determination perspective. We predicted positive associations between controlled orientation (a chronic orientation toward pressures and experiencing a lack of choice in one's behaviors), and drinking as a means of regulating affect (enhancement and coping motives) and social approval (social rewards and conformity motives). Contingent self-esteem involves deriving self-worth from meeting expectations and was expected to mediate the relation between controlled orientation and drinking motives, which were in turn expected to predict alcohol consumption and related consequences. College students' (N?=?204) controlled orientation, contingent self-esteem, motives for drinking, and patterns of alcohol use were assessed. Mediation analyses provided support for our theoretical framework. Results suggest that “controlled” individuals drink to regulate affect and social approval in part because they have a greater tendency to base self-worth on contingencies.     

Early and late mismatch negativity elicited by words and speech-like stimuli in children

In auditory perception the brain's attentional and preattentional mechanisms select certain stimuli for preferential processing and filter out irrelevant input. This study investigated nonattentive auditory processing in children. Event-related potentials (ERPs) provide a means to study neural correlates related to language and speech-sound processing. Mismatch negativity (MMN) is an ERP wave that indicates attention-independent perceptual change detection. In this study cortical ERPs were elicited by complex tones, naturally spoken words, and pseudowords, with each stimulus type containing equal acoustical elements. Tones elicited a bifurcated mismatch negativity (MMN), with early MMN (peaking at 150-200 ms) being more dominant. On the other hand, words elicited a strong late MMN, peaking at about 400-450 ms after stimulus onset. The MMN wave form was significantly weaker for pseudowords than for words. The late MMN wave, especially for word differences, was found to reflect summating MMN generators and memory trace formation on gestalt bases. Results suggest that the auditory processing, even nonattended, is highly associated with the cognitive meaning of the stimuli.