Response to Algarabel et al., 2012 “Recognition memory deficits in mild cognitive impairment”. Reconsidering claims of familiarity disruptions in mild cognitive impairment

There is some debate over the relative impairment of recollection and familiarity in mild cognitive impairment (MCI). A recent publication by Algarabel et al. (2012, Recognition memory deficits in mild cognitive impairment, Aging, Neuropsychology, and Cognition, 19, 608–619) claims to undermine previous studies reporting preserved familiarity in patients with MCI. Here, we respond to their main criticisms, concluding that they are not sufficiently supported by the data presented. The role of recollection and familiarity in MCI remains unresolved and further work will be required to disentangle the mixed literature.     

Recognition memory deficits in mild cognitive impairment

ABSTRACT There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (MCI). Whereas lower performance in recollection is the hallmark of MCI, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed light on the pattern of responding in recollection and familiarity in MCI. Five groups of participants were tested. The main participant samples were those formed by two MCI groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups. Whereas one of the control groups served to assess the performance of the MCI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in MCI. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MCI stage.     

Recognition memory deficits in mild cognitive impairment

ABSTRACT

There is no agreement on the pattern of recognition memory deficits characteristic of patients diagnosed with mild cognitive impairment (MCI). Whereas lower performance in recollection is the hallmark of MCI, there is a strong controversy about possible deficits in familiarity estimates when using recognition memory tasks. The aim of this research is to shed light on the pattern of responding in recollection and familiarity in MCI. Five groups of participants were tested. The main participant samples were those formed by two MCI groups differing in age and an Alzheimer's disease group (AD), which were compared with two control groups. Whereas one of the control groups served to assess the performance of the MCI and AD people, the other one, composed of young healthy participants, served the purpose of evaluating the adequacy of the experimental tasks used in the evaluation of the different components of recognition memory. We used an associative recognition task as a direct index of recollection and a choice task on a pair of stimuli, one of which was perceptually similar to those studied in the associative recognition phase, as an index of familiarity. Our results indicate that recollection decreases with age and neurological status, and familiarity remains stable in the elderly control sample but it is deficient in MCI. This research shows that a unique encoding situation generated deficits in recollective and familiarity mechanisms in mild cognitive impaired individuals, providing evidence for the existence of deficits in both retrieval processes in recognition memory in a MCI stage.     

Recollection and Familiarity in Aging Individuals with Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review

Memory impairment is a central cognitive symptom in mild cognitive impairment (MCI) and Alzheimer Disease (AD). Recognition tasks are often used to characterize and define the nature of memory deficits. Dual-process theories posit that familiarity and recollection are independently involved in the recognition of previously encountered material and both contribute to successful recognition. Recent evidence indicates that there is a double dissociation in the neuronal substrates of those two processes. More precisely, it has been suggested that perirhinal and entorhinal areas are selectively involved in familiarity-based recognition, while the hippocampus is associated with recollection. Interestingly, these regions are among the first to be targeted by neurofibrillary tangles, one of AD’s neuropathological hallmarks. Impairment in recognition performance can occur in the very early stages of AD, such as MCI. To define the nature of recognition impairment in these clinical populations, we reviewed the current literature on familiarity and recollection performance in individuals with MCI and AD. Together with clinical features, methodological factors are taken into consideration in the interpretation of findings.     

An evaluation of recollection and familiarity in Alzheimer’s disease and mild cognitive impairment using receiver operating characteristics

There is a need to investigate exactly how memory breaks down in the course of Alzheimer’s disease (AD). Examining what aspects of memorial processing remain relatively intact early in the disease process will allow us to develop behavioral interventions and possible drug therapies focused on these intact processes. Several recent studies have worked to understand the processes of recollection and familiarity in patients with mild cognitive impairment (MCI) and very mild AD. Although there is general agreement that these patient groups are relatively unable to use recollection to support veridical recognition decisions, there has been some question as to how well these patients can use familiarity. The current study used receiver operating characteristic (ROC) curves and a depth of processing manipulation to understand the effect of MCI and AD on the estimates of recollection and familiarity. Results showed that patients with MCI and AD were impaired in both recollection and familiarity, regardless of the depth of encoding. These results are discussed in relation to disease pathology and in the context of recent conflicting evidence as to whether familiarity remains intact in patients with MCI. The authors highlight differences in stimuli type and task difficulty as possibly modulating the ability of these patients to successfully use familiarity in support of memorial decisions.     

Recollection and familiarity in recognition memory: adult age differences and neuropsychological test correlates

Dual process theories account for age-related changes in memory by proposing that old age is associated with deficits in recollection together with invariance in familiarity. The authors evaluated this proposal in recognition by examining recollection and familiarity estimates in young and older adults across 3 process estimation methods: inclusion/exclusion, remember/know, and receiver operating characteristics (ROC). Consistent with a previous literature review (Light, Prull, LaVoie, & Healy, 2000), the authors found age invariance in familiarity when process estimates were derived from the inclusion/exclusion method, but the authors found age differences favoring the young when familiarity estimates were derived from the remember/know and ROC methods. Recollection estimates were lower for older adults in all 3 methods. Recollection and familiarity had variable relationships with frontal- and temporal-lobe measures of neuropsychological functioning in older adults, depending on which method was used to generate process estimates. These data suggest that although recollection deficits appear to be the rule in aging, not all estimates of familiarity show age invariance.     

Dissociations in visual attention deficits among persons with mild cognitive impairment

Impairments in visual attention and visual information processing have been identified as part of the neuropsychological features of Alzheimer's disease (AD), even in its earliest stages. There is increasing recognition that these deficits may be selective rather than global, with some attentional subtypes being more vulnerable than others. The few studies that have investigated attentional deficits in mild cognitive impairment (MCI), a putatively prodromal phase of AD, have not satisfactorily addressed the possible selectivity in attentional deficits in MCI. This study examined potential dissociations in visual attention deficits in MCI using a measure that assesses simple, divided, and selective attention. The results indicated a hierarchy of attentional impairments, with divided attention being the most affected and simple attention the least. Among participants with MCI, 53% showed evidence of impairment in divided attention compared to 19% of controls (OR = 4.81, p < .001). Poorer visual attention was also associated with poorer overall cognitive status. The implications of these findings for early identification of MCI, prevention of functional decline in MCI, and delay/reversal of cognitive degradation in MCI are discussed.     

ERP evidence for task modulations on face perceptual processing at different spatial scales

Does the perceptual processing of faces flexibly adapt to the requirements of the categorization task at hand, or does it operate independently of this cognitive context? Behavioral studies have shown that the fine and coarse spatial scales of a face are differentially processed depending on the categorization task performed, thus suggesting that the latter can influence stimulus perception. Here, we investigated the time course of these task influences on perceptual processing by examining the visual N170 face‐sensitive Event‐Related Potential (ERP), while observers categorized faces for their gender and familiarity. Stimuli were full spectrum, or filtered versions that preserved either coarse or fine scale information of the faces. Behavioral results replicated previous findings of a differential processing of coarse and fine spatial scales across tasks. In addition, the N170 amplitude was larger in the Gender task as compared to the Familiarity task for LSF faces exclusively, thus showing that task demands differentially modulated the spatial scale processing on faces. These results suggest that the diagnosticity of scale‐specific cues in categorization tasks can modulate face processing.     

认知和情绪冲突的监控与解决：来自轻度认知损伤的证据

轻度认知损伤(mild cognitive impairment, MCI)是介于正常老化和痴呆之间的过渡阶段。近年来, 执行控制的损伤被认为是MCI的核心特征之一。当前, 在MCI执行控制的领域内, 对冲突监控与解决的特征及其神经机制的研究较少。本研究拟通过认知及情绪冲突实验范式, 结合脑成像技术, 探讨遗忘型MCI (amnestic MCI, aMCI)认知和情绪冲突的监控与解决的特征及相应的脑激活模式; 通过对比aMCI和正常老年人在认知和情绪冲突任务中激活的神经环路, 考察aMCI是否在执行加工的神经网络上存在激活异常。在上述研究基础上, 研究者拟探讨aMCI在执行控制的冲突监控与解决上是否存在一般性的损伤机制, 同时试图寻找aMCI在执行控制的冲突监控与解决方面的认知及神经生物学标记。这对深入理解痴呆的发病进程并有针对性的开展痴呆的早期识别与干预具有重要的理论意义和实践意义。     

Familiarity breeds attraction: effects of exposure on the attractiveness of typical and distinctive faces

Several studies have shown that facial attractiveness is positively correlated with both familiarity and typicality. Here we manipulated the familiarity of typical and distinctive faces to measure the effect on attractiveness. In our first experiment, we collected ratings of attractiveness, distinctiveness, and familiarity using three different groups of participants. Our stimuli included 84 images of female faces, presented in a full-face view. We replicated the finding that attractiveness ratings negatively correlate with distinctiveness ratings. In addition, we showed that attractiveness ratings were positively correlated with familiarity ratings. In our second experiment, we demonstrated that increasing exposure to faces increases their attractiveness, although there was no differential effect of exposure on typical and distinctive faces. Our results suggest that episodic familiarity affects attractiveness ratings independently of general or structural familiarity. The implications of our findings for the 'face-space' model are discussed.     

自我信息加工优势中的熟悉性问题

熟悉性对于自我信息加工优势的影响往往与自我相关性的作用交织在一起,从而使其成为该领域的一个研究重点和难点。文章分别介绍了自我参照效应、自我面孔和人名识别研究中对该问题进行考察的主要思路与发现。现有证据显示,熟悉性与自我特异性在自我信息的加工优势中是可分离的,从而表明自我信息所固有的高熟悉性可能并不是造成其具有加工优势的决定性因素。文章在展望部分将熟悉性进一步细分为材料的熟悉性与任务的熟悉性,并提出未来的研究应该特别注意考察任务熟悉性可能存在的影响作用。     

Dissociations in Visual Attention Deficits among Persons with Mild Cognitive Impairment

ABSTRACT

Impairments in visual attention and visual information processing have been identified as part of the neuropsychological features of Alzheimer's disease (AD), even in its earliest stages. There is increasing recognition that these deficits may be selective rather than global, with some attentional subtypes being more vulnerable than others. The few studies that have investigated attentional deficits in mild cognitive impairment (MCI), a putatively prodromal phase of AD, have not satisfactorily addressed the possible selectivity in attentional deficits in MCI. This study examined potential dissociations in visual attention deficits in MCI using a measure that assesses simple, divided, and selective attention. The results indicated a hierarchy of attentional impairments, with divided attention being the most affected and simple attention the least. Among participants with MCI, 53% showed evidence of impairment in divided attention compared to 19% of controls (OR = 4.81, p < .001). Poorer visual attention was also associated with poorer overall cognitive status. The implications of these findings for early identification of MCI, prevention of functional decline in MCI, and delay/reversal of cognitive degradation in MCI are discussed.     

The influence of phonological neighborhood on visual word perception

In the research reported here, we investigated the influence of phonological neighborhood density on the processing of words in the visual lexical decision task. The results of the first experiment revealed that words with large phonological neighborhoods were verified more rapidly than words with small phonological neighborhoods. In the second experiment, we replicated this effect with a more tightly controlled set of stimuli. These results demonstrate the importance of phonological codes when processing visually presented letter strings. We relate this research to previous results on semantic and orthographic neighborhoods and discuss the results within the context of a model in which lexical decisions are based on stimulus familiarity.     

The Role of Memory in the Relationship between Affect and Familiarity

Abstract

Two previous studies have demonstrated that stimuli which elicit affect are seen as more familiar than stimuli that elicit little or no affect, but it is not clear why this effect occurs. To begin to understand the effect, the question of whether it is due to improved memory for affect-eliciting stimuli was examined. Recognition judgements were obtained for faces that varied in the strength and valence of affect elicited. Improved memory for affect-eliciting faces was not observed. Instead, the results show a bias to claim recognition for faces that are especially likely to elicit affect, whether or not those faces have been seen before, suggesting that affect can induce a sense of familiarity. The finding of a previous study indicating that both positive and negative affect increase perceived familiarity was replicated. The relevance of the results to an understanding of basic affective processes and processes involved in the assessment of familiarity is discussed. An explanation which can account for the data is proposed.     

Issues surrounding the cognitive neuroscience of obsessive-compulsive disorder

Obsessive-compulsive disorder (OCD) has been studied extensively in recent years, with increased emphasis on understanding OCD’s biological substrates. There has been significant progress in documenting abnormal brain function in OCD patients, particularly in the orbitofrontal cortex, basal ganglia, and thalamus. Similar progress has broadened our understanding of the cognitive and behavioral manifestations of the disorder, including deficits in set shifting, hyperattention, and visuospatial construction abilities. Unfortunately, these results have not been replicated consistently. This report comprises a review of previous attempts to characterize the neurobiology and neuropsychology of OCD, and a discussion of several factors in OCD research that can help to explain previous inconsistencies.     

Executive functioning in older adults with mild cognitive impairment: MCI has effects on planning, but not on inhibition

In this study, we compared executive functioning in 32 mild cognitive impairment (MCI) individuals with that of normally aging controls. Cognitive planning tests (Trail Making, Porteus Maze Test, verbal fluency tests) show a group difference favoring the normal controls, but tests for inhibition of prepotent responses (no-go accuracy, two measures of the Stroop effect, and negative priming) failed to uncover a significant group difference. The results indicate that there is no general executive control function impairment in MCI; rather, the deficits found are compatible with the hypothesis that MCI is an accelerated form of normal aging.     

Mild cognitive impairment: a neuropsychological perspective

Mild cognitive impairment (MCI) is a clinical diagnosis in which deficits in cognitive function are evident but not of sufficient severity to warrant a diagnosis of dementia. For the majority of patients, MCI represents a transitional state between normal aging and mild dementia, usually Alzheimer's disease. Multiple subtypes of MCI are now recognized. In addition to presentations featuring memory impairment, symptoms in other cognitive domains (eg, executive function, language, visuospatial) have been identified. Neuropsychological testing can be extremely useful in making the MCI diagnosis and tracking the evolution of cognitive symptoms over time. A comprehensive test battery includes measures of baseline intellectual ability, attention, executive function, memory, language, visuospatial skills, and mood. Informant-based measures of neuropsychiatric symptoms, behaviors, and competency in instrumental activity are also included. Careful assessment can identify subtle deficits that may otherwise elude detection, particularly in individuals of superior baseline intellectual ability. As we move closer to disease-modifying therapy for Alzheimer's disease, early identification becomes critical for identifying patients who have an opportunity to benefit from treatment.     

Executive Functioning in Older Adults with Mild Cognitive Impairment: MCI Has Effects on Planning,But Not on Inhibition

ABSTRACT

In this study, we compared executive functioning in 32 mild cognitive impairment (MCI) individuals with that of normally aging controls. Cognitive planning tests (Trail Making, Porteus Maze Test, verbal fluency tests) show a group difference favoring the normal controls, but tests for inhibition of prepotent responses (no-go accuracy, two measures of the Stroop effect, and negative priming) failed to uncover a significant group difference. The results indicate that there is no general executive control function impairment in MCI; rather, the deficits found are compatible with the hypothesis that MCI is an accelerated form of normal aging.     

Not all triads are created equal: further support for the importance of visual and semantic proximity in object identification

Identification deficits were investigated in ELM, a temporal lobe stroke patient with category-specific deficits. We replicated previous work done on FS, a patient with category specific deficits as a result of herpes viral encephalitis. ELM was tested using novel, computer generated shapes that were paired with artifact labels. We paired semantically close or disparate labels to shapes and ELM attempted to learn these pairings. Overall, ELM's shape-label confusions were most detrimentally affected when we used labels that referred to objects that were visually and semantically close. However, as with FS, ELM had as many errors when shapes were paired with the labels "donut," "tire," and "washer" as he did when they were paired with visually and semantically close artifact labels. Two explanations are put forth to account for the anomalous performance by both patients on the triad of donut-tire-washer.