The efficacy of massage on short and long term outcomes in preterm infants

Purpose

Premature infants lack the tactile stimulation they would have otherwise experienced in the womb. Infant massage is a developmentally supportive intervention that has been documented for several decades to have a positive effect on both full term and preterm infants. The purpose of this study was to assess the short and long term benefits of massage on stable preterm infants.

Methods

A quasi experimental design was used, 66 infants were recruited from two university hospitals with tertiary level NICUs; 32 infants received the massage therapy by their mothers. Data collection by a researcher blind to the infants’ group assignments included weight at discharge, pain responses on the PIPP scale at discharge, length of stay in hospital, neuro-developmental outcome (Bayley scores) and breastfeeding duration at 12 months corrected age.

Results

Infants who were massaged had significantly lower scores on the PIPP after a heel-stick compared to before the massage and had lower PIPP scores at discharge compared to the control group. Massaged infants had higher cognitive scores at 12 months corrected age. Weight gain, length of stay, breastfeeding duration and motor scores did not differ between groups.

Conclusion

Stable preterm infants benefit from massage therapy given by their mothers and may be a culturally acceptable form of intervention to improve the outcomes of preterm infants.     

Developmental and medical factors associated with parenting stress in mothers of toddlers born very preterm in a neonatal follow-up clinic

The purpose of this exploratory, cross-sectional study was to identify child-related factors associated with maternal parenting stress in toddlers born very preterm and followed in a neonatal follow-up (NFU) clinic. The study aimed to describe the associations of current medical complications and presence of developmental delays with total parenting stress. Participants were 53 mother–child dyads presenting in a NFU clinic. Mothers completed the Parenting Stress Index-Short Form (PSI-SF), and children were administered the Brigance Early Head Start Screen II. Medical variables were also collected from the child's medical record. Approximately 24% of mothers had at least one elevated subscale score on the PSI-SF. Regression analyses indicated that receipt of early intervention services was associated with increased parenting stress among mothers of toddlers born very preterm, though number of current medical complications was not. Parents of children born very preterm are at increased risk for parenting stress that extends beyond discharge from the neonatal intensive care unit . Clinicians working in NFU clinics are positioned to monitor for increased parenting stress, particularly among families of children with emerging signs of developmental delay.     

Atomic geometry and energetics of carbon nanotube necking

Molecular mechanics simulations were performed to probe the incipient plastic deformation in carbon nanotubes (CNTs), which involves nucleation of Stone–Wales (SW) defects and spiral glide of 5/7 dislocation dipoles that lead to quantized necking through a stepwise reduction in tube diameter. Quantification of the strain-dependent energetics of dislocation glide reveals that such dislocation motions are energetically favoured at high tensile strain. Pre-existing dislocations critically affect subsequent nucleation and separation of SW defects, as manifested by the competing deformation modes of symmetric versus asymmetric necking. The results provide a quantitative basis for the dislocation dynamics simulations of superplastically deformed CNTs.     

Pressure dependence of the electrical resistivity of natural cassiterite SnO2 and of undoped and Co-doped nanocrystalline SnO2

The pressure dependence of the electrical resistivity of three different samples of cassiterite, namely natural cassiterite SnO₂, synthetic nanocrystalline SnO₂ (with crystallite size 46?nm) and nanocrystalline Co-doped SnO₂ (with crystallite size 32?nm), has been measured up to 7?GPa at room temperature. The resistivity of natural cassiterite SnO₂ decreases from 2.5?×?10⁴?Ωm at normal pressure and temperature to 1.7?×?10⁴?Ωm at 7.0?GPa. The nanocrystalline SnO₂ has a high resistivity 6.0?×?10⁵?Ωm at normal pressure and temperature and decreases with pressure reaching a value of 2.98?×?10⁵?Ωm at 7?GPa. The activation energy of the electrical conduction of the studied samples were found to be 0.32?eV for the natural SnO₂, 0.40?eV for the nanocrystalline SnO₂ sample and 0.28?eV for the nanocrystalline Co-doped SnO₂. Measurements of the pressure dependence of the electrical resistivity of the Co-doped SnO₂ showed a decrease from 3.60?×?10⁵ to 5.4?×?10⁴?Ωm at 7.0?GPa. We did not observe any pressure-induced phase transition in SnO₂ up to 7?GPa. This study of the high-pressure phase stability of cassiterite corroborates the experimental findings of SnO₂ nanoinclusions in diamonds.     

Extended energy-loss fine structure analysis of 3d transition metals using L ionization edges

The extended energy-loss fine structure (EXELFS) in electron-energy-loss spectroscopy has been compared experimentally with the extended X-ray absorption fine structure (EXAFS), for determining local structure around 3d transition metals. Since the EXELFS spectrum is acquired in an analytical transmission electron microscope, the probing beam can be focused to offer a lateral spatial resolution in the nanometre range, which is several orders of magnitude better than that of X-rays. Also, the microscope allows the area of interest to be imaged and analysed by other methods. However, difficulties in the analysis of EXELFS of 3d transition metals arise from the overlap of the edges in the accessible L series. EXELFS of L ionization edges of crystalline Ni and Cu were examined as test specimens. The overlapped L₁,L₂ and L₃ edges were separated and compared with the K-edge EXAFS of the same samples. The first- and second-nearest-neighbour distances from EXELFS are in agreement with those measured from EXAFS and X-ray diffraction. As a structural probe, however, the accuracy of quantitative analysis of EXAFS is still superior since the L-edge EXELFS decays more rapidly than K-edge EXAFS.     

Predicting cognitive development and early symptoms of autism spectrum disorder in preterm children: The value of temperament and sensory processing

This study was the first to longitudinally explore the extent to which early temperament and sensory processing were of predictive value for cognitive development and Autism Spectrum Disorder (ASD) symptomatology in a sample of preterm children (N = 50, 22 girls, mean gestational age 27 weeks). At the corrected ages of 10, 18, and 24 months, sensory processing and temperament were assessed, as were cognitive development and ASD symptoms at 36 months. Better cognitive development was predicted by fewer hospitalisation days at birth and by lower Activity Level at 18 months. Temperamental subscales of Negative Affect showed associations with both parent-reported and observational measures of ASD symptomatology, whereas sensory processing only had predictive value for parent-reported symptoms of ASD. The usefulness of temperament and sensory processing for prediction of ASD symptom severity and cognitive outcomes became clear in the second year of life. The results indicate that this area of research is worth additional investigation in the extreme and very preterm population, to explore in further detail whether these two concepts might be able to provide information about which preterms are more likely to develop ASD or cognitive impairments.     

Electrical conductivity of Nd and Ce co-doped Gd2Zr2O7 ceramics

In this study, (Gd_{1? x} Nd _x )₂(Zr_{1? x} Ce _x )₂O₇ (0 ≤ x ≤ 0.5) ceramics have been prepared by pressureless sintering at 1973 K to investigate the influence of Nd and Ce co-doping on their electrical conductivity. The electrical conductivity of the ceramics was investigated by impedance spectroscopy measurements from 723 to 1173 K over the frequency range of 20 Hz to 2 MHz in air. The measured values obey the Arrhenius relation. For each composition, the grain conductivity gradually increases with increasing temperature from 723 to 1173 K. At a given temperature, it gradually decreases with increasing neodymium and cerium contents from x = 0 to 0.3; thereafter, the grain conductivity exhibits a slight increase with further increasing neodymium and cerium contents up to x = 0.5.     

Phonon densities of states of gamma-cerium and delta-cerium measured by time-of-flight inelastic neutron scattering

Time-of-flight inelastic neutron scattering spectra were measured on cerium metal at temperatures near the fcc (gamma)-to-bcc (delta) transition temperature. Phonon density-of-states (DOS) curves were extracted from data acquired over a wide range of momentum transfers. A large softening of the phonon DOS was found in going from gamma-cerium to delta-cerium, and this accounts for an increase in vibrational entropy of (0.71 +/- 0.05)k _B/atom. To be consistent with the latent heat of the gamma-delta transition, this increase in vibrational entropy must be accompanied by a large decrease in electronic entropy. The results not only confirm the recent discovery of a significant electronic contribution to the gamma-delta transition but also suggest that it may be twice that previously reported.     

The effects of baby bath and massage by fathers on the family system: The sunraysia australia intervention project

Instruction in baby massage and the Burleigh Relaxation Bath technique was given to one-half of our sample of 32 couples who had just had their first child. This brief intervention, given at 4 weeks post-partum, led to beneficial behavioural and psychological effects for the family system when assessed at 12 weeks postpartum. Depression and marital satisfaction were assessed with mothers and fathers at 4 weeks and 12 weeks after the birth of their child, and self-esteem was measured at 12 weeks only. The mothers and fathers who were shown baby bathing and massage techniques showed higher degrees of marital satisfaction and self-esteem, as well as lower levels of depression at 12 weeks post-partum, than parents who did not receive instruction. It seems likely that brief interventions which educate new parents concerning functional techniques of baby care may favourably affect their feelings of competence and be of benefit to the entire family system.     

Investigations of the optical spectra and EPR g-factors for the tetragonal Ce3+ centers in YPO4 and LuPO4 crystals

The optical spectral band positions and EPR g-factors (g_‖ , g _⊥) for the tetragonal Ce³⁺ centers in YPO₄ and LuPO₄ crystals with the zircon-structure are calculated using a complete diagonalization (of the energy matrix) method (CDM) related to 4f¹ ions in tetragonal symmetry. In this method, the Zeeman interaction term are added to the Hamiltonian in the conventional CDM and so no perturbation calculations are required to obtain the g factors. The crystal-field parameters used in the calculations are obtained from the superposition model in which the local lattice relaxation related to the bonding lengths is considered. The calculated results are in reasonable agreement with the experimental values. It is found that the four observed optical bands for both the systems can be attributed to Ce³⁺ ions in a tetragonal crystal field.     

The effect of hydrogen plasma on the properties of a-Si:H/a-Si1-xNx:H superlattices

Abstract

A hydrogen plasma introduced during the interrupting interval when alternating two gases affects the properties of a-Si:H/a-Si_1-xN_x:H superlattices resulting in the creation of fewer interface defects than the superlattices prepared without the hydrogen plasma.     

Theoretical explanation for Raman and ESR spectra of V3+ ions in salt guanidinium vanadium sulfate hexahydrate

The Raman spectra and electronic spin resonance (ESR) parameters (spin-Hamiltonian parameter g factors, zero-field splitting parameter D, and hyperfine structure constant A) for the trigonal V³⁺ centers in salt guanidinium vanadium sulfate hexahydrate (GVSH) are calculated from the complete diagonalization (of energy matrix) method. The theoretical results are in agreement with the experimental findings and the trigonal crystal-field parameters are determined. The difficulty in explaining ESR parameters of V³⁺ in GVSH is removed.     

Differential effects of stimulus characteristics during knee joint perturbation on hamstring and quadriceps reflex responses

When stretching muscles of the ankle joint, stretch velocity and amplitude were shown to selectively influence specific parts of the stretch reflex. The present study investigated whether similar effects can be observed at the knee joint. Seventeen subjects were exposed to sudden anterior tibial translations. The influence of stimulus amplitude was analyzed by applying a low (LIMP) or high impulse (HIMP). To investigate the influence of velocity, rate of force development of the perturbation was chosen either low (LRFD) or high (HRFD). Activation of biceps femoris (BF), semitendinosus (ST), vastus medialis (VM) and vastus lateralis (VL) was calculated in four consecutive timeframes (P0, P1, P2, P3). During P1, RFD (ST: p < .05; BF: p < .01; VM: p < .05; VL: p > .05) and during P2, impulse (ST: p < .05; BF: p < .01; VM: p < .01; VL: p < .01) did significantly influence reflex activation. The present study showed that stimulus characteristics influenced specific reflex components of knee joint muscles. As only hamstring muscles were stretched, whereas quadriceps was unloaded, it is concluded that different mechanisms like homonymous and heteronymous muscle afferents as well as joint and skin afferents might contribute to the reflex responses.     

Stability of nanocrystalline disordered NiAl synthesized by mechanical alloying

The thermal stability of highly disordered mechanically alloyed nanocrystalline NiAl has been evaluated. The reordering of disordered NiAl(Cr) shows extremely fast kinetics on isothermal annealing at and above 673K, while the process is quite sluggish below this temperature. On the other hand, significant reordering in NiAl(Fe) takes place even at 573K. A unique dependence of reordering on the grain growth of the nanophase is evident during thermal treatment. Rapid grain coarsening begins only as the absolute temperature approaches approximately 0.4 T m, where T m is the melting point of the aluminide.     

Defect formation in Nd2Fe14B grains caused by Zn diffusion

Defect formation in Nd₂Fe₁₄B grains, caused by a low-pressure-pack-sublimation Zn coating process, has been investigated. The results indicate that, in the Zn-affected region, low-angle boundaries decorated with precipitates form within the Nd2Fe14B grains. Zn, which is almost insoluble in Nd₂Fe₁₄     

Absorption and photoluminescence spectroscopy of Er3+-doped SrAl2O4 ceramic phosphors

A spectroscopic characterization of Er³⁺-doped SrAl₂O₄ phosphor materials synthesized by a solid-state reaction method with Er concentrations varying from 0.1 to 1?mol% has been performed by studying photoluminescence (PL) in the temperature range 10 to 360?K and absorption spectra. PL signals containing five emission bands at 1492, 1529, 1541, 1558, and 1600?nm, respectively, have been observed at room temperature for Er³⁺ transitions in the near infrared region. The samples exhibit a main luminescence peak at 1.54?µm, which is assigned to recombination via an intra-4f Er³⁺ transition. Sharp bands centered at around 378, 488, 521, 651, 980, 1492, and 1538?nm in the absorption spectra can be associated with transitions from ⁴I_15/2 level to ²H_9/2, ⁴F_7/2, ²H_11/2, ⁴F_9/2, ⁴I_11/2, ²H_11/2, and ⁴I_13/2 levels, respectively. The sharp emission peaks and excellent luminescence properties show that SrAl₂O₄ is a suitable host for rare-earth-doped phosphors, which may be suitable for optical applications.     

Effects of 7.5% CO2 inhalation on allocation of spatial attention to facial cues of emotional expression

Increased vigilance to threat-related stimuli is thought to be a core cognitive feature of anxiety. We sought to investigate the cognitive impact of experimentally induced anxiety, by means of a 7.5% CO₂ challenge, which acts as an unconditioned anxiogenic stimulus, on attentional bias for positive and negative facial cues of emotional expression in the dot-probe task. In two experiments we found robust physiological and subjective effects of the CO₂ inhalation consistent with the claim that the procedure reliably induces anxiety. Data from the dot-probe task demonstrated an attentional bias to emotional facial expressions compared with neutral faces regardless of valence (happy, angry, and fearful). These attentional effects, however, were entirely inconsistent in terms of their relationship with induced anxiety. We conclude that the previously reported poor reliability of this task is the most parsimonious explanation for our conflicting findings and that future research should develop a more reliable paradigm for measuring attentional bias in this field.     

Kinetics of diffusion via divacancies in a concentrated random fcc alloy

The diffusion kinetics in a concentrated fcc alloy are described by means of divacancies. The model chosen is the random alloy model with bound divacancies. We show that for the fcc structure the Manning formalism developed originally for monovacancies can be used intact to describe diffusion via divacancies. Monte Carlo simulation results for both tracer and collective correlation factors are in good agreement with the results of the formalism for a wide range of the component atom exchange frequencies with the divacancy except for the slower-moving component.     

Effects of prone and supine positions on sleep state and stress responses in preterm infants

Aim

The purpose of the study is to assess the influence of prone or supine position on sleep states and on withdrawal and approach reactions of preterm infants.

Methods

Thirty-two preterm infants from Meir Medical Center, Israel, mean post menstrual age 30.37 ± 2.57, mean birth weight 1250 g ± 313.86, participated in the study. Infants were studied during 48 h. Positions (prone and supine) were alternated every 3-4 h after feedings. Sleep states were assessed by Actigraph measurement and by two daily 30-min Naturalistic Observations of Newborn Behavior (NONB) to confirm sleep states and for recording the behavioral reactions (approach and withdrawal).

Results

In the prone position there were more approach reactions as compared to withdrawal reactions (p < .001) while in the supine position, the approach and withdrawal reactions were comparable. In the prone position more sleep patterns (deep sleep, light sleep, drowsy) were observed as opposed to more awake patterns (quiet awake, active awake and agitated fussy) that were seen in the supine position.

Conclusions

Clinical implications encourage placing the preterm infant in the prone position while in the NICU. This enables important achievements such as longer periods of quality sleep, and production of adaptive self-regulatory reactions.     

The genetic versus pharmacological invalidation of the cannabinoid CB(1) receptor results in differential effects on 'non-associative' memory and forebrain monoamine concentrations in mice

The endocannabinoid CB(1) receptor has been implicated in the inhibitory control of learning and memory. In the present experiment, we compared the behavioral response of CB(1) receptor knockout mice (CB(1)R(-/-)) with animals administered CB(1) receptor antagonist/inverse agonist SR141716A (rimonabant; 3 mg/kg IP, 30 min pre-trial) in terms of acquisition and retention of a habituation task and changes in cerebral monoamines. The results can be summarized as follows: (i) the acute and chronic invalidation of the CB(1) receptor resulted in an increase of behavioral habituation during the first exposure to an open field, indicative of enhanced acquisition of the task; (ii) CB(1)R(-/-) mice, but not rimonabant-treated animals, showed enhanced retention of the habituation task when re-tested 48 h and 1 week subsequent to the first exposure to the open field, respectively; (iii) the facilitation of retention of the habituation task in CB(1)R(-/-) mice was accompanied by a selective and site-specific increase in serotonin activity in hippocampus; and (iv) rimonabant-treated animals displayed 'antidepressant-like' neurochemical alterations of cerebral monoamines, that is, most parameters of monoaminergic activity were increased especially in dorsal striatum and hippocampus. Taken together, the present findings demonstrate that the genetic disruption of the CB(1) receptor gene can cause an improvement of behavioral habituation, which is considered to represent a form of 'non-associative' learning. Furthermore, our data support the assumption of a rimonabant-sensitive cannabinoid receptive site that is different from the 'classical' CB(1) receptor and which, under physiological conditions, might be involved in the inhibitory control of the acquisition but not retention of non-associative learning tasks.