强脉冲光子脱毛并发症的防治

为了探讨强脉冲光的脱毛疗效与并发症之间的关系,应用SpaTouchTM 强脉冲光脱毛仪去除体表多余毛发,一般需要3次～5次治疗,每次治疗间隔1个月～2个月,记录每例疗效及并发症发生的情况。结果显示,332例中434个部位接受治疗,患者均能耐受,无需麻醉,治疗后可正常工作及生活。有26个部位出现并发症,总发生率5.99%。10例治疗后出现红斑,15例出现水疱,1例出现色素沉着。末次治疗6个月后随访,422个部位治疗后毛发基本完全脱落,部分患者有少数细软毳毛再生,总有效率为97.24%。因此,强脉冲光脱毛效果可靠、操作简单、快捷、并发症少,是一种理想的脱毛方法。并发症发生原因主要是治疗时光斑能量过大,治疗前应进行测试,选择个体化光斑能量以减少并发症的发生。     

Young children's comprehension of English SVO word order revisited: Testing the same children in act-out and intermodal preferential looking tasks

Act-out and intermodal preferential looking (IPL) tasks were administered to 67 English children aged 2–0, 2–9 and 3–5 to assess their comprehension of canonical SVO transitive word order with both familiar and novel verbs. Children at 3–5 and at 2–9 showed evidence of comprehending word order in both verb conditions and both tasks, although children at 2–9 performed better with familiar than with novel verbs in the act-out task. Children at 2–0 showed no evidence of comprehending word order in either task with novel verbs; with familiar verbs they showed competence in the IPL task but not in the act-out task. The difference in performance for familiar and novel verbs from the same children at 2–0, on the IPL task, and at 2–9, on the act-out task, is consistent with the hypothesis that early linguistic/cognitive representations are graded in strength, with early representations still weak and very task dependent. However, these representations also become more abstract with development, as indicated by the familiarity effect even in the more sensitive IPL task.     

The left superior longitudinal fasciculus within the primary sensory area of inferior parietal lobe plays a role in dysgraphia of kana omission within sentences

Functional neurological changes after surgery combined with diffusion tensor imaging (DTI) tractography can directly provide evidence of anatomical localization of brain function. Using these techniques, a patient with dysgraphia before surgery was analyzed at our hospital in 2011. The patient showed omission of kana within sentences before surgery, which improved after surgery. The brain tumor was relatively small and was located within the primary sensory area (S1) of the inferior parietal lobe (IPL). DTI tractography before surgery revealed compression of the branch of the superior longitudinal fasciculus (SLF) by the brain tumor. These results suggest that the left SLF within the S1 of IPL plays a role in the development of dysgraphia of kana omission within sentences.     

Acoustically evoked brain stem potentials in chronic alcoholism and withdrawal

BAEP studies hint at different neurophysiological findings between gamma and delta alcoholics. On the first day of withdrawal gamma alcoholics show slight vegetative withdrawal symptoms in the form of CNS hyperexitability trough the shortening of the early IPL. However delta alcoholics show prolongations of the late IPL which can be interpreted as a consequence of brain stem transmission disorders resulting from chronic intoxication. After four weeks the BAEP deviations found in both groups indicate a clear tendency of recovery which points to functional disorders.     

The effects of perceptual similarity and category membership on early word-referent identification

We investigated the impact of perceptual and categorical relatedness between a target and a distracter object on early referent identification in infants and adults. In an intermodal preferential looking (IPL) task, participants looked at a target object paired with a distracter object that could be perceptually similar or dissimilar and drawn from the same or different global category. The proportion of target looking measures revealed that infants and adults were sensitive to the interplay between category membership and perceptual similarity. Online latency measures demonstrated an advantage for perceptually dissimilar items regardless of their categorical status, indicating that different IPL measures index different processes during target identification. Results suggest that perceptual similarity and category membership of the objects lead to competition effects in word recognition and referent identification in both adults and infants and that lexical categorization and nonlinguistic categorization processes are closely related during infancy.     

Acoustic evoked brain stem potentials in chronic alcoholic Korsakoff syndrome

29 patients with Korsakoff syndrome (KS) were examined by means of brainstem auditory evoked potentials. The interpeak-latencies were delayed cumulative with the most accentuation of IPL I-VI. BAEP are suitable for subdividing of KS. It is suggested that BAEP shall observed in alcoholics for detection of norm-deviations.     

Human trace fear conditioning: right-lateralized cortical activity supports trace-interval processes

Pavlovian conditioning requires the convergence and simultaneous activation of neural circuitry that supports conditioned stimulus (CS) and unconditioned stimulus (US) processes. However, in trace conditioning, the CS and US are separated by a period of time called the trace interval, and thus do not overlap. Therefore, determining brain regions that support associative learning by maintaining a CS representation during the trace interval is an important issue for conditioning research. Prior functional magnetic resonance imaging (fMRI) research has identified brain regions that support trace-conditioning processes. However, relatively little is known about whether this activity is specific to the trace CS, the trace interval, or both periods of time. The present study was designed to disentangle the hemodynamic response produced by the trace CS from that associated with the trace interval, in order to identify learning-related activation during these distinct components of a trace-conditioning trial. Trace-conditioned activity was observed within dorsomedial prefrontal cortex (PFC), dorsolateral PFC, insula, inferior parietal lobule (IPL), and posterior cingulate (PCC). Each of these regions showed learning-related activity during the trace CS, while trace-interval activity was only observed within a subset of these areas (i.e., dorsomedial PFC, PCC, right dorsolateral PFC, right IPL, right superior/middle temporal gyrus, and bilateral insula). Trace-interval activity was greater in right than in left dorsolateral PFC, IPL, and superior/middle temporal gyrus. These findings indicate that components of the prefrontal, cingulate, insular, and parietal cortices support trace-interval processes, as well as suggesting that a right-lateralized fronto-parietal circuit may play a unique role in trace conditioning.     

Space and the parietal cortex

Current views of the parietal cortex have difficulty accommodating the human inferior parietal lobe (IPL) within a simple dorsal versus ventral stream dichotomy. In humans, lesions of the right IPL often lead to syndromes such as hemispatial neglect that are seemingly in accord with the proposal that this region has a crucial role in spatial processing. However, recent imaging and lesion studies have revealed that inferior parietal regions have non-spatial functions, such as in sustaining attention, detecting salient events embedded in a sequence of events and controlling attention over time. Here, we review these findings and show that spatial processes and the visual guidance of action are only part of the repertoire of parietal functions. Although sub-regions in the human superior parietal lobe and intraparietal sulcus contribute to vision-for-action and spatial functions, more inferior parietal regions have distinctly non-spatial attributes that are neither conventionally 'dorsal' nor conventionally 'ventral' in nature.     

Move it! Visual feedback enhances validity of preferential looking as a measure of individual differences in vocabulary in toddlers

Forty toddlers aged 20 to 24 months were presented with 32 pairs of images with the auditory stimulus Look followed by the name of the target image (e.g. Look . . . tree) in an intermodal preferential looking (IPL) paradigm. The same series of 16 items was presented first with one image as target and then with the other member of the pair as target. Half the children were given feedback, in the form of movement of the target image at the end of the trial, while the other half were presented with static images. IPL performance was quantified in terms of number of words showing at least 15% increase in proportion of looking time in the post-naming interval. Looking preference for the named item was correlated with parental report of vocabulary, this effect being stronger for those receiving feedback. The correlation with parental report of vocabulary comprehension was .65 for those receiving feedback, but only .37 for those with no feedback. It is concluded that the preferential looking task, which has been widely used in group studies, has the potential to act as a reliable index of comprehension level in individual children, especially when movement feedback is used to maintain attention.     

A key role for experimental task performance: effects of math talent, gender and performance on the neural correlates of mental rotation

The neurophysiological mechanisms underlying superior cognitive performance are a research area of high interest. The majority of studies on the brain-performance relationship assessed the effects of capability-related group factors (e.g. talent, gender) on task-related brain activations while only few studies examined the effect of the inherent experimental task performance factor. In this functional MRI study, we combined both approaches and simultaneously assessed the effects of three relatively independent factors on the neurofunctional correlates of mental rotation in same-aged adolescents: math talent (gifted/controls: 17/17), gender (male/female: 16/18) and experimental task performance (median split on accuracy; high/low: 17/17). Better experimental task performance of mathematically gifted vs. control subjects and male vs. female subjects validated the selected paradigm. Activation of the inferior parietal lobule (IPL) was identified as a common effect of mathematical giftedness, gender and experimental task performance. However, multiple linear regression analyses (stepwise) indicated experimental task performance as the only predictor of parietal activations. In conclusion, increased activation of the IPL represents a positive neural correlate of mental rotation performance, irrespective of but consistent with the obtained neurocognitive and behavioral effects of math talent and gender. As experimental performance may strongly affect task-related activations this factor needs to be considered in capability-related group comparison studies on the brain-performance relationship.     

Cognitive control of a simple mental image in patients with obsessive--compulsive disorder

The nature of obsessions has led researchers to try to determine if the main problem in obsessive-compulsive disorder (OCD) is impaired inhibitory control. Previous studies report that the effort to suppress is one of the factors that increase the frequency of obsessive thoughts. Based on these results and those of the present study that suggest inferior parietal lobe (IPL) abnormality in OCD and findings of a recent study that reported the importance of the right posterior parietal cortex in cognitive control of a simple mental image, the present cognitive control paradigm study aimed to determine whether there is a difference in brain dynamics between OCD patients and non-obsessive controls while performing tasks that necessitate cognitive control of a simple mental image, and whether the right posterior parietal region is one of the regions in which a difference in activity between the OCD patients and controls would be observed. Functional brain imaging was performed while the participants attempted to suppress, imagine, or manipulate a mental image. The general linear model showed that there was a main effect of group and main effect of task. Accordingly, in all contrasts (suppression minus free-imagination, erasing minus free-imagination, and imagination minus free-imagination), the right IPL, right posterior cingulate cortex, and right superior frontal gyrus activity were lower in the OCD patients than in the healthy controls. These results and the observed correlations between activity levels, and symptom and subjective performance scores are discussed. In conclusion, the results of the present study and those of previous studies suggest that the main problem in OCD might be difficulty activating the right frontoparietal networks during tasks that require cognitive control, which might result in the intrusiveness of obsessive thoughts.     

Fronto-parietal mirror neuron system modeling: Visuospatial transformations support imitation learning independently of imitator perspective

Although the human mirror neuron system (MNS) is critical for action observation and imitation, most MNS investigations overlook the visuospatial transformation processes that allow individuals to interpret and imitate actions observed from differing perspectives. This problem is not trivial since accurately reaching for and grasping an object requires a visuospatial transformation mechanism capable of precisely remapping fine motor skills where the observer’s and imitator’s arms and hands may have quite different orientations and sizes. Accordingly, here we describe a novel neural model to investigate the dynamics between the fronto-parietal MNS and visuospatial processes during observation and imitation of a reaching and grasping action. Our model encompasses i) the inferior frontal gyrus (IFG) and inferior parietal lobule (IPL), regions that are postulated to produce neural drive and sensory predictions, respectively; ii) the middle temporal (MT) and middle superior temporal (MST) regions that are postulated to process visual motion of a particular action; and iii) the superior parietal lobule (SPL) and intra-parietal sulcus (IPS) that are hypothesized to encode the visuospatial transformations enabling action observation/imitation based on different visuospatial viewpoints. The results reveal that when a demonstrator executes an action, an imitator can reproduce it with similar kinematics, independently of differences in anthropometry, distance, and viewpoint. As with prior empirical findings, similar model synaptic activity was observed during both action observation and execution along with the existence of both view-independent and view-dependent neural populations in the frontal MNS. Importantly, this work generates testable behavioral and neurophysiological predictions. Namely, the model predicts that i) during observation/imitation the response time increases linearly as the rotation angle of the observed action increases but remain similar when performing both clockwise and counterclockwise rotation and ii) IPL embeds essentially view-independent neurons while SPL/IPS includes both view-independent and view-dependent neurons. Overall, this work suggests that MT/MST visuomotion processes combined with the SPL/IPS allow the MNS to observe and imitate actions independently of demonstrator-imitator spatial relationships.     

Controlling anger in self-reported sober and alcohol intoxicated states: moderating effects of trait anger and alcohol consumption

Controlling anger in self-reported sober and alcohol intoxicated states: Moderating effects of trait anger and alcohol consumption. Scandinavian Journal of Psychology 52, 382-388. Retrospective self-reports about prior sober and alcohol intoxicated states were explored to reveal moderating effects of trait anger and alcohol consumption on anger control. The analyses were based on self-reports of trait anger and alcohol consumption as well as self-reports of the participants' typical levels of anger control in sober and alcohol intoxicated states in a population based sample of Finnish twins and their siblings (N = 4,852). The reported levels of anger control were lower regarding prior alcohol intoxicated states than sober states. A three-way interaction between alcohol consumption, trait anger and anger control was found. Whereas no interaction between alcohol consumption and trait anger was found in the self-reported sober state, there was an interactive effect of trait anger and alcohol consumption on anger control in the intoxicated state, indicating that the difference in anger control between those with high levels of alcohol consumption and those with low levels, was greater at higher levels of trait anger. Women had lower levels of anger control than men, but the relationship between trait anger, alcohol consumption and anger control was similar for both genders. In conclusion, the results showed that those with high levels of trait anger and alcohol consumption showed the lowest levels of anger control in self-reported alcohol intoxicated states, and indicate the importance of separating between anger control when sober and intoxicated since anger control seems to be differently related to at least trait anger and alcohol consumption in these states.     

Alcohol expectancies, alcohol use, and hostility as longitudinal predictors of alcohol-related aggression

The direct and interactive effects of alcohol expectancies for aggression, dispositional hostility, and heavy alcohol consumption on alcohol-related physical aggression were examined across the first four years of marriage in a sample of 634 newlywed couples. For husbands, alcohol aggression expectancies predicted increases in alcohol-related aggression; across husbands and wives, however, aggression expectancies were not found to interact with hostility or alcohol consumption to predict physical aggression. Consistent with previous research, hostility and alcohol consumption interacted with each other to predict alcohol-related aggression. Specifically, for both husbands and wives high in dispositional hostility, heavy alcohol consumption was positively associated with the occurrence of alcohol-related aggression; for those low in dispositional hostility, however, there was no association between alcohol consumption and alcohol-related aggression. Findings are contrasted with previous longitudinal research on alcohol aggression expectancies and physical aggression in married couples. The article discusses the extent to which findings may vary depending on whether expectancies are assessed in relation to alcohol's effect on one's own behavior versus alcohol's effect on others' behavior.     

Effects of practice and alcohol on performance of a perceptual-motor task

Practice may modify the effects of alcohol on perceptual-motor performance in at least three different ways: (1) alcohol may affect learning—that is, the rate at which performance of a skill improves with practice; (2) alcohol may have a greater effect on performance when the skill is unfamiliar than when it is practised; and (3) practice with alcohol may allow adaptation to its effects. These were investigated using a simple computer game in which subjects attempted to destroy a tank by pressing a key to release a bomb from a plane horizontally traversing the screen above it. The results demonstrated that (1) performance improved with practice; (2) with alcohol (0.8 mg/kg body weight), subjects were more variable and less accurate; (3) improvement with alcohol was greater than without alcohol, but as performance was impaired by alcohol, there was greater scope for improvement; (4) those who practised with alcohol still improved when switched to no alcohol late in practice; and (5) alcohol had the same effect early and late in practice. It is therefore concluded that there is no evidence to support any of the three suggestions outlined above.     

Effect of alcohol on quantity of creative production using the Purdue tests

An experiment was performed to test whether a moderate dose of alcohol (1 ml of 100% alcohol/kg body weight) facilitates the production of creative solutions as measured with a standard creativity test and whether a creative attitude interacts with alcohol in this respect. The 60 subjects were randomly assigned to either an alcohol, a placebo, or a control group, with 10 women and 10 men in each group. Two different personality tests measuring the creative attitude were administered a priori. Analysis indicated that both the placebo and alcohol groups produced significantly less creative solutions to the ten stimulus pictures. The a priori attitude scores significantly predicted the creativity scores for the placebo and alcohol subjects but not for the control subjects. Results were discussed in terms of disinhibition and cognitive changes under alcohol.     

The effects of familial risk, personality, and expectancies on alcohol use and abuse

This study tested a structural model of the association between familial risk, personality risk, alcohol expectancies, and alcohol abuse in a sample of 224 young adult offspring of alcoholics and 209 offspring of nonalcoholics. The results provided support for 2 personality-risk pathways, a social deviance proneness and an excitement/pleasure seeking path, that accounted for a significant portion of the association between a familial alcoholism and alcohol abuse. The path from familial alcoholism to social deviance proneness lead directly to alcohol problems. The path from familial alcoholism to excitement/pleasure seeking was associated with increased drinking, which, in turn, was associated with alcohol problems. Positive alcohol expectancies accounted for part of the association between excitement seeking and alcohol use. The results suggest 2 different biopsychosocial mechanisms that elevate risk for abuse in the offspring of alcoholics.     

Implicit and Explicit Attitudes to Alcohol in Alcohol Dependent and Non-Alcohol Dependent Samples

Measures of implicit and explicit attitudes to alcohol have been used to predict drinking behavior. Early studies with the bipolar Implicit Association Test (IAT) indicated that heavy drinkers hold negative implicit attitudes to alcohol. More recent studies using the unipolar IAT have found that positive implicit attitudes to alcohol are associated with drinking behavior in samples of university students. The present study is the first to use a unipolar single target IAT to assess positive alcohol-related attitudes in two samples with alcohol dependency compared to a non-alcohol dependent control group. A group of recently detoxed alcohol dependent adults entering a treatment program (n?=?22), a group of alcohol dependent adults who had been in treatment for 3 months (n?=?22), and a group of age matched adults who had no history of alcohol dependence (n?=?22) were compared on a positive unipolar single target IAT and an explicit attitude measure. Results indicated that alcohol dependent participants showed stronger positive implicit attitudes, and stronger negative explicit associations compared to non-alcohol dependent participants, but there were no differences between the two groups with alcohol dependency. The findings are discussed in terms of the role of the IAT as an assessment tool for those undertaking treatment for alcohol problems and the implications for targeting unconscious attitudes to alcohol in a clinical setting.     

Tri-ethnic alcohol use and religion,family, and gender

Nine different behavioral responses to alcohol by over two hundred ninth-graders in Austin, Texas, were examined in a survey designed to identify the relationship between adolescents' alcohol use, religious affiliation, religiosity, and gender. The relationship between alcohol use and family adaptability was also examined. While religious affiliation was found to be mildly predictive of use, religiosity determined only specific behavior. Gender differences in alcohol use appeared to be narrowing. Family adaptability was the most predictive variable, showing a relationship with six of the nine kinds of alcohol behavior. Future studies of family influences on adolescents' alcohol behavior and alcohol use among females are recommended.     

Evolutionary neurology,responsive equilibrium,and the moral brain

The relation between morality and the brain is a topic usefully examined through the evolutionary neurology of John Hughlings-Jackson, who considered higher mental function to be progressively inclusive integration of sensori-motor processes. His view, based on careful observations of patients with neurological disorders, implies that moral reasoning involves integration and coordination of behaviour through a process of representation and re-representation encompassing broader and broader types of information sensitive to environmental contingencies. The relevant information is processed in diverse brain areas: superior temporal sulcus (STS), inferior parietal lobule (IPL), inferior frontal gyrus (IFG), dorsolateral prefrontal (DLPF) areas, as well as anterior temporal (AT) structures. Moral function can be regarded as maximally integrating emotion, social cognition, and other-regarding sensibilities using propositionally organised cognitive structures that map a shared world of human activity and relationships so that they take account of what in social and personal life counts as something.