Neuropsychological Effects at Early School Age of Fetal Alcohol Exposure of Varying Duration

A comprehensive neuropsychological assessment was performed with forty-six 5- to 9-year-old children exposed to alcohol in utero for varying durations. The children were subdivided according to duration of maternal alcohol abuse, as follows: during trimester I (n = 16), during trimesters I and II (n = 16), and throughout pregnancy (n = 14). A control group (n = 26) consisted of unexposed children. Fetal alcohol exposure throughout pregnancy had significant, diffuse effects on the development of the children, whereas exposure only during early pregnancy did not. Observed cognitive deficits included problems in naming, receptive language, attention, and visual-motor functions. Verbal and visual memory and manual motor precision did not significantly differ between the groups.     

The Long-Term Neurocognitive Consequences of Prenatal Alcohol Exposure: A 14-Year Study

Prenatal alcohol exposure, at doses not generally associated with maternal alcohol problems, produces a broad array of neurocognitive deficits in offspring even in the absence of effects on growth and morphology. This report presents a summary of neurobehavioral, growth, and morphology findings from long-term follow-up of a birth cohort of 500 from apopulation-based study that has revealed attention, memory, and information processing deficits from birth through 14 years. Also observed (from school age through 14 years) have been problems with antisocial and delinquent behaviors, and classroom learning and behaviors; some of these problems may be secondary to earlier neurocognitive disabilities. Continuing research in behavioral and neurobehavioral teratology provides important opportunities for the neurosciences and for improved health of future generations.     

Functional Neuroimaging in the Examination of Effects of Prenatal Alcohol Exposure

Functional neuroimaging offers the opportunity to understand the effect of prenatal alcohol exposure on the activities of the brain as well as providing a window into the relationship between neural activation and the behavioral outcomes that have been described in affected individuals. Several different methodologies have been used to examine the neurophysiological signal changes associated with different brain functions in prenatally exposed individuals and those diagnosed with fetal alcohol syndrome (FAS) or other fetal alcohol spectrum disorders (FASD). These include electroencephalography (EEG), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI). These studies demonstrate that it is feasible to use these technologies with this clinical population and that the damage to the central nervous system associated with prenatal alcohol exposure has widespread functional implications; however, currently, the literature in these areas is limited and unsystematic. Functional MRI with this clinical population has just begun to explore the implications of prenatal alcohol exposure with the first paper published in 2005. Other methodologies are similarly limited in scope. Nonetheless, these functional neuroimaging studies suggest that prenatal alcohol exposure, or a diagnosis of FAS, may lead to restrictions in neural efficiency or a global decrement in processing resources.     

Distress Tolerance as a Mechanism Linking Violence Exposure to Problematic Alcohol use in Adolescence

Research on Child and Adolescent Psychopathology - Adolescents exposed to violence are at elevated risk of developing most forms of psychopathology, including depression, anxiety, and alcohol...     

Inattention/Overactivity Following Early Severe Institutional Deprivation: Presentation and Associations in Early Adolescence

The current study examined the persistence and phenotypic presentation of inattention/overactivity (I/O) into early adolescence, in a sample of institution reared (IR) children adopted from Romania before the age of 43 months. Total sample comprised 144 IR and 21 non-IR Romanian adoptees, and a comparison group of 52 within-UK adoptees, assessed at ages 6 and 11 years. I/O was rated using Rutter Scales completed by parents and teachers. I/O continued to be strongly associated with institutional deprivation, with continuities between ages 6 and 11 outcomes. There were higher rates of deprivation-related I/O in boys than girls, and I/O was strongly associated with conduct problems, disinhibited attachment and executive function but not IQ more generally, independently of gender. Deprivation-related I/O shares many common features with ADHD, despite its different etiology and putative developmental mechanisms. I/O is a persistent domain of impairment following early institutional deprivation of 6 months or more, suggesting there may be a possible pathway to impairment through some form of neuro-developmental programming during critical periods of early development.     

Social Information Processing Skills in Children with Histories of Heavy Prenatal Alcohol Exposure

Based on caregiver report, children with prenatal alcohol exposure have difficulty with social functioning, but little is known about their social cognition. The current study assessed the social information processing patterns of school-age children with heavy prenatal alcohol exposure using a paradigm based on Crick and Dodge’s reformulated six-stage model. Fifty-two children (aged 7–11) with and without heavy prenatal alcohol exposure were tested using a structured interview measure of social information processing involving 18 videotaped vignettes of children in group entry and provocation situations. Alcohol-exposed children displayed maladaptive processing patterns on the goal, response generation, and response evaluation steps in group entry situations, and encoding, attribution, response evaluation, and enactment steps during provocation situations. Children with heavy prenatal alcohol exposure also had difficulty on the Test of Problem Solving, and performance correlated with social information processing measures. Such difficulties may lead to problems in social functioning and warrant early intervention.     

The Effects of Prenatal Alcohol Exposure on Behavior: Rodent and Primate Studies

The use of alcohol by women during pregnancy is a continuing problem. In this review the behavioral effects of prenatal alcohol from animal models are described and related to studies of children and adults with FASD. Studies with monkeys and rodents show that prenatal alcohol exposure adversely affects neonatal orienting, attention and motor maturity, as well as activity level, executive function, response inhibition, and sensory processing later in life. The primate moderate dose behavioral findings fill an important gap between human correlational data and rodent mechanistic research. These animal findings are directly translatable to human findings. Moreover, primate studies that manipulated prenatal alcohol exposure and prenatal stress independently show that prenatal stress exacerbates prenatal alcohol-induced behavioral impairments, underscoring the need to consider stress-induced effects in fetal alcohol research. Studies in rodents and primates show long-term effects of prenatal and developmental alcohol exposure on dopamine system functioning, which could underpin the behavioral effects.     

Bidirectional Influences of Violence Exposure and Adjustment in Early Adolescence: Externalizing Behaviors and School Connectedness

This study utilized cross-lagged longitudinal models to examine prospective, bidirectional relationships between witnessing violence and victimization and three adjustment variables—delinquency, conduct problems, and school connectedness. Participants included 603 early adolescent boys and girls (78% African American, 20% Caucasian). Witnessing violence was related to subsequent lower levels of school connectedness and more conduct problems. For Caucasian but not African American adolescents, witnessing violence also predicted later delinquency. Victimization was linked with lower school connectedness over time, and for boys but not girls also with more conduct problems. Only adolescent delinquency was associated with subsequent witnessing violence and victimization. This research was partially supported by the Centers for Disease Control and Prevention Grant No. R49–CCR418569.     

Imaging the Impact of Prenatal Alcohol Exposure on the Structure of the Developing Human Brain

Prenatal alcohol exposure has numerous effects on the developing brain, including damage to selective brain structure. We review structural magnetic resonance imaging (MRI) studies of brain abnormalities in subjects prenatally exposed to alcohol. The most common findings include reduced brain volume and malformations of the corpus callosum. Advanced methods have been able to detect shape, thickness and displacement changes throughout multiple brain regions. The teratogenic effects of alcohol appear to be widespread, affecting almost the entire brain. The only region that appears to be relatively spared is the occipital lobe. More recent studies have linked cognition to the underlying brain structure in alcohol-exposed subjects, and several report patterns in the severity of brain damage as it relates to facial dysmorphology or to extent of alcohol exposure. Future studies exploring relationships between brain structure, cognitive measures, dysmorphology, age, and other variables will be valuable for further comprehending the vast effects of prenatal alcohol exposure and for evaluating possible interventions.     

Dynamics of Peer Victimization in Early Adolescence

ABSTRACT

This study addressed the stability of victimization across four consecutive years from Grades 4 to 7, and the concurrent correlates, short-term consequences, and predictors of victimization in early adolescence. Participants were 600 students (49% girls) enrolled in 10 elementary schools in Grades 4-5 and 2 middle schools in Grades 6-7 in an ethnically diverse school system. Data collection included peer nominations, self-reports, and teacher reports in each year. Victimization was highly stable across all years, including the transition from elementary to middle school. Both concurrent and short-term consequences showed that victimized 6th graders, especially girls, experienced significantly greater maladaptive outcomes than their nonvictim counterparts. For both genders, risk factors for adolescent victimization included externalizing and internalizing behaviors, while protective factors included academic and peer sociability elements. Implications for prevention and intervention are discussed.     

青少年早期父母惩罚的特点

采用问卷法考察青少年早期父母惩罚的特点。发现,父亲与母亲对青少年的惩罚具有相当的一致性;城市父母的惩罚多于农村父母,他们对青少年的限制与严厉多于农村父母;父母对男青少年的惩罚多于对女青少年,对男青少年的体罚与限制多于女青少年;城市父亲对初三青少年的惩罚多于初一和初二青少年,农村父亲和城市母亲的体罚随年龄而下降;父母惩罚以限制为主,其次是体罚,严厉最少。     

Exposure and Occluded Duration Effects in a Ball-Catching Skill

Male Ss (N=48) from a university population attempted single-handed catches of lawn tennis balls delivered by a mechanical projection machine. The within-and between-S variables in a split-plot factorial design were the period for which the ball was illuminated (VP) and the subsequent period of occlusion (OP). Both variables and their interaction were significant sources of variation. Generally the effect of VP diminished as OP was extended. This was discussed in terms of (1) information processing time and (2) motion prediction. With respect to the first issue, the most important variable was not VP, but a composite term VP + OP. On the second issue, support was provided for an hypothesis to account for prediction error raised in a previous study.     

Peer Group and Family Relationships in Early Adolescence

This study explored the possible interface between family and peer group systems in early adolescence. Sixth-graders who were identified as group members were interviewed and given questions regarding their attitudes toward the group and group dynamics. Family atmosphere and parent-adolescent relationships were evaluated from the parents' perspective. The results show two different linkages of peer and family processes: On the one hand, family relationships are related to the perception of the peer group as a source of support, especially when individual growth is respected within an atmosphere of acceptance and support in the family. On the other hand, family life characterized by conflict and lack of support for individual development is related to an increased involvement with groups and more conformity to group pressure. Results are discussed in line with theories dealing with the role of the family in adolescent development.     

Social Withdrawal Subtypes during Early Adolescence in India

The overarching goal of this study was to examine the associations between three social withdrawal subtypes (shyness, unsociability, avoidance), peer isolation, peer difficulties (victimization, rejection, exclusion, low acceptance), and loneliness in India during early adolescence. Participants were 194 adolescents in Surat, India (M age = 13.35 years). Peer nominations of peer relations and socioemotional behaviors were gathered, along with self-reports of reasons for being alone and loneliness. Preliminary evidence of validity for the self-report measure of withdrawal subtypes and isolation was found, and factor analyses indicated that shyness, unsociability, and avoidance represent related, but distinct forms of withdrawal that are distinct from isolation. Shyness and avoidance were uniquely associated with loneliness and exclusion, but unsociability was not. The association between avoidance and loneliness was mediated by exclusion. Findings suggest that social withdrawal may be best conceptualized as a multifaceted construct during childhood and adolescence, in Western and non-Western societies.     

Cognitive and Behavioural Attention in Children with Low-Moderate and Heavy Doses of Prenatal Alcohol Exposure: a Systematic Review and Meta-analysis

Neuropsychology Review - Attention problems are thought to be a hallmark feature of prenatal alcohol exposure (PAE). Despite decades of research however, these findings have never been pooled to...     

Exposure Duration as a Confounding Methodological Factor in Projective Testing

Summary: Exposure duration has been found to have a strong impact on the affective value attributed to a variety of stimuli. The purpose of the study reported here was to examine the impact of this variable in projective testing, and im particular in the affective value subjects attribute to the TAT cards. Using 34 undergraduate students, a linear decrease in pleasantness was found as a function of exposure duration. Factors leading to variation in exposure dur'ation might therefore be confounded with the interpretations made of a subject's protocol. It was suggested that the time a subject views a projective test stinlulus should be controlled in the administration.     

Violence Exposure and Early Adolescent Alcohol Use: An Exploratory Study of Family Risk and Protective Factors

In this short-term longitudinal exploratory interview study, the relations between exposure to community violence and subsequent alcohol use were examined, with a focus on caregiver and family variables as moderators. Maternal caregivers and their children (N =101 families; 98% African American; M child age = 11.2 yrs) were interviewed separately and completed measures of violence exposure, caregiver and child adjustment, including substance use, and family functioning. Family interaction was also videotaped and coded. Child alcohol use at Time 2 was positively associated with all forms of violence exposure, and was negatively related to felt acceptance from caregiver, but was not associated with caregiver-rated family competence, observer-rated family interaction, maternal problems with alcohol, or maternal psychopathology. Logistic regression analyses predicting child alcohol use at Time 2 indicated that exposure to community violence increased risk of alcohol use, and felt acceptance from the caregiver decreased the likelihood of alcohol use, but did not buffer the effects of violence exposure on alcohol use. Implications and future directions are discussed.     

Predicting ADHD Symptoms in Adolescence from Early Childhood Temperament Traits

Extreme levels of certain temperament traits can be early markers of different developmental pathways of attention-deficit/hyperactivity disorder (ADHD). However, the long-term utility of using these traits as predictors of ADHD is not fully known. This study includes 64 male adolescents (M age = 13.5), who have been followed since birth as part of a longitudinal study. The primary aim was to test effortful control (EC), activity level, and anger, measured in early childhood – both with mother’s reports and laboratory assessments –as predictors of ADHD symptoms in adolescence. Further, we investigated the specificity of this prediction to the different ADHD symptom domains. The results demonstrated that early temperament dimensions of EC and activity level were predictive of ADHD symptoms about 10 years later, when the participants reached adolescence. Moreover, activity level showed specificity only to hyperactivity-impulsivity symptoms whereas EC was a predictor of the two symptom domains. Anger had a predictive correlation with ADHD symptoms; however, it did not have a unique predictive contribution. These results emphasize the relevance of EC and activity level in the developmental course of ADHD. Identification of early risk factors can lead to more efficient design and implementation of intervention programs.