Two distinct neural networks functionally connected to the human hippocampus during pattern separation tasks

Previous studies from the human, rodent, and computational research have identified the hippocampus as a core structure mediating pattern separation. However, these investigations have generally focused on the role of distinct subregions of the hippocampus. Less well-understood is how the human hippocampus interacts with other brain regions to support pattern separation. The purpose of this study was to identify the functional networks connected to the hippocampus during delayed matching-to-sample pattern separation tasks promoting either spatial or temporal interference. Results revealed that the hippocampus was functionally connected to two distinct networks. The first network was characterized by correlated activation with the hippocampus primarily in bilateral temporal regions. This network was differentially related to spatial and temporal conditions, suggesting hippocampal connectivity to this network is modulated by interference type. A secondary network was characterized by correlations between the left hippocampus and several other sparsely distributed brain regions, including bilateral cerebellum and frontal and temporal cortices. This network was not modulated by interference type, suggesting that it may be a domain-general pattern separation network. We suggest that the hippocampus may play a role in integrating information from these networks to support performance on pattern separation tasks.     

Passive and active processes in visuo-spatial memory: double dissociation in developmental learning disabilities

The distinction between passive and active visuo-spatial memory has been useful to interpret various pattern of deficits reported in individual differences studies. However, this interpretation raises the issue of task difficulty, since active tasks could be failed simply because more complex and the corresponding deficit could reflect a reduced capacity of the system. We describe two children with Nonverbal Learning Disability whose performance provides evidence of a dissociation between passive and active memory processes. One of the children showed a selective impairment in passive tasks and performed flawlessly in active tasks, whereas the second child displayed the opposite pattern. These data suggest that a qualitative difference between passive and active processes does exist and that differences in performance do not reflect a lower/higher level of task difficulty. Further, these data underlie the importance of formulating theoretical models of visuo-spatial memory including both material-related (i.e., visual vs spatial) and process-related (i.e., passive vs active) distinctions.     

Implicit Learning of Affective Responses in Dementia Patients: A Face-Emotion-Association Paradigm

ABSTRACT

Young and older adults performed verbal and spatial storage-only and storage-plus-processing working memory tasks while performing a secondary finger tapping task, and the effects on both the maximum capacity (measured as the longest series correct) and the reliability (measured as the proportion of items correct) of working memory were assessed. Tapping tended to produce greater disruption of working memory tasks that place greater demands on executive processes (i.e., storage-plus-processing tasks compared to storage-only span tasks). Moreover, tapping produced domain-general interference, disrupting both verbal and spatial working memory, providing further support for the idea that tapping interferes with the executive component of the working memory system, rather than domain-specific maintenance processes. Nevertheless, tapping generally produced equivalent interference effects in young and older adults. Taken together, these findings are inconsistent with the hypothesis that age-related declines in working memory are primarily attributable to a deficit in the executive component.     

Memory for object location: a span study in children.

The aim of the present study was to analyze the developmental changes in three spatial processes, namely, in positional reconstruction involving the retention of spatial locations per se (Positional encoding task), in the assignment of objects to positions (Object-to-position assignment task), and in the integration of these two (Combined task). A span procedure was used to assess the development of spatial memory in children aged 6, 8, and 10 years tested in these three tasks. The findings of the present study provide developmental spans for each relocation task. Results show an age-dependent improvement in all tasks, suggesting that spatial position is not automatically encoded. The results also show different developmental patterns for the relocation tasks considered, suggesting that spatial memory comprises a number of different component processes.     

Task switching and serial memory: looking into the nature of switches and tasks

Task switching research has so far focused on the impact of switching task-sets between two-choice classification tasks that require little or no memory load. Empirical work is lacking however to determine whether the switching cost can be extended to other cognitive activities and to different types of switches. In the present study, switching between the content – verbal to spatial – of the tasks was contrasted with switching cognitive processes — categorization to serial memory. Our pattern of results revealed the absence of local and general switch costs on serial memory tasks, while substantial costs were observed with two-choice judgement tasks. Such a finding challenges the widely accepted assumption that task alternation comes with a considerable cost in performance regardless of the cognitive tasks undertaken. Our results are discussed in context of the predominant models of task switching.     

Working memory for movements

Movement to spatial targets that can, in principle, be carried out by more than one effector can be distinguished from movements that involve specific configurations of body parts. The experiments reported here investigate memory span for a series of hand configurations and memory span for a series of hand movements to spatial locations. Spans were produced normally, or in conditions in which a suppression task was carried out on the right or the left hand while the movements to be remembered were presented. All movements were recalled using the right hand. There were two suppression tasks. One involved repeatedly squeezing a tube and so changing the configuration of the hand, and the other involved tapping a repeated series of spatial targets. The spatial tapping task interfered with span for spatial locations when it was presented on either the right or the left hand but did not affect span for movement pattern. The movement suppression task interfered with memory for movement pattern when it was presented on either the right or the left hand, but did not interfere with span for spatial locations. It is concluded that memory for movement configurations involves different processes from those used in spatial tasks and that there may be a need for a subsystem of working memory that is specific for movement configuration.     

Working memory components and imagery instructions in the elaboration of a spatial mental model

The paper investigates the involvement of verbal and visuo-spatial working memory during the processing of spatial texts via a dual-task paradigm. Subjects were presented with three texts describing locations from a route perspective, and had either to imagine themselves moving along a route in surroundings or to rehearse verbal information. Concurrently they had to perform a spatial tapping task, an articulatory task, or no secondary task. Performance on a verification test used to assess the product of comprehension showed that the concurrent tapping task impaired performance in the imagery instructions group but not in the repetition instructions group, and caused the beneficial effect of imagery instructions to vanish. This result was not observed with the articulatory task, where interference effects were similar in both instructions groups. Performance on the concurrent tasks confirmed the pattern obtained with the verification test. In addition, results seem partly dependent on the capacity of spatial working memory as measured by the Corsi Blocks Test. We argue that these results clarify the processes of the construction of a spatial mental model, and confirm that the visuo-spatial working memory is involved in mental imagery.     

Cognitive processes in children's reading and attention: The role of working memory,divided attention,and response inhibition

Children experiencing attention difficulties have documented cognitive deficits in working memory (WM), response inhibition and dual tasks. Recent evidence suggests however that these same cognitive processes are also closely associated with reading acquisition. This paper therefore explores whether these variables predicted attention difficulties or reading among 123 children with and without significant attention problems sampled from the school population. Children were screened using current WM and attention task measures. Three factors explained variance in WM and attention tasks. Response inhibition tasks loaded mainly with central executive measures, but a dual processing task loaded with the visual‐spatial WM measures. Phonological loop measures loaded independently of attention measures. After controls for age, IQ and attention‐group membership, phonological loop and ‘central processing’ measures both predicted reading ability. A ‘visual memory/dual‐task’ factor predicted attention group membership after controls for age, IQ and reading ability. Results thus suggest that some of the processes previously assumed to be predictive of attention problems may reflect processes involved in reading acquisition. Visual memory and dual‐task functioning are, however, purer indices of cognitive difficulty in children experiencing attention problems.     

n-back任务下视觉工作记忆负荷研究

实验采用n-back范式,考察了视觉工作记忆负荷与反应时、辨别力和主观评价的关系,以及空间位置记忆负荷与图形记忆负荷的差异。结果发现,随着记忆负荷的增大,反应时延长,辨别力降低,主观负荷提高。视觉图形记忆任务的负荷水平高于视觉空间位置记忆任务的负荷水平;同时也为视觉图形记忆和视觉空间记忆具有不同的加工过程提供了证据。     

Midazolam amnesia and short-term/working memory processes

We examined whether midazolam impairs short-term/working memory processes. We hypothesize that prior dissociations in midazolam's effects on short-term/working memory tasks and episodic memory tasks arise because midazolam has a larger effect on episodic memory processes than on short-term/working memory processes. To examine these issues, .03 mg/kg of participant's bodyweight of midazolam was administered in a double-blind placebo-controlled within-participant design. Performance on the digit span and category generation/recall tasks was examined. The results of Experiment 1 demonstrated that: (1) midazolam impaired performance on the digit span task; (2) midazolam did not impair performance on the category generation task; (3) midazolam impaired performance on the category recall task; and (4) midazolam's effect on category recall was four times as large as its effect on digit span. The results of Experiment 2 demonstrated that midazolam did not impair digit span performance when the digit span task was administered at a later time. These results suggest that midazolam can impair short-term/working memory processes, but these effects are substantially smaller than midazolam's effect on episodic memory processes. Moreover, they demonstrate that conscious awareness of materials during study is not sufficient to produce episodic memory.     

Working memory in chess

Three experiments investigated the role of working memory in various aspects of thinking in chess. Experiment 1 examined the immediate memory for briefly presented chess positions from master games in players from a wide range of abilities, following the imposition of various secondary tasks designed to block separate components of working memory. Suppression of the articulatory loop (by preventing subvocal rehearsal) had no effect on measures of recall, whereas blocking the visuospatial sketchpad (by manipulation of a keypad) and blocking the central executive (by random letter generation) had equivalent disruptive effects, in comparison with a control condition. Experiment 2 investigated the effects of similar secondary tasks on the solution (i.e., move selection) of tactical chess positions, and a similar pattern was found, except that blocking the central executive was much more disruptive than in Experiment 1. Experiment 3 compared performance on two types of primary task, one concerned with solving chess positions as in Experiment 2, and the other a sentence-rearrangement task. The secondary tasks in each case were both designed to block the central executive, but one was verbal (vocal generation of random numbers), while the other was spatial in nature (random generation of keypresses). Performance of the spatial secondary task was affected to a greater extent by the chess primary task than by the verbal primary task, whereas there were no differential effects on these secondary tasks by the verbal primary task. In none of the three experiments were there any differential effects between weak and strong players. These results are interpreted in the context of the workingmemory model and previous theories of the nature of cognition in chess.     

Electromyographic evidence for response conflict in the exclude recognition task

How do memory retrieval processes lead to overt responses in strategic recognition tasks (responding “old” to one class of familiar stimulus and “new” to another)? Many current theories of memory retrieval ignore the response requirements in such memory tasks, instead modeling them using memory processes (e.g., familiarity and recollection) alone (see Yonelinas, 2002). We argue that strategic recognition involves conflict in response processing similar to canonical conflict tasks (e.g., the Stroop task). The parallel task set (PTS) model (Seymour, 2001) accounts for performance in strategic recognition tasks (e.g., the exclude recognition task) by suggesting that motor response conflict occurs when one responds “new” to familiar stimuli. We tested this prediction using surface electromyography, a measure incontrovertibly related to motor execution. Overall, results are consistent with the PTS model’s assumption that recognition, motor, and control processes interact in strategic retrieval tasks. The implications of these data for models of memory retrieval and response conflict are discussed.     

Patterns of impaired verbal,spatial, and object working memory after thalamic lesions

Working memory processes in six individuals with isolated thalamic lesions were assessed. Participants were given a verbal, spatial, and object n-back task, each at three levels of task load (1-back, 2-back, and 3-back). Relative to a control group, the patients were impaired on the verbal and spatial n-back tasks, and possibly on the object n-back task as well. None of the patients showed impaired short-term memory as measured by digit span. Group differences on trials measuring matching, sequencing, and inhibitory abilities were consistent with other reports suggesting that thalamic lesions may impair the operation of executive processes.     

The effect of articulatory suppression and manual tapping on serial recall

Concurrent tasks, such as articulatory suppression and manual tapping, are used to understand the mechanisms underlying short-term memory by overloading domain-specific resources. The present study addresses the debate regarding the theoretical frameworks accounting for interference in serial recall by comparing the effects of both the modality of concurrent tasks (verbal vs. spatial) as well as the state of the tasks (steady vs. changing) in both verbal and spatial recall. The findings indicate that the verbal changing-state concurrent task significantly impaired digit recall, whereas the spatial changing-state concurrent task significantly impaired block recall. The theoretical implications are discussed in the context of a multimodal working memory model with domain-specific resources and a unitary approach to short-term memory.     

Central executive involvement in children's spatial memory

Previous research with adults found that spatial short-term and working memory tasks impose similar demands on executive resources. We administered spatial short-term and working memory tasks to 8- and 11-year-olds in three separate experiments. In Experiments 1 and 2 an executive suppression task (random number generation) was found to impair performances on a short-term memory task (Corsi blocks), a working memory task (letter rotation), and a spatial visualisation task (paper folding). In Experiment 3 an articulatory suppression task only impaired performance on the working memory task. These results suggest that short-term and working memory performances are dependent on executive resources. The degree to which the short-term memory task was dependent on executive resources was expected to be related to the amount of experience children have had with such tasks. Yet we found no significant age-related suppression effects. This was attributed to differences in employment of cognitive strategies by the older children.     

Susceptibility of spatial and verbal working memory to demands of the central executive

We used a dual-task paradigm to examine the degree to which domain-specific spatial and verbal subsystems depend on the domain-general central executive. Forty participants were asked to retain spatial or verbal information while performing a concurrent secondary task related to simple arithmetic. The secondary tasks consisted of three cognitive processes: single-digit addition, a digit-carrying operation, and digit reading. The single-digit addition and carry operation include central executive functioning, while digit reading relies solely on the phonological loop. The single-digit addition caused a performance decrement on the spatial working memory task, while the digit reading impaired performance on the verbal working memory task. The carry operation interfered with recall accuracy on both working memory tasks. The spatial working memory task was significantly correlated with the verbal working memory task only when the secondary task was more demanding on the central executive. Our results suggest that spatial working memory rather than verbal working memory is susceptible to failure of central executive functioning and that the central executive plays an important role in regulating the cognitive demands of different domains.     

Central executive involvement in children's spatial memory

Previous research with adults found that spatial short-term and working memory tasks impose similar demands on executive resources. We administered spatial short-term and working memory tasks to 8- and 11-year-olds in three separate experiments. In Experiments 1 and 2 an executive suppression task (random number generation) was found to impair performances on a short-term memory task (Corsi blocks), a working memory task (letter rotation), and a spatial visualisation task (paper folding). In Experiment 3 an articulatory suppression task only impaired performance on the working memory task. These results suggest that short-term and working memory performances are dependent on executive resources. The degree to which the short-term memory task was dependent on executive resources was expected to be related to the amount of experience children have had with such tasks. Yet we found no significant age-related suppression effects. This was attributed to differences in employment of cognitive strategies by the older children.     

The influence of levels of processing on recall from working memory and delayed recall tasks

Recent research in working memory has highlighted the similarities involved in retrieval from complex span tasks and episodic memory tasks, suggesting that these tasks are influenced by similar memory processes. In the present article, the authors manipulated the level of processing engaged when studying to-be-remembered words during a reading span task (Experiment 1) and an operation span task (Experiment 2) in order to assess the role of retrieval from secondary memory during complex span tasks. Immediate recall from both span tasks was greater for items studied under deep processing instructions compared with items studied under shallow processing instructions regardless of trial length. Recall was better for deep than for shallow levels of processing on delayed recall tests as well. These data are consistent with the primary-secondary memory framework, which suggests that to-be-remembered items are displaced from primary memory (i.e., the focus of attention) during the processing phases of complex span tasks and therefore must be retrieved from secondary memory.