Cortical involvement in the semantic processing of coarticulated speech cues

Auditory evoked responses (AER) were recorded from scalp locations over the left and right temporal regions in response to CVC words and nonsense syllables. Various components of the AER were found to vary systematically with changes in stimulus meaning. One such component reflected subcortical involvement in semantic processing. Other components reflected changes in voicing and place of articulation as well as hemisphere differences.     

Left hemisphere sensitivity to consonant sounds not displayed by the right hemisphere: electrophysiological correlates

Auditory evoked responses (AER) to a series of consonant-vowel syllables were recorded from frontal, temporal, and parietal scalp locations from 14 right-handed college students. Averaged AERs were submitted to principal components analysis and analysis of variance. Six components of the group's AERs were found to reflect various aspects of the stimulus parameters. One component reflected changes over only the left hemisphere to different consonants. A second component changed systematically over both hemispheres but did not discriminate between all consonants.     

An auditory evoked potential study of consonant perception in different vowel environments

Auditory evoked responses (AER) to series of consonant—vowel syllables were recorded from temporal and parietal scalp locations from 20 right-handed female college students. Averaged AERs were submitted to principal components analysis and analysis of variance. Seven components of the group's AERs were found to reflect various aspects of the stimulus parameters. One component reflected changes over only the left hemisphere to different consonants independent of the following vowel sound. A second component changed systematically over both hemispheres in response to only consonant changes. A third component systematically changed for the different consonants depending on the following vowel.     

The right hemisphere and temporal processing of consonant transition durations: electrophysiological correlates

Auditory evoked responses (AER) were recorded from frontal, temporal, and parietal scalp regions to a series of consonant-vowel syllables which varied in the duration of the consonant transition. Multivariate analyses of the AER waveforms identified one component of the AERs occurring only over right hemisphere regions which discriminated between differences in transition durations. A second component detected over only left hemisphere areas discriminated differences in place of articulation. These data are consistent with previous behavioral and electrophysiological reports that the right hemisphere is sensitive to temporal discriminations.     

Auditory evoked potentials and sex-related differences in brain development

Auditory evoked potentials (AEPs) were obtained to probe tones which were delivered during the presentation of complex verbal and nonverbal auditory stimulation to 3-month-old infants. Significant sex-dependent AEP amplitude asymmetries were found. Females produced higher-amplitude responses from the left hemisphere and males produced higher-amplitude responses from the right hemisphere during both the verbal and nonverbal presentations. No significant AEP asymmetries were obtained in an independent group of infants that received only the probe tones. These findings are consistent with theories and behavioral data suggesting differences between males and females in the development of language and spatial functions.     

Abnormalities of visual evoked potentials by checkerboards in children with specific reading disability

Visual evoked potentials by checkerboards of varying check sizes were recorded in the two hemispheres of 16 specific reading disabled and 8 normal children. In most of the disabled subjects a gross hemisphere asymmetry was assessed, while in the control group the usual evoked potential symmetry was observed. In some disabled subjects the evoked potentials had a larger amplitude in the right hemisphere, while in others the amplitude was larger in the left hemisphere. In a small subgroup the evoked potentials were symmetrical, but they had a smaller amplitude than in the control subjects. The results, giving evidence of a dysfunction in basic visual processing, are discussed in the context of current literature on clinical subgroups and the interhemispheric relationship in the dyslexic syndrome.     

Is Happy Facial Expression Identified by the Left or Right Hemisphere？

1IntroductionCorrectly identifying other people′s facial ex-pressions of emotions is important to human socialinteraction in all societies.Many studies suggestthat the identification of facial expressions in par-ticular and perceptual processing of emotional infor-mation is carried out mainly by the right hemi-sphere of the brain[1￣7].Damage to the righthemisphere generally produces more significant im-pairment in recognition of all facial expressions ofemotion than damage to the left hemisp…     

Lateral asymmetry of the scalp distribution of somatosensory evoked potential amplitude

Somatosensory potentials evoked by brief low-intensity electrical pulses delivered separately to the left and right index fingers were recorded from the scalp over the posterior half of the contralateral hemisphere in normal human subjects. In two experiments it was found that the scalp areas enclosed by 75 and 90% of maximum-amplitude isopotential contour lines of the early cortically generated complexes were more restricted over the left hemisphere. This asymmetrical evoked potential distribution supports the proposal by Semmes from her observations of brain-damaged patients that elementary somatosensory representation is focal in the left hemisphere and diffuse in the right.     

Electrographic correlates of lateral asymmetry in the processing of verbal and nonverbal auditory stimuli

A veraged evoked potentials (AEP) to verbal (digits) and nonverbal (clicks) auditory stimuli were recorded from left and right temporal leads in ten right-handed Ss. With dichotic presentation, there was no significant difference in accuracy of report of the clicks heard in each ear, but significantly more digits were identified correctly from the right ear than from the left. Dichotic verbal stimuli elicited AEP whose early components were of greater amplitude, and whose later components were of shorter latency, from the left hemisphere than from the right. No consistent latency or amplitude differences were observed between AEP from the left and right hemispheres when clicks were presented dichotically.     

Neuroelectrical correlates of hemisphere and handedness factors in a cognitive task

Principal-components analysis was performed on a set of averaged evoked potentials in order to extract components of cerebral activity functionally related to hemisphere, handedness, processing task, and stimulus feature variables. Eight such components were isolated. Degree of dextrality, hemispheric differences, and cognitive operations in processing distinct stimulus characteristics were identified as reflected in functionally distinct components of brain activity.     

Cerebral organization of oral and signed language responses: case study evidence from amytal and cortical stimulation studies

A normally hearing left-handed patient familiar with American Sign Language (ASL) was assessed under sodium amytal conditions and with left cortical stimulation in both oral speech and signed English. Lateralization was mixed but complementary in each language mode: the right hemisphere perfusion severely disrupted motoric aspects of both types of language expression, the left hemisphere perfusion specifically disrupted features of grammatical and semantic usage in each mode of expression. Both semantic and syntactic aspects of oral and signed responses were altered during left posterior temporal-parietal stimulation. Findings are discussed in terms of the neurological organization of ASL and linguistic organization in cases of early left hemisphere damage.     

Impairments of nonverbal oral movements after left hemisphere damage: A followup analysis of errors

Acquisition of a task requiring the imitation of a series of nonverbal oral movements is most severely impaired in patients with aphasic disturbance. However, nonaphasic patients with left hemisphere damage also perform more poorly than patients with right hemisphere damage or normal control subjects. Analysis of the errors made on the multiple oral movements task reveals that left, but not right, hemisphere damage is highly associated with perseverative responses. Patients with right hemisphere damage do not differ significantly from normal control subjects in the acquisition of or in the type of errors made on the task. It is suggested that the left hemisphere plays an important role in the control of nonverbal oral movement production.     

Speech dominance and handedness in the normal human

Spectral analysis was used to measure the coherence or similarity of form between occipital and temporal evoked potentials. In both right- and left-handers, coherence was greater in the left hemisphere for click stimuli and in the right hemisphere for flash stimuli. Similar asymmetries occurred in left but not right speech dominant patients whose speech lateralization has been determined by the intracarotid amytal test. Right-handers and males, however, showed significantly larger amplitudes of auditory responses in the right hemisphere. Left-handers and females reversed this pattern. It was concluded that within a basically left speech dominant organization, males and right-handers would emphasize the verbal, temporal structure of auditory information and the nonverbal, spatial structure of visual information. Females and left-handers would tend to reverse this emphasis.     

Right-hemispheric language evidence from cortical stimulation

While the left-hemispheric dominance for language in most right-handers is unquestionable, clinical observations suggest that the right, nondominant hemisphere has a considerable capacity for language. Under certain neuroanatomical conditions, the right-hemispheric capacity becomes functional and, thus, measurable. This study focuses on evoked language responses during electrical stimulation of the right hemisphere in three left-dominant patients undergoing temporal lobe resections for medically intractable seizures.     

Hemispheric specialization for temporal information: Implications for the perception of voicing cues during speech perception

Developmental research reporting electrophysiological correlates of voice onset time (VOT) during speech perception is reviewed. By two months of age a right hemisphere mechanism appears which differentiates voiced from voiceless stop consonants. This mechanism was found at 4 years of age and again with adults.A new study is described which represents an attempt to determine a more specific basis for VOT perception. Auditory evoked responses (AER) were recorded over the left and right hemispheres while 16 adults attended to repetitive series of two-tone stimuli. Portions of the AERs were found to vary systematically over the two hemispheres in a manner similar to that previously reported for VOT stimuli. These findings are discussed in terms of a temporal detection mechanism which is involved in speech perception.     

Hemispheric Asymmetry in Transient Visual Evoked Potentials Induced by the Spatial Factor of the Stimulation

In order to enhance the effect of spatial frequency on the hemispheric asymmetry of visual evoked potentials (VEP), the response amplitudes to ON-OFF modulated gratings were compared with the responses to pattern reversal stimulation. Sinusoidal gratings of different spatial frequencies were presented to six righthanders. VEPs were recorded from temporal leads on each hemisphere. In the left hemisphere, the amplitude was constant for the two modes of presentation and independent of spatial frequency. In the right hemisphere, the response amplitude was larger to the ONSET stage of ON-OFF stimulation than to reversal and presented the characteristic spatial frequency tuning curve. This asymmetry is assumed to reflect a difference in sensitivity of the two hemispheres to the spatiotemporal characteristics of the stimulus. The relevance of these findings is discussed in relation to the other hemispheric specialization models.     

A comparison of hemispheric asymmetries in speech-related brain potentials of autistic and dysphasic children

In a previous study (G. Dawson, C. Finley, S. Phillips, & L. Galpert, 1986, Child Development, 57, 1440-1453) it was found that measures of hemispheric asymmetry during speech processing were predictive of level of language ability in autistic children. The purpose of the present study was to determine whether a similar relationship between pattern of hemispheric asymmetry and language ability exists for language-impaired children without autism. Ten autistic children (8-13 years), 10 dysphasic children (6-15 years), and 10 normal children (8-13 years) were compared in terms of their patterns of hemispheric asymmetry in the averaged cortical evoked response to a simple speech stimulus, and the relationship between pattern of hemispheric asymmetry and language ability was assessed for each clinical group. It was found that, for both the autistic and dysphasic groups, the majority of subjects showed a reversed direction of hemispheric asymmetry from that characteristic of the normal group. A strong relationship between pattern of asymmetry and level of language ability was found for autistic subjects; autistic subjects with more severe language impairments were more likely to show reversed asymmetry than subjects with less severe language impairments. In contrast, no relationship between language ability and direction of hemispheric asymmetry in the evoked response was found for dysphasic subjects. Separate analyses of right and left hemisphere evoked responses indicated that language ability was related to right hemisphere activity for autistic subjects, and to left hemisphere activity for dysphasic subjects.     

Development of differences in response latencies to right and left visual fields

Robust lateralization developed in right-handed adults who were asked to judge letter pairs as "same" or "different" during 4608 trials. By the end of the first two blocks (768 trials) "same" responses were favored when presented in the RVF (transmitted directly to the left hemisphere) and "different" responses were favored when presented in the LVF (transmitted direction to the right hemisphere). This gradually reversed over sessions with "same" responses becoming faster for letters presented in the LVF, and "different" responses becoming faster for stimuli presented in the RVF. The laterality acquired under these conditions was cumulative and reproducible, appeared in all 16 subjects, and was preserved between sessions a week apart. The data suggest that laterality is a flexible and reversible characteristic of the human brain even when stimulus and task remain constant.     

Reaction times and evoked potentials as indicators of hemispheric differences for laterally presented name and physical matches

Letter pairs, which could be name matches, physical matches, or mismatches, were presented at fixation or 2.5 degrees left or right of fixation. During different experimental sessions, the locations and the types of matches were fixed (and therefore known in advance by the subject) or were randomized. Right visual field superiority in reaction time occurred for name matches only when location was randomized, and then the extent of the superiority depended on whether the types of match called for were predictable. Evoked potentials to the letter pairs during this task revealed hemispheric and neural pathway differences that were independent of expectancy condition. Right hemisphere responses were larger than left. For some components, amplitudes were smaller and latencies were shorter for direct than for indirect projection of stimuli to each cerebral hemisphere. Indirect-direct differences in P300 amplitude varied for each cerebral hemisphere according to whether a physical or name match occurred. The P130 and N170 components manifested hemispheric differences that depended on whether the two letters of a pair were in the same or different cases.     

Effects of semantic discrimination of Chinese words on N400 component of event-related potentials.

20 subjects' event-related brain potentials were measured during a lexical decision task in which Chinese characters were used in both conditions of related (antonym) and unrelated words. Analysis indicated that the mean reaction time for unrelated words was 130 msec. longer than that elicited by related words. The condition of unrelated words elicited a significant N450, and an obvious P500 was evoked by related words at each of the 17 recording sites. Furthermore, the amplitudes of N210 and N450 were larger in the left hemisphere than in the right hemisphere but the amplitude of P500 was larger in the right hemisphere than in the left hemisphere.