Environmental invariants in the representation of motion: Implied dynamics and representational momentum,gravity, friction,and centripetal force

Memory for the final position of a moving target is often shifted or displaced from the true final position of that target. Early studies of this memory shift focused on parallels between the momentum of the target and the momentum of the representation of the target and called this displacementrepresentational momentum, but many factors other than momentum contribute to the memory shift. A consideration of the empirical literature on representational momentum and related types of displacement suggests there are at least four different types of factors influencing the direction and magnitude of such memory shifts: stimulus characteristics (e.g., target direction, target velocity), implied dynamics and environmental invariants (e.g., implied momentum, gravity, friction, centripetal force), memory averaging of target and nontarget context (e.g., biases toward previous target locations or nontarget context), and observers’ expectations (both tacit and conscious) regarding future target motion and target/context interactions. Several theories purporting to account for representational momentum and related types of displacement are also considered.     

Does Estrogen Protect Against Cognitive Aging in Women?

ABSTRACT— Although there is evidence from randomized controlled trials that estrogen therapy protects against aspects of cognitive decline that occur with normal aging in women, findings from the Women's Health Initiative Memory Study and from some cross-sectional and longitudinal studies failed to find neuroprotective effects of estrogen in older women. There is growing empirical support for the critical-period hypothesis, formulated in the attempt to resolve these discrepancies. It holds that estrogen therapy has protective effects on verbal memory and on working memory only when it is initiated closely in time to menopause, whereas starting treatment many years following menopause does not protect and may even be harmful. Supporting evidence for this hypothesis from basic neuroscience and from animal and human studies is evaluated for its ability to explain the inconsistencies and to describe the conditions under which estrogen may protect cognitive function in aging women.     

Genetics of human episodic memory: dealing with complexity

Episodic memory is a polygenic behavioral trait with substantial heritability estimates. Despite its complexity, recent empirical evidence supports the notion that behavioral genetic studies of episodic memory might successfully identify trait-associated molecules and pathways. The development of high-throughput genotyping methods, of elaborated statistical analyses and of phenotypic assessment methods at the neural systems level will facilitate the reliable identification of novel memory-related genes. Importantly, a necessary crosstalk between behavioral genetic studies and investigation of causality by molecular genetic studies will ultimately pave the way towards the identification of biologically important, and hopefully druggable, genes and molecular pathways related to human episodic memory.     

Memory performance in abstinent 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") users

Research with animals and humans has suggested that acute and subacute use of 3,4-methylenedioxymethamphetamine (MDMA "ecstasy") may lead to memory impairment. However, research is limited by (1) low power due to small sample sizes, (2) the possible confound of polydrug use, and (3) the failure to consider intelligence as a covariate. The present study compared the memory performance on the Wechsler Memory Scale-III of 26 abstinent (2-wk. minimum) recreational MDMA users with 26 abstinent (2-wk. minimum) recreational polydrug users. Despite significantly greater polydrug use amongst these MDMA users, no significant group differences in memory were observed. Regression of total lifetime amount of MDMA use also did not predict memory performance after accounting for intelligence. In addition, the length of time since abstinence (at least 2 wk.) was not associated with an increase in memory performance. Greater total lifetime cocaine use, rather than total lifetime MDMA use, was significantly associated with greater decrements in General Memory and Delayed Verbal Memory performance.     

老年无症状性脑梗死患者的临床研究

SCI患者110例和110例健康对照组之间血脂、超敏C反应蛋白（Hs-CRP）等指标的差异进行研究,同时用临床记忆量表检测两组的记忆能力。提示SCI组的记忆商和指向记忆、人像特点联想回忆分显著低于健康对照组。两组的甘油三酯、高密度脂蛋白及Hs-CRP之间差异有显著性。而SCI患者头昏、记忆力减退较为常见,易出现高甘油三酯、高密度脂蛋白降低、Hs-CRP升高、动脉硬化程度重,进一步加重认知功能损害,需早期防治。     

The Importance of Social Versus Temporal Comparison Appraisals Among Older Adults1

It has been suggested that social comparisons become less frequent and less important to one's self-evaluation, and temporal comparisons become more frequent and more important to self-evaluation in later life. In this study, the influence of social and temporal comparison appraisals on global self-ratings in 3 domains (health, income, and memory) was assessed among individuals ranging in age from 53 to 90 years. Although social comparison appraisals were significantly related to self-ratings in all 3 domains, temporal comparison appraisals were only related to self-rated memory. There was also no evidence that the effect of social or temporal comparison appraisals on self-evaluations differed with age among our sample of middle-aged and older adults. Social comparison appraisal appears to be a viable mechanism by which esteem can be preserved in old age, despite increasing loss and impairment.     

Recollection and Familiarity in Aging Individuals with Mild Cognitive Impairment and Alzheimer’s Disease: A Literature Review

Memory impairment is a central cognitive symptom in mild cognitive impairment (MCI) and Alzheimer Disease (AD). Recognition tasks are often used to characterize and define the nature of memory deficits. Dual-process theories posit that familiarity and recollection are independently involved in the recognition of previously encountered material and both contribute to successful recognition. Recent evidence indicates that there is a double dissociation in the neuronal substrates of those two processes. More precisely, it has been suggested that perirhinal and entorhinal areas are selectively involved in familiarity-based recognition, while the hippocampus is associated with recollection. Interestingly, these regions are among the first to be targeted by neurofibrillary tangles, one of AD’s neuropathological hallmarks. Impairment in recognition performance can occur in the very early stages of AD, such as MCI. To define the nature of recognition impairment in these clinical populations, we reviewed the current literature on familiarity and recollection performance in individuals with MCI and AD. Together with clinical features, methodological factors are taken into consideration in the interpretation of findings.     

Treating the core features of autism: are we there yet?

A wide variety of nonestablished treatments have been proposed as "cures" for the core features of autism and are used frequently despite having largely escaped scientific scrutiny. In contrast, a growing body of empirical evidence supports the use of a few forms of theory-based and empirically validated treatment for some aspects of the core features of autism. These include behavioral/psychoeducational interventions and specific forms of medication treatment, which can produce significant improvements in communication, social interaction, and problem behaviors that both maintain over time and generalize across settings. While there is no doubt that treatment and educational services for persons with autism have improved over the past 6 decades, it also appears that significant issues remain with respect to (1) the routine application of validated treatments for the majority of cases with autism, (2) the resistance to even validated forms of treatment for a substantial minority of cases with autism, and (3) the extent to which validated treatments effectively treat the specific core features of autism that are most disabling for persons with autism and their families.     

Extending the Theory of Planned Behavior: A Review and Avenues for Further Research

This paper describes and reviews the theory of planned behavior (TPB). The focus is on evidence supporting the further extension of the TPB in various ways. Empirical and theoretical evidence to support the addition of 6 variables to the TPB is reviewed: belief salience measures, past behavior/habit, perceived behavioral control (PBC) vs. self-efficacy, moral norms, self-identity, and affective beliefs. In each case there appears to be growing empirical evidence to support their addition to the TPB and some understanding of the processes by which they may be related to other TPB variables, intentions, and behavior. Two avenues for expansion of the TPB are presented. First, the possibility of incorporating the TPB into a dual-process model of attitude–behavior relationships is reviewed. Second, the expansion of the TPB to include consideration of the volitional processes determining how goal intentions may lead to goal achievement is discussed.     

An Integrative View of Conflict Adaptation and Active Maintenance

The conflict adaptation (CA) effect refers to the reduction in the interference effect observed in conflict tasks that follow incongruent compared to congruent trials. It has been suggested that CA is caused by the exertion of flexible cognitive control, supported by many behavioral and neuroimaging studies; however, it remains unclear how conflict‐related features of the preceding trial are conveyed to subsequent trials for following adaptation. This review aims to summarize evidence supporting the top‐down modulation of the dorsolateral prefrontal cortex and passive short‐term maintenance in the posterior brain areas as mechanisms underlying CA, respectively, and to suggest a new integrated view of CA, including active maintenance in working memory. We review empirical evidences suggesting that both dorsolateral prefrontal cortex and posterior brain regions play critical roles in CA, rather than either top‐down modulation or passive maintenance alone. Although the active maintenance view of CA appears to explain many existing findings, empirical studies are required to directly test this view.     

Adapting Homework for an Older Adult Client With Cognitive Impairment

There is growing evidence that psychosocial treatments incorporating behavioral intervention strategies can be effective in the treatment of depression in older adults with cognitive impairment. However, less work with such cases has focused on the use of cognitive interventions in tandem with these behavioral intervention strategies. This case study describes how cognitive behavioral intervention strategies and related homework assignments were tailored and integrated to successfully treat depressive symptoms in an older African American diagnosed with probable Alzheimer’s disease. Examples of the homework strategies utilized are introduced by phase of treatment. We also discuss ways to overcome barriers to homework completion as well as methods to incorporate the client’s sociocultural context and personal history into homework.     

Serial Mediators of Memory Support Strategies Used With Cognitive Therapy for Depression: Improving Outcomes Through Patient Adherence and Treatment Skills

Patient memory for treatment is poor. Memory support strategies can be integrated within evidence-based psychological treatments to improve patient memory for treatment, and thereby enhance patient outcomes. The present study evaluated possible mechanisms of these memory support strategies. Specifically, we tested whether therapist use of memory support strategies indirectly predicts improved patient outcomes via serial improvements in (a) patient adherence throughout treatment and (b) patient utilization and competency of treatment skills. Adults with major depressive disorder (N = 178, mean age = 37.93, 63% female, 17% Hispanic or Latino) were randomized to Cognitive Therapy plus a Memory Support Intervention or Cognitive Therapy-as-usual. Because therapists from both treatment groups used memory support strategies, data from conditions were combined. Blind assessments of depression severity and overall impairment were conducted before treatment, immediately posttreatment (POST), at 6-month follow-up (6FU), and at 12-month follow-up (12FU). Patient adherence to treatment was rated by therapists and averaged across treatment sessions. Patients completed measures of treatment mechanisms—namely, utilization and competency in cognitive therapy skills—at POST, 6FU, and 12FU. Results of serial mediation models indicated that more therapist use of memory support predicted lower depression severity at POST, 6FU, and 12FU indirectly and sequentially through (a) increased patient adherence during treatment and (b) more utilization and competency of Cognitive Therapy skills at POST, 6FU, and 12FU. The same patterns were found for serial mediation models predicting lower overall impairment at POST, 6FU, and 12FU. Together, boosting memory for treatment may represent a promising means to enhance pantreatment mechanisms (i.e., adherence and treatment skills) as well as patient outcomes.     

Frontal lobe dysfunction and memory impairment in patients with chronic progressive multiple sclerosis

Deficits in semantic encoding have been described in patients with frontal lobe disease who also show memory impairments. As a group, patients with multiple sclerosis (MS) exhibit memory impairment, fail to make effective use of semantic encoding to aid memory, and perform poorly on verbal fluency and concept formation tests which are sensitive to frontal lobe damage. In the present study the semantic encoding capacity of MS patients was measured using a modification of Wicken's release from proactive interference (PI) paradigm. Individual patients varied considerably in the severity of their impairments on verbal fluency, verbal recognition memory and on Wisconsin Card Sorting Task, but even patients who evidenced both memory impairment and signs of frontal lobe dysfunction showed normal release from PI after a categorical shift. Memory disturbances in MS are unlikely to result from an incapacity for semantic encoding, which seems preserved in MS, but may arise instead from deficits in processing information rapidly.     

The effect of midazolam on implicit memory tests

Substantial empirical evidence exists suggesting that there are distinct forms of explicit and implicit memory. However, methodological problems have hampered attempts to identify the nature of the information processing underlying these forms of memory. These problems include the contamination of performance on implicit memory tests by explicit memory processes, as well as a host of difficulties inherent in correlational approaches that involve amnesiac subjects. In this paper we attempt to explore whether midazolam, a benzodiazepine used in surgical anesthesia, might be useful for studying implicit memory. Specifically, we attempt to determine whether midazolam produces selective effects on explicit, as opposed to implicit, memory. We focus on midazolam because of prior studies demonstrating that benzodiazepines do not affect implicit memory and because its rapid pharmacokinetics ensure that sedative effects are minimized when testing occurs at relatively short retention intervals. The results of an experiment using free recall, fragment completion and perceptual identification tests suggest that midazolam diminishes memory in implicit and explicit memory tests, although the diminution is proportionally larger in explicit memory. These results constrain the inferences that may be drawn when midazolam is used to explore implicit memory.     

Reflecting on imagery: a clinical perspective and overview of the special issue of memory on mental imagery and memory in psychopathology

The authors provide an overview of the papers in the special issue of Memory on mental imagery and memory in psychopathology. The papers address emotional, intrusive mental imagery across a range of psychological disorders including post-traumatic stress disorder (PTSD), agoraphobia, body dysmorphic disorder, mood disorders, and psychosis. They include work on information processing issues including modelling cravings, conditioning, and aversions, as well as imagery qualities such as vividness and emotionality. The overview aims to place the articles in a broader context and draw out some exciting implications of this novel work. It provides a clinical context to the recent growth in this area from a cognitive behavioural therapy (CBT) perspective. We begin with PTSD, and consider links to imagery in other disorders. The clinical implications stemming from this empirical work and from autobiographical memory theory are discussed. These include consideration of a variety of techniques for eliminating troublesome imagery, and creating healthy, realistic alternatives.     

Supplemental group discussions in memory training for older adults

Memory training was compared in adults aged 60-80. Groups 1 and 2 studied a self-instructional memory training manual; Group 2 also attended supplementary group discussions of typical problems of later life, related coping methods, and the techniques in the self-instructional manuals. Group 3 was a wait-list control group. Memory performance on 2 word lists significantly improved in the supplemental discussion group but not in the group that only studied the self-instructional manual. Enhanced performances were maintained at a 1-month follow-up. Bibliotherapy alone may be inferior to treatment involving a group component, although the mechanisms of such enhancement remain unexplored with respect to memory training. Neither treated group improved their digit span or recall of names and a brief prose passage; teaching older adults the strategies of chunking and use of imagery may not be beneficial.     

Cognitive dysfunction in compulsive checkers: Further explorations

Recent evidence suggests a relationship between certain memory deficits and compulsive-checking behavior. The present study explores this relationship in the context of several additional memory capacities not yet investigated. Using the Maudsley Obsessional-Compulsive Inventory and the Everyday Checking Behavior Scale four groups of Ss were identified: (1) frequent checkers, (2) occasional checkers, (3) infrequent checkers and (4) noncheckers. Consistent with previous research, a memory-for-actions task indicated a deficit among compulsive checkers. Furthermore, checking status was found to be negatively related to memory functioning as measured by the Wechsler Memory Scale (WMS) and the Cognitive Failures Questionnaire (CFQ). This memory deficit was most pronounced on the Logical Memory subtest of the WMS. Checkers appear to have difficulty recalling details of meaningfully linked sequences, either presented in narrative form or engaged in personally. Although the reasons for these checking-related deficits are not clear, a complete understanding of checking phenomena will involve an appreciation of the role played by memory deficits.     

回溯式时距估计的计时机制

回溯式时距估计是以记忆为主要成分, 且事后才知要对两个相继事件之间的间隔时间或某一事件持续时间的长短进行估计。可分为近时和远时的回溯式时距估计, 两者的计时机制与记忆有关, 但各有侧重：前者侧重短时或长时记忆, 直接证据来源于即时回忆单一或多个认知任务以估计时间, 间接证据则聚焦于物理、生理、心理因素的影响; 后者侧重自传体记忆, 可从问卷或访谈的测量方式以及主客体特征的影响两个方面来寻找证据。今后需以整合的观点深入探究回溯式时距估计的计时机制, 拓展回溯式时距估计行为测量的研究, 并开展对回溯式时距估计神经生物学基础的探讨。     

Memory training and strategy use in older adults: results from the ACTIVE study

Little is known about the long-term effects of memory training in later life on strategy use. Data from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study (n = 1,401) were used to describe strategy use in a community-dwelling sample of older adults. Strategy clustering scores on verbal list learning tasks of episodic memory were used to test the impact of memory training on strategy use and study longitudinal associations between strategy clustering, memory performance, and everyday functioning. Results suggested that younger, female, white, healthier, and more educated participants show higher strategy clustering scores initially but no characteristics were consistently associated with different trajectories in strategy clustering across all strategy clustering measures together. Memory training had significant immediate effects on all measures of strategy use that were maintained through five years of follow-up. With respect to longitudinal mediation, pre-post training changes in most strategy clustering scores mediate changes in objective memory performance and everyday functioning, implying that strategies can be modified and are closely related to both memory ability and the ability to function independently. This study provides evidence that older adults can be trained to use cognitive strategies, the effects are durable, and strategies are associated with memory and everyday functioning.     

The relationship between executive function and verbal memory in Parkinson's disease

A growing body of evidence suggests that the various cognitive symptoms found in Parkinson's disease (PD) are secondary to executive dysfunction. Studies addressing this possibility for memory impairment specifically have not included measures of working memory nor have they ruled-out potential mediating variables such as overall level of cognitive impairment or depression. The purpose of this study was to include measures of these variables in determining the relationship between multiple aspects of executive function and delayed verbal recall in 32 idiopathic PD patients. Results were consistent with the original hypothesis and further suggest that working memory is a key factor in recall memory and may mediate the relationship between other executive measures and recall in PD.