The physiological basis of transcranial magnetic stimulation

Transcranial magnetic stimulation (TMS) is the noninvasive method of choice for studying the causal relevance of a cortical area in the human brain. The success of TMS, however, is contrasted by limited insight into its mechanism of action. A recent study by Allen and colleagues offers stunning new insight into the physiological underpinnings of TMS. Their findings expand our understanding about a method that is widely used for stimulating research in the cognitive neurosciences.     

The Pavlovian basis of reciprocal inhibition therapy

While there is a slight disagreement between Wolpe’s views and Pavlov’s statements concerning the application of experimental psychology to the study of psychiatry, Wolpe indicates that he owes much to Pavlov. A Pavlovian analysis of therapy by reciprocal inhibition, which includes the physiological constructs as well as Pavlovian methodology, will increase our understanding of Reciprocal Inhibition therapy. The major techniques of Reciprocal Inhibition therapy are discussed in the terms of Pavlovian method and theory. Desensitization based on systematic relaxation appears to be effective because the excitatory stimulus is presented when the subject’s cortex is predominantly in an inhibitory state while relaxed. Assertive training relies mainly on building up the excitatory process by use of the second signal system. Thought-stopping is analogous to the external inhibition procedure with the use of the second signaling system as the “extra” stimulus. Deductions from Pavlov’s typology predict that an excitable subject will be difficult to desensitize and somewhat easier to train in assertive behavior and thought-stopping. Some implications of relating Pavlovian method and theory to Reciprocal Inhibition therapy are discussed.