Do pulmonary function and smoking behavior predict cognitive function? findings from a british sample

Abstract

The relationship of smoking behavior, pulmonary function, and four measures of cognitive function was studied in a sample of 4,399 men and women (mean age = 44.7 f 17.1 years; age range: 18 to 94 years) randomly selected from British electoral registers. Each subject was assessed with a face-to-face structured interview (including demographic data, smoking history, and health-related questions) as well as cognitive testing [simple reaction time (SRT), choice reaction time (CRT), incidental memory, and spatial reasoning] and pulmonary function testing. Results indicated that smoking was associated with somewhat better performance on the CRT and memory tasks, and that smoking behavior was not associated with decrements in cognitive performance. Impaired pulmonary function was generally associated with poorer cognitive performance on all of the cognitive measures, suggesting that pulmonary function may be a relevant factor to consider in experimental studies of smoking and cognitive function among healthy adults.     

Relationship between 24-Hour Ambulatory Blood Pressure and Cognitive Function in Healthy Elderly People

The idea that activity, both physical and mental, may be a protective factor against cognitive decline in later life has enjoyed currency in both the popular and general medical literature. However, considerable uncertainty remains about the relationship between activity and cognitive performance due to differing definitions of activity and to the use of select samples. The current report analysed data from a probability sample of 887 participants recruited from the community, aged 70-93 years in 1991 and followed up in 1994 and 1998. Activity was assessed using a six-item scale comprising activities that are both commonly undertaken and relevant to old age. Latent growth curves were fitted to longitudinal outcomes including activity, cognitive performance and health measures. Reduction in activity over the course of the study was observed in most participants. Substantial correlations between rates of change in activity and cognitive and health measures were observed. Decline in cognitive performance was also observed in a sub-sample of participants who maintained activity over the three waves of measurement. It was concluded that decline in mental and physical activity in older age is paralleled by decline in cognitive functioning and health. The results do not preclude the possibility that introduced modifications in activity might change the course of cognitive performance later in the life span. Further research is required to establish the causal nature of the relationship between activity and cognition.     

Both odor identification and ApoE-ε4 contribute to normative cognitive aging

Research indicates that apoliprotein E (ApoE) plays a role in the development of Alzheimer's disease (AD) and possibly in the cognitive decline associated with normative aging. More recently, researchers have shown that ApoE is expressed in olfactory brain structures, and a relationship among ApoE, AD, and olfactory function has been proposed. In the current analyses, we investigated the contribution of ApoE and odor identification in decline trajectories associated with normative cognitive aging in various domains, using longitudinal data on cognitive performance available from the Swedish Adoption/Twin Study of Aging. Data on both ApoE status and olfactory functioning were available from 455 individuals ranging in age from 50 to 88 years at the first measurement occasion. Odor identification was measured via a mailed survey. Cognitive performance was assessed in up to 5 waves of in-person testing covering a period of 16 years. Latent growth curve analyses incorporating odor identification and ApoE status indicated a main effect of odor identification on the performance level in three cognitive domains: verbal, memory, and speed. A main effect of ApoE on rates of decline after age 65 was found for verbal, spatial, and speed factors. The consistency of results across cognitive domains provides support for theories that posit central nervous system-wide origins of the olfaction-cognition-ApoE relationship; however, olfactory errors and APOE ε4 show unique and differential effects on cognitive trajectory features.     

The Executive Decline Hypothesis of Cognitive Aging: Do Executive Deficits Qualify as Differential Deficits and Do They Mediate Age-Related Memory Decline?

This paper reports the results of two studies which investigated whether aging is associated with a differential deficit in executive function, compared with deficits in general cognitive ability (Wechsler Adult Intelligence Scale-Revised performance). Further, the studies investigated the specificity of the executive decline hypothesis of memory and aging by examining whether declines in executive function mediate age-related memory decline over and above the variance in memory accounted for by general cognitive ability. The results of Study 1 showed no consistent evidence of a differential decline in executive function among a sample of participants aged between 18 and 75 years. The results of Study 2 indicated a differential decline in one indicator of executive function, the Modified Card Sorting Test, among an older sample aged between 60 and 89 years. Both studies demonstrated that measures of executive function accounted for age-related variance in free recall, recognition, and serial recall, even after controlling for general cognitive ability. However, in Study 1, once variance attributed to speed of processing was taken into account, executive function did not contribute further to the age-related variance.     

Effects of noise on identification and serial recall of nonsense syllables in older and younger adults

The present experiment investigated the hypothesis that age-related declines in cognitive functioning are partly due to a decrease in peripheral sensory functioning. In particular, it was suggested that some of the decline in serial recall for verbal material might be due to even small amounts of degradation due to noise or hearing loss. Older and younger individuals identified and recalled nonsense syllables in order at a number of different speech-to-noise ratios. Performance on the identification task was significantly correlated with performance on a subsequent serial recall task. However, this was restricted to the case in which the stimuli were presented in a substantial amount of noise. These data show that even small changes in sensory processing can lead to real and measurable declines in cognitive functioning as measured by a serial recall task.     

Effects of Noise on Identification and Serial Recall of Nonsense Syllables in Older and Younger Adults

ABSTRACT

The present experiment investigated the hypothesis that age-related declines in cognitive functioning are partly due to a decrease in peripheral sensory functioning. In particular, it was suggested that some of the decline in serial recall for verbal material might be due to even small amounts of degradation due to noise or hearing loss. Older and younger individuals identified and recalled nonsense syllables in order at a number of different speech-to-noise ratios. Performance on the identification task was significantly correlated with performance on a subsequent serial recall task. However, this was restricted to the case in which the stimuli were presented in a substantial amount of noise. These data show that even small changes in sensory processing can lead to real and measurable declines in cognitive functioning as measured by a serial recall task.     

Personality development in old age relates to physical health and cognitive performance: Evidence from the Berlin Aging Study II

We examine how late-life personality development relates to overall morbidity as well as specific performance-based indicators of physical and cognitive functioning in 1,232 older adults in the Berlin Aging Study II (aged 65–88 years). Latent growth models indicated that, on average, neuroticism and conscientiousness decline over time, whereas extraversion and openness increase and agreeableness remains stable. Higher morbidity and worse grip strength were associated with higher neuroticism. Lower grip strength was further associated with lower openness, attenuated increases in extraversion, decreases in agreeableness and accelerated declines in conscientiousness. Moreover, those with poor perceptual speed reported higher neuroticism and lower conscientiousness. We also found age- and gender-differential associations between physical health and cognitive performance with levels of and changes in personality.     

The association between change in cognitive ability and cause-specific mortality in a community sample of older adults

While there is consistent evidence that initial levels of cognitive ability predict mortality, there is mixed evidence for a relationship between changes in cognition and mortality. There have been few studies that have examined whether the level and slope of cognitive performance is predictive of subsequent mortality from all causes or from cardiovascular disease, stroke, heart disease, respiratory disease, or cancer. This study aimed to assess whether the level and slope of cognitive ability were associated with all-cause or cause-specific mortality. A cohort of 896 community-based elderly people in Australia was interviewed four times over 12 years, with vital status followed for up to 17 years. Of these, 592 participants completed two or more interviews and were included in survival models of six mortality outcomes. Cognitive change in five domains of ability was estimated using latent growth models. Poorer initial processing speed or verbal fluency was significantly associated with greater all-cause and/or cardiovascular mortality. In addition, declines in global ability were associated with greater all-cause, cardiovascular, and heart disease mortality. Vocabulary and episodic memory were not associated with mortality, and none of the cognitive tests significantly predicted respiratory or cancer mortality. Initial levels of cognitive ability tended to be better predictors of subsequent mortality than were changes in ability. The results suggest that vascular events may be largely responsible for the overall relationship between cognition and mortality.     

Interrelation between functional decline and dementia: The potential role of balance assessment

ObjectiveThere has been growing interest in the past few years on the relationship between impairment of motor functions and cognitive decline, so that the first can be considered a marker of dementia. In MCI patients, the deficit in processing visual information interferes with postural control, causing oscillations and instability. Postural control is usually evaluated through the Short Physical Performance Battery (SPPB) test or Tinetti scale, but, to our knowledge, there are no many studies that considered the Biodex Balance System (BBS) in the evaluation of postural controls in MCI patients. The aim of this study was first to confirm the bi- directional relationship between cognitive and motor performance, and then to compare traditional evaluation scales (SPPB and Tinetti) with a biomechanical tool, the BBS.Materials and methodsObservational retrospective study. In 45 elderly patients with cognitive impairment we evaluated cognition, assessed with the MMSE and MoCA, malnutrition with the MNA, and sarcopenia with DEXA (ASMMI). Motor performance was assessed with SPPB, Tinetti, and BBS.ResultsMMSE correlated more with BBS than with the traditional scales, while MoCA was also correlated with SPPB and Tinetti scores.ConclusionsBBS had a stronger correlation with cognitive performance compared with the traditional scales. The relationship between MoCA executive items and the BBS tests suggests the usefulness of targeted interventions involving cognitive stimulation to improve motor performance, and motor training to slow the progression of cognitive decline, particularly in MCI.     

Intra-individual variability in gait and in cognitive performance are not related in the elderly

As humans age, the amount of intra-individual variability (IIV) present in both their gait and their cognitive performance tends to increase. Both gait and cognitive IIV are associated with attentional control and with cerebrovascular disease, suggesting that the IIV in gait and cognitive function should be strongly correlated in the elderly. In this study temporal gait variability was determined from a 60-second period of walking. Cognitive variability was determined from two decision-time tasks assessing inhibition. Despite the presence of substantial amounts of gait and cognitive IIV in 71 elderly individuals, there were no significant correlations between measures of cognitive and gait IIV, suggesting that different factors drive IIV in the motor and cognitive performance of older individuals. These results are not consistent with the common cause theory of aging, which predicts that cognitive and sensorimotor performance should show related declines due to age-related disruption of a common neurological substrate.     

Social relationships, social support, and patterns of cognitive aging in healthy, high-functioning older adults: MacArthur studies of successful aging.

This study examines the relationship of social ties and support to patterns of cognitive aging in the MacArthur Studies of Successful Aging (see L. F. Berkman et al., 1993), a cohort study of 1,189 initially high-functioning older adults. Baseline and longitudinal data provide information on initial levels as well as changes in cognitive performance over a 7.5-year period. Linear regression analyses revealed that participants receiving more emotional support had better baseline performance, as did those who were unmarried and those reporting greater conflict with network members. Greater baseline emotional support was also a significant predictor of better cognitive function at the 7.5-year follow-up, controlling for baseline cognitive function and known sociodemographic, behavioral, psychological, and health status predictors of cognitive aging. The findings suggest the potential value of further research on the role of the social environment in protecting against cognitive declines at older ages.     

情景记忆成功年老化的神经机制

随着年龄的增长,大部分老年人的情景记忆会出现衰退,但也会有一部分老年人的情景记忆表现出成功的年老化,即记忆成绩较好或随增龄的衰退程度较小。脑保持理论、神经去分化理论、认知储备理论以及神经补偿理论分别从不同角度解释了情景记忆成功年老化的神经机制。基于选择性优化与补偿模型对现有理论进行整合,发现情景记忆成功年老化可能与个体的认知储备水平直接相关：高认知储备的老年人能够对情景记忆相关的脑区和脑网络进行优化且具备更强的神经补偿能力,因而其脑功能(比如,神经表征和神经加工通路的特异性)可能会保持地更好。未来研究需要更多地采用纵向设计来考察各理论之间的关系及其影响因素,从而更好地解释记忆成功年老化的神经机制并为提升老年人的脑与认知健康提供支持。     

Differential trajectories of age-related changes in components of executive and memory processes

Several studies have demonstrated age-related declines in general executive function and memory. In this study, we examined cross-sectional and longitudinal age effects in more specific cognitive processes that constitute executive function and memory. We postulated that, whereas some components of executive and memory functions would show age differences and longitudinal declines, other specific abilities would be maintained or even improve with repeated testing. In a sample of individuals ≥55 years old from the Baltimore Longitudinal Study of Aging, we found longitudinal declines in inhibition, manipulation, semantic retrieval, phonological retrieval, switching, and long-term memory over a maximum of 14 years follow-up. In contrast, abstraction, capacity, chunking, discrimination, and short-term memory were maintained or even improved longitudinally, probably due in part to repeated testing. Moreover, whereas several different abilities were correlated across participants' cross-sectional performance, longitudinal changes in performance showed more heterogeneous trajectories. Finally, compared with cross-sectional performance, longitudinal trajectories showed better distinction between participants with and those without later cognitive impairment. These results show that longitudinal cognitive aging of executive and memory functions is not a uniform process but a heterogeneous one and suggest that certain executive and memory functions remain stable despite age-related declines in other component processes. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Inferior Parietal Perfusion, Lateralization, and Neuropsychological Dysfunction in Alzheimer's Disease

The severity of inferior parietal perfusion deficits in Alzheimer's disease (AD) is strongly associated with global intellectual decline. The relationship to specific losses of neuropsychological functioning, however, is less clear, as is the relative importance of the side (left vs. right) of hemispheric deficit. In this study, 53 patients with probable AD and 35 elderly controls received both a resting¹³³Xe rCBF measurement and neuropsychological examination. AD patients demonstrated the expected bilateral deficits in inferior parietal perfusion, as well as impairment on measures of mental status, intelligence, verbal and visual memory, attention, language, and construction abilities. The severity of this bilateral parietal deficit, in turn, was associated with virtually all of these AD-related neuropsychological impairments, most strongly with declining Performance IQ. Left-sided deficits correlated better with overall declines in IQ, as well as with declining attention and language fluency. Right-sided deficits, on the other hand, correlated best with declines in mental status and—paradoxically—verbal memory and contributed independently to declines in Full Scale and Performance IQ. In terms of the number and strength of their association to neuropsychological measures, left-sided deficits appear much more predictive of cognitive decline in AD. Right-sided deficits, however, may be most important for predicting aspects of performance skill that are only indirectly assessed in standard paper-and-pencil format. Overall, it appears that both sides make significant, but independent contributions to general functional decline in AD, but that left-sided deficits are more closely associated with cognitive decline as measured by most standard neuropsychological measures.     

Proactive interference in working memory is related to adult age and cognitive factors: cross-sectional and longitudinal evidence from the Betula study

ABSTRACT

In working memory (WM), successful maintenance of information is affected by interference. Older adults may be especially susceptible to the effects of interference, which may cause age-related cognitive impairments. A relative score of IC was derived from cross-sectional (n = 869) and longitudinal (n = 443) data to investigate (1) if IC is reduced in normal aging, (2) if individual differences in IC related to individual performance in other cognitive domains, and (3) if 5-year change in IC is related to change in general cognition. Older age was associated with reduced IC, but no decline in IC occurred over 5 years. Also, the ability to control interference in WM was related to performance in episodic memory, verbal fluency, and block design. We also found that IC mediates the relationship between age and cognition, suggesting that age-related cognitive decline is linked to IC. Finally, we demonstrate that change in IC was related to decline in episodic memory.     

Cognitive functioning in young "social drinkers": is there impairment to detect?

Literature on the cognitive effects of nonexcessive alcohol use suggests that relatively high-quantity-per-occasion use may be related to subsequent decreases in sober-state abstracting skills in adults, but provides no clear prediction for youth. The need to identify persistent alcohol-intake effects on cognition is particularly acute for the period of adolescence and young adulthood because even slight damage may impair developmentally significant skills. We examine the relation between multiple measures of neuropsychological status and both continuous and categorical measures of alcohol-use patterns in an age- and sex-stratified sample of 1,308 18-, 21-, and 24-year-olds. The results of correlational and hierarchial regression analyses suggest that cognitive performance bears little direct relation to drinking behaviors in young nonclinical males and females. Although the data provide no strong support for the hypothesis of a causal relationship between alcohol use and cognitive functioning, there is a slight suggestion that frequent high-quantity consumption may become a salient parameter of use as subjects age. Prospective longitudinal data are needed to explore the directional causality of effects.     

Relationship between physical prowess and cognitive function

There is some evidence about the low relationship between physical prowess and cognitive function (Posthuma, Mulder, Boomsma & de Geus, 2002). The aim of this paper is to investigate the relationship between cognitive variables (spatial ability, reasoning, numerical ability, inductive reasoning, and reasoning and verbal comprehension) and physical prowess in sport performance (agility circuit, coordination circuit, horizontal jump, swimming and sprint racing). Two studies were performance. In the first one we applied a battery of standardized cognitive tests and a battery of physical grading tests to 400 subjects. When we applied factor analysis to the physical prowess and the cognitive variables, we found one general factor in cognitive variables and one general factor in physical prowess. We found a low relationship between both factors (.21). In the second study we compare the cognitive abilities in elite and amateur sport people. Results show that elite gymnastics people present higher cognitive abilities than amateur sportspeople. It should be relevant in order to clarify the total set of variables involved in sport performance.     

Declarative verbal memory impairments in middle-aged women who are caregivers of offspring with autism spectrum disorders: The role of negative affect and testosterone

Caring for offspring diagnosed with a chronic psychological disorder such as autism spectrum disorder (ASD) is used in research as a model of chronic stress. This chronic stress has been reported to have deleterious effects on caregivers' cognition, particularly in verbal declarative memory. Moreover, such cognitive decline may be mediated by testosterone (T) levels and negative affect, understood as depressive mood together with high anxiety and anger. This study aimed to compare declarative memory function in middle-aged women who were caregivers for individuals with ASD (n = 24; mean age = 45) and female controls (n = 22; mean age = 45), using a standardised memory test (Rey's Auditory Verbal Learning Test). It also sought to examine the role of care recipient characteristics, negative mood and T levels in memory impairments. ASD caregivers were highly sensitive to proactive interference and verbal forgetting. In addition, they had higher negative affect and T levels, both of which have been associated with poorer verbal memory performance. Moreover, the number of years of caregiving affected memory performance and negative affect, especially, in terms of anger feelings. On the other hand, T levels in caregivers had a curvilinear relationship with verbal memory performance; that is, increases in T were associated with improvements in verbal memory performance up to a certain point, but subsequently, memory performance decreased with increasing T. Chronic stress may produce disturbances in mood and hormonal levels, which in turn might increase the likelihood of developing declarative memory impairments although caregivers do not show a generalised decline in memory. These findings should be taken into account for understanding the impact of cognitive impairments on the ability to provide optimal caregiving.     

Influence of divergent and convergent thinking on visuomotor adaptation in young and older adults

Visuomotor adaptation declines in older age. This has been attributed to cognitive impairments. One relevant cognitive function could be creativity, since creativity is implicated as mediator of early learning. The present study therefore evaluates whether two aspects of creativity, divergent and convergent thinking, are differentially involved in the age-dependent decline of visuomotor adaptation.In 25 young and 24 older volunteers, divergent thinking was assessed by the alternative-uses-task (AUT), convergent thinking by the Intelligenz-Struktur-Test-2000 (IST), and sensorimotor-adaptation by a pointing task with 60° rotated visual feedback.Young participants outperformed older participants in all three tasks. AUT scores were positively associated with young but not older participants’ adaptive performance, whereas IST scores were negatively associated with older but not young participants’ adaptive performance. This pattern of findings could be attributed to a consistent relationship between AUT, IST and adaptation; taking this into account, adaptation deficits of older participants were no longer significant.We conclude that divergent thinking supports workaround-strategies during adaptation, but doesn’t influence visuomotor recalibration. Furthermore, the decay of divergent thinking in older adults may explain most of age-related decline of adaptive strategies. When the age-related decay of divergent thinking coincides with well-preserved convergent thinking, adaptation suffers most.