Developmental changes in neural activity to familiar words and gestures

Infants younger than 20 months of age interpret both words and symbolic gestures as object names. Later in development words and gestures take on divergent communicative functions. Here, we examined patterns of brain activity to words and gestures in typically developing infants at 18 and 26 months of age. Event-related potentials (ERPs) were recorded during a match/mismatch task. At 18 months, an N400 mismatch effect was observed for pictures preceded by both words and gestures. At 26 months the N400 effect was limited to words. The results provide the first neurobiological evidence showing developmental changes in semantic processing of gestures.     

Does the generation effect occur for pictures?

The generation effect is the finding that self-generated stimuli are recalled and recognized better than read stimuli. The effect has been demonstrated primarily with words. This article examines the effect for pictures in two experiments: Subjects named complete pictures (name condition) and fragmented pictures (generation condition). In Experiment 1, memory was tested in 3 explicit tasks: free recall, yes/no recognition, and a source-monitoring task on whether each picture was complete or fragmented (the complete/incomplete task). The generation effect was found for all 3 tasks. However, in the recognition and source-monitoring tasks, the generation effect was observed only in the generation condition. We hypothesized that absence of the effect in the name condition was due to the sensory or process match effect between study and test pictures and the superior identification of pictures in the name condition. Therefore, stimuli were changed from pictures to their names in Experiment 2. Memory was tested in the recognition task, complete/incomplete task, and second source-monitoring task (success/failure) on whether each picture had been identified successfully. The generation effect was observed for all 3 tasks. These results suggest that memory of structural and semantic characteristics and of success in identification of generated pictures may contribute to the generation effect.     

A funny thing happened on the way to articulation: N400 attenuation despite behavioral interference in picture naming

We measured Event-Related Potentials (ERPs) and naming times to picture targets preceded by masked words (stimulus onset asynchrony: 80 ms) that shared one of three different types of relationship with the names of the pictures: (1) Identity related, in which the prime was the name of the picture ("socks" - ), (2) Phonemic Onset related, in which the initial segment of the prime was the same as the name of the picture ("log" - ), and (3) Semantically related in which the prime was a co-category exemplar and associated with the name of the picture ("cake" - ). Each type of related picture target was contrasted with an Unrelated picture target, resulting in a 3×2 design that crossed Relationship Type between the word and the target picture (Identity, Phonemic Onset and Semantic) with Relatedness (Related and Unrelated). Modulation of the N400 component to related (versus unrelated) pictures was taken to reflect semantic processing at the interface between the picture's conceptual features and its lemma, while naming times reflected the end product of all stages of processing. Both attenuation of the N400 and shorter naming times were observed to pictures preceded by Identity related (versus Unrelated) words. No ERP effects within 600 ms, but shorter naming times, were observed to pictures preceded by Phonemic Onset related (versus Unrelated) words. An attenuated N400 (electrophysiological semantic priming) but longer naming times (behavioral semantic interference) were observed to pictures preceded by Semantically related (versus Unrelated) words. These dissociations between ERP modulation and naming times suggest that (a) phonemic onset priming occurred late, during encoding of the articulatory response, and (b) semantic behavioral interference was not driven by competition at the lemma level of representation, but rather occurred at a later stage of production.     

Dual-coding, context-availability, and concreteness effects in sentence comprehension: an electrophysiological investigation.

Event-related potentials were recorded in 2 experiments while participants read sentences in a word-by-word congruency judgment task. Sentence final words were either congruent, semantically anomalous (Experiments 1 and 2), or neutral (Experiment 2) with respect to sentence context. Half of all final words referred to concrete and half to abstract concepts. A different scalp distribution of the N400 to concrete and abstract final words was found for anomalous and neutral, but not congruent sentences. Although the interaction of context and concreteness is consistent with the context-availability model, the differential scalp distribution of effects for concrete and abstract words, as well as larger context effects for concrete words, was interpreted as being more consistent with an extended dual-code account of semantic processing.     

Preserved word-stem-completion priming of semantically encoded information in Alzheimer's disease

Alzheimer's disease (AD) patients and normal elderly control subjects completed 80 standardized sentence frames with single words, yielding a measure of semantic memory. Memory for best fit sentence endings was then tested either explicitly, with a forced-choice recognition task, or implicitly, with a word-stem-completion task. The patients completed fewer sentences with best fit word endings than did the control subjects. Explicit retention was markedly defective in the AD group, but word-stem completion was normal. The preserved word-stem completion in AD is discussed in terms of encoding operations and transfer-appropriate processing.     

Dysnomia in Alzheimer's disease: an evaluation of neurobehavioral subtypes.

The relative influence of perceptual and semantic features on naming performance was investigated with reference to the neurobehavioral profiles displayed by patients with Alzheimer's disease (AD). Forty-one patients were classified as manifesting a verbal, visual, or global subtype based upon their pattern of neuropsychological functioning. Perceptual characteristics of to-be-named pictures were varied by manipulating the amount of line detail, whereas semantic qualities were varied by altering word frequency norms. All AD subtypes were less accurate than normal elderly controls in naming low frequency pictures. Patients and controls took longer to name low frequency and high complexity pictures, and this effect was comparable across the AD groups. Patients with predominantly visual deficits were significantly slower in naming than controls, and those with verbal impairments made a higher proportion of semantic naming errors when compared to patients displaying visual or severe global impairments. These results suggest that deficits in semantic processing contribute to naming dysfunction in AD, and they highlight the importance of examining dissociations among neurobehavioral subtypes.     

Modulating younger and older adults’ performance in ignoring pictorial information during a word matching task

Using both behavioural and event-related potential (ERP) data, the current study sought to examine the neurophysiological underpinnings for the effect of distracting pictorial information on semantic word matching performance in younger and older adults. This was tested in the context of semantic relations between task-relevant word pairs, a task-irrelevant picture and the resultant N400 differences in ERP. Younger and older adults were shown a context word superimposed on a to-be-ignored picture, followed by a test word. Their task was to determine whether the prime and test words were semantically related. The to-be-ignored pictures were interfering (for ‘No’ trials), facilitating (for ‘Yes’ trials), or neutral (for both ‘Yes’ and ‘No’ trials) to the expected responses. The interfering and facilitatory effects of to-be-ignored pictures were assessed under more automatic and more controlled conditions by manipulating the context–test interstimulus-interval (ISI) as 50 ms and 1000 ms, respectively. The analysis of the N400 at centro-parietal sites during test word display revealed similar N400 amplitudes for the ‘No’ response trials at the two ISIs, suggesting that younger and older adults showed an equivalent effect from interfering pictures. In contrast, younger adults showed greater reductions in the N400, as compared to older adults, for ‘Yes’ trials indicating differential effects in facilitation from to-be-ignored pictorial information, but only in the long ISI condition. The data are discussed in terms of age differences in resource demanding strategy use during a semantic word matching task, specifically during controlled retrieval.     

Modulating younger and older adults’ performance in ignoring pictorial information during a word matching task

Using both behavioural and event-related potential (ERP) data, the current study sought to examine the neurophysiological underpinnings for the effect of distracting pictorial information on semantic word matching performance in younger and older adults. This was tested in the context of semantic relations between task-relevant word pairs, a task-irrelevant picture and the resultant N400 differences in ERP. Younger and older adults were shown a context word superimposed on a to-be-ignored picture, followed by a test word. Their task was to determine whether the prime and test words were semantically related. The to-be-ignored pictures were interfering (for ‘No’ trials), facilitating (for ‘Yes’ trials), or neutral (for both ‘Yes’ and ‘No’ trials) to the expected responses. The interfering and facilitatory effects of to-be-ignored pictures were assessed under more automatic and more controlled conditions by manipulating the context–test interstimulus-interval (ISI) as 50 ms and 1000 ms, respectively. The analysis of the N400 at centro-parietal sites during test word display revealed similar N400 amplitudes for the ‘No’ response trials at the two ISIs, suggesting that younger and older adults showed an equivalent effect from interfering pictures. In contrast, younger adults showed greater reductions in the N400, as compared to older adults, for ‘Yes’ trials indicating differential effects in facilitation from to-be-ignored pictorial information, but only in the long ISI condition. The data are discussed in terms of age differences in resource demanding strategy use during a semantic word matching task, specifically during controlled retrieval.     

Behavioral and electrical brain measures of semantic priming in patients with Alzheimer's disease: implications for access failure versus deterioration hypotheses

This study investigated the nature of anomia and semantic memory deficits in patients with Alzheimer's disease (DAT). We measured reaction time (RT) and the N400 event-related brain potential (ERP) in a word-picture semantic priming paradigm for DAT patients and elderly controls. For patients, pictures were classified as a function of the individual's naming ability to determine whether naming deficits reflected a failure to access a picture's name or reflected a deterioration of its semantic representation. As expected, DAT patients had significantly poorer naming performance than controls. For successfully named pictures, robust RT and ERP priming effects were obtained in both groups. In DAT patients, priming for unnamed pictures was heterogeneous. The results are discussed in terms of current hypotheses of semantic memory deficits in DAT.     

Differential impacts of age of acquisition on letter and semantic fluency in Alzheimer's disease patients and healthy older adults

The degree to which the typical age of acquisition (AoA) of words and word frequency have separable influences on verbal production tasks has been strongly debated. To examine the overlap between these factors in verbal fluency tasks, the performance of Alzheimer's disease (AD) patients (N = 34) and normal elderly controls (N = 36) was compared on semantic (e.g., vegetables) and letter (e.g., words that begin with F) fluency tasks. These comparisons revealed that words generated for the semantic fluency task had an earlier AoA while words generated for the letter fluency task had a higher word frequency. Differences in AoA between AD patients and controls were larger for semantic than letter fluency. These results suggest that AoA has an effect on verbal production that is independent of word frequency and that AoA has a semantic locus.     

Three kinds of rhymes: An ERP study

In a simple prime-target visual rhyming paradigm, pairs of words, nonwords, and single letters elicited similar event-related potential (ERP) rhyming effects in young adults. Within each condition, primes elicited contingent negative variation (CNV) while nonrhyming targets elicited more negative waveforms than rhyming targets within the 320-500ms (N400/N450) time window. The target rhyming effect, apparently primarily an index of phonological processing, was similar across conditions but tended to be smaller in mean amplitude for letters. One of the first reports of such a letter rhyming effect in the ERP literature, these findings could be important developmentally because letter rhyme tasks simultaneously index the two best predictors of ease of learning to read: letter name knowledge and phonological awareness.     

新颖词汇学习中大脑激活模式的fMRI研究

该研究利用功能磁共振脑成像(fMRI)技术,比较在新颖语言学习和母语学习过程中大脑皮层参与的异同。实验设置德语学习和汉语学习两个条件,采用跨通道联结学习范式,要求被试在听到听觉词汇后,按键判断屏幕上所呈现的图片是否与所听词汇匹配。行为数据显示,被试在六段实验后基本掌握了德语语音和语义之间的联结关系;脑成像数据显示,两种学习任务都激活了语言加工的主要脑区,而德语词汇学习过程相比汉语参照条件对应的颞叶激活强度与范围有较大的差异,并且比汉语条件表现出更显著的前额叶区域激活。     

On the Brain Response to Syntactic Anomalies: Manipulations of Word Position and Word Class Reveal Individual Differences

In two experiments, event-related brain potentials (ERPs) were recorded from 13 scalp locations while subjects read sentences containing a syntactically or a semantically anomalous word. The position (sentence-embedded vs sentence-final) and word class (open vs closed) of the syntactic anomalies were manipulated. In both experiments, semantically anomalous words elicited an enhanced N400 component. Syntactically anomalous closed class words elicited a widely distributed late positive wave (P600) regardless of the word's position and a smaller negative-going effect that was largest over anterior sites when the anomaly occurred in sentence-final position. The response to syntactically anomalous open class words revealed striking qualitative individual differences: These words elicited a P600 response in the majority of subjects and an N400 response in others. The proportion of subjects exhibiting the N400 response was greater when the anomaly occurred in sentence-final position. These results are interpreted in the context of prior findings, and implications for the hypothesis that syntactic and semantic anomalies elicit distinct brain potentials are discussed.     

Event-related potentials and the semantic matching of pictures

Event-related potentials (ERPs) were recorded from one midline and three pairs of lateral electrodes while subjects determined whether pairs of sequentially presented pictures were semantically associated. The ERPs evoked by the second picture of each pair differed as a consequence of whether it was associated with its predecessor, such that ERPs to nonassociated pictures were more negative-going than those to associated items. These differences resulted from the modulation of two ERP components, one frontally distributed and centered on an N300 deflection, the other distributed more widely over the scalp and encompassing an N450 deflection. The modulation of N450 is interpreted as further evidence that the "N400" ERP component is sensitive to semantic relationships between nonverbal stimuli. The earlier N300 effects, which do not appear to occur when ERPs are evoked by semantically primed and unprimed words, could suggest that the semantic processing of pictorial stimuli involves neural systems different from those associated with the semantic processing of words.     

汉字词和图片命名与分类的比较

采用命名与分类任务考察了汉字词和图片命名与分类的特点,揭示义符在汉字词和图片命名与分类中的作用。结果表明,汉字词和图片的命名与分类与拼音文字的词和图片的命名和分类既有共性,又有差异。汉字词和图片的命名与分类具有不对称性：汉字词的命名快于汉字词的分类,图片的分类快于图片的命名。义符对于汉字词和图片的命名与分类的影响具有不对称性：对汉字词的加工有重要影响,对图片的加工无影响;对汉字词的分类有重要影响,对汉字词的命名无影响。被试对有标示类别的义符的词的分类显著快于对无标示类别的义符的词的分类,甚至快于对图片的分类。所以如此,与汉字词的结构特点有关。汉字形声字多用义符来标记事物的类别,提供了重要的类别信息。根据上述结果,作者构建了汉字词和图片认知加工的综合模型     

Picture priming in normal aging and Alzheimer's disease

The present study investigated age invariance for naming pictures and whether implicit memory is spared in Alzheimer's disease (AD). During the study phase, young adults, AD patients, and older controls were shown outlines of familiar pictures. After a distracter task, implicit memory was assessed incidentally. The results showed similar visual priming for the three groups, although young adults responded faster than the two older groups. Moreover, the number of errors was smaller for studied than for non-studied pictures. This pattern of results was repeated across the three groups, although AD patients produced more errors than young adults and older controls, and there were no differences between these latter groups. These results confirmed previous visual and haptic findings showing unimpaired perceptual priming in normal aging and AD patients when implicit memory is assessed using identification tasks. These results are interpreted from a cognitive neuroscience perspective.     

内隐重复效应影响外显工作记忆的年龄差异

采用延迟样本匹配任务并控制被试对部分项目的有意识学习经验, 当前研究考察了老年被试与青年被试在追逐靶、排除分心物的过程中, 重复启动效应如何受到项目外显学习经验的影响。老年被试和青年被试首先学习一些物体图片, 这些熟悉的图片与一些新图片作为之后工作记忆任务的靶或分心物。结果发现, 老年被试与青年被试在追逐靶和排除分心物的过程中均受到项目之前学习经验的影响。无论是老年被试还是青年被试, 对靶的反应时均快于对分心物的反应时, 对外显学习过的靶(即熟悉靶)的反应时快于对未学习过的靶(即新靶)的反应时, 而拒绝熟悉的分心物需要的时间长于拒绝新分心物的时间。其次, 老年被试与青年被试均表现出对靶的重复效应, 即当靶(无论是熟悉的还是新的)在任务中重复出现时, 对其的反应时加快; 然而, 对分心物的重复效应显著减小。随着项目多次重复, 重复效应整体上减小, 但该效应的变化受到项目属性(靶或分心物)以及项目之前学习经验的影响。重要的是, 当熟悉的分心物反复出现时, 老年被试不但没有出现重复效应, 反而在拒绝该熟悉分心物上表现出困难, 反应时显著延长, 而在青年被试上没有该表现。这些结果说明, 老年被试的工作记忆任务成绩容易受到内隐熟悉性的干扰, 重复出现的干扰项产生的熟悉性使得老年被试难以拒绝。     

双语即时切换下非目标语言语音和语义的激活状态

本研究采用双语即时切换范式, 探讨非熟练中英双语者在对目标语言(启动词)语音或语义的加工过程中非目标语言的激活状态。实验1设置了与启动词的翻译对等词存在语音相关或无关的两类配对词, 要求被试进行语音判断任务, 结果表明, 不论哪种切换条件, 两类配对词在反应时和P200成分上都没有差异, 说明目标语言在语音加工过程中非目标语言的语音层面没有得到自动激活, 从而没有产生启动效应。实验2则设置了语义相关和无关配对词, 并进行语义判断任务, 结果在两种切换条件下都发现明显的语义启动效应及N400差异, 说明非目标语言在语义层面上有得到自动激活, 但激活的程度表现出切换方向上的不一致, L1-L2切换下的语义启动量要明显大于L2-L1, 并且L1-L2的N400差异主要表现在前部脑区, 持续时间更久, 而L2-L1的N400差异主要表现在后部脑区, 但持续时间较短, 表明对于非熟练的双语者来说, 不同切换方向下对共享语义表征的激活加工是不一样的。     

Iconic gestures prime related concepts: An ERP study

To assess priming by iconic gestures, we recorded EEG (at 29 scalp sites) in two experiments while adults watched short, soundless videos of spontaneously produced, cospeech iconic gestures followed by related or unrelated probe words. In Experiment 1, participants classified the relatedness between gestures and words. In Experiment 2, they attended to stimuli, and performed an incidental recognition memory test on words presented during the EEG recording session. Event-related potentials (ERPs) time-locked to the onset of probe words were measured, along with response latencies and word recognition rates. Although word relatedness did not affect reaction times or recognition rates, contextually related probe words elicited less-negative ERPs than did unrelated ones between 300 and 500 msec after stimulus onset (N400) in both experiments. These findings demonstrate sensitivity to semantic relations between iconic gestures and words in brain activity engendered during word comprehension.     

The role of age of acquisition in picture and word naming in dyslexic adults

To date, there has been numerous reports that early acquired pictures and words are named faster than late acquired pictures and words in normal reading but it is not established whether age of acquisition (AoA) has the same impact on adult dyslexic naming, especially in a transparent orthography such as Turkish. Independent ratings were obtained for AoA, frequency, name agreement, and object familiarity in Turkish for all items in the Snodgrass and Vanderwart line drawing set. Dyslexic (N= 15) and non-dyslexic (N= 15) university undergraduates were asked to name 30 early acquired and 30 late acquired pictures and picture names standardized and selected from these norms. As predicted, there were main effects for (a) AoA with reaction times (RTs) for Early items named faster than Late items, (b) reader status with non-dyslexic students faster than dyslexic students, and (c) stimuli types with pictures named slower than words. A two-way interaction between reader status and stimuli type was also significant. Implications of the results for theoretical frameworks of AoA within the cognitive architecture and normal and impaired models of reading are discussed.