HIV, Sex, and Social Change: Applying ESID Principles to HIV Prevention Research

The HIV epidemic has been the most significant public health crisis of the last 2 decades. Although Experimental Social Innovation and Dissemination (ESID) principles have been used by many HIV prevention researchers, the clearest application is the series of model-building and replication experiments conducted by Kelly and colleagues. The model mobilized, trained, and engaged key opinion leaders to serve as behavior change and safe-sex endorsers in their social networks. This paper illustrates how ESID principles were used to develop, test, and disseminate an innovative social model and discusses the challenges of applying ESID methodology in the midst of a public health emergency.     

Reassessing the Ethics of Molecular HIV Surveillance in the Era of Cluster Detection and Response: Toward HIV Data Justice

Abstract

In the United States, clinical HIV data reported to surveillance systems operated by jurisdictional departments of public health are re-used for epidemiology and prevention. In 2018, all jurisdictions began using HIV genetic sequence data from clinical drug resistance tests to identify people living with HIV in “clusters” of others with genetically similar strains. This is called “molecular HIV surveillance” (MHS). In 2019, “cluster detection and response” (CDR) programs that re-use MHS data became the “fourth pillar” of the national HIV strategy. Public health re-uses of HIV data are done without consent and are a source of concern among stakeholders. This article presents three cases that illuminate bioethical challenges associated with re-uses of clinical HIV data for public health. We focus on evidence-base, risk-benefit ratio, determining directionality of HIV transmission, consent, and ethical re-use. The conclusion offers strategies for “HIV data justice.” The essay contributes to a “bioethics of the oppressed.”     

Working Memory,Fluid Intelligence,and Attention Are Predictors of Multitasking Performance,but Polychronicity and Extraversion Are Not

This study explored predictors of multitasking performance. Based on cognitive psychology research, attention and working memory were assumed to be predictors. Fluid intelligence, polychronicity (as the preference for multitasking and the belief that their preference is the best way to handle things), and Extraversion were argued to be additional predictors. Multitasking performance was measured with the scenario "Simultaneous capacity/Multi-tasking (SIMKAP)" (n = 122). Hierarchical multiple regression analyses revealed that working memory was the most important predictor in addition to attention and fluid intelligence. The latter two constructs contributed significantly to the explained variance, but to a lesser extent. Polychronicity was not a significant predictor, nor was Extraversion. Implications for personnel selection and for time management are discussed.     

Focused attention is not enough to activate discontinuities in lines, but scrutiny is

We distinguish between the roles played by spatial attention and conscious intention in terms of their impact on the processing of segmentation signals, like discontinuities in lines, associated with the act of scrutinizing. We showed previously that the processing of discontinuities in lines can be activated. This is evidenced by an impairment in the detection of a gap between parallel elements when it follows a gap between collinear elements in the same location and orientation. This effect is no longer observed if attention is divided between two gaps in the first stimulus. The results from this study show that focusing attention on a gap between collinear elements is not enough to observe a modulation, consistently with the need to integrate, rather than to separate, collinear elements in usual conditions. The modulation is sensitive to the conscious expectations of subjects, suggesting that an intention can trigger modulations that spatial attention cannot.     

Developing a Prevention Synthesis and Translation System to Promote Science‐Based Approaches to Teen Pregnancy,HIV and STI Prevention

The Interactive Systems Framework for Dissemination and Implementation (ISF) is a multi‐system framework that can guide research‐to‐practice efforts by building and supporting the work of three interacting systems: the Prevention Delivery, Support, and Synthesis and Translation Systems. The Synthesis and Translation system is vital to bridging science and practice, yet how to develop it and train support system partners to use it is under‐researched. This article bridges this gap by offering a case example of the planning, development, and use of a synthesis and translation product called Promoting Science‐based Approaches to Teen Pregnancy Prevention using Getting To Outcomes. The case presented documents the process used for developing the synthesis and translation product, reports on efforts to engage the Prevention Support system to use the product, and how we approached building interaction between the Synthesis and Translation System and the Support System partners. Practice‐oriented evaluation data are also presented. Implications for practice, policy and research are discussed. Special Issue: Advances in Bridging Research and Practice Using the Interactive System Framework for Dissemination and Implementation; Guest Editors: Abraham Wandersman, Paul Flaspohler, Catherine A. Lesesne, Richard Puddy; Action Editor: Emilie Phillips Smith     

Medical Students' Perceptions of and Willingness to Treat Patients Who Are HIV Infected1

The purpose of this study is to examine the independent and joint influences of a patient's mode of acquisition of illness (blood transfusion vs. multiple sexual partners), attributions of responsibility (self-blame vs. chance blame), and sexual orientation (homosexual vs. heterosexual) on female and male medical students' attitudes toward and willingness to treat a patient who is HIV infected. One hundred nineteen 1st through internship-year medical students were randomly assigned to read and respond to case vignettes. Greater consistency between attribution of blame and mode of acquisition was related to more positive perceptions. Furthermore, the patient's sexual orientation influenced the providers' willingness to offer treatment, particularly for male medical students. Implications concerning health practices and medical education are considered.     

The control of stimulus-driven saccades is subject not to central, but to visual attention limitations

In three experiments, we investigated whether the control of reflexive saccades is subject to central attention limitations. In a dual-task procedure, Task 1 required either unspeeded reporting or ignoring of briefly presented masked stimuli, whereas Task 2 required a speeded saccade toward a visual target. The stimulus onset asynchrony (SOA) between the two tasks was varied. In Experiments 1 and 2, the Task 1 stimulus was one or three letters, and we asked how saccade target selection is influenced by the number of items. We found (1) longer saccade latencies at short than at long SOAs in the report condition, (2) a substantially larger latency increase for three letters than for one letter, and (3) a latency difference between SOAs in the ignore condition. Broadly, these results match the central interference theory. However, in Experiment 3, an auditory stimulus was used as the Task 1 stimulus, to test whether the interference effects in Experiments 1 and 2 were due to visual instead of central interference. Although there was a small saccade latency increase from short to long SOAs, this difference did not increase from the ignore to the report condition. To explain visual interference effects between letter encoding and stimulus-driven saccade control, we propose an extended theory of visual attention.     

脑血管病防治任重而道远

目前,我国居民前5位死亡原因依次是脑血管病、恶性肿瘤、呼吸系统疾病、心脏病以及损伤和中毒.全国每年新发病例250万,死于脑血管病超过150万,幸存者600万～700万,残疾率高达75%.中国脑血管病直接医疗费用年平均增长速度为18.04%,年均增长速度几乎倍于同期GDP增长速度(8.95%).更为严重的是,随着人口老龄化、城市化进程的加快及不良生活方式的影响,我国脑血管病发病呈逐年上升的趋势,防治形势将日益严峻.国际间比较研究显示,中国人群脑血管病的发病率和死亡率高于国际平均水平,仅次于前苏联或东欧等少数几个国家.     

HIV母婴传播防治中的现存问题和对策

通过研究分析国内外艾滋病母婴传播的防治情况,了解HIV母婴传播防治中现存的一些的问题,并提出相应的应对措施,为今后HIV母婴传播防治工作中相关政策的制定以及我国如何建立预防艾滋病母婴传播的模式提供参考,以利于HIV母婴传播防治工作的顺利开展和有效进行.     

Activity engagement is related to level, but not change in cognitive ability across adulthood

It is unclear whether the longitudinal relation between activity participation and cognitive ability is due to preserved differentiation (active individuals have higher initial levels of cognitive ability), or differential preservation (active individuals show less negative change across time). This distinction has never been evaluated after dividing time-varying activity into its two sources of variation: between-person and within-person variability. Further, few studies have investigated how the association between activity participation and cognitive ability may differ from early to older adulthood. Using the PATH Through Life Project, we evaluated whether between- and within-person variation in activity participation was associated with cognitive ability and change within cohorts aged 20-24 years, 40-44 years, and 60-64 years at baseline (n = 7,152) assessed on three occasions over an 8-year interval. Multilevel models indicated that between-person differences in activity significantly predicted baseline cognitive ability for all age cohorts and for each assessed cognitive domain (perceptual speed, short-term memory, working memory, episodic memory, and vocabulary), even after accounting for sex, education, occupational status, and physical and mental health. In each case, greater average participation was associated with higher baseline cognitive ability. However, the size of the relationship involving average activity participation and baseline cognitive ability did not differ across adulthood. Between-person activity and within-person variation in activity level were both not significantly associated with change in cognitive test performance. Results suggest that activity participation is indeed related to cognitive ability across adulthood, but only in relation to the starting value of cognitive ability, and not change over time.     

Bullying is detrimental to health, but all bullying behaviours are not necessarily equally damaging

The aim of this paper is to investigate the impact of 'negative behaviours' and 'bullying' in the workplace on the health and well-being of employees, to what extent the effects remain beyond the period of the experience as well as the extent to which they affect third-parties or witnesses. The paper also raises the question whether some behaviours associated with bullying may be more damaging than others. Potential sex differences and differences between occupational contexts are considered. To achieve these aims, a national cross-sectional study (N=5,388) was carried out. In absolute terms those who labelled their experience as bullying had substantially worse health than those who were not bullied. However, counter to what was expected, stronger associations were found between negative behaviour and adverse health effects than for self-reported (self-labelled) bullying and health. Previous targets as well as witnesses also reported worse health than those who were neither bullied nor had witnessed bullying. The findings also imply that some negative behaviours were more difficult to deal with than others. In all cases differences between the sexes and between occupational contexts emerged.     

Coping Strategies,Substance Use,Sexual Activity,and HIV Sexual Risks in a Sample of Gay Male STD Patients1

The relationships of coping strategies with levels of substance use and sexual activity, and with HIV sexual risks, are examined in a sample of gay male STD clinic patients (n = 416). Previous research has suggested that use of problem-focused coping strategies should be negatively related to levels of substance use, levels of sexual activity, and HIV sexual risks; use of emotion-focused coping strategies should be positively related to these outcomes. It is argued that substance use and sexual activity clearly fit within a coping perspective, but that the HIV sexual risks/coping relationship is less clear. In multivariate analysis, the problem-focused strategy of advice seeking is negatively related to the number of types of drugs used and to the number of sexual partners; the problem-focused strategy of support seeking is negatively related to the number of days using drugs; and the use of emotion-focused strategies is positively related to the number of types of drugs used. Problem-focused coping strategies are less directly related to engaging in HIV sexual risks when measures of substance use and of sexual activity are included in the prediction; emotion-focused coping strategies are more stably related to HIV risk. Indirect effects of coping on HIV risk are also identified through the effects of coping on the number of types of drugs used, number of sex partners, and number of times having sex. It is proposed that the relationships between coping and levels of substance use and sexual activity reflect the use of these activities as ways of relieving strain, but that relationships between coping and HIV sexual risks involve less clearly understood direct and indirect relationships.     

Agreeableness is related to social‐cognitive,but not social‐perceptual,theory of mind

We hypothesise on a number of grounds that the personality dimension of Agreeableness may be associated with inter‐individual differences in theory of mind (ToM) functioning. However, it is important to distinguish social‐perceptual from social‐cognitive ToM. Previous findings on ToM in psychopathic individuals, sex differences in ToM and the associations between ToM and social relationships, all suggest that social‐cognitive ToM is more likely than social‐perceptual ToM to relate to Agreeableness. In separate empirical studies, we find that Agreeableness is substantially correlated with social‐cognitive ToM performance, but uncorrelated with social‐perceptual ToM performance. We suggest that the propensity or motivation to attend to the mental states of others may be central to the personality dimension of Agreeableness. Copyright © 2008 John Wiley & Sons, Ltd.     

Parallel averaging of size is possible but range-limited: A reply to Marchant,Simons, and De Fockert

In their recent paper, Marchant, Simons, and De Fockert (2013) claimed that the ability to average between multiple items of different sizes is limited by small samples of arbitrarily attended members of a set. This claim is based on a finding that observers are good at representing the average when an ensemble includes only two sizes distributed among all items (regular sets), but their performance gets worse when the number of sizes increases with the number of items (irregular sets). We argue that an important factor not considered by Marchant et al. (2013) is the range of size variation that was much bigger in their irregular sets. We manipulated this factor across our experiments and found almost the same efficiency of averaging for both regular and irregular sets when the range was stabilized. Moreover, highly regular sets consisting only of small and large items (two-peaks distributions) were averaged with greater error than sets with small, large, and intermediate items, suggesting a segmentation threshold determining whether all variable items are perceived as a single ensemble or distinct subsets. Our results demonstrate that averaging can actually be parallel but the visual system has some difficulties with it when some items differ too much from others.     

Memories of "Bad" Days Are More Biased Than Memories of "Good" Days: Past Saturdays Vary, but Past Mondays Are Always Blue

In a survey of 202 participants, Monday was cited most frequently as the worst morning (65%) and evening (35%); whereas Friday (43%) and Saturday (45%) were the best evening and morning, respectively. Test–retest reliability was higher for worst morning (.89) and evening (.83) judgments, compared to best morning (.44) and evening (.61) judgments. In a second survey of 353 participants, ratings of typical moods were lowest on Monday, rising to a peak on Saturday, but actual momentary moods showed little or no variation by day. Remembered moods from the previous Monday were more strongly related to typical moods than to actual moods, but the reverse was true of remembered moods from the previous Friday and Saturday.