Test of Alternative Hypotheses Explaining the Comorbidity Between Attention-Deficit/Hyperactivity Disorder and Conduct Disorder

There is significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD). The conclusions of studies that examined the causes of comorbidity between ADHD and CD conflict, with some researchers finding support for the three independent disorders model and others finding support for the correlated risk factors model. We tested these models and eleven alternative hypotheses using the same analytical approach. The participants were 110 monozygotic twin pairs and 181 dizygotic twin pairs recruited from the Colorado Learning Disabilities Research Center Twin Study. The three independent disorders model did not fit the data, whereas the correlated risk factors model fit the data well. Several other comorbidity models fit the data as well as or better than the correlated risk factors model. The results suggest that correlated risk factors are a better explanation for the comorbidity between ADHD and CD than a third, independent ADHD+CD subtype.     

Environmental contributions to preschoolers' semantic fluency

Semantic fluency was examined in Hebrew‐speaking 5‐year‐old monozygotic and dizygotic twins (N = 396, 198 pairs), 22% of them with mother‐reported speech‐related problems. There were positive correlations of similar magnitudes among monozygotic, same‐sex dizygotic, and opposite‐sex dizygotic twins. Analyses showed no genetic effects, alongside significant shared (39%) and non‐shared environmental (61%) effects on fluency scores. The presence of speech‐related problems in one twin affected the fluency score of the co‐twin. A multivariate regression analysis revealed that parental education and length of stay at daycare significantly predicted fluency scores. We suggest that semantic fluency performance is highly affected by environmental factors at age 5 although genetic effects might emerge later on.     

Genetic and environmental contributions to loneliness in children

This report presents the results of the first behavioral genetic studies of children's loneliness. Data were collected using both an adoption design and a twin-sibling design. As part of the Colorado Adoption Project, 133 sibling pairs (69 biologically related pairs and 64 unrelated pairs in adoptive families) completed a general loneliness scale when they were 9, 10, 11, and 12 years old. As part of the San Diego Sibling Study, 142 sibling pairs (22 monozygotic twin, 40 dizygotic twin, and 80 full-sibling pairs) between the ages of 8 and 14 years old completed a scale assessing loneliness at school. Both studies showed significant heritability and nonshared environmental influences for children's loneliness.     

The genetics of economic risk preferences

We examine the influence of genetics on economic risk preferences by administering a measure of these preferences to monozygotic (MZ) (i.e., identical) and dizygotic (DZ) (i.e., non‐identical) twin pairs. Our analysis supports a dominant genetic effect and virtually no additive genetic effect on economic risk preferences, with the heritability of preferences estimated at 0.63. These findings suggest that over half of the variation in such preferences can be explained by genetic factors, with the remainder of the variance explained by environmental influences not shared among sibling twins. We discuss the implications of our findings for the study of individual differences in economic risk preferences. Copyright © 2009 John Wiley & Sons, Ltd.     

Sex differences in genetic and environmental effects on aggression

The aim of the present study was to investigate the genetic and environmental factors influencing teacher and parental rated aggression in boys and girls, asking whether the magnitude of these effects is similar across rater and sex. The study is part of an ongoing nationwide twin‐family study of behavioral development and health habits carried out in Finland. The sample consisted of 1651 twin pairs (264 monozygotic male, 300 monozygotic female, 292 dizygotic male, 278 dizygotic female, and 517 dizygotic opposite‐sex twin pairs), representing subsets of five 11‐ to 12‐year‐old twin cohorts (b. 1983–1987). The data were collected using the teacher and parental rating forms of the Multidimensional Peer Nomination Inventory. Structural equation models of sex‐limitation assessed sex differences in genetic and environmental influences on aggression. The results suggested significant genetic, common environmental, and specific environmental effects on aggression in both boys and girls, but the best fitting model differed depending on the informant. For both ratings, boys showed lower levels of heritability and higher levels of common environment than girls. In addition, the teacher rating data also suggested the presence of either sex‐specific common environmental effects or sex‐specific genetic effects. Support is provided also for sibling contrast effects, either at the behavioral level or as a rater bias. Aggr. Behav. 29:55–68, 2003. © 2003 Wiley‐Liss, Inc.     

The association between g and K in a sample of 4246 Swedish twins: A behavior genetic analysis

Whereas the heritability of general intelligence (g) is very well documented, there are relatively few reports of the heritability of life history speed (K). Moreover, the correlation between g and K is of great theoretical significance. Here, we examine the heritabilities of g and K in a sample of 2123 complete Swedish twin pairs, as well as looking for evidence of common genetic variance between the two. We find a significant albeit very small correlation between relatively strong measures of g (the Wiener Matrizen Test) and K (the Mini-K; r = .03, p < .05). Controlling for attenuation by reliabilities and imperfect validity using validity generalization increased the correlation to rho = .05 (p < .05). There was no significant common additivity between g and K, however path elimination in behavior genetic structural equations modeling suggests that the small common variance is nonetheless likely to stem from shared additive genetic influences rather than from environmental influences. The implications of this are discussed. Our new estimate of the heritability of the life history in the Swedish population is a particularly significant result, as the heritability of life history speed has never before been established in non-US samples.     

Blood pressure reactivity in adult male twins

The purpose of the present investigation was to examine possible genetic contributions to cardiovascular reactivity by contrasting patterns of association in 82 monozygotic (MZ) and 88 dizygotic (DZ) adult male twin pairs (age range = 21 to 61 years, M = 35 years). Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded during baseline and during a mental arithmetic task (i.e., serial subtraction). The task produced significant elevations in all three cardiovascular measures (i.e., 10 mmHg SBP, 8 mmHg DBP, and 6 bpm HR, respectively). Levels of SBP and DBP reactivity were significantly correlated in MZ pairs but not in DZ pairs. Statistical tests suggest a heritability estimate of about 50% that was marginally significantly for SBP and DBP changes during the task. There was no indication of a genetic influence on HR reactivity. Resting level and static task period measures of SBP, DBP, and HR demonstrated statistically significant heritability estimates of 60% to 80%.     

Genetic influences on core self-evaluations,job satisfaction,and work stress: A behavioral genetics mediated model

In this study we investigated the mediated influence of core self-evaluations (CSE) on employee health problems via job satisfaction and work stress, and the degree to which genetic factors explain these mediated relationships. Based on data obtained from a sample of 594 Swedish twins (114 monozygotic twin pairs and 183 dizygotic twin pairs), conventional path analysis results supported the mediated effects of CSE on employee health via job satisfaction and work stress, after controlling for conscientiousness and extraversion. Behavioral genetic analyses showed significant heritability of all four variables. Moreover, we found that the mediated relationships via job satisfaction and work stress are explained by genetic factors, such that the genetic source of job satisfaction and work stress mediates the genetic influence of CSE on health problems. These results highlight the role played by genetic factors in better understanding the relationships between CSE, work attitudes, and health outcomes.     

Heritability of personality disorders in childhood: a preliminary investigation

The heritability of personality disorder features was investigated in 112 child (ages 4-15 years) twin pairs (70 monozygotic and 42 dizygotic pairs). Parents assessed personality disorder features using the Coolidge Personality and Neuropsychological Inventory for Children (CPNI; Coolidge, 1998) that measures 12 personality disorders according to the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (American Psychiatric Association, 1994). Structural equation model-fitting methods indicated that the median heritability coefficient for the 12 scales was .75 (ranging from .81 for the Dependent and Schizotypal Personality Disorder scales to .50 for the Paranoid and Passive-Aggressive Personality Disorder scales). These results suggest that childhood personality disorders have a substantial genetic component and that they are similar to heritability estimates of personality disorder traits in adults and counter hypotheses that only temperaments and higher-order personality disorder traits have significant genetic components (Paris, 1997).     

A possible genetic basis of accuracy in personality perception

An analysis was conducted to assess whether individuals are more accurate in perceiving those personality characteristics of other' that have a larger genetic component. Adult monozygotic (MZ) twins (63 pairs) and same-sex dizygotic (DZ) twins (35 pairs) completed the Personality Research Form-E (PRF) and the Sibling Evaluation of Personality Characteristics (SEPC) which consists of 20 sets of adjectives corresponding to the 20 trait scales of the PRF. Subjects also evaluated their co-twin with the SEPC. Self-other agreement correlations were then correlated with the heritability estimates of the PRF traits calculated on the same twin sample. The results suggest that accuracy in perceiving the co-twin's personality does increase with the heritability component of the personality dimension.     

Stability and change in genetic and environmental components of personality in old age

Stability and change in the mean levels and sources of variation in personality was examined. A sample of 149 monozygotic and 202 dizygotic twin pairs over 80 years were studied three times with a 2-year interval between measurement occasions. The Eysenck Personality Inventory to measure extraversion and neuroticism was used. Linear mixed models and Cholesky variance decomposition were carried out (age, gender and mortality controlled). High mean level stability was found in extraversion and neuroticism. Mortality was related to lower scores in extraversion and higher scores in neuroticism. In extraversion and neuroticism, genetic effects were moderate. Though no new genetic contributions emerged over time, significant new environmental effects were found over time. Controlling for mortality slightly increased genetic effect in extraversion.     

Sex and age effects on the inheritance of alcohol problems: a twin study.

Male monozygotic cotwins of probands with Alcohol Abuse-Dependence (n = 85) were more likely than male same-sex dizygotic cotwins (n = 96) to report alcohol, drug, and conduct disorder problems. For women, rates of problem behavior did not differ between monozygotic (n = 44) and same-sex dizygotic (n = 43) cotwins. Opposite-sex dizygotic twin data (n = 88) revealed significant cross-sex transmission; alcohol problems were greatest among male cotwins of female probands. For men, proportion of liability variance associated with additive genetic factors was significantly greater when proband had an early (h2 = .73 +/- .18) rather than late (h2 = .30 +/- .26) age of onset. For women, heritability did not vary as a function of proband's age of onset, and the pooled estimate suggested little genetic influence (h2 = .00, SE not computable). Findings suggest that genetic influences may be substantial only in the etiology of early-onset male alcoholism.     

Genetic and environmental influences on adult attachment styles

The heritability of adult attachment styles as measured by the Relationship Scales Questionnaire (RSQ) was estimated on data from a volunteer general population sample of 220 adult twin pairs (116 monozygotic pairs. 104 dizygotic pairs). Additive genetic effects accounted for 37%, 43%, and 25% of the variance in the secure, fearful, and preoccupied adult attachment styles, respectively, but none of the variance in the dismissing style. Nonshared environmental influences accounted for the majority of the variance in all styles: 63% secure, 57% fearful, 75% preoccupied, and 71% dismissing. Shared environmental effects were negligible for all styles except dismissing (29%).     

A behavioral genetic study of trait emotional intelligence

Numerous models of emotional intelligence (EI) have proposed the existence of hitherto undiscovered mental abilities, competencies, and skills. The theory of trait emotional intelligence suggests that the content domains of these models invariably contain permutations of personality traits. The two studies in this article examine the heritability of trait EI scores with a view to demonstrating empirically that the construct has a similar level of genetic influence as other personality traits. Study 1 was a family design of 133 high-school students and their parents. Regressions of offspring on midparent scores suggested median upper-limit heritability estimates of .18 at facet level, .25 at factor level, and .32 at the global trait EI level. Study 2 was a twin design (213 pairs of monozygotic [MZ] twins and 103 pairs of dizygotic [DZ] twins). It yielded median heritabilities of .42 for the facets, .44 for the factors, and .42 for global trait EI. Overall, our findings are in accordance with studies of the major personality dimensions and provide further empirical support for the conceptualization of EI as a personality trait.     

Just a minute meditation: Rapid voluntary conscious state shifts in long term meditators

Meditation induces a modified state of consciousness that remains under voluntary control. Can meditators rapidly and reversibly bring about mental state changes on demand? To check, we carried out 128 channel EEG recordings on Brahma Kumaris Rajayoga meditators (36 long term: median 14240 h meditation; 25 short term: 1095 h) and controls (25) while they tried to switch every minute between rest and meditation states in different conditions (eyes open and closed; before and after an engaging task). Long term meditators robustly shifted states with enhanced theta power (4–8 Hz) during meditation. Short term meditators had limited ability to shift between states and showed increased lower alpha power (8–10 Hz) during eyes closed meditation only when pre and post task data were combined. Controls could not shift states. Thus trained beginners can reliably meditate but it takes long term practice to exercise more refined control over meditative states.     

Genetic Support for the Dual Nature of Attention Deficit Hyperactivity Disorder: Substantial Genetic Overlap Between the Inattentive and Hyperactive–impulsive Components

Objective Attention deficit hyperactivity disorder (ADHD) is a common, complex and highly heritable disorder, characterised by inattentive, impulsive and overactive behaviour. Evidence for the heritability of ADHD measures in twin population samples has come from the analysis of total scores that combine inattentive and hyperactive–impulsive symptoms subscales. This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder. Materials and Methods Parents of 6,222 approximately 8-year-old twin pairs from the Twins Early Development Study (TEDS) population sample completed the two subscales of the Conners’ 18-item DSMIV checklist, a screening instrument for ADHD symptoms. Results Both subscales were highly heritable (hyperactive–impulsive: 88%; inattentive: 79%). Bivariate genetic modelling indicated substantial genetic overlap between the two components; however, there were significant independent genetic effects. Conclusions These findings suggest that many genes associated with the hyperactivity–impulsivity dimension will also be associated with the inattentive dimension but that there is significant genetic heterogeneity as well. These results provide genetic support for combining the two behavioural dimensions that define ADHD, but also suggest that some symptom-specific genes will also be identified. Correspondence and reprint requests to Gráinne McLoughlin, SGDP Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, Tel: +44(0) 207-848-5261; Email: g.mcloughlin@iop.kcl.ac.uk.     

Genetic and environmental influences on applied creativity: A reared-apart twin study

Applied creativity involves bringing innovation to real-life activities. The first reared-apart twin study assessing genetic and environmental origins of applied creativity, via Draw-a-House (DAH) and Draw-a-Person (DAP) tasks, is presented. Participants included 69 MZA and 53 DZA twin pairs from the Minnesota Study of Twins Reared Apart. Drawings were evaluated by four artists and four non-artists. Genetic effects were demonstrated for the DAP (.38–.47), but not for the DAH. Creative personality showed genetic effects (.50), and modest, but significant correlations with scores on the two drawings (rs = .17–.26). Both genetic and nonshared environmental influences underlie variance in applied creativity. Individuals concerned with enhancing creativity among students and others may better understand individual differences in performance and training.     

Examining genetic and environmental effects on reactive versus proactive aggression

This study compared the contribution of genes and environment to teacher-rated reactive and proactive aggression in 6-year-old twin pairs (172 pairs: 55 monozygotic girls, 48 monozygotic boys, 33 dizygotic girls, 36 dizygotic boys). Genetic effects accounted for 39% of the variance of reactive aggression and for 41% of the variance of proactive aggression. The remainder of the variance was explained by unique environmental effects. Genetic as well as unique environmental effects were significantly correlated across reactive and proactive aggression (genetic correlation = .87, environmental correlation = .34), but this overlap was largely due to a common underlying form of aggression (i.e., teacher-rated physical aggression). Once common etiological factors due to physical aggression were accounted for, reactive and proactive aggression shared no other genes and only a few environmental influences, although additional specific genetic and environmental effects were observed for both reactive and proactive aggression. These specific effects indicate that both reactive and proactive aggression may be influenced mostly by socialization experiences that are specific to each type of aggression and only to a very small degree by specific genes.     

Genetic and Environmental Influences on Two Measures of Speed of Information Processing and their Relation to Psychometric Intelligence: Evidence from the German Observational Study of Adult Twins

Speed of information processing, as measured by reaction times (RTs) in elementary cognitive tasks (ECTs), has been found to be an important correlate of human psychometric intelligence. While the heritability of psychometric intelligence is well understood, we know only a little about genetic and environmental influences on ECT performance, particularly about genetic and environmental contributions to ECT–intelligence relation. These questions were studied by employing two widely used ECTs (Sternberg's memory scanning and Posner's letter-matching task) as well as two psychometric intelligence tests (Advanced Progressive Matrices and Leistungs–Prüf System) in a large sample of 169 monozygotic (MZ) and 131 dizygotic (DZ) twin pairs. As expected, RTs correlated negatively with psychometric intelligence. Moreover, heritability estimates were substantial for both psychometric intelligence and RTs in ECTs. Finally, multivariate genetic analyses suggested that most of the phenotypic correlation between mental speed and intelligence is due to genetic factors.     

Modeling Rater Disagreement for ADHD: Are Parents or Teachers Biased?

The present study is the first to utilize twin modeling to examine whether parent-teacher disagreement for ADHD ratings is due to parent or teacher bias, or due to raters observing different but valid ADHD behaviors. A joint analysis was conducted with 106 twin pairs, including twins selected for ADHD and control twin pairs. Total ADHD scores were analyzed using multiple rater models that estimate genetic and environmental contributions common to both raters and unique to each rater. Results suggest that 1) disagreement in ADHD ratings is strongly due to parents and teachers observing different ADHD behaviors, some of which is valid and some of which is due to bias, and 2) parents may be more biased than teachers in their ADHD ratings.