Functional Consequences of HIV-Associated Neuropsychological Impairment

This review focuses on the “real world” implications of infection with HIV/AIDS from a neuropsychological perspective. Relevant literature is reviewed which examines the relationships between HIV-associated neuropsychological impairment and employment, driving, medication adherence, mood, fatigue, and interpersonal functioning. Specifically, the relative contributions of medical, cognitive, psychosocial, and psychiatric issues on whether someone with HIV/AIDS will be able to return to work, adhere to a complicated medication regimen, or safely drive a vehicle will be discussed. Methodological issues that arise in the context of measuring medication adherence or driving capacity are also explored. Finally, the impact of HIV/AIDS on mood state, fatigue, and interpersonal relationships are addressed, with particular emphasis on how these variables interact with cognition and independent functioning. The purpose of this review is to integrate neuropsychological findings with their real world correlates of functional behavior in the HIV/AIDS population.     

Heterogeneity of Neuropsychological Impairment in HIV Infection: Contributions from Mild Cognitive Impairment

Despite longstanding acknowledgement of the heterogeneity of HIV-associated neurocognitive disorders (HAND), existing HAND diagnostic methods classify according to the degree of impairment, without regard to the pattern of neuropsychological strengths and weaknesses. Research in mild cognitive impairment (MCI) has demonstrated that classifying individuals into subtypes by both their level and pattern of impairment, using either conventional or statistical methods, has etiologic and prognostic utility. Methods for characterizing the heterogeneity of MCI provide a framework that can be applied to other disorders and may be useful in clarifying some of the current challenges in the study of HAND. A small number of studies have applied these methods to examine the heterogeneity of neurocognitive function among individuals with HIV. Most have supported the existence of multiple subtypes of neurocognitive impairment, with some evidence for distinct clinicodemographic features of these subtypes, but a number of gaps exist. Following a review of diagnostic methods and challenges in the study of HAND, we summarize the literature regarding conventional and empirical subtypes of MCI and HAND and identify directions for future research regarding neurocognitive heterogeneity in HIV infection.     

The Ontogenesis of Language Impairment in Autism: A Neuropsychological Perspective

Autistic Disorder (AD) is a phenotypically heterogeneous condition characterized by impairments in social interaction, communication, and the presence of repetitive behavior and restricted interests. It is a model syndrome to investigate neural interaction and integration at the nexus of language and social cognition. This paper considers the problems of language acquisition in AD from an evolutionary and ontogenetic context. Following a review of normal language development during the formative years of brain development, we examine what is known about infant linguistic and nonlinguistic precursors of language acquisition in AD and examine how anomalies of several processes relate to language abnormalities manifest by the early elementary school years. Population heterogeneity and practical limitations inherent to the study of children currently limit a comprehensive understanding of the significance of specific neurological abnormalities in relation to observed deficits. However, convergent evidence implicates anomalies of a widely distributed neural network, involving superior temporal sulcus, superior temporal gyrus, supramarginal gyrus, insula, inferior frontal gyrus, hippocampus, amygdala and cerebellum. These anomalies reflect the cumulative effects of genetic, epigenetic and environmental influences. Neuropsychological studies of language in AD provide an important means to define the phenotypic variation resulting from alterations in neural architecture. By mapping broad relationships between key symptoms, neuropsychological impairment and neural substrate, information derived from these studies enable a level of analysis that bridges the gap between the genome and the syndrome. Further study of children during the critical first 2 years of life using behavioral, electrophysiological, and functional neuroimaging methods is essential.     

面孔识别特异性本质的ERP研究

本研究记录了16名被试在完成有整体结构变化和局部特征变化的面孔/房屋图片的一致性判断时的脑内时程变化,以期对面孔识别的特异性本质进行探讨。结果显示,N170波幅和潜伏期的刺激类型主效应显著;面孔/房屋所诱发的N170成分在波幅和潜伏期上均不存在加工方式上的显著差异。晚期成分(300～700ms)上也得到类似的结果。这表明:面孔与房屋(非面孔)的加工在早期和晚期成分上都有差异性,体现出面孔的加工在早期视觉刺激的加工和晚期识别的加工上都具有特异性;晚期识别加工的脑电结果不支持"面孔识别是整体的,结构的,而非面孔客体的识别是局部的,基于特征的"加工观点。     

Repeated Repetition Priming in Face Recognition

Prior exposure to an item can facilitate subsequent recognition of that item. This effect, known as repetition priming, has been found for the recognition of many stimuli including faces (Bruce & Young, 1986). Three experiments are reported, which investigated whether repetition priming is limited to the first repetition or whether subsequent repetitions continually act to increase the speed of face processing. Experiment 1 demonstrated that repetition can reduce categorization time for faces after the first exposure, and this effect is independent of practice effects. Experiment 2 demonstrated that the relationship between reaction time and number of repetitions fits a negative power function. Experiment 3 investigated how delay affects this power function. Delay was found to decrease the negative gradient of the power curve. The effects of priming and delay are discussed in terms of the predictions made by Burton's (1994) interactive activation and competition with learning (IACL) model of face recognition and accounts of automaticity.     

面孔识别的认知发展机制

关于面孔识别能力的认知发展机制问题,目前存在两种不同的观点。一种是面孔特殊性发展理论,认为儿童的面孔识别之所以不如成人,是由于儿童和成人对面孔的加工方式不同,代表性理论有部分加工-结构加工理论,内部特征-外部特征加工理论,多维空间理论等。另一种是一般认知能力观点,认为儿童很早就具备了成人式的面孔加工方式,之后面孔识别任务中成绩的提高都可归因于一般认知能力的发展。在对两种观点进行评述的基础上,对未来的面孔识别研究提出了建议。     

面孔识别的本族效应理论述评

面孔识别的本族效应指,个体对本族面孔总是比不熟悉的异族面孔有更好的再认。研究者对该效应提出多种解释。这些理论可分成三大类：侧重于社会认知的接触假说、效用分析;侧重于面孔表征的多维空间理论、整体/部分假说;侧重于加工过程的认知忽视和注意、加工水平说、内群/外群模型、双加工理论。每种观点与其他观点既有区别,又有联系,但均不能很好地解释现有的研究结果。未来的研究需致力于直接操纵可能影响本族效应的因素     

新生儿面孔识别中的两种偏好现象

面孔偏好和吸引力偏好是新生儿（0~1个月）面孔识别中两种重要的偏好现象。面孔偏好（face preference）是指呈现面孔和非面孔刺激时个体偏好面孔的现象;吸引力偏好（attractiveness preference）是指呈现面孔刺激时个体偏好有吸引力面孔的现象。文章从行为研究和原因探析两个方面对新生儿面孔偏好和吸引力偏好的研究概况进行了介绍,认为主体、客体、环境三方面都在不同程度上影响着新生儿的面孔识别行为,指出未来的研究还应在实验对象、实验材料等方面进一步努力。     

Functional Aspects of Recollective Experience in Face Recognition

This article describes two experiments on awareness in recognition memory for novel faces. Two kinds of awareness, recollective experience and feelings of familiarity in the absence of recollective experience, were measured by "remember" and "know" responses. Experiment 1 showed that "remember" but not "know" responses were reduced by divided attention at study. Experiment 2 showed that massed versus spaced repetition of faces in the study list had the opposite effects on "remember" and "know" responses. Massed repetition increased "know" responses and reduced "remember" responses. Spaced repetition increased "remember" responses and reduced "know" responses. The results of both experiments replicate previous findings from the verbal domain in the domain of face recognition, and hence they increase the ecological validity of this experiential approach to memory and awareness and the generality of its database. These findings are discussed from a rehearsal perspective on factors influencing the two states of awareness and in relation to the alternative "process dissociation" procedure.     

内隐面孔记忆的编码机制*

为了探究内隐面孔再认在记忆形成过程中的认知加工状态,该实验以陌生面孔为刺激,采用事件相关电位(ERP)技术,并结合相继记忆(Dm)范式和迫选再认测验,把学习阶段的面孔分为相继记住、相继启动及相继忘记三类,以相继记住与相继启动的 ERP 差异为外显记忆 Dm 效应,以相继启动与相继忘记的差异为内隐记忆的 Dm效应。结果表明,内隐记忆表现为400~500 ms额中央区负走向的 Dm效应,可能反映了额叶皮层对信息的精加工过程,而外显记忆表现为400 ms开始顶区正走向的Dm效应,可能反映了记忆系统对加工后信息的自动登记过程。由此推测,只有经过额叶加工并被内侧颞叶自动登记的信息,随后才能被有意识地提取出来,而未进入内侧颞叶的信息在随后测验中不可能产生有意识地记忆提取现象,但储存的知觉表征可能触发微弱的记忆痕迹,从而产生内隐面孔记忆。     

Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory

In addiction, notably Alcohol Use Disorder (AUD), patients often have a tendency to fail to acknowledge the reality of the disease and to minimize the physical, psychological, and social difficulties attendant to chronic alcohol consumption. This lack of awareness can reduce the chances of initiating and maintaining sobriety. Presented here is a model focusing on compromised awareness in individuals with AUD of mild to moderate cognitive deficits, in particular, for episodic memory impairment—the ability to learn new information, such as recent personal experiences. Early in abstinence, alcoholics can be unaware of their memory deficits and overestimate their mnemonic capacities, which can be investigated with metamemory paradigms. Relevant neuropsychological and neuroimaging results considered suggest that the alcoholics’ impairment of awareness of their attenuated memory function can be a clinical manifestation explained mechanistically by neurobiological factors, including compromise of brain systems that result in a mild form of mnemonic anosognosia. Specifically, unawareness of memory impairment in AUD may result from a lack of personal knowledge updating attributable to damage in brain regions or connections supporting conscious recollection in episodic memory. Likely candidates are posterior parietal and medial frontal regions known to be integral part of the Default Mode Network (DMN) and the insula leading to an impaired switching mechanism between the DMN and the Central-Executive Control (i.e., Lateral Prefronto-Parietal) Network. The cognitive concepts and neural substrates noted for addictive disorders may also be relevant for problems in self-identification of functional impairment resulting from injury following war-related blast, sport-related concussion, and insidiously occurring dementia.     

面孔识别异族效应的研究

异族效应是面孔识别过程中一种非常稳定的现象,表现为对本族面孔的识别与再认成绩显著高于异族面孔.脑成像研究也证实了这两类面孔在神经表征上的差异.关于该效应主要有知觉经验说与社会分类说两种理论解释,但围绕着其心理机制仍然存在着很多争议然,未来的研究需要考虑族群认同等社会-人格因素对于异族效应的影响,并注意考察本族面孔与异族面孔有提取阶段可能存在的神经活动的差异.     

Development of Recognition of Face Parts from Unfamiliar Faces

The present study examined developmental changes in the ability to recognize face parts. In Experiment 1, participants were familiarized with whole faces and given a recognition test with old and new eyes, noses, mouths, inner faces, outer faces, or whole faces. Adults were above chance in their recognition of the eye and mouth regions. However, children did not naturally encode and recognize face parts independently of the entire face. In addition, all age groups showed comparable inner and outer face recognition, except for 8‐ to 9‐year‐olds who showed a recognition advantage for outer faces. In Experiment 2, when participants were familiarized with eyes, noses, or mouths and tested with eyes, noses, or mouths, respectively, all ages showed above‐chance recognition of eyes and mouths. Thirteen‐ to 14‐year‐olds were adult‐like in their recognition of the eye region, but mouth recognition continued to develop beyond 14 years of age. Nose recognition was above chance among 13‐ to 14‐year‐olds, but recognition scores remained low even in adulthood. The present findings reveal unique developmental trajectories in the use of isolated facial regions in face recognition and suggest that featural cues (as a class) have a different ontogenetic course relative to holistic and configural cues. Copyright © 2012 John Wiley & Sons, Ltd.     

自闭症谱系障碍者面孔识别的神经机制

自闭症谱系障碍（ASD）是一种心理状况的谱系障碍,其症状是社交及沟通上的广泛性异常、异常局限性的兴趣和高度重复性的刻板行为。包括自闭症、亚斯伯格症候群和待分类的广泛性发展障碍3类。研究主要以事件相关电位和功能性磁共振成像两种技术为线索,通过深入分析ASD患者在面孔识别认知过程中脑的异常变化,探讨其面孔识别障碍的神经机制问题。研究表明,ASD患者面孔识别能力的损伤主要与N170、N300、P400和Nc等ERPs成份异常及梭状回面孔区和杏仁核的低激活有关。研究推论ASD患者面孔识别障碍是多个异常脑区联合作用的结果,且主要受异常脑区的数量和损伤程度的影响。     

面孔识别中的构形加工与特征加工

面孔信息的分类方法一直复杂多样, 相关研究数据丰富, 但所用概念混杂。构形加工与特征加工作为使用最频繁的分类方法, 其可靠性越来越受研究者们关注。从近40年来的相关文献中选择引用率高的文献做参考, 遵循不同研究方法相互印证的原则分析数据, 提出构形加工与特征加工的区分是面孔识别中重要并且可靠的加工类型划分, 但确认两者在知觉加工上的先后关系以及在个体发展上的先后顺序尚缺乏稳定一致性的实验依据。     

Development of Face Recognition in 5- to 15-Year-Olds

This study focuses on the development of face recognition in typically developing preschool- and school-aged children (aged 5 to 15 years old, n = 611, 336 girls). Social predictors include sex differences and own-sex bias. At younger ages, the development of face recognition was rapid and became more gradual as the age increased up until the age of 11, after which point the influence of age was insignificant. This development could not be sufficiently explained by the improvement in visual attention or design memory tasks. Girls were slightly better than boys at recognizing faces in the youngest age group, but the effect of sex was minor. No significant own-sex bias was found for girls or boys.