Normal auditory negative priming in schizophrenic patients

Performance of 28 schizophrenic patients and 28 matched controls was compared in an auditory priming task. A large auditory negative priming effect was obtained for the patients as well as for the control group, and the size of the negative priming effect was approximately the same for both groups. Under the same conditions, positive or repetition priming for the patients was enhanced compared to that of the control group. The present findings from an auditory priming task are consistent with a growing body of evidence from the visual domain showing normal rather than reduced or eliminated negative priming in schizophrenic patients.     

Auditory negative priming in younger and older adults

Two experiments are reported in which performance of old and young adults in an auditory negative priming task was compared. Auditory negative priming was not smaller in old than in young adults. This result was independent of whether or not conditions were present that had previously been assumed to favour episodic retrieval, as opposed to inhibitory processes, as a basis of the negative priming phenomenon. The data from the present auditory negative priming experiments are incompatible with the global assumption that the efficiency of inhibitory attentional processes in general diminishes across the adult life span.     

ERP correlates of auditory negative priming

Negative priming refers to slowed down reactions when the distractor on one trial becomes the target on the next. Following two popular accounts, the effect might be due either to inhibitory processes associated with the frontal cortex, or to an ambiguity in the retrieval of episodic information. We used event-related brain potentials (ERPs) to identify the processing stage primarily associated with negative priming. In an auditory categorization task, reactions in negative priming trials were compared to reactions in a standard control (unrelated primes and probes) and a repetition control (attended prime=ignored probe) condition. Reactions were slower for negative priming than for standard control (Delta32 ms) and repetition control trials (Delta64 ms). The corresponding ERP effect was reflected in an attenuation of a sustained parietal positivity extending from 300 to 600 ms. Because corresponding ERP components were found to be sensitive to stimulus recognition and familiarity, the results may be interpreted to support an episodic retrieval account of negative priming.     

Priming T2 in a visual and auditory attentional blink task

Participants performed an attentional blink (AB) task including digits as targets and letters as distractors within the visual and auditory domains. Prior to the rapid serial visual presentation, a visual or auditory prime was presented in the form of a digit that was identical to the second target (T2) on 50% of the trials. In addition to the "classic" AB effect, an overall drop in performance on T2 was observed for the trials on which the stream was preceded by an identical prime from the same modality. No cross-modal priming was evident, suggesting that the observed inhibitory priming effects are modality specific. We argue that the present findings represent a special type of negative priming operating at a low feature level.     

IMPLICIT MEMORY IN AMNESIC PATIENTS:

Abstract— Previous observations of spared priming in amnesic patients have been based almost entirely on data from visual implicit memory tests Our research examined perceptual priming.in amnesic patients and control subjects on an auditory identification task in which previously spoken words and new words were presented in white noise We manipulated type of encoding task (semantic vs nonsemantic) and speaker's voice at study and test (same vs different) Priming was little affected.by either manipulation, and amnesic patients exhibited normal priming in all experimental conditions On an explicit test of recognition memory, by contrast, amnesic patients exhibited.severely impaired performance following the semantic study task, all subjects showed poor explicit memory following the nonsemantic study task Results are consistent with the idea that auditory priming depends largely on a presemantic auditory perceptual representation system     

The effects of focus of attention on attributional bias in patients experiencing auditory hallucinations

Cognitive models suggest that auditory hallucinations occur as the result of internal events attributed to an external source. The present study represents an attempt to evaluate the source monitoring performance of people who experience auditory hallucinations, specifically in terms of the suggested links between source monitoring, emotionality of stimuli and self-focused attention. The source monitoring performance of a group of 30 patients with a diagnosis of a schizophrenia spectrum disorder who experience auditory hallucinations was compared following successful experimental manipulation of their attention, designed to increase and decrease their levels of self-focused attention. The inclusion of words previously rated as emotionally salient by schizophrenic patients assessed the effect of emotionality on source monitoring performance. This study demonstrated that participants' ratings of both internality and control of their responses to the word association task were lower in the external focus condition than the internal focus condition. Furthermore, it was found that ratings of internality and control were lower for responses to both positive and negative stimuli compared to responses to neutral stimuli, and the magnitude of these differences was amplified in the internal focus condition relative to the external focus condition. Focus of attention has a significant effect on source monitoring performance in people experiencing auditory hallucinations. The theoretical and clinical implications of these findings are discussed.     

Evidence of vocal and manual event files in auditory negative priming

Negative priming with auditory as well as with visual stimuli has been shown to involve the retrieval of prime response information as evidenced by an increase of prime response errors to the probes of ignored repetition trials compared to control trials. We investigated whether prime response retrieval processes were also present for response modalities other than manual responding. In an auditory four alternative forced choice task participants either vocally or manually identified a target sound while ignoring a distractor sound. Negative priming was of equal size in both response modalities. What is more, for both response modalities, there was evidence of increased prime response errors in ignored repetition trials compared to control trials. The findings suggest that retrieval of event files of the prime episode including prime response information is a general mechanism underlying the negative priming phenomenon irrespective of stimulus or response modality.     

Auditory,visual, and cross-modal negative priming

Auditory, visual, and cross-modal negative priming was investigated using a task in which participants judged whether stimuli were animals or musical instruments. Negative priming was observed, but only if the attended and the ignored primes evoked different responses. This pattern—negative priming after conflict, but not after nonconflict, primes—was demonstrated with visual stimuli and replicated with auditory stimuli, as well as across modalities, both auditory to visual and visual to auditory. Implications for theories of negative priming are discussed.     

死亡启动影响自我参照记忆的年龄差异

以往研究表明对死亡不可避免性的认识使人类产生死亡焦虑,并且为了降低该焦虑,年轻人倾向于抑制生理自我加工;然而相比年轻人,老年人对死亡的接受程度更高,并且自我抑制能力减弱。因此本研究采用死亡启动范式,探讨了死亡对自我相关记忆的影响以及可能存在的年龄差异。实验一以大学生为被试,结果发现死亡启动后,个体对自我相关信息的再认率显著低于消极启动后;实验二以老年人为被试,结果发现死亡启动后,个体对自我相关信息的再认率与消极启动后无差异。上述结果说明,死亡启动对自我相关记忆的影响存在年龄差异。在大学生中,死亡启动使个体抑制自我相关信息,而在老年人中该抑制效应并不存在。     

Semantic negative priming in picture categorization and naming

Ignoring a particular stimulus can hamper subsequent attended processing of the same stimulus, a phenomenon known as 'negative priming'. Previous research has yielded partial support for the claim that the effect results from the attentional inhibition of central representations, as suggested by the fact that it appears to extend to semantic associates of ignored stimuli. In the current experiment, participants categorized or named pictorial stimuli with superimposed distractor pictures; the effect of unrelated, identical, or categorically related previously ignored pictures was investigated. Furthermore, visual similarity between categorically related picture pairs was manipulated in the naming task. The results indicated negative priming from identical ignored pictures irrespective of task. However, semantic negative priming was observed in the categorization task only. In the naming task, even visual overlap between categorically related picture pairs failed to induce negative priming. These findings argue against a central locus of the negative priming effect.     

An event-related brain potential substrate of disturbed response monitoring in paranoid schizophrenic patients.

Response monitoring in schizophrenic patients and healthy controls was assessed by measuring performance and event-related brain potentials in the flanker priming task. Three visual-context conditions were construed: Flankers and targets pointed either into the same direction or into different directions. Stimuli without any response assignment were used as flankers in the neutral context condition. The schizophrenic patients were further subdivided into paranoid (n = 19) and nonparanoid (n = 10) patients and compared with healthy controls (n = 18). Performance scores revealed that the flankers induced a similar degree of distraction by visual context in all 3 groups. Although the schizophrenic patients showed normal error correction performance, the error negativity (NE) was significantly reduced in paranoid schizophrenic patients. The attenuation of the NE possibly reflects disturbed response monitoring in these patients.     

Episodic retrieval processes take place automatically in auditory negative priming

Episodic retrieval processes involved in negative priming have been argued to be susceptible to the proportion of attended repetition trials. The more trials with the same prime and probe response, the more beneficial should it be to retrieve the prime episode, particularly its response. Retrieval of the prime episode, however, is task-inappropriate for ignored repetition trials, leading to negative priming. Correspondingly, visual negative priming increases with the proportion of attended repetition trials. We tested whether the same is true for the auditory modality. Three attended repetition proportion groups (0–25–50%) showed the same amount of negative priming. All groups committed more prime response errors in ignored repetition than in control trials, implying that prime response retrieval took place. Thus, retrieval processes in auditory negative priming appear to be automatic and cannot be influenced as easily as in the visual domain. In Experiment 2, the proportion of ignored repetition trials was manipulated (25–50–75%) to test whether auditory negative priming can be strategically manipulated at all. Similar to the visual modality negative priming was reduced with increasing proportion of ignored repetition trials. Differences between visual and auditory short-term memory are discussed to account for the results.     

Linking sight and sound: fMRI evidence of primary auditory cortex activation during visual word recognition

We describe two studies that used repetition priming paradigms to investigate brain activity during the reading of single words. Functional magnetic resonance images were collected during a visual lexical decision task in which nonword stimuli were manipulated with regard to phonological properties and compared to genuine English words. We observed a region in left-hemisphere primary auditory cortex linked to a repetition priming effect. The priming effect activity was observed only for stimuli that sound like known words; moreover, this region was sensitive to strategic task differences. Thus, a brain region involved in the most basic aspects of auditory processing appears to be engaged in reading even when there is no environmental oral or auditory component.     

Priming involuntary autobiographical memories in the lab

Involuntary autobiographical memories (IAMs) are recollections of personal past that frequently and spontaneously occur in daily life. Initial studies by Mace (2005) showed that deliberately reminiscing about a certain lifetime period (e.g., high school) significantly increased the number of different IAMs from the same period in subsequent days, suggesting that priming may play a significant role in the retrieval of IAMs in everyday life. In the present study, we used a modified experimental paradigm, originally used by Schlagman and Kvavilashvili (2008), to study IAMs under well-controlled laboratory conditions. Participants completed a monotonous vigilance task twice and reported the occurrence of any spontaneous thoughts that were later classed as IAMs or other thoughts. Priming was manipulated by having experimental participants reminiscing about high school period between the two vigilance tasks and control participants playing simple games. Results showed that participants in the experimental group reported IAMs relating to high school period more frequently during the second vigilance task than those in the control group. In the experimental group, the number of high school memories was marginally higher in the second vigilance task compared to the first vigilance task with the medium effect size, but this within subjects effect was not significant in the control group. Finally, priming also enhanced the retrieval of more remote IAMs in the experimental group compared to the control group. These results suggest that priming may play a significant role in the activation and recall of IAMs and open up interesting avenues for future research.     

Prior cognitive activity implicitly modulates subsequent emotional responses to subliminally presented emotional stimuli

It has been reported that engagement in several kinds of cognitive activity can successfully inhibit unpleasant emotions. In this study, we tried to replicate the previous finding that cognitive activity can modulate subsequent psychological and physiological emotional processes and to investigate whether prior cognitive activity can attenuate implicit emotional processes triggered by subliminal emotional stimuli. Sixty students were randomly divided into three groups (cognitive task group, noncognitive task group, control group). The cognitive task group was asked to engage in an n-back task, while the control group was asked to stay calm. The noncognitive task group was asked to do a handgrip-squeezing task. All participants then engaged in a version of a subliminal affective priming task where they were unconsciously exposed to affectively negative pictures. The cognitive task group showed lower negative experiences after the subliminal affective priming task and a substantial reduction in their heart rate responses, as compared with the other groups. These results provide evidence that engagement in cognitive activity can attenuate emotional processes in an automatic and unconscious manner.     

Auditory priming: implicit and explicit memory for words and voices.

Five experiments explore priming effects on auditory identification and completion tasks as a function of semantic and nonsemantic encoding tasks and whether speaker's voice is same or different at study and test. Auditory priming was either unaffected by the study task manipulation (Experiments 2, 4, and 5) or was less affected than was explicit memory (Experiments 1 and 3). Study-to-test changes of speaker's voice had nonsignificant effects on priming when white noise masked target items on the identification test (Experiments 1 and 2) or the stem-completion test (Experiment 5). However, significant voice change effects were observed on priming of completion performance when stems were spoken clearly (Experiments 3 and 4). Results are consistent with the idea that a presemantic auditory perceptual representation system plays an important role in the observed priming. Alternative explanations of the presence or absence of voice change effects under different task conditions are considered.     

A negative order-repetition priming effect: inhibition of order in unattended auditory sequences?

A novel negative priming (NP) effect is reported in which serial recall for a sequence of visually presented digits was poorer if the same sequence was presented as an irrelevant auditory sequence on the previous trial (Experiments 1 and 2). The effect was enhanced when attention was divided between the to-be-repeated auditory sequence and the concurrent to-be-remembered (TBR) sequence (Experiment 3). When the TBR sequences were also presented auditorily, NP arose only when the repeated TBR sequence was in the same voice as the previous irrelevant sequence; a voice mismatch produced positive priming (Experiment 4). The results suggest that the order of auditory events is registered preattentively and that inhibition may be applied to the acoustic transitions between irrelevant events.     

Affective Priming Effects in the Left and Right Cerebral Hemispheres in Patients With Alzheimer's Disease

Alzheimer’s disease (AD) patients and control subjects were tested in an affective priming paradigm associated with an affective discrimination task. Two pictures, one affectively positive or affectively negative and the other neutral, were presented simultaneously in the right and in the left visual fields; the participants had to decide which of the two pictures was the most affectively positive or negative. The target pictures were preceded by a prime picture that was either affectively positive, affectively negative, or neutral. The principal result was the observation, in AD patients as well as in control subjects, of negative affective priming effects for targets presented in the right hemisphere, and of positive affective priming effects for targets presented in the left hemisphere. The presence of affective priming effects suggests that AD patients have no particular deficit in the automatic activation of emotional information; the fact that priming effects were also observed for targets presented in the left hemisphere showed that AD patients probably have no left hemisphere deficit in the automatic activation of emotional information. However, in AD patients, affective priming effects were significant with negative targets but not with positive targets, which could suggest that AD patients processed positive targets in a more semantic way than negative targets.     

The effects of divided attention on auditory priming

Traditional theorizing stresses the importance of attentional state during encoding for later memory, based primarily on research with explicit memory. Recent research has begun to investigate the role of attention in implicit memory but has focused almost exclusively on priming in the visual modality. The present experiments examined the effect of divided attention on auditory implicit memory, using auditory perceptual identification, word-stem completion and word-fragment completion. Participants heard study words under full attention conditions or while simultaneously carrying out a distractor task (the divided attention condition). In Experiment 1, a distractor task with low response frequency failed to disrupt later auditory priming (but diminished explicit memory as assessed with auditory recognition). In Experiment 2, a distractor task with greater response frequency disrupted priming on all three of the auditory priming tasks as well as the explicit test. These results imply that although auditory priming is less reliant on attention than explicit memory, it is still greatly affected by at least some divided-attention manipulations. These results are consistent with research using visual priming tasks and have relevance for hypotheses regarding attention and auditory priming.     

The relationship between cognitive inhibition and psychotic symptoms

Cognitive models of schizophrenia have highlighted deficits of inhibitory attentional processes as central to the disorder. This has been investigated using "negative priming" (S. P. Tipper, 1985), with schizophrenia patients showing a reduction of negative priming in a number of studies. This study attempted to replicate these findings, but studied psychotic symptoms rather than the broad diagnostic category of schizophrenia. Psychotic individuals exhibiting positive symptoms were compared with asymptomatic psychiatric patients and with a normal control group. As predicted, the symptomatic group failed to show the usual negative priming effect, which was present in the asymptomatic and normal groups. A modest but significant correlation was found between negative priming and delusions. Neither diagnosis, nor affective or negative symptoms, nor chronicity, nor medication, was related to negative priming. These data replicate previous findings that positive symptoms are related to a reduction in cognitive inhibition, although considerable variability was observed among the psychotic patients.