Neural mechanisms of the automatic processing of emotional information from faces and voices

Theoretical accounts suggest an increased and automatic neural processing of emotional, especially threat-related, facial expressions and emotional prosody. In line with this assumption, several functional imaging studies showed activation to threat-related faces and voices in subcortical and cortical brain areas during attentional distraction or unconscious stimulus processing. Furthermore, electrophysiological studies provided evidence for automatic early brain responses to emotional facial expressions and emotional prosody. However, there is increasing evidence that available cognitive resources modulate brain responses to emotional signals from faces and voices, even though conflicting findings may occur depending on contextual factors, specific emotions, sensory modality, and neuroscientific methods used. The current review summarizes these findings and suggests that further studies should combine information from different sensory modalities and neuroscientific methods such as functional neuroimaging and electrophysiology. Furthermore, it is concluded that the variable saliency and relevance of emotional social signals on the one hand and available cognitive resources on the other hand interact in a dynamic manner, making absolute boundaries of the automatic processing of emotional information from faces and voices unlikely.     

What has fMRI told us about the Development of Cognitive Control through Adolescence?

Cognitive control, the ability to voluntarily guide our behavior, continues to improve throughout adolescence. Below we review the literature on age-related changes in brain function related to response inhibition and working memory, which support cognitive control. Findings from studies using functional magnetic resonance imaging (fMRI) indicate that processing errors, sustaining a cognitive control state, and reaching adult levels of precision, persist through adolescence. Developmental changes in patterns of brain function suggest that core regions of the circuitry underlying cognitive control are on-line early in development. However, age-related changes in localized processes across the brain, and in establishing long range connections that support top-down modulation of behavior, more effective neural processing for optimal mature executive function. While great progress has been made in understanding the age-related changes in brain processes underlying cognitive development, there are still important challenges in developmental neuroimaging methods and the interpretation of data that need to be addressed.     

前额叶皮质损伤患者的情绪异常

人类前额叶皮质与情绪之间有着密切的关系,文章在相关的临床和神经成像研究结果基础上,分析了前额叶皮质损伤对情绪行为造成的影响,分别概述了精神分裂症、重性抑郁和焦虑患者的情绪变化、前额叶切除对情绪的影响以及左右前额叶皮质与情绪的关系,重点阐述了前额叶功能异常的神经生理学特点,认为情绪的改变会随着前额叶皮质不同部位的结构缺损或功能变化而有所不同,此有利于对前额叶皮质损伤患者情绪异常的评价与防治。     

情绪识别研究中被“冷落”的线索:躯体表情加工的特点、神经基础及加工机制

躯体和面孔是个体情绪表达与识别的重要线索。与面部表情相比,躯体表情加工的显著特点是补偿情绪信息,感知运动与行为信息,及产生适应性行为。情绪躯体与面孔加工的神经基础可能相邻或部分重合,但也存在分离;EBA、FBA、SPL、IPL等是与躯体表情加工相关的特异性脑区。今后应系统研究面孔、躯体及语音情绪线索加工潜在的神经基础,探讨躯体情绪加工的跨文化差异,考察情绪障碍患者的躯体表情加工特点。     

Prefrontal brain activity predicts temporally extended decision-making behavior

Although functional neuroimaging studies of human decision-making processes are increasingly common, most of the research in this area has relied on passive tasks that generate little individual variability. Relatively little attention has been paid to the ability of brain activity to predict overt behavior. Using functional magnetic resonance imaging (fMRI), we investigated the neural mechanisms underlying behavior during a dynamic decision task that required subjects to select smaller, short-term monetary payoffs in order to receive larger, long-term gains. The number of trials over which the longterm gains accrued was manipulated experimentally (2 versus 12). Event-related neural activity in right lateral prefrontal cortex, a region associated with high-level cognitive processing, selectively predicted choice behavior in both conditions, whereas insular cortex responded to fluctuations in amount of reward but did not predict choice behavior. These results demonstrate the utility of a functional neuroimaging approach in behavioral psychology, showing that (a) highly circumscribed brain regions are capable of predicting complex choice behavior, and (b) fMRI has the ability to dissociate the contributions of different neural mechanisms to particular behavioral tasks.     

框架效应的神经机制

框架效应指人们对一个客观上相同问题的不同描述有不同反应的现象。近年来的认知神经研究发现框架效应的产生,可能源自以杏仁核为代表的情绪过程,而以前扣带回与前额叶皮层为代表的认知过程对此可能起到抑制与监控的作用。单侧化研究揭示了大脑两半球所擅长的不同思维方式也可能对框架效应产生影响。未来的研究应整合框架效应的神经机制与理论解释、探索框架效应的领域特异性并探究框架效应的产生根源。     

On the relation between conceptual priming, neural priming, and novelty assessment

A consistently reported finding in functional neuroimaging studies which compare processing of new information to processing of old information is a reduction in blood flow, and hence neural activity, associated with the old condition. This deactivation has been labeled neural priming. Some investigators have hypothesized that neural priming is the physiological mechanism underlying conceptual priming—a facilitation in the semantic processing of repeated information. Others, however, have hypothesized that neural priming reflects novelty assessment—a mechanism which minimizes the probability that redundant information will be stored in long‐term memory. In this paper, the conceptual priming and novelty assessment hypotheses are compared and contrasted in order to ask, and tentatively answer, the question: Are conceptual priming and novelty assessment cognitively and neurophysiologically distinct? Based on a review of the literature, it is suggested that whereas novelty assessment and conceptual priming are distinct cognitive entities, they cannot be presently separated neurophysiologically. That is, some novelty assessment deactivations may in fact reflect priming, and some priming deactivations may in fact reflect novelty assessment.     

工作记忆中的积极效应：情绪效价与任务相关性的影响

积极效应指相比于年轻人, 老年人更倾向于优先加工积极情绪刺激而非消极情绪刺激。近年来工作记忆的研究发现积极效应会受到情绪效价与任务相关性的影响：情绪效价作为任务相关属性的研究支持工作记忆中存在积极效应, 具体表现为老年人对积极情绪刺激记忆的增强, 以及对消极情绪刺激记忆的减弱; 情绪效价作为工作记忆任务无关属性的研究相对较少, 且未发现一致的积极效应, 提示情绪效价及任务相关性均为影响工作记忆积极效应的关键因素。脑成像的研究初步表明, 工作记忆中情绪加工上的年龄效应与背侧执行系统和腹侧情绪系统的随龄功能变化有关。社会情绪选择理论与双竞争模型对工作记忆中的积极效应具备较大的解释力, 而动态整合理论尚缺乏实证研究支持。未来研究可进一步探究老年人工作记忆不同阶段情绪加工的特点, 澄清不同情绪材料内在编码过程上的差异对积极效应发生机制的潜在影响, 探讨情绪效价及任务相关性影响工作记忆积极效应的关键神经环路, 并揭示情绪工作记忆训练提升老年人认知功能与情绪体验的内在机制及其潜在应用价值。     

Syntactic processing in the human brain: what we know, what we don't know, and a suggestion for how to proceed

For every claim in the neuroimaging literature about a particular brain region supporting syntactic processing, there exist other claims implicating the target region in different linguistic processes, and, in many cases, in non-linguistic cognitive processes (e.g., Blumstein, 2009). We argue that traditional group analysis methods in neuroimaging may obscure functional specificity because of inter-subject anatomical variability (Fedorenko & Kanwisher, 2009). In Fedorenko, Hsieh, Nieto-Castanon, Whitfield-Gabrieli, and Kanwisher (2010) we presented a functional localizer that allows quick and reliable identification of key language-sensitive regions in each individual brain. This approach enables pooling data from corresponding functional regions across subjects rather than from the same locations in stereotaxic space that may differ functionally due to inter-subject anatomical variability. In the current paper we demonstrate that the individual-subjects functional localization approach is superior to the traditional methods in its ability to distinguish among conditions in a brain region’s response. This ability is at the core of all neuroimaging research and is critical for answering questions of functional specialization (e.g., does a brain region specialize for processing syntactic aspects of the linguistic signal), which is in turn essential for making inferences about the precise computations conducted in each brain region. Based on our results, we argue that supplementing existing methods with an individual-subjects functional localization approach may lead to a clearer picture of the neural basis of syntactic processing, as it has in some other domains, such as high-level vision (e.g., Kanwisher, 2010) and social cognition (e.g., Saxe & Kanwisher, 2003).     

Neural correlates of emotional intelligence in adolescent children

The somatic marker hypothesis posits a key role for the ventromedial prefrontal cortex, amygdala, and insula in the ability to utilize emotions to guide decision making and behavior. However, the relationship between activity in these brain regions and emotional intelligence (EQ) during adolescence, a time of particular importance for emotional and social development, has not been studied. Using functional magnetic resonance imaging (fMRI), we correlated scores from the Bar-On Emotional Quotient Inventory, Youth Version (EQ-i:YV) with brain activity during perception of fearful faces in 16 healthy children and adolescents. Consistent with the neural efficiency hypothesis, higher EQ correlated negatively with activity in the somatic marker circuitry and other paralimbic regions. Positive correlations were observed between EQ and activity in the cerebellum and visual association cortex. The findings suggest that the construct of self-reported EQ in adolescents is inversely related to the efficiency of neural processing within the somatic marker circuitry during emotional provocation.     

青少年抑郁及其自动情绪调节的研究概述

本文旨在梳理近年来国内外青少年抑郁及其自动情绪调节在相关研究领域的研究成果,以进一步促进青少年抑郁的自动情绪调节研究。首先,阐明了青少年脑发展与抑郁之间的关系,并概括了三种青少年抑郁模型。然后,澄清了自动情绪调节的内涵和经典范式,而且从时间和空间方面,总结了青少年抑郁的自动情绪调节的神经机制的相关文献。最后,未来要加强功能连接研究,采用经颅直流电刺激(t DCS)、重复经颅磁刺激(r TMS)技术开展干预研究。     

情绪信息的多通道整合

自然环境中人类情绪信息的交流是依靠多个感觉通道实现的,多通道整合是情绪加工的基础。近年来的行为学、电生理学与神经成像的研究表明,情绪信息的加工具有跨通道自动整合的特点,它发生在认知加工的早期阶段,与颞上回、颞中回、海马旁回和丘脑等脑区密切相关。不同情绪的整合既有共同的神经基础,又有各自独特的加工区域。情绪信息的整合机制还可能与加工类型及注意资源有关。在未来研究中,实验的标准化、动态化、自然化有助于提高研究的准确性和研究间的可比性,而对特殊群体的研究,以及综合研究情绪加工与注意等其他认知过程则有助于我们进一步探索多通道整合的神经机制。     

数字加工的脑功能成像研究进展及其皮层定位

数字加工是人类最重要的认知功能之一。当前的脑功能成像研究有助于对数字加工与皮层之间的联系进行更精确的定位。基于对上世纪80年代来有关数字加工脑功能成像研究的主要成果的回顾,尤其是一些重要区域,如双侧顶叶与前额叶等在数字加工中的地位与作用,以及不同脑区之间的关系进行了探讨,并对一个广泛运用的数字加工神经机制模型进行了简要评述。在此基础上,对数字加工的皮层定位问题进行了简要的总结。     

赌博障碍的认知功能缺陷及神经基础

赌博障碍是指持续且反复的赌博行为,给个人、家庭和社会都带来了严重后果,近年来受到越来越多研究者的关注。本研究总结了赌博障碍的认知功能缺陷及其神经基础,主要集中在如下四个方面：①认知扭曲、②奖赏和惩罚敏感性、③注意偏向和④决策。未来研究应多从认知神经科学角度深入探究赌博障碍的发生机制和发展过程,关注大脑结构变化及功能网络改变,并将其整合到一个统一的神经生物机制框架中,找到更加有效的干预和治疗手段。     

Differentiating emotional processing and attention in psychopathy with functional neuroimaging

Individuals with psychopathy are often characterized by emotional processing deficits, and recent research has examined the specific contexts and cognitive mechanisms that underlie these abnormalities. Some evidence suggests that abnormal features of attention are fundamental to emotional deficits in persons with psychopathy, but few studies have demonstrated the neural underpinnings responsible for such effects. Here, we use functional neuroimaging to examine attention–emotion interactions among incarcerated individuals (n = 120) evaluated for psychopathic traits using the Hare Psychopathy Checklist–Revised (PCL-R). Using a task designed to manipulate attention to emotional features of visual stimuli, we demonstrate effects representing implicit emotional processing, explicit emotional processing, attention-facilitated emotional processing, and vigilance for emotional content. Results confirm the importance of considering mechanisms of attention when evaluating emotional processing differences related to psychopathic traits. The affective-interpersonal features of psychopathy (PCL-R Factor 1) were associated with relatively lower emotion-dependent augmentation of activity in visual processing areas during implicit emotional processing, while antisocial-lifestyle features (PCL-R Factor 2) were associated with elevated activity in the amygdala and related salience network regions. During explicit emotional processing, psychopathic traits were associated with upregulation in the medial prefrontal cortex, insula, and superior frontal regions. Isolating the impact of explicit attention to emotional content, only Factor 1 was related to upregulation of activity in the visual processing stream, which was accompanied by increased activity in the angular gyrus. These effects highlight some important mechanisms underlying abnormal features of attention and emotional processing that accompany psychopathic traits.     

Functional Neuroimaging in the Examination of Effects of Prenatal Alcohol Exposure

Functional neuroimaging offers the opportunity to understand the effect of prenatal alcohol exposure on the activities of the brain as well as providing a window into the relationship between neural activation and the behavioral outcomes that have been described in affected individuals. Several different methodologies have been used to examine the neurophysiological signal changes associated with different brain functions in prenatally exposed individuals and those diagnosed with fetal alcohol syndrome (FAS) or other fetal alcohol spectrum disorders (FASD). These include electroencephalography (EEG), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI). These studies demonstrate that it is feasible to use these technologies with this clinical population and that the damage to the central nervous system associated with prenatal alcohol exposure has widespread functional implications; however, currently, the literature in these areas is limited and unsystematic. Functional MRI with this clinical population has just begun to explore the implications of prenatal alcohol exposure with the first paper published in 2005. Other methodologies are similarly limited in scope. Nonetheless, these functional neuroimaging studies suggest that prenatal alcohol exposure, or a diagnosis of FAS, may lead to restrictions in neural efficiency or a global decrement in processing resources.     

Race, Behavior, and the Brain: The Role of Neuroimaging in Understanding Complex Social Behaviors

Recent advances in brain imaging techniques have allowed us to explore the neural basis of complex human behaviors with more precision than was previously possible. As we begin to uncover the neural systems of behaviors that are socially and culturally important, we need to be clear about how to integrate this new approach with our psychological understanding of these behaviors. This article reviews findings about the neural systems involved in processing race group information, in particular the recognition of same-race versus other-race faces and the explicit and implicit evaluation of race groups. Combining the psychological and neural approaches can advance our understanding of these complex human behaviors more rapidly and with more clarity than could be achieved with either approach alone. However, it is inappropriate to assume that the results of neuroimaging studies of a given behavior are more informative than the results of psychological studies of that behavior.     

赌博障碍的认知功能缺陷及神经基础

赌博障碍是指持续且反复的赌博行为,给个人、家庭和社会都带来了严重后果,近年来受到越来越多研究者的关注。本研究总结了赌博障碍的认知功能缺陷及其神经基础,主要集中在如下四个方面：①认知扭曲、②奖赏和惩罚敏感性、③注意偏向和④决策。未来研究应多从认知神经科学角度深入探究赌博障碍的发生机制和发展过程,关注大脑结构变化及功能网络改变,并将其整合到一个统一的神经生物机制框架中,找到更加有效的干预和治疗手段。     

Functional Neuroimaging Studies of Cognitive Recovery After Acquired Brain Damage in Adults

The first two decades of cognitive neuroimaging research have provided a constant increase of the knowledge about the neural organization of cognitive processes. Many cognitive functions (e.g.working memory) can now be associated with particular neural structures, and ongoing research promises to clarify this picture further, providing a new mapping between cognitive and neural function. The main goal of this paper is to outline conceptual issues that are particularly important in the context of imaging changes in neural function through recovery process. This review focuses primarily on studies made in stroke and traumatic brain injury patients, but most of the issues raised here are also relevant to studies using other acquired brain damages. Finally, we summarize aset of methodological issues related to functional neuroimaging that are relevant for the study ofneural plasticity and recovery after rehabilitation. Deceased