Social relationships,stressful life events,and self-reported physical health: Genetic and environmental influences

Abstract

This study investigates how the associations between self-reported health, stressful life events, and social relationships are mediated by genetic and environmental influences and how much of the variance in health is in common with variation in these psychosocial factors. The analyses are based on questionnaire data from 576 pairs of twins reared apart and twins reared together. The data revealed that for men environmental influences were solely important for variation in the psychosocial measures and were the primary mediators of the relationship with health. For women, on the other hand, a substantial portion of the variance in the psychosocial factors was due to genetic influences and these influences also contributed to the bulk of the correlations with health. The gender differences for the relationships and their mediation indicate that what should be regarded as a psychosocial factor of importance for health might differ between genders.     

Development and the epigenome: the ‘synapse’ of gene–environment interplay

This paper argues that there is a revolution afoot in the developmental science of gene–environment interplay. We summarize, for an audience of developmental researchers and clinicians, how epigenetic processes – chromatin structural modifications that regulate gene expression without changing DNA sequences – may offer a strong, parsimonious account for the convergence of genetic and contextual variation in the genesis of adaptive and maladaptive development. Epigenetic processes may play a plausible explanatory role in understanding: divergent trajectories and sexual dimorphisms in brain development; statistical interactions between genes and environments; the biological embedding of early psychosocial adversities; the linkages of such adversities to disorders of mental health; the striking individual variation in the strength of those linkages; the molecular origins of critical and sensitive periods; and the transgenerational inheritance of risk and protection. Taken together, these arguments converge in a claim that epigenetic processes constitute a promising and illuminating point of connection – a ‘synapse’ – between genes and environments.     

Social support,social integration,and health-related quality of life over time: Results from the Fitness and Arthritis in Seniors Trial (FAST)

The present study tested whether baseline perceived social support and social integration predicted baseline and follow-up measures of health-related quality of life for 364 older adults with osteoarthritis. The findings are secondary analyses of a randomized controlled trial of an exercise intervention. Multiple regression analyses indicate that perceived social support was related to baseline measures of functioning in psychological (depressive symptoms, social functioning, and life satisfaction) and physical domains (self-rated disability, observed physical function, and perceived health), after accounting for demographic and clinical status factors. At 18-month follow-up (additionally controlling for exercise intervention and baseline outcomes), social support significantly predicted changes in psychosocial functioning, but was unrelated to changes in self-reported and observed physical health. The findings indicate that social support is an important predictor of long-term psychosocial outcomes, but is less important than baseline clinical status for physical health endpoints in this cohort of older adults. In contrast, social integration was not a consistent predictor of outcomes.     

Direct and Indirect Effects of Caregiver Social Support on Adolescent Psychological Outcomes in Two South African AIDS-Affected Communities

Caregiver social support has been shown to be protective for caregiver mental health, parenting and child psychosocial outcomes. This is the first known analysis to quantitatively investigate the relationship between caregiver social support and adolescent psychosocial outcomes in HIV‐endemic, resource–scarce Southern African communities. A cross‐sectional household survey was conducted over 2009–2010 with 2,477 South African adolescents aged 10–17 and their adult caregivers (18 years or older) in one urban and one rural community in South Africa’s KwaZulu‐Natal province. Adolescent adjustment was assessed using adult caregiver reports of the Strengths and Difficulties questionnaire (SDQ), which measures peer problems, hyperactivity, conduct problems, emotional symptoms and child prosocial behavior. Hierarchical linear regressions and multiple mediation analyses, using bootstrapping procedures, were conducted to assess for: (a) direct effects of more caregiver social support on better adolescent psychosocial wellbeing; and (b) indirect effects mediated by better parenting and caregiver mental health. Direct associations (p < .001), and indirect associations mediated through better parenting, were found for all adolescent outcomes. Findings reinforce the importance of social support components within parenting interventions but also point to scope for positive intervention on adolescent psychosocial wellbeing through the broader family social network.     

Three Laws of Behavior Genetics and What They Mean

Behavior genetics has demonstrated that genetic variance is an important component of variation for all behavioral outcomes, but variation among families is not. These results have led some critics of behavior genetics to conclude that heritability is so ubiquitous as to have few consequences for scientific understanding of development, while some behavior genetic partisans have concluded that family environment is not an important cause of developmental outcomes. Both views are incorrect. Genotype is in fact a more systematic source of variability than environment, but for reasons that are methodological rather than substantive. Development is fundamentally nonlinear, interactive, and difficult to control experimentally. Twin studies offer a useful methodological shortcut, but do not show that genes are more fundamental than environments.     

Dopamine and serotonin systems modify environmental effects on human behavior: A review

The relative influences of genetic and environmental factors in the development of human behavior have been a long‐term topic for an intense debate. Recent behavioral genetic studies suggest focusing on the joint effect of genes and environment, and especially on the life‐course developmental interplay between nature and nurture. Vulnerability to environmental adversities and sensitivity to its benefits may be conditional on genetic background, and regarding psychological outcomes, these kinds of gene × environment interactions may be of higher importance than direct gene–trait associations. In our recent series of studies, we have shown that different variants of serotonergic and dopaminergic genes may moderate the influence of environmental conditions on a range of psychological outcomes, i.e. temperament, depression, hostility, and educational attainment. These studies suggest that depending on their genotype, people may be differentially sensitive to the environmental conditions they encounter. In the light of these results it seems highly plausible that the effects of genes may become evident only when studied in the context of environmental factors.     

Later life health optimism,pessimism and realism: Psychosocial contributors and health correlates

Prior research has established positive outcomes of health optimism (appraising one's health as good despite poor objective health (OH)) and negative outcomes of health pessimism (appraising health as poor despite good OH), yet little is known about their contributors. We examined the role of psychosocial factors (life event stress, depression, dispositional optimism, perceived social support) in health realism (appraising health in accordance with OH), optimism and pessimism among 489 older men and women. We then accounted for the psychosocial factors when examining multiple health correlates of health realism, optimism and pessimism. Controlling for age, gender and income, regression results indicate that depression and social support were associated with less health optimism, while dispositional optimism was associated with greater health optimism among those in poor OH. Dispositional optimism was associated with less health pessimism and life event stress was associated with greater pessimism among those in good OH. Beyond the effects of the psychosocial factors, structural equation model results indicate that health optimism was positively associated with healthy behaviours and perceived control over one's health; health pessimism was associated with poorer perceived health care management. Health optimism and pessimism have different psychosocial contributors and health correlates, validating the health congruence approach to later life well-being, health and survival.     

Later life health optimism, pessimism and realism: psychosocial contributors and health correlates

Prior research has established positive outcomes of health optimism (appraising one's health as good despite poor objective health (OH)) and negative outcomes of health pessimism (appraising health as poor despite good OH), yet little is known about their contributors. We examined the role of psychosocial factors (life event stress, depression, dispositional optimism, perceived social support) in health realism (appraising health in accordance with OH), optimism and pessimism among 489 older men and women. We then accounted for the psychosocial factors when examining multiple health correlates of health realism, optimism and pessimism. Controlling for age, gender and income, regression results indicate that depression and social support were associated with less health optimism, while dispositional optimism was associated with greater health optimism among those in poor OH. Dispositional optimism was associated with less health pessimism and life event stress was associated with greater pessimism among those in good OH. Beyond the effects of the psychosocial factors, structural equation model results indicate that health optimism was positively associated with healthy behaviours and perceived control over one's health; health pessimism was associated with poorer perceived health care management. Health optimism and pessimism have different psychosocial contributors and health correlates, validating the health congruence approach to later life well-being, health and survival.     

American Indian health disparities: psychosocial influences

The American Indian (AI) population suffers from significant health disparities. Death rates from diabetes, cancer, infant mortality, and other causes are higher among AIs. Numerous psychosocial influences, including a history of genocide and boarding school experiences, have led to unresolved historical trauma and its associated poor health outcomes. Adverse childhood experiences are also a strong predictor of risk for numerous chronic and behavioral health conditions. Food programs for impoverished populations historically have led to high rates of formula feeding of infants and intake of high‐calorie, low nutritional value foods. Adverse adulthood experiences, including poverty, racism, and substance abuse, lead to depression, anxiety, and poor health outcomes. These social circumstances can have an impact on the quality of parenting skills for the next generation, leading to continued intergenerational health disparities. Additional research into the psychosocial influences and social determinants of health is needed to ensure improved policy and program development.     

低家庭社会阶层大学生为何更容易社交焦虑？——心理社会资源和拒绝敏感性的多重中介作用

在阶层的社会认知理论和备用容量模型框架下,探讨心理社会资源、拒绝敏感性在家庭社会阶层与大学生社交焦虑间的多重中介作用。选取1400名在校大学生为被试,采用与积极心理变量结果相关度最高的乐观、控制感、自尊和外向性四种人格特质问卷作为心理社会资源的测量工具,同时施测了MacArthur主观社会阶层量表、拒绝敏感性问卷、Liebowitz社交焦虑量表,还收集了被试的父母亲职业、受教育程度及月收入水平等客观家庭社会阶层指标。Bootstrap中介效应检验结果表明,家庭社会阶层显著负向预测大学生社交焦虑,心理社会资源水平、拒绝敏感性在二者间起到中介作用,同时家庭社会阶层还顺序性地通过先影响心理社会资源、再影响拒绝敏感性这一链式路径对社交焦虑产生影响。因此为了预防和干预低阶层大学生社交焦虑,未来可以考虑提升心理社会资源水平和降低拒绝威胁敏感性两种途径。     

低家庭社会阶层大学生为何更容易社交焦虑？——心理社会资源和拒绝敏感性的多重中介作用

在阶层的社会认知理论和备用容量模型框架下,探讨心理社会资源、拒绝敏感性在家庭社会阶层与大学生社交焦虑间的多重中介作用。选取1400名在校大学生为被试,采用与积极心理变量结果相关度最高的乐观、控制感、自尊和外向性四种人格特质问卷作为心理社会资源的测量工具,同时施测了MacArthur主观社会阶层量表、拒绝敏感性问卷、Liebowitz社交焦虑量表,还收集了被试的父母亲职业、受教育程度及月收入水平等客观家庭社会阶层指标。Bootstrap中介效应检验结果表明,家庭社会阶层显著负向预测大学生社交焦虑,心理社会资源水平、拒绝敏感性在二者间起到中介作用,同时家庭社会阶层还顺序性地通过先影响心理社会资源、再影响拒绝敏感性这一链式路径对社交焦虑产生影响。因此为了预防和干预低阶层大学生社交焦虑,未来可以考虑提升心理社会资源水平和降低拒绝威胁敏感性两种途径。     

An Interactionist Perspective on Genetic and Environmental Contributions to Personality

It is now well established that nature and nurture are both important contributors to variation in human personality. As a result, the field of personality behavior genetics is moving beyond simply estimating the magnitude of genetic and environmental influences on various personality constructs. Recent methodological advances provide for the study of how these different sources of influence interact in the development of personality. Specifically, newer biometrical moderation models allow for group‐specific estimates of heritability and environmental influences on personality (a form of gene–environment interaction). In the current paper, we review selected recent research using these models. Furthermore, we explore how moderation might also be important in understanding links between specific genes and personality. Accounting for the contingencies between genes and environment will be an important catalyst for the molecular genetic study of personality, as unmoderated ‘main effect’ types of gene → personality associations have been elusive.     

DRD4基因与亲社会行为的关联及其潜在脑机制

DRD4基因是亲社会行为的重要候选基因,且与环境交互影响亲社会行为的发生发展。通过梳理既有研究,本文从性别差异、亲社会行为的不同类型及发展动态性等角度探讨了亲社会行为遗传研究存在分歧的原因,并在此基础上探索了DRD4基因作用于亲社会行为的潜在脑机制。未来研究应采用纵向设计探究DRD4基因影响亲社会行为的发展动态性问题,并深入探索其性别差异;采用多质多法分析考察不同类型亲社会行为遗传机制的差异性;采用影像遗传学设计揭示“DRD4基因—脑—亲社会行为”作用机制。     

Psychosocial Perspectives on Pregnancy: Prenatal Maternal Stress and Coping

Pregnancy is a momentous life event experienced by most women that involves biomedical and psychosocial changes that are potentially stressful. High levels of maternal stress in pregnancy contribute to adverse fetal, infant, child, and adult outcomes, including cognitive, emotional, neurodevelopmental, and physical health effects. This article discusses definition, measurement, and effects of stress in pregnancy and describes current research questions such as whether the timing or pattern of prenatal stress accentuates its effects and whether prenatal stress accounts for ethnic disparities in adverse birth outcomes in the United States. We review research on the ways that women cope with prenatal stress and research examining associations of coping with maternal emotional state, health, and birth outcomes. Additionally, we describe important factors that improve women's psychosocial adaptation to pregnancy, their health, and their birth outcomes, specifically trait optimism, social support, and physical activity, and we emphasize interventions that utilize these factors.     

Survey of mental health of foreign students

The multifaceted nature of problems foreign students face have led some researchers to conclude that these students tend to suffer from poor health during their overseas sojourn. This assertion is examined among foreign students at the University of Bergen by means of a questionnaire survey. Loneliness, tiredness, sadness and worrying were reported as a frequent source of problem by nearly one in four of over 300 respondents. Students reported a decline in their general state of health as well as a rise in the occurrence of syndrome-like tendencies resembling paranoia, anxiety, depression and somatic complaints. These tendencies were attributed to certain psychosocial factors such as information received regarding study opportunities, social contacts with other tenants in the hall of residence and future job opportunities. Scandinavian students on the whole tended to have better mental health than students from the other countries. The implications of impaired health among foreign students is discussed.     

The Impact of Cancer on Psychological and Social Outcomes

Cancer is now the biggest cause of mortality worldwide. Although the debilitating physical symptoms of cancer have long been known, the psychological and social impacts of cancer have become the subject of examination only relatively recently. The psychological outcomes that have been examined are primarily negative emotional variables, e.g., anxiety, but emerging research has focused on positive emotional variables, e.g., post‐traumatic growth, or cognitive outcomes. In this article, we provide a synthesis of reviews that have addressed the psychosocial impact of cancer. The framework for this synthesis is provided by a conceptualisation in which the presence of cancer impacts on psychosocial outcomes either directly or via mediating variables, including physical symptoms and treatment, and that this effect may be moderated by several variables, some characteristic of the person with cancer (demographic or personality‐related variables) and some characteristic of their environment (social support and medical variables). We also briefly examine the impact of cancer on the broader family unit following cancer diagnosis, treatment, survivorship and bereavement. We conclude that the heterogeneity of the cancer experience highlights the need for theoretically driven research and consistency in measurement approaches to determine mechanisms by which cancer exerts influence on psychosocial outcomes. This would allow development and delivery of targeted psychological interventions and a clearer delineation of the roles of the various parties, including clinical psychologists, family members and policymakers.     

The Role of Optimism,Social Constraints,Coping, and Cognitive Processing in Psychosocial Adjustment Among Breast Cancer Survivors

The social-cognitive processing model suggests that a socially constrained environment may impede adjustment to a chronic illness. The present study primarily investigated the mediating psychological pathways through which social constraints on cancer-related disclosure, low optimism, disengagement-oriented coping, and brooding could be associated with low levels of psychosocial adjustment. One hundred twenty-five female breast cancer survivors participated in a cross-sectional study. Path analysis was used to examine the proposed model. Low optimism, increased social constraints, and higher levels of brooding appeared to be risk factors for poor psychosocial adjustment to breast cancer. Disengagement-oriented coping and brooding partially mediated the relationship between social constraints and adjustment. Brooding totally mediated the relationship between disengagement-oriented coping and adjustment. The current findings provide support for the value of the social-cognitive processing model among breast cancer survivors. The mapping of psychological pathways of adjustment to breast cancer may have useful clinical implications for better adjustment outcomes.     

羞怯:来自行为遗传学的观点

羞怯是指社交情境中的不舒服和/或者抑制,会妨碍个体对人际目标或职业目标的追求;表现为过分地自我关注、全神贯注于个人的想法,以及某些情绪和生理的反应.近几年,从行为遗传学的角度探讨羞怯的成因成为该领域研究的前沿与热点.早期的双生子研究与分子遗传学的研究结果表明,羞怯与遗传密切相关;5-HTTLPR短型基因与羞怯的关系尤为密切;羞怯可能是多种基因以及基因与环境交互作用的结果.     

Positive affect and psychosocial processes related to health

Positive affect is associated with longevity and favourable physiological function. We tested the hypothesis that positive affect is related to health‐protective psychosocial characteristics independently of negative affect and socio‐economic status. Both positive and negative affect were measured by aggregating momentary samples collected repeatedly over 1 day, and health‐related psychosocial factors were assessed by questionnaire in a sample of 716 men and women aged 58–72 years. Positive affect was associated with greater social connectedness, emotional and practical support, optimism and adaptive coping responses, and lower depression, independently of age, gender, household income, paid employment, smoking status, and negative affect. Negative affect was independently associated with negative relationships, greater exposure to chronic stress, depressed mood, pessimism, and avoidant coping. Positive affect may be beneficial for health outcomes in part because it is a component of a profile of protective psychosocial characteristics.