Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior

Sex differences in the genetic and environmental influences on childhood conduct disorder and adult antisocial behavior were examined in a large community sample of 6,383 adult male, female, and opposite-sex twins. Retrospective reports of childhood conduct disorder (prior to 18 years of age) were obtained when participants were approximately 30 years old, and lifetime reports of adult antisocial behavior (antisocial behavior after 17 years of age) were obtained 8 years later. Results revealed that either the genetic or the shared environmental factors influencing childhood conduct disorder differed for males and females (i.e., a qualitative sex difference), but by adulthood, these sex-specific influences on antisocial behavior were no longer apparent. Further, genetic and environmental influences accounted for proportionally the same amount of variance in antisocial behavior for males and females in childhood and adulthood (i.e., there were no quantitative sex differences). Additionally, the stability of antisocial behavior from childhood to adulthood was slightly greater for males than females. Though familial factors accounted for more of the stability of antisocial behavior for males than females, genetic factors accounted for the majority of the covariation between childhood conduct disorder and adult antisocial behavior for both sexes. The genetic influences on adult antisocial behavior overlapped completely with the genetic influences on childhood conduct disorder for both males and females. Implications for future twin and molecular genetic studies are discussed.     

Developmental Links Between Trajectories of Physical Violence,Vandalism, Theft,and Alcohol-Drug Use from Childhood to Adolescence

Differences in developmental trajectories of physical violence, vandalism, theft, and alcohol-drug use from ages 10 to 15 were studied. For females and for males, three trajectories of theft and of alcohol-drug use increased from 10 years to 15 years, while only the high trajectory of vandalism increased from ten to 14. All trajectories of physical violence decreased. Children who engaged in the high trajectories of vandalism, theft, and alcohol-drug use had a high probability of also being high in physical violence. Compared to males, females were less likely to be on the high trajectory of physical violence, and their trajectories of other antisocial behaviors were less strongly associated with high levels of physical violence. The results suggest that physical violence during pre-adolescence and adolescence has a different developmental pattern than other forms of antisocial behavior, and that its relation to these other forms of antisocial behavior differs by sex.     

Adult Outcomes of Child Conduct Problems: A Cohort Study

The present study assessed the mental health and criminal records of 6,449 males and 6,268 females who presented conduct problems as children by examining an unselected birth cohort followed up to age 30. Conduct problems were defined by teacher ratings of behavior problems and/or antisocial behavior in the community. There was little overlap in the children identified by teachers and by the community. These two groups of children were at differential risk for adult mental disorder. Seventy-six percent of the males and 30% of females with childhood conduct problems had either a criminal record, a mental disorder, or both by age 30. Risk ratios for adult criminality and/or mental disorders, however, were greater for females than for males with a history of childhood conduct problems. Almost all of the mental disorders were severe substance abuse. Mental disorders and crime were strongly associated among males with a history of childhood conduct problems.     

Socioeconomic,family, and social stress correlates of adolescent antisocial and delinquent behavior

A total of 84 male and female adolescents were surveyed for SFS, family systemic functioning, and four types of social stress (Induced Transitions, Daily Hassles, Developmental Transitions, and Circumscribed Life Events) in relation to level of antisocial and delinquent behavior to determine the individual and cumulative effect of these psychosocial predictors. Univariate analyses indicated that perceived and Desired Family Cohesion, Daily Hassles, Circumscribed Life Events, and Developmental Transitions correlated significantly with reported antisocial and delinquent behavior, but SES and gender did not. Multivariate analyses affirmed that SES was of little use in understanding such behavior, at least among the general population, and that family functioning and social stress contributed interactively. Desired Cohesion was the most reliable indicator, with other family and stress variables' importance differing for males and females. These findings suggest that a family's ability to support each other and to harness that support to cope with transitions and stress during adolescence relates to a lower level of antisocial behavior.     

Perceived positive outcomes as a mediator between adolescent callous-unemotional traits and antisocial behavior

This study investigated perceived positive outcomes as a mediator of the relation between callous-unemotional (CU) traits and antisocial behavior (i.e., delinquency, aggression) and the potential moderational influence of anxiety in that model. Participants were 149 adolescents, ages 16–19 years (124 males, 25 females) in a residential setting. Perceived positive outcomes for antisocial behavior mediated the relation between CU traits (callousness and uncaring) and such behaviors. Additionally, anxiety had a moderating effect on the relation between callousness and perception of positive outcomes, and the indirect effect of callousness on antisocial behavior was conditional based on varying levels of anxiety. These results suggest a potential mechanism through which CU traits are associated with adolescent behavioral problems.     

Genetic and environmental influences on antisocial behavior: a meta-analysis of twin and adoption studies

A meta-analysis of 51 twin and adoption studies was conducted to estimate the magnitude of genetic and environmental influences on antisocial behavior. The best fitting model included moderate proportions of variance due to additive genetic influences (.32), nonadditive genetic influences (.09), shared environmental influences (.16), and nonshared environmental influences (.43). The magnitude of familial influences (i.e., both genetic and shared environmental influences) was lower in parent-offspring adoption studies than in both twin studies and sibling adoption studies. Operationalization, assessment method, zygosity determination method, and age were significant moderators of the magnitude of genetic and environmental influences on antisocial behavior, but there were no significant differences in the magnitude of genetic and environmental influences for males and females.     

Motor impairment and antisocial behavior in adolescent males at high risk for schizophrenia

A familial link between schizophrenia and antisocial behavior has been established (e.g., Silverton, 1985). This study examined this relationship in a Danish cohort. The subjects were 36 high-risk males (offspring of a schizzophrenic parent) and 36 low-risk males (offspring of parents without psychopathology). This high-risk subjects exhibited more antisocial behavior than the low-risk subjects. We tested the hypothesis of a correlation between neurointegrative deficits, as defined by motor impairment, and antisocial behavior, rated at ages 10–13, in subjects at genetic risk for schizophrenia. Path analyses were conducted from motor impairment at 1 year and motor impairment at 10–13 years to antisocial behavior separately for high-risk and low-risk subjects. Adolescent motor impairment was a significant predictor of antisocial behavior for high-risk subjects. Motor impairment at 1 year was also associated with antisocial behavior for these subjects, although the association was partly due to the indirect effects of motor impairment at 1 year on motor impairment at 10–13 years, which, in turn, was associated with changes in antisocial behavior. As predicted, none of the path coefficients nor the effect coefficient was significant for low-risk subjects.     

Fear of failure and student athletes’ interpersonal antisocial behaviour in education and sport

Background. The link between fear of failure and students’ antisocial behaviour has received scant research attention despite associations between fear of failure, hostility, and aggression. Also, the effect of sport experience on antisocial behaviour has not been considered outside of the sport context in adult populations. Further, to date, sex differences have not been considered in fear of failure research. Aims. To examine whether (a) fear of failure and sport experience predict antisocial behaviour in the university and sport contexts in student athletes, and whether this prediction is the same in males and females; and (b) sex differences exist in antisocial behaviour and fear of failure. Sample. British university student athletes (n= 176 male; n= 155 female; M_age= 20.11 years). Method. Participants completed questionnaires assessing fear of failure, sport experience, and antisocial behaviour in both contexts. Results. (a) Fear of failure and sport experience positively predicted antisocial behaviour in university and sport and the strength of these predictions did not differ between males and females; (b) females reported higher levels of fear of devaluing one's self‐estimate than males whereas males reported higher levels of fear of important others losing interest than females. Males engaged more frequently than females in antisocial behaviour in both contexts. Conclusions. Fear of failure and sport experience may be important considerations when trying to understand antisocial behaviour in student athletes in education and sport; moreover, the potential effect of overall fear of failure and of sport experience on this frequency does not differ by sex. The findings make an important contribution to the fear of failure and morality literatures.     

Brain structure abnormalities in young women who presented conduct disorder in childhood/adolescence

The phenotype and genotype of antisocial behavior among females are different from those among males. Previous studies have documented structural brain alterations in males with antisocial behavior, yet little is known about the neural correlates of female antisocial behavior. The present study examined young women who had presented conduct disorder (CDW) prior to age 15 to determine whether brain abnormalities are present in adulthood and whether the observed abnormalities are associated with comorbid disorders or maltreatment that typically characterize this population. Using magnetic resonance imaging and voxel-based morphometry, we compared gray matter volumes (GMV) of 31 women who presented CD by midadolescence and 25 healthy women (HW), age, on average, 23 years. Participants completed structured, validated interviews to diagnose mental disorders, and validated questionnaires to document physical and sexual abuse. Relative to HW, CDW presented increased GMV in the left superior temporal gyrus that was associated with past alcohol and drug dependence, current use of alcohol and drugs, and current anxiety and depression symptoms and maltreatment. Additionally, CDW displayed reduced GMV in lingual gyrus, hippocampus, and anterior cingulate cortex that was associated with past comorbid disorders, current alcohol and drugs use, current anxiety and depression symptoms, and maltreatment. The CDW also presented reduced total GMV that was associated with past comorbid disorders and current anxiety/depression symptoms. Alterations of brain structure were observed among young adult females with prior CD, relative to HW, all of which were associated with internalizing and externalizing disorders and maltreatment that typically accompany CD.     

Predictors and outcomes of persistent or age‐limited registered criminal behavior: a 30‐year longitudinal study of a Swedish urban population

This study uses data from the longitudinal research program Individual Development and Adaptation, where an entire school‐grade cohort of children in a middle‐size Swedish city (n～1.300) has been followed from ages 10 to 43 and 48 for women and men, respectively. Our findings indicate that the patterns of offending across the life‐course differ between genders, where males seem to initiate their offending earlier than females. Further, there are very few women on a persistent offending‐trajectory. Focusing on precursors to as well as consequences of offending as indexed in official registers, our results indicate that individuals in the persistent offender group have the most pronounced adjustment problems in school‐ as well as in middle age. Individual characteristics and behaviors (e.g., aggression, hyperactivity, antisocial behavior) vary systematically between individuals with different developmental offending patterns. The combination of an unstable upbringing and own antisocial behavior seems to be especially predictive for criminality. For persistent offenders, the prevalence of alcohol and psychiatric problems at adult age is high for males and extremely high for females (nine out of ten and six out of ten for each of the two problem types for females). Further, the importance for adjustment of the two‐dimensional variation in the number of crimes committed during adolescence and adult age seems to have been surprisingly well captured by the “crude” division into the four offender groups that were used. Aggr. Behav. 35:164–178, 2009. © 2009 Wiley‐Liss, Inc.     

Binge drinking and violence against intimate partners in Russia

This study is the first to provide information on the association between intimate partner violence (IPV) and binge drinking among Russian university students. Using data from 500 (58% female) university students from the four Russian sites of the International Dating Violence Study, we found gender differences in rates of IPV perpetration and in the association between binge drinking and IPV. Specifically, more females than males perpetrated IPV, and the associations between binge drinking and IPV were stronger for the female students than for the male students. In addition, antisocial traits and behavior (ATSB) were significantly related to both binge drinking and IPV perpetration for males and females. For males, the relatively weak associations between binge drinking and IPV perpetration disappeared once ASTB was accounted for. For females, the relationship decreased but remained significant when ATSB was statistically controlled. Path analyses confirmed that this pattern of relationships would be consistent with ATSB serving as a partial mediator between binge drinking and IPV perpetration. However, other alternative mediation and moderation models for the relationships between binge drinking, IPV perpetration, and ATSB could not be ruled out with this one-wave correlational study.     

The Use of the MacAndrew Alcoholism Scale in Detecting Substance Abuse and Antisocial Personality

We evaluated the hypothesis that characterological factors, particularly antisocial personality, influence scores on the MacAndrew Alcoholism Scale (MAC). Using the Washington University research criteria to establish diagnoses, the following subgroups were defined: subjects who received no psychiatric diagnoses; subjects who received diagnoses other than alcoholism, drug dependence, or antisocial personality; and subjects who received a diagnosis of alcoholism, drug dependence, and/or antisocial personality, alone or in combination with other psychiatric diagnoses. The highest MAC scores were obtained by subjects diagnosed as having antisocial personality without alcoholism or drug dependence and subjects diagnosed with antisocial personality, drug dependence, and alcoholism. Alcoholics without antisocial personality or drug dependence, and subjects with other psychiatric diagnoses scored lowest. Although higher MAC scores were obtained by males, MAC scores greater than 24 correctly classified the greatest number of males and females as alcoholic, drug dependent and/or antisocial. These findings are interpreted as consistent with MacAndrew's reinterpretation of the scale as assessing a dimension of personality, rather than solely a tendency to addiction.     

The use of the MacAndrew Alcoholism Scale in detecting substance abuse and antisocial personality

We evaluated the hypothesis that characterological factors, particularly antisocial personality, influence scores on the MacAndrew Alcoholism Scale (MAC). Using the Washington University research criteria to establish diagnoses, the following subgroups were defined: subjects who received no psychiatric diagnoses; subjects who received diagnoses other than alcoholism, drug dependence, or antisocial personality; and subjects who received a diagnosis of alcoholism, drug dependence, and/or antisocial personality, alone or in combination with other psychiatric diagnoses. The highest MAC scores were obtained by subjects diagnosed as having antisocial personality without alcoholism or drug dependence and subjects diagnosed with antisocial personality, drug dependence, and alcoholism. Alcoholics without antisocial personality or drug dependence, and subjects with other psychiatric diagnoses scored lowest. Although higher MAC scores were obtained by males, MAC scores greater than 24 correctly classified the greatest number of males and females as alcoholic, drug dependent and/or antisocial. These findings are interpreted as consistent with MacAndrew's reinterpretation of the scale as assessing a dimension of personality, rather than solely a tendency to addiction.     

Synergistic interaction of child manageability problems and parent-discipline tactics in predicting future growth in externalizing behavior for boys.

Manageability problems during early childhood for boys were hypothesized to disrupt parental discipline practices. In turn, disrupted parental discipline practices were hypothesized to interact with manageability problems during late childhood to predict change in antisocial behavior during the transition from elementary to middle school. Results indicated that maternal retrospective perceptions of unmanageability predicted observed maternal discipline practices, even when maternal antisocial behavior and depressed mood and the disruptive and antisocial behavior of the boy were statistically controlled. Graphical analyses and latent class growth models indicated that level of temper tantrums interacted with maternal discipline in predicting change in teacher ratings of antisocial behavior. The nature of the interaction indicated that maternal discipline was a risk factor for growth in antisocial behavior only for boys with high levels of tantrums.     

The prediction of violent and nonviolent criminal behavior in a methadone maintenance population

The utility of traits associated with Antisocial Personality Disorder in making risk assessments of violent and nonviolent crimes was examined in 254 subjects sampled from a methadone maintenance population. A factor analysis of a number of baseline measures resulted in five factors measuring hostility, insecure attachment, impaired reality testing, antisocial personality, and empathy. These factors were used in logistic regression analysis to predict charges for violent and nonviolent crimes over a 2-year period. Individuals with high scores on the antisocial personality factor had an increased risk of both violent and nonviolent criminal charges. Individuals with low scores on the empathy factor were at high risk for violent crimes. In an analysis using the factor components rather than the factors, the measures of perspective-taking and a socialization were associated with violent criminal charges, and the measure of psychopathy, but not antisocial behavior, was associated with nonviolent criminal charges. The results support the use of measures of personality traits in addition to measures of a history of antisocial behavior in making violence risk assessments in substance-dependent patients. The DSM construct and diagnosis of Antisocial Personality Disorder may be enhanced by greater emphasis on personality traits associated with antisocial behavior.     

Stability and predictors of psychopathic traits from mid‐adolescence through early adulthood

High levels of psychopathic traits in youth are associated with multiple negative outcomes including substance misuse, aggressive behavior, and criminality. Evidence regarding stability of psychopathic traits is contradictory. No previous study has examined long‐term stability of psychopathic traits assessed with validated clinical measures. The present study examined the stability of psychopathic traits from mid‐adolescence to early adulthood and explored adolescent factors that predicted psychopathic traits five years later. The sample included 99 women and 81 men who had consulted a clinic for substance misuse in adolescence. At an average age of 16.8 years, the adolescents were assessed using the Psychopathy Checklist: Youth Version (PCL: YV) and five years later using the PCL‐Revised (PCL‐R). Additionally, extensive clinical assessments of the adolescents and their parents were completed in mid‐adolescence. Among both females and males, moderate to high rank‐order stability was observed for total PCL and facet scores. Among both females and males, there was a decrease in the mean total PCL score, interpersonal facet score, affective facet score, and lifestyle facet score. However, the great majority of females and males showed no change in psychopathy scores over the five‐year period as indicated by the Reliable Change Index. Despite the measures of multiple family and individual factors in adolescence, only aggressive behavior and male sex predicted PCL‐R total scores in early adulthood after taking account of PCL:YV scores. Taken together, these results from a sample who engaged in antisocial behavior in adolescence suggest that factors promoting high psychopathy scores act early in life.     

Concurrent and prospective associations between facial affect recognition accuracy and childhood antisocial behavior

This study examined the concurrent and prospective associations between children's ability to accurately recognize facial affect at age 8.5 and antisocial behavior at age 8.5 and 10.5 years in a sub sample of the Avon Longitudinal Study of Parents and Children cohort (5,396 children; 2,644, 49% males). All observed effects were small. It was found that at age 8.5 years, in contrast to nonantisocial children; antisocial children were less accurate at decoding happy and sad expressions when presented at low intensity. In addition, concurrent antisocial behavior was associated with misidentifying expressions of fear as expressions of sadness. In longitudinal analyses, children who misidentified fear as anger exhibited a decreased risk of antisocial behavior 2 years later. The study suggests that concurrent rather than future antisocial behavior is associated with facial affect recognition accuracy. Aggr. Behav. 36:305–314, 2010. © 2010 Wiley‐Liss, Inc.     

Adolescent Self-Regulation as Resilience: Resistance to Antisocial Behavior within the Deviant Peer Context

This study tests the hypothesis that self-regulation serves as a resiliency factor in buffering youth from negative influences of peer deviance in middle to late adolescence. The interactive effects between peer deviance and self-regulation were investigated on change in antisocial behavior from age 17 to 19 years in an ethnically diverse sample of adolescents. A multi-agent construct was created using adolescent, parent, and teacher reports of self-regulation and peer deviance. Results indicated that self-regulation shows convergent validity and covaries as expected with developmental patterns of adolescent antisocial behavior. Self-regulation moderated the association of peer deviance with later self-reported adolescent antisocial behavior after controlling for prior levels of antisocial behavior. The implications of these findings for models for the development of antisocial behaviors and for intervention science are discussed.     

Overt and Covert Dimensions of Antisocial Behavior in Early Childhood

The present study was designed to assess both the prevalence and structure of antisocial behavior in a normative sample of preschoolers. Prevalence estimates suggested that 40% of preschoolers exhibit at least one antisocial behavior each day. Furthermore, 10% of preschoolers exhibit six or more antisocial behaviors each day. Consistent with research based on older children, factor analyses provided support for conceptualizing antisocial behavior in early childhood as consisting of both overt and covert dimensions. While both overt and covert behaviors had acceptable test–retest reliability, only overt behaviors had acceptable interrater reliability. Finally both overt and covert dimensions of antisocial behavior were uniquely related to general measures of conduct problems, hyperactivity, and adult and peer conflict in the classroom setting. Findings are discussed with regard to early assessment and the developmental course of antisocial behavior.