Functional Disability in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis

Accumulating evidence suggests that the pre-dementia syndrome mild cognitive impairment (MCI) is characterized by decrements in instrumental activities of daily living (IADL). The current review was a quantitative synthesis of the available literature to objectively characterize IADL disability in MCI while clarifying inconsistencies in findings across studies. It was hypothesized that individuals with MCI would display significantly greater functional impairment relative to cognitively intact controls. Candidate moderators specified a priori included functional assessment approach, MCI subtype, depressive symptoms, and language conducted. Online databases (PubMed/MEDLINE and PsycINFO) and reference lists were searched to identify peer-reviewed publications assessing IADL in MCI compared to normal aging. A total of 151 effect sizes derived from 106 studies met inclusionary criteria (N?=?62,260). Random effects models yielded a large overall summary effect size (Hedges’ g?=?0.76, 95 % confidence interval: 0.68???0.83, p?<?.001) confirmed in multi-level analyses adjusted for nesting of effect sizes within studies (g?=?0.78, 95 % confidence interval: 0.69???0.87). Functional assessment strategy and MCI subtype were significant moderators of effect size, whereas depressive symptoms and language were not. Results convincingly demonstrate that MCI is associated with significant difficulties in the performance of complex everyday tasks. It appears that functional decline, like cognitive decline, exists on a continuum from healthy aging to dementia onset. Implications for clinical practice and research priorities are discussed.     

Exercise Improves Cognitive Control: Evidence from the Stop Signal Task

The aim of this study was to test the hypothesis that exercise improves executive control. We compared the performance of physically active and passive young participants in two versions of the stop signal task: a strategic (more executive) and a standard version. The results showed that active participants were more efficient than passive at inhibiting a response in the strategic version, suggesting that (1) physical exercise appears positively associated with improved cognitive control in healthy young participants, adding to evidence gathered in children, aging and clinical populations; and that (2) the strategic version of the stop signal task constitutes a more sensitive task than executive tasks previously used. Although the data point out a link between physical activity and executive control, they also have potential practical implications for health authorities and the general public by strengthening the view that exercise, beyond its physical health benefits, also has positive effects on cognitive functioning. Copyright © 2013 John Wiley & Sons, Ltd.     

Functional Magnetic Resonance Imaging of Language in Epilepsy

Functional magnetic resonance imaging (fMRI) has revolutionized our understanding of functional networks and cerebral organization in both normal and pathological brains. In the present review, we describe the use of fMRI for mapping language in epilepsy patients prior to surgical intervention including a discussion of methodological issues and task design, comparisons between fMRI and the intracarotid sodium amobarbital test, fMRI studies of language reorganization, and the use of fMRI laterality indexes to predict outcome after anterior temporal lobectomy.     

A Meta-Analysis of the Distinction between Reactive and Proactive Aggression in Children and Adolescents

The present meta-analytic review aimed to clarify divergent findings concerning the relation between reactive and proactive aggression in children and adolescents. Fifty-one studies with 17,965 participants were included in the analysis. A significant correlation between reactive and proactive aggression was found. The strength of this relation varied considerably between studies, from -.10 to .89. Observational assessment and tilt/noise tasks were associated with smaller correlations than questionnaires. Within the large group of questionnaire studies, studies disentangling the form and function of aggression found lower correlations than studies that did not disentangle form and function. Among questionnaire studies, higher reliability was associated with larger correlations. Effect size did not depend on other study characteristics such as sample type, age, and informant type. It is concluded that reactive and proactive aggression are most clearly distinguished with behavioral observations and questionnaires that unravel form and functions of aggression.     

Role of Functional Magnetic Resonance Imaging in Drug Discovery

In this review, we survey the state of the field of functional magnetic resonance imaging (fMRI) as it relates to drug discovery and drug development. We highlight the advantages and limitations of fMRI for this purpose and suggest ways to improve the use of fMRI for developing new therapeutics, with emphasis on treatments for anxiety disorders. Fundamentally, pharmacological studies with standard psychiatric treatments using standardized behavioral probes during fMRI will need to be carried out to determine characteristic brain signatures that could be used to predict whether novel compounds are likely to have specific therapeutic effects.     

运动、语言和学习：小脑的功能磁共振成像研究

对小脑功能的认识在过去的100年里经历了缓慢而稳定的发展。在最近20年,随着活体神经影像技术尤其是功能磁共振成像（fMRI）的出现,这一领域取得了更加显著的进展。文章简要总结了我们最近关于小脑的fMRI研究,考察了该结构在运动、语言和学习任务中的作用;并通过回顾相关文献,讨论了这些研究的理论意义。小脑的功能本质似乎是一般性的而非通道特异的,动态的而非静态的,联系的而非孤立的。作者提出,研究小脑与大脑之间的相互作用和合作机制将是小脑研究领域的新的生长点     

Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis

Neuropsychology Review - Depression has been shown to negatively impact neurocognitive functions, particularly those governed by fronto-subcortical networks, such as executive functions. Converging...     

Working Memory in Pediatric Epilepsy: A Systematic Review and Meta-Analysis

Neuropsychology Review - Working memory is a multicomponent system that is supported by overlapping specialized networks in the brain. Baddeley’s working memory model includes four...     

Use of Functional Magnetic Resonance Imaging in the Early Identification of Alzheimer's Disease

A growing body of evidence suggests that a preclinical phase of Alzheimer's disease (AD) exists several years or more prior to the overt manifestation of clinical symptoms and is characterized by subtle neuropsychological and brain changes. Identification of individuals prior to the development of significant clinical symptoms is imperative in order to have the greatest treatment impact by maintaining cognitive abilities and preserving quality of life. Functional magnetic resonance imaging (fMRI) offers considerable promise as a non-invasive tool for detecting early functional brain changes in asymptomatic adults. In fact, evidence to date indicates that functional brain decline precedes structural decline in preclinical samples. Therefore, fMRI may offer the unique ability to capture the dynamic state of change in the degenerating brain. This review examines the clinical utility of blood oxygen level dependent (BOLD) fMRI in those at risk for AD as well as in early AD. We provide an overview of fMRI findings in at-risk groups by virtue of genetic susceptibility or mild cognitive decline followed by an appraisal of the methodological issues concerning the diagnostic usefulness of fMRI in early AD. We conclude with a discussion of future directions and propose that BOLD-fMRI in combination with cerebral blood flow or diffusion techniques will provide a more complete accounting of the neurovascular changes that occur in preclinical AD and thus improve our ability to reliably detect early brain changes prior to disease onset.     

Neurocognitive Functioning in Depressed Young People: A Systematic Review and Meta-Analysis

Background: Depression is among the most common mental health problems for young people. In adults, depression is associated with neurocognitive deficits that reduce the effectiveness of treatment and impair educational and vocational functioning. Compared to adults, less is known about the neurocognitive functioning of young people with depression, and existing research has reported inconsistent findings. Method: This systematic review and meta-analysis synthesized the literature on neurocognitive functioning in currently depressed youth aged 12–25 years in comparison to healthy controls. Results: Following a systematic review of the literature, 23 studies were included in the meta-analysis. Poorer performance in the domains of attention (SMD: .50, 95% CI: .18–.83, p?=?.002), verbal memory (SMD: .78, 95% CI: .50–1.0, p?<?.001), visual memory (SMD: .65, 95% CI: .30–.99, p?<?.001), verbal reasoning/knowledge (SMD: .46; 95% CI: .14–.79; p?<?0.001) and IQ (SMD: .32; 95% CI: .08–.56; p?=?0.01) were identified in depressed youth. Relative weaknesses in processing speed/reaction time and verbal learning were also evident, however, these findings disappeared when the quality of studies was controlled for. Moderator analysis showed a tendency for poorer set-shifting ability in younger depressed participants relative to controls (although non-significant; p?=?.05). Moderator analysis of medication status showed taking medication was associated with poorer attentional functioning compared to those not taking medication. Conclusion: The findings suggest that currently depressed young people display a range of neurocognitive weaknesses which may impact treatment engagement and outcome. The findings support the need to consider neurocognitive functioning when treating youth with depression.     

Neuropsychological Test Administration by Videoconference: A Systematic Review and Meta-Analysis

The purpose of the current systematic review and meta-analysis was to assess the effect of videoconference administration on adult neurocognitive tests. We investigated whether the scores acquired during a videoconference administration were different from those acquired during on-site administration. Relevant counterbalanced crossover studies were identified according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Twelve studies met criteria for analysis. Included samples consisted of healthy adults as well as those with psychiatric or neurocognitive disorders, with mean ages ranging from 34 to 88 years. Heterogenous data precluded the interpretation of a summary effect for videoconference administration. Studies including particpants with a mean age of 65–75, as well as studies that utilized a high speed network connection, indicated consistent performance across videoconference and on-site conditions, however studies with older participants and slower connections were more variable. Subgroup analyses indicated that videoconference scores for untimed tasks and those allowing for repetition fell 1/10th of a standard deviation below on-site scores. Test specific analyses indicated that verbally-mediated tasks including digit span, verbal fluency, and list learning were not affected by videoconference administration. Scores for the Boston Naming Test fell 1/10th of a standard deviation below on-site scores. Heterogenous data precluded meaningful interpretation of tasks with a motor component. The administration of verbally-mediated tasks by qualified professionals using existing norms was supported, and the use of visually-dependent tasks may also be considered. Variability in previous studies indicates a need for further investigation of motor-dependent tasks. We recommend the development of clinical best practices for conducting neuropsychological assessments via videoconference, and advocate for reimbursement structures that allow consumers to benefit from the increased access, convenience, and cost-savings that remote assessment provides.     

Interference Control in Children with and without ADHD: A Systematic Review of Flanker and Simon Task Performance

The present review systematically summarizes the existing research that has examined two reaction-time-based interference control paradigms, known as the Eriksen Flanker task and the Simon task, in children with and without ADHD. Twelve studies are included, yielding a combined sample size of 272 children with ADHD (M age 9.28 yrs) and 280 typically developing children (M age 9.38 yrs). As predicted, specific disadvantages were found in the ADHD group in terms of reaction time, percentage of errors, and efficiency of performance on incongruent relative to congruent trials, providing evidence for weaker interference control in this group.     

情绪对信任的影响:来自元分析的证据

采用元分析方法探讨情绪对信任的影响。通过中英文献检索,共有21篇文章70个独立样本符合元分析标准（N=4745）。其中积极情绪对信任的影响有47个独立样本,消极情绪对信任的影响有23个独立样本。元分析的结果表明,相对于中性情绪,积极情绪对信任起到一定的促进作用,呈中等效应量（d=0.49）;消极情绪对信任起到一定的抑制作用,呈较小效应量（d=-0.23）。调节效应检验发现,情绪的诱发方式、信任对象熟悉性以及信任测量方式的调节作用均不显著。     

Facial Emotion Processing in Borderline Personality Disorder: A Systematic Review and Meta-Analysis

A body of work has developed over the last 20 years that explores facial emotion perception in Borderline Personality Disorder (BPD). We identified 25 behavioural and functional imaging studies that tested facial emotion processing differences between patients with BPD and healthy controls through a database literature search. Despite methodological differences there is consistent evidence supporting a negative response bias to neutral and ambiguous facial expressions in patients. Findings for negative emotions are mixed with evidence from individual studies of an enhanced sensitivity to fearful expressions and impaired facial emotion recognition of disgust, while meta-analysis revealed no significant recognition impairments between BPD and healthy controls for any negative emotion. Mentalizing studies indicate that BPD patients are accurate at attributing mental states to complex social stimuli. Functional neuroimaging data suggest that the underlying neural substrate involves hyperactivation in the amygdala to affective facial stimuli, and altered activation in the anterior cingulate, inferior frontal gyrus and the superior temporal sulcus particularly during social emotion processing tasks. Future studies must address methodological inconsistencies, particularly variations in patients’ key clinical characteristics and in the testing paradigms deployed.     

A Systematic Review and Meta-Analysis on the Efficacy of Self-Help Interventions in Tinnitus

This study is a review and meta-analysis on the efficacy of cognitive-behavioural therapy (CBT) self-help interventions for tinnitus. Randomized controlled trials were identified by searching in databases (e.g. ISI Web of Knowledge, PubMed, Cochrane Library, and PSYNDEX) and by manual search. Ten studies with 1188 participants in total were included in the meta-analysis. Participants were 49.2 years old and had tinnitus for 5.2 years. Self-help interventions significantly reduced tinnitus distress (d = 0.48) and depressiveness (d = 0.25) when compared with a passive control (e.g. information only and discussion forums) at post-assessment. There was no difference to the face-to-face controls (group treatment). The presence of therapists and the methodological quality of the studies did not influence the results. Sensitivity analysis revealed that there might be a publication bias regarding the comparison to the face-to-face control. However, the results suggest that CBT self-help interventions are an effective treatment for tinnitus distress. Since few studies were identified, this conclusion must be supported by future meta-analyses.     

道德推理与道德行为关系的元分析

目前道德心理学中存在对道德推理作用的质疑, 这一质疑源自哲学领域的著名争论。从经典道德心理学理论来说, 道德推理应该是道德行为的重要决定因素, 但新近的观点则否定这一重要作用。本研究采用元分析技术探讨道德推理与道德行为的关系。通过文献搜索与检查, 获得了50项研究和83个独立效应量, 共包含16738名被试。检验表明发表偏差不会影响元分析的结果, 选择随机效应模型是准确的。通过随机效应模型的元分析表明, 道德推理与道德的行为有显著的正相关, 与不道德的行为有显著的负相关。调节效应分析表明, 道德推理测量工具的类型会影响道德推理与道德行为的关系, 被试年龄阶段会影响道德推理与不道德行为的关系。这些结果肯定了道德推理的作用, 也强调了研究过程中要关注测量工具的类型, 指出了需要开发更全面的道德推理测量工具。