Alcohol dependence and the priming effect.

The concepts of loss of control and craving are reviewed and relevant experimental findings are discussed. Speed of drinking is proposed as a behavioural measure of craving and an experiment is described to test the hypothesis that craving is primed by a moderate dose of alcohol (45 gm). The hypothesis was confirmed, but only for the severely dependent alcoholics. The results indicated that the behavioural measure of craving and the assessment of severity of dependence were crucial. Failure to measure either of them would have resulted in failure to identify a priming effect.     

Amnesia,folklore and folks: recovered memories in clinical practice

The concepts of loss of control and craving are reveiwed and relevant experimental findings are discussed. Speed of drinking is suggested as a behavioural measure of craving and an experiment is described to test the hypothesis that craving is primed by a moderate dose of alcohol (45 gms). The hypothesis was confirmed but only for the severely dependent alcoholics.     

The relative role of nicotine dependence and smoking-related cognitions in adolescents' process of smoking cessation

The present study evaluates the role of distinct components of nicotine dependence (craving, withdrawal, behavioural dependence) in comparison to smoking-related cognitions (attitudes, perceived social approval, self-efficacy) in adolescent smoking cessation. In the process towards smoking cessation, we distinguish between distinct behavioural transitions, respectively, short-term abstinence, reduction in smoking behaviour and prolonged cessation, to evaluate differences in cessation-related antecedents as a function of varying behavioural outcomes. A total of 850 adolescent smokers (age 14-16) participated in the present study. Smoking behaviour was assessed 1 year after baseline. Results showed that all dependence components had a distinct role in the prediction of behavioural change towards cessation. Furthermore, each behavioural transition was predicted by a distinct set of variables, indicating that contributions of cessation-related factors vary across the course towards cessation. Overall, our findings suggest that smoking-related cognitions are particularly relevant in the initiation of behavioural change, such as short-term abstinence, whereas nicotine dependence, craving in particular, becomes increasingly important in the prediction of maintained behavioural change, such as prolonged cessation. Implications encompass enhanced attention to the multidimensional nature of nicotine dependence and the value of comparing different behavioural outcomes in a comprehensive understanding of cessation-related factors.     

The relative role of nicotine dependence and smoking-related cognitions in adolescents’ process of smoking cessation

The present study evaluates the role of distinct components of nicotine dependence (craving, withdrawal, behavioural dependence) in comparison to smoking-related cognitions (attitudes, perceived social approval, self-efficacy) in adolescent smoking cessation. In the process towards smoking cessation, we distinguish between distinct behavioural transitions, respectively, short-term abstinence, reduction in smoking behaviour and prolonged cessation, to evaluate differences in cessation-related antecedents as a function of varying behavioural outcomes. A total of 850 adolescent smokers (age 14–16) participated in the present study. Smoking behaviour was assessed 1 year after baseline. Results showed that all dependence components had a distinct role in the prediction of behavioural change towards cessation. Furthermore, each behavioural transition was predicted by a distinct set of variables, indicating that contributions of cessation-related factors vary across the course towards cessation. Overall, our findings suggest that smoking-related cognitions are particularly relevant in the initiation of behavioural change, such as short-term abstinence, whereas nicotine dependence, craving in particular, becomes increasingly important in the prediction of maintained behavioural change, such as prolonged cessation. Implications encompass enhanced attention to the multidimensional nature of nicotine dependence and the value of comparing different behavioural outcomes in a comprehensive understanding of cessation-related factors.     

Conditioned craving cues elicit an automatic approach tendency

In two experiments, we used a Pavlovian differential conditioning procedure to induce craving for chocolate. As a result of repeated pairing with chocolate intake, initially neutral cues came to elicit an automatic approach tendency in a speeded stimulus-response compatibility reaction time task. This automatic approach tendency, moreover, seemed to be sensitive to manipulations of extinction and renewal in the Pavlovian conditioning procedure. These findings corroborate and extend previous reports of automatic approach tendencies elicited by substance-relevant cues in addiction, while controlling for alternative accounts for such observations. Moreover, our data lend support to and extend learning models of cue-induced craving and addiction. Finally, we argue that the procedure we present here provides an ecologically valid behavioural tool that allows studying processes involved in cue-induced craving, addiction and relapse without relying on verbal report.     

辣食渴求者抑制控制能力的行为和ERP研究

采用事件相关电位(ERP)技术,探讨一般线索Go/Nogo和辣食线索Go/Nogo任务过程中,辣食渴求者和非辣食渴求者的抑制控制能力。（1）行为结果显示,两组被试辣食线索的反应时和错误率无显著差异,均在任务类型上有差异,即对辣食线索的反应更慢;（2）ERP结果显示,在辣食相关线索Go/Nogo任务中辣食渴求者的N2b和P3波幅都显著小于非辣食渴求者,N2a没有差异;在一般线索Go/Nogo任务中,ERP成分没有发现显著差异。结果提示,辣食渴求者只在辣食相关线索的抑制控制能力弱于非辣食渴求者,这可能意味着他们对辣食线索抑制反应的缺失。     

The DRD4 VNTR polymorphism influences reactivity to smoking cues

Recent research has indicated that craving for tobacco can be reliably elicited by exposure to smoking cues, suggesting that cue-elicited craving for tobacco may be a useful phenotype for research on genetic factors related to nicotine dependence. Given the potential role of dopamine in cue-elicited craving, the authors examined whether the DRD4 VNTR polymorphism is associated with cue-elicited craving for tobacco. Participants who were homozygous or heterozygous for the 7 repeat (or longer) allele were classified as DRD4 L, and all other participants were classified as DRD4 S. Participants were exposed to smoking cues before smoking either high-nicotine cigarettes or control cigarettes. Analyses suggested that participants in the L group demonstrated significantly greater craving, more arousal, less positive affect, and more attention to the smoking cues than did the participants in the S group.     

Moderating effect of emotional intelligence on the role of negative affect in the motivation to drink in alcohol-dependent subjects undergoing protracted withdrawal

In order to understand how emotional aspects evolve and are related to craving for alcohol, different emotion-related variables were examined in relationship to craving during a protracted withdrawal. To this end state affectivity (PANAS), emotional intelligence (EI) (TEIQue), and craving (OCDS) were assessed at the onset (T1: day 1 or 2) and at the end (T2: day 14 to 18) of three-week protracted withdrawal among alcohol-dependent inpatients (DSM-IV, N = 41). A significant decrease in craving and negative affectivity (NA) was observed from T1 to T2 while EI scores remained low. At both baseline and follow-up, there was a significant moderation effect of EI on the link between NA and craving for alcohol. Negative mood at the onset of the cure was linked to craving at the end of the withdrawal period but only among patients with low trait EI scores. The merits of using psychotherapeutic approaches were discussed in the treatment of alcohol addiction.     

Effect of Islamic psycho-spiritual therapy in managing craving,withdrawal symptoms,and mental health problems among cannabis users

ABSTRACT

The present study is an examination of Islamic psycho-spiritual therapy in managing craving, withdrawal symptoms, and mental health problems among cannabis users. Homogeneous purposive sampling was used in the selection of the sample. The therapy and administration of three scales (Marijuana Craving Scale Short Form; Cannabis Withdrawal Scale; Mental Health Inventory) were undertaken among 40 Muslim male cannabis users whose age ranged between 14 and 37 years on pre- and post-test analysis. The results highlighted the significant differences in the respective dimensions of the Craving and Withdrawal Scales and the Mental Health Inventory such as compulsivity, emotionality, expectancy and purposefulness, withdrawal intensity and negative impact of withdrawal symptoms, anxiety, depression, loss of behavioural/emotional control, emotional ties, life satisfaction, psychological distress, psychological well-being, and mental health index.     

Virtual reality cue reactivity assessment in cigarette smokers.

Drug craving has purportedly been linked to relapse and to substance use. For over two decades, cue reactivity has been a viable method to assess craving and physiological reactions to drug stimuli. However, traditional cue reactivity has faced the following limitations: austere situations or stimuli, lack of complex cues, lack of standardization, and limited generalization outside of the lab setting. In order to improve cue methodologies, a virtual reality (VR) nicotine cue reactivity assessment system (VR-NCRAS) was developed and tested in a controlled experimental trial. Ten nicotine dependent smokers were exposed to VR smoking cues and VR neutral cues in a standardized, timed, computer controlled experiment. Subjective craving and physiological responses were recorded and compared across VR-NCRAS stimuli. Subjective cigarette craving increased significantly and corresponding physiological reactivity was observed in response to VR smoking cues. VR neutral cues did not result in subjective or physiological changes consistent with craving. Implications of these findings on substance abuse research and treatment are discussed.     

Food cravings consume limited cognitive resources

Using Tiffany's (1990) cognitive model of drug use and craving as a theoretical basis, the present experiments investigated whether cravings for food expend limited cognitive resources. Cognitive performance was assessed by simple reaction time (Experiment 1) and an established measure of working memory capacity, the operation span task (Experiment 2). In each experiment, female undergraduate students were randomly assigned to a craving or control condition. Participants in the craving condition abstained from eating chocolate for 24 hours prior to testing and performed the cognitive task in the presence of chocolate, a manipulation that successfully elicited chocolate cravings. In both experiments, there was no main effect of craving condition on cognition, but there was a significant interaction between condition and trait chocolate craving. In support of Tiffany's model, our results show that habitual food cravers direct limited cognitive resources to craving-related cues, at the cost of competing cognitive demands. (PsycINFO Database Record (c) 2008 APA, all rights reserved).     

The DRD4 VNTR polymorphism moderates craving after alcohol consumption.

Recent research has suggested that alterations in mesolimbic dopamine neurotransmission are central to the development and expression of craving for alcohol. Because the D4 dopamine receptor gene, variable numbers of tandem repeats (DRD4 VNTR) polymorphism putatively expresses functional differences in dopamine receptors, the present study tested whether this polymorphism influences the effects of a priming dose of alcohol on craving. Participants consumed 3 alcoholic drinks or 3 control drinks and completed measures of craving after each drink. Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele were classified as DRD4 L, whereas the other participants were classified as DRD4 S. Results suggested that DRD4 L participants demonstrated significantly higher craving after consumption of alcohol as compared with the control beverage.     

Return of experimentally induced chocolate craving after extinction in a different context: divergence between craving for and expecting to eat chocolate

Unlike in fear conditioning, little attention has been devoted to extinction and renewal in appetitive conditioning, despite its relevance for extinction-based addiction treatments. We developed a paradigm, using a specific tray as a conditioned stimulus (CS) for eating chocolate (unconditioned stimulus, US), to investigate the effects of context change on acquisition and extinction of conditioned chocolate craving using an ABA renewal design. In Study 1 (n=32), participants successfully acquired chocolate craving, but unlike what is commonly observed in fear conditioning, craving did not extinguish. In Study 2, we separately assessed craving and US expectancy in a between-subjects design (n=64). US-expectancy data showed acquisition, extinction and renewal in the ABA group. The craving data did not follow this pattern, suggesting different mechanisms for craving and US expectancy. Similarities and differences between craving and US expectancy, as well as practical implications, are discussed.     

Evaluating the relative effectiveness of three aversion therapies designed to reduce craving among cocaine abusers

Crack cocaine use and dependence has been steadily increasing since the mid‐1980s. Treatment approaches vary from simple psychotherapy to intensive medication regimens. One clear phenomenon that has been implicated in the continued use and abuse of crack cocaine is craving. Craving is believed to be a response that has been conditioned with previous drug using episodes, and is elicited by environmental cues. The current study investigated the use of three aversion therapies (chemical, covert sensitization, and faradic) designed to eliminate craving for cocaine. Seventy subjects were randomly assigned to one of three aversion treatments or a relaxation control condition. Results indicate that aversion therapy reduces crack cocaine craving. The use of aversion therapy as an adjunct to traditional treatment programs for reducing craving is discussed. Copyright © 2004 John Wiley & Sons, Ltd.     

Do time in abstinence,emotional intelligence and psychopathology predict the sensation of craving in persons with SUD?

IntroductionSubstance use is a global health problem. Craving is one of the main predictors of relapse. If the presence of psychopathology and the deficit of emotional intelligence are combined, the course and outcome of the disease can worsen.ObjectiveThe aim is to analyze the impact of time in abstinence, psychopathology, and emotional intelligence on the sensation of the craving in people with substance use disorders in treatment, comparing two methodologies (hierarchical linear regressions and comparative qualitative analysis).MethodThe participants, after signing the informed consent, were assessed in abstinence, psychopathology (SA-45), emotional intelligence (TMMS-24), and craving.ResultsThe results showed that craving was positively associated with psychopathology, shorter abstinence times, and younger age. Increased emotional attention was associated with increased psychopathology. Craving was explained by less time in abstinence using hierarchical regression models. In QCA models, high levels of craving were predicted by the interaction between high levels of psychopathology, shorter abstinence times, lower emotional repair, and high emotional attention. Low levels of craving were due to less psychopathology, prolonged abstinence, and emotional intelligence.ConclusionThe methodologies are complementary because combining them makes it easier to understand the problem of consumption.     

背景性渴求与事件性渴求:区分心理渴求对尼古丁成瘾的不同作用路径

大量研究发现心理渴求机制的紊乱是尼古丁成瘾的核心机制之一。线索暴露是探索心理渴求与尼古丁成瘾关系的重要研究范式。但最近研究者提出该范式较难区分事件性渴求与背景性渴求,导致无法清楚定位渴求在尼古丁成瘾中扮演的角色。通过对以往文献的回顾,对不同成瘾概念、作用机制和生理基础进行对比分析,认为事件性渴求与背景性渴求两者在维持成瘾行为上的确存在不同的作用路径。未来研究应改进实验范式,分别探讨两种心理渴求与尼古丁成瘾的内在联系,完善心理渴求与尼古丁成瘾的关系模型,为尼古丁成瘾的治疗和干预等方法提供一定的理论依据。     

The association between religiosity and alcohol use: the mediating role of meaning in life and media exposure

We examined whether meaning in life and exposure to media mediate the association between religiosity and alcohol use among members of the Jewish-orthodox community in Israel. One hundred and ten young adult men self-identified as orthodox (n?=?57) or secular (n?=?53) participated in the study. Participants completed self-report measures designed to assess meaning in life, media exposure, alcohol use, and craving. Our findings show that orthodox participants consumed less alcohol and reported less alcohol craving compared to their secular counterparts. Importantly, search for meaning in life and media exposure mediated the relationship between religiosity and alcohol craving. Our findings suggest that religion provides a sense of meaning that serves as a protective factor against alcohol craving, supporting existential theories. Furthermore, our studies show that practices that are associated with a religious lifestyle such as low exposure to mass media also serve as protective factors for alcohol use and craving.     

Visuospatial tasks suppress craving for cigarettes

The Elaborated Intrusion (EI) theory of desire posits that visual imagery plays a key role in craving. We report a series of experiments testing this hypothesis in a drug addiction context. Experiment 1 showed that a mental visual imagery task with neutral content reduced cigarette craving in abstaining smokers, but that an equivalent auditory task did not. The effect of visual imagery was replicated in Experiment 2, which also showed comparable effects of non-imagery visual working memory interference. Experiment 3 showed that the benefit of visual over auditory interference was not dependent upon imagery being used to induce craving. Experiment 4 compared a visuomotor task, making shapes from modeling clay, with a verbal task (counting back from 100), and again showed a benefit of the visual over the non-visual task.We conclude that visual imagery supports craving for cigarettes. Competing imagery or visual working memory tasks may help tackle craving in smokers trying to quit.     

中国人限制性饮食和食物渴求的认知神经机制

物质丰富的时代, 如何抵御美味食物线索带来的食物渴求, 并限制饮食从而保持健康成为人们关注的重要话题之一。近年来, 国内学者为了探讨节食成功的原因, 创建中国食物图片库, 考察限制性饮食的认知神经机制, 以及成功和失败限制性饮食者的脑机制差异; 开展了特质食物渴求及中国特色的辣食渴求的认知神经研究。对推进饮食行为研究的理论发展, 也为肥胖、饮食失调等健康干预工作提供重要支持。