Different Perspectives Regarding Quality of Life in Chronically ill and Healthy Individuals

The areas that were suggested as most important with regard to Quality of Life (QoL) were examined in groups of individuals who were healthy, and those with a chronic condition. An electronic survey was completed by 892 participants (261 healthy and 631 with a chronic condition). They answered three questions relating to QoL: what is most important to you; what areas most impact your QoL; and an open question what does QoL mean to you. Across the three questions both groups highlighted physical functioning, independence and mobility as key areas for QoL. However, the group with a chronic condition tended to find issues of functioning such as pain, fatigue, and sleep as more important to their QoL than the healthy participants. In contrast, the healthy participants tended to note the importance of relationships and family as more important than the group with a chronic condition. That there were such differences between the groups might suggest that different aspects of QoL could be rated as more important when examining this issue with samples with a chronic condition and those without such a condition.     

Congestive Heart Failure and Quality of Life

Our study aimed to assess the quality of life (QoL) of patients with congestive heart failure (CHF) and to correlate the different aspects of QoL with relevant socio-demographic variables, CHF severity, somatic comorbidities, other clinical variables and depressive symptomatology. In a cross-sectional study design, a community sample of 103 adult patients with CHF (mean age 68 years, 73 % male) was recruited from an outpatient cardiology practice. CHF severity was assessed with physician ratings of the New York Heart Association (NYHA) functional class and measurement of brain natriuretic peptide (BNP) levels. The psychometric evaluation of quality of life was made using the Medical Outcomes Study Short Form-36 (SF-36) and the Kansas City Cardiomyopathy Questionnaire (KCCQ). The Beck Depression Inventory Second Edition (BDI-II) assessed depressive symptoms. Using multiple linear regression, predictors of poorer QoL included being a female, being older, living alone, NYHA functional class ≥ II, higher levels of BNP comorbidity (such as renal insufficiency and cerebrovascular disease), fluid retention, depressive symptomatology (assessed by BDI-II) and treatment with anti-dyslipidemics, diuretics and β-blockers. Among these correlates, psychological distress was the most strongly related to QoL. Also, functional status measured by NYHA demonstrated a high impact on QoL. Our findings suggest the need to address such factors in developing effective care to improve psychological and functional status in order to enhance QoL in these patients.     

Fragmentation of monocular afterimages in individuals with and without normal binocular vision

Monocular afterimages of a vertical line were generated in each eye of binocularly normal individuals and of those lacking binocular single vision or stereopsis as a consequence of childhood strabismus. Fragmentations and disappearances of the afterimages occurred less frequently in the strabismic than in the normal subjects; they were also less frequent in the dominant (nonamblyopic) eyes of the strabismics than in their amblyopic eyes. The afterimages remained visible for longer when presented to the dominant eyes of the strabismic subjects, and a similar effect was found between the sighting dominant and nondominant eyes of normal subjects.     

Electrooculographic indices of changes in simulated flying performance

Recent investigations have revealed statistically reliable relationships between signal detection by human subjects performing vigilance tasks and changes in the electrophysiologically recorded waveform of the eyeblink. Thus, this relatively simple and easy-to-obtain measure may have potential use as a predictor of impaired performance. This report describes a study in which eyeblink data were recorded on analog tape while subjects (instrument-rated pilots) “flew” a computer-generated flight plan in a General Aviation Trainer (GAT-1). Eyeblink data were reduced and scored with an adaptation of software from the Washington University Behavioral Research Laboratory. Subjects’ “flying” performance was evaluated with the Pilot Performance Evaluating System (PPES) implemented on a Digital Equipment Corporation (DEC), PDP-11/34 computer. The PPES samples each of four primary flight instruments once per second. It scores performance by generating a combined error score for each maneuver it assigns on the flight-plan display in the cockpit. The PPES/GAT-1 linkup has proved to be a valuable research tool with which to realistically evaluate stress effects and physiological correlates of flying performance in a laboratory setting. This study examined the relationships between eyeblink and flying performance scores collected during a pilot-fatigue study. Analysis of the data supports the use of computers cored eye movement measures as predictors of flying performance decrements.     

Psychological androgyny and personality adjustment in college and psychiatric populations

In two separate studies, 106 female and 84 male undergraduates and 48 female and 48 male psychiatric inpatients were administered the Bem Sex Role Inventory (BSRI) and the Faschingbauer Abbreviated Minnesota Multiphasic Personality Inventory. The masculine, feminine, androgynous, and undifferentiated groups identified from the BSRI differed on a variety of personality scales in both normal and clinical populations. Androgynous females were significantly lower on the Depression (D) and Social Introversion (Si) scales than feminine females, and, in the college sample, were also lower on the Schizophrenia and Mania scales than masculine females. In the hospitalized male sample, this pattern was partially sustained, with androgynous and masculine subjects being significantly less deviant than feminine on the Si scale, and tending to score lower on the D scale. In the group of college males, androgynous males scored lower on the Si scale than feminine males. Hypotheses concerning the relationship of sex-role flexibility (androgyny) to mental health appear to be supported for females in both college and psychiatric populations by these results. These results also indicate that sex-role conformity may relate differently to personality development and psychological functioning for males and females.     

On the use of physiological measures in assertion research

This study examined the effects of assertion role-play variations on physiological arousal as a function of scene length (single vs. multiple responses), scene type (live prompts, taped prompts, and taped prompts with imaginal responses), and subject type. Subjects who scored in the upper quartile on the Marlowe-Crowne Social Desirability Scale (M-C) and below the median on the Assertion Inventory (AI) discomfort scale became the high-social desirability (SD) group, previously shown to have significant cognitive interference in attempts at assertive behavior. Subjects in the lower two M-C quartiles were subdivided into high- and low-anxious groups on the basis of scores above or below the median on the AI discomfort scale. Heart rate, GSR, and blood pressure were recorded as 36 male and female undergraduates responded to assertion scenes. Multiple-response scenes produced significantly more arousal than single-response scenes. Live prompts produced the most arousal, and imagery the least. During multiple-response scenes with live prompts, high-SD subjects had the largest heart-rate increases, and low-anxious subjects the smallest.     

Cultures and creativity within hierarchical organizations

This study examined cultural pluralism along the lines of hierarchy among eight large public accounting firms. Although no significant cultural differences among the different functional units (auditing, tax, and management consulting) of the firms were found, culture was found to be related to hierarchical level. Specifically, top level managers (partners) perceived the culture of their organization as significantly more innovative and supportive than did individuals at lower hierarchical levels (managers/supervisors and senior/ staff accountants). Creativity was not affected by culture.     

Impact of Sluggish Cognitive Tempo and Attention-Deficit/Hyperactivity Disorder Symptoms on Adults’ Quality of Life

The symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) have been linked to dysfunction in numerous life domains for both children and adults. As such, it is likely that individuals with these and other related symptoms (e.g., sluggish cognitive tempo, SCT) may also experience impaired quality of life. The current study examines the association between ADHD and SCT symptoms and quality of life (QOL) in a community sample of adults. Quality of life data collected from 983 participants (M age = 45.6 years) were analyzed primarily through a series of hierarchical multiple regressions employing SCT and ADHD symptom clusters, demographic, and anxiety and depression scale variables as predictors. Results generally supported the hypothesis that ADHD and SCT symptoms would negatively associate with QOL. Amongst the indicators, inattention and SCT emerged as the strongest predictors of low QOL. These findings underscore the negative impact of ADHD symptoms in adulthood, the independent contribution of SCT, and the importance of considering QOL in prospective research and intervention.     

Early Versus Late Onset of Spinal Cord Injury Among the Elderly

The objective of this study is to compare elderly individuals with late (60 years old) versus early (<60 years old) onset spinal cord injury (SCI) across quality of life (QOL) domains for which cross-sectional design was used. The outcome measures selected were secondary medical complications (e.g., pneumonia, autonomic dysreflexia, number of days hospitalized), Functional Independence Measure (FIM), Satisfaction With Life Scale (SWLS), and the Craig Handicap Assessment and Reporting Technique (CHART). Analyses between groups showed that individuals with SCI onset 60 years of age or older were significantly older, had a greater proportion of incomplete lesions, were more likely to have SCI resulting from medical complication, and were less likely to be working. After controlling for differences in demographic and lesion characteristics, the majority of QOL domains were similar between groups. However, overall self-reported handicap (CHART-total score) was significantly greater among elderly with late onset SCI, particularly in the areas of physical independence and social integration. Differences in QOL between elderly with late versus early onset SCI were most prominent in the area of physical independence and social integration. The importance of appropriate statistical control, theoretical implications, and future directions are discussed.     

Cognitive control and the COMT Val158Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency

The study investigated whether successful transfer of game-based cognitive improvements to untrained tasks might be modulated by preexisting neuro-developmental factors, such as genetic variability related to the catechol-O-methyltransferase (COMT)—an enzyme responsible for the degradation of dopamine. The COMT Val¹⁵⁸Met genotype may differentially affect cognitive stability and flexibility, and we hypothesized that Val/Val homozygous individuals (who possess low prefrontal dopamine levels) show more pronounced cognitive flexibility than Met/-carriers (who possess high prefrontal dopamine levels). We trained participants, genotyped for the COMT Val¹⁵⁸Met polymorphism on playing “Half-Life 2”, a first-person shooter game which has been shown to improve cognitive flexibility. Pre-training (baseline) and post-training measures of cognitive flexibility were acquired by means of a task-switching paradigm. As expected, Val/Val homozygous individuals showed larger beneficial transfer effects than Met/-carriers. Our findings support the idea that genetic predisposition modulates transfer effects and that playing first-person shooter games promotes cognitive flexibility in individuals with a suitable genetic predisposition.     

Sex,sex roles,and response styles for negative affect: Selectivity in a free recall task

Study 1 examined how responses to negative affect may be influenced by sex differences in response styles [S. Nolen-Hoeksema (1987), “Sex Differences in Unipolar Depression: Evidence and Theory,” Psychological Bulletin, Vol. 101, pp. 259–282] and situational norms. Male and female experimental subjects were led to experience negative affect by reading and rating sad stories, and were then given either nonnormative or normative feedback. Nonnormative subjects were informed that their story ratings were more negative than other participants' ratings. Normative subjects were informed that their ratings were similar to others' ratings. For nonnormative subjects, men recalled less negative material than women, suggesting that response styles are most apparent when negative affect is considered inappropriate. As both sex and sex role orientation are predictive of response styles, Study 2 examined the hypothesis that both sex and sex role orientation are predictive of recall in a manner similar to sex in Study 1. Male and female subjects high and low in masculinity and femininity were assigned to negative-nonnormative and neutral affect conditions. In addition to a marginally significant sex effect consistent with Study 1, results revealed that high-masculinity individuals tended to recall more positive material in the negative-nonnormative condition than in the neutral affect condition. In contrast, low-masculinity individuals recalled less positive material in the negative-nonnormative condition than in the neutral affect condition. The implications of this research for the impact of negative affect on recall are addressed.     

Orienting responses to pleasant stimuli when expecting pleasant or unpleasant events

The aim was to investigate further the effect of more vigorous orienting to stimuli denoting common fears than to neutral stimuli in subjects threatened with shock. In two experiments, orienting responses (ORs) to pleasant and to neutral words were compared. In Experiment I, the subjects were expecting shock and, in Experiment II, pleasant music. In neither experiment were there differences either in the magnitudes or in the habituation rates of the electrodermal ORs. For clarification, there should be control both of the subjective salience of the stimuli and also of the level of expectation.     

Impact of Institutional Review Boards on cancer research

The concepts of informed consent and surveillance of human research designed to protect human subjects is commendable. The regulations of the Institutional Review Board (IRB) are having a major impact on clinical cancer research. There is greater administrative time needed of the investigator, the mechanisms of patient care have become cumbersome and some patients reject optional medical management that could be life saving. IRB regulations must be flexible to meet the needs of human subjects as well as those of the clinical investigator.     

Deaf signers and serial recall in the visual modality: Memory for signs,fingerspelling, and print

This study investigated serial recall by congenitally, profoundly deaf signers for visually specified linguistic information presented in their primary language, American Sign Language (ASL), and in printed or fingerspelled English. There were three main findings. First, differences in the serial-position curves across these conditions distinguished the changing-state stimuli from the static stimuli. These differences were a recency advantage and a primacy disadvantage for the ASL signs and fingerspelled English words, relative to the printed English words. Second, the deaf subjects, who were college students and graduates, used a sign-based code to recall ASL signs, but not to recall English words; this result suggests that well-educated deaf signers do not translate into their primary language when the information to be recalled is in English. Finally, mean recall of the deaf subjects for ordered lists of ASL signs and fingerspelled and printed English words was significantly less than that of hearing control subjects for the printed words; this difference may be explained by the particular efficacy of a speech-based code used by hearing individuals for retention of ordered linguistic information and by the relatively limited speech experience of congenitally, profoundly deaf individuals.     

Tracing the evolution of knowledge structures

The goal of the research described here is to understand the evolution of knowledge structures as novices learn to use text editors. Two groups of individuals were trained to use one of two text editing systems: the IBM Displaywriter and UCSD-Pascal. Individuals rated the similarity among pairs of editing commands before and after training. Before training, subjects’ similarity ratings are characterized by heavy reliance on natural language denotations of command names. After training, subjects’ similarity ratings are explainable in terms of a small set of identifiable properties of underlying knowledge structures that are typical of experts’ knowledge about a text editor. These properties reflect functional features of command actions, and the psychological salience of a property for a given individual is related to editing performance.     

Lexical contribution to nonword-repetition effects: Evidence from event-related potentials

Two experiments investigated the modulation of event-related potentials (ERPs) by the repetition of orthographically legal and illegal nonwords. In Experiment 1, subjects silently counted occasional words against a background of nonwords, a proportion of which were repetitions of an immediately preceding legal or illegal item. ERPs to repeated legal items showed a sustained, topographically diffuse, positive-going shift. In contrast, repeated illegal nonwords gave rise to ERPs showing a smaller and temporally more restricted positive-going modulation. In an attempt to equalize depth of processing across legal and illegal nonwords, subjects in Experiment 2 were required to count items containing a nonalphabetic character against the same background of nonword items. ERPs to repeated legal items showed a modulation similar to, although smaller than, that found in Experiment I, but no effects of repetition were observed in the ERPs to the illegal nonwords. It was concluded that the effects of repeating nonwords, at least as manifested in concurrently recorded ERPs, differ as a consequence of whether items can access lexical memory, and that this is inconsistent with the attribution of such effects solely to the operation of episodic memory processes.     

Risk Patterns and Correlated Brain Activities. Multidimensional Statistical Analysis of fMRI Data in Economic Decision Making Study

Decision making usually involves uncertainty and risk. Understanding which parts of the human brain are activated during decisions under risk and which neural processes underly (risky) investment decisions are important goals in neuroeconomics. Here, we analyze functional magnetic resonance imaging (fMRI) data on 17 subjects who were exposed to an investment decision task from Mohr, Biele, Krugel, Li, and Heekeren (in NeuroImage 49, 2556–2563, 2010b). We obtain a time series of three-dimensional images of the blood-oxygen-level dependent (BOLD) fMRI signals. We apply a panel version of the dynamic semiparametric factor model (DSFM) presented in Park, Mammen, Wolfgang, and Borak (in Journal of the American Statistical Association 104(485), 284–298, 2009) and identify task-related activations in space and dynamics in time. With the panel DSFM (PDSFM) we can capture the dynamic behavior of the specific brain regions common for all subjects and represent the high-dimensional time-series data in easily interpretable low-dimensional dynamic factors without large loss of variability. Further, we classify the risk attitudes of all subjects based on the estimated low-dimensional time series. Our classification analysis successfully confirms the estimated risk attitudes derived directly from subjects’ decision behavior.     

Inverse statistics and misperception of exponential growth

Exponential growth presented by numerical series or graphs is grossly underestimated by human subjects. This misperception was considerably lessened by presenting decreasing functions; this conclusion holds for both numeric and graphic stimuli. In the numerical conditions, about 25% of the subjects performed according to the statistical norm. In contrast with previous results, considerable individual differences with respect to sensitivity for rate of growth were observed. This finding was interpreted in terms of task difficulty: Extrapolation of ascending series is too difficult a task to be discriminative. Extrapolation of descending series is much easier, and may therefore better discriminate among subjects.