Telomeres in a Life-Span Perspective: A New "Psychobiomarker"?

ABSTRACT— In order to more fully understand associations between psychological stress and health, it is helpful for researchers to identify "psychobiomarkers," or biological measures that are regulated in part by psychological function and that predict longevity. Telomere length appears to be such a measure. Telomeres, the protective caps at the tips of chromosomes, shorten with age, and this shortening predicts disease and longevity. Leukocyte telomere length may be best viewed through a life-span approach, as it reflects in part the cumulative number of cell divisions that have occurred and the long-term biochemical environment. Recently, a critical mass of studies demonstrated that telomeres appear to shorten with chronic stress, although the mechanisms are unknown. This paper reviews what appear to be malleable determinants of rate of telomere attrition, focusing on early life chronic stressors and metabolic adversity (poor nutrition during development, and obesity). The next generation of research will benefit from experimental and longitudinal models integrating genetic variation, social environments, life experience, and health behaviors.     

从端粒和端粒酶探析冥想对压力的缓解作用

冥想是一种维持自我注意的身心调节技术,是缓解因压力所致的抑郁、焦虑等消极情绪的有效方法。端粒是维持染色体稳定和完整的DNA片段,大量有关冥想对端粒及端粒酶活性影响的研究阐明,通常情况下压力人群经过冥想训练能提高端粒长度并增加端粒酶活性,这种改变与压力缓解密切相关。这一积极效果主要得益于皮质醇和炎症等生物因素及心理和环境等非生物因素。未来可以通过对比不同冥想练习的效果、增加追踪研究、多学科联合及扩大样本等找到最有利于提高端粒长度和端粒酶活性的冥想方式。     

Effects of Mindfulness-Based Stress Reduction on Psychological Symptoms and Telomere Length: A Randomized Active-Controlled Trial

Much research has demonstrated the beneficial effects of mindfulness-based stress reduction (MBSR) on psychological and physical health, but it is not known whether MBSR may impact cellular aging in healthy populations. Further, little research has evaluated MBSR against an active control condition, which precludes strong conclusions regarding the unique effects of mindfulness on psychological functioning. The present study examined the effects of MBSR versus music therapy–based stress reduction (MTSR) on trait mindfulness, self-compassion, and several psychological health outcomes, as well as leukocyte telomere length (LTL). One hundred and fifty eight Singaporean Chinese adults were recruited and randomly assigned to an eight-week MBSR or MTSR course. Participants provided blood samples and completed a battery of self-report measures pre- and post-intervention. Analyses showed that participants in the MBSR condition demonstrated significantly greater improvements in depressive symptoms, trait mindfulness, and self-compassion compared to the control condition. Treatment condition did not predict changes in LTL, anxiety, stress, or happiness, though there was a trend for duration of home mindfulness practice to predict increases in LTL. Overall, the study demonstrated MBSR’s unique effects in reducing depressive symptoms. Improvements in trait mindfulness and self-compassion correspond with theorized mechanisms of change underlying mindfulness training. The lack of intervention effect with regards to LTL suggests that a more intensive intervention may be required for mindfulness to exert noticeable impact on aging at the cellular level, or that the effect may only emerge over a longer term.     

Bedeutung von Stress bei chronischer Ersch?pfung

In this review article a novel approach to the explanation of chronic fatigue is presented. It has long been known that patients suffering from chronic fatigue syndrome (CFS) have reported increased occurrencesof traumatic experiences early in life compared to healthy individuals. Such experiences have been found to substantially impact on biological regulation processes later in life and thus alter sensitivity to stressful stimuli in adulthood. In CFS research has shown that patients display altered endocrine and immune stress regulation. A summary of current research in this area is given and the role of both childhood and adulthood stressors in biological regulation processes in CFS is discussed.     

Enhancing attributional style as a resiliency factor in depressogenic stress generation

Abstract

There is a growing body of evidence that suggests depression and cognitive vulnerabilities to depression may lead individuals to generate stressful events. However, there has been no study to date that has directly examined factors that may lead individuals to be less likely to generate stressful events. The present study examines whether an enhancing attributional style, the tendency to make global and stable inferences following occurrence of a positive event, functions as a resiliency factor in stress generation. One hundred and sixty-seven female students completed measures of depression symptoms and attributional style at baseline and occurrence of life events since baseline at a four-week follow-up. Results indicated that an enhancing attributional style predicted decreased levels of stressful events over the following four weeks, even when controlling for depression symptoms. The findings of this study suggest that there may be resiliency factors that can help protect individuals from the generation of stressful events.     

Personality and Health, Subjective Well-Being, and Longevity

ABSTRACT Personality traits can be employed to guide understanding of trajectories to health and longevity, but long-term longitudinal study and multifaceted assessment of healthy aging are crucial. Following up on the life span study initiated by Lewis Terman, we assessed 4 validated factors of personality in young adulthood in 1940, constructed a multifactor measure of participants' healthy aging in 1986, and collected death certificates through 2007 (to determine longevity) on a sample of 1,312 Terman participants (732 men). Neuroticism predicted worse physical health and subjective well-being in old age and, for women, higher mortality risk, but for men, neuroticism predicted decreased mortality risk. For both sexes, extraversion predicted old-age social competence, whereas conscientiousness predicted men's old-age productivity. Differential patterns of association between personality traits and healthy aging components are informative about individual personality characteristics and long-term health outcomes.     

Religion, personality, and aging: a life span perspective

A life span model of development provides the framework for examining the relation between religion and personality in aging persons. This article emphasizes the interplay of constancy and change in adult religious life. Important contextual factors that influence religion and personality are noted. A discussion of generativity and ego integrity shows how the maturing personality can embrace religiously motivated acts of justice and mercy as well as a deepening of spiritual life. Also discussed are the ways religion encourages generativity and ego integrative processes. The article concludes with suggestions for future studies of religion, personality, and aging utilizing a life span model of development.     

Purpose in life and reasons for living as mediators of the relationship between stress,coping, and suicidal behavior

Positive psychological factors that help protect vulnerable persons from suicidal behavior are vital in understanding resiliency and suicide prevention. The purpose of the current study was to examine whether positive factors (including purpose in life, reasons for living, and coping styles) mediate the relationship between stressful life events and suicidal behaviors among 416 college student volunteers. Reasons for living inversely predicted suicidal behavior and thoughts directly as well as indirectly via an inverse relationship with depression. Purpose in life indirectly predicted suicidal behavior and thoughts via an inverse effect on depression, whereas emotion-focused coping indirectly predicted suicidal behavior and thoughts both through an effect on depression and an inverse effect on reasons for living. In addition, avoidant coping indirectly predicted suicidal behavior via a direct, positive effect on reasons for living. Reasons for living and emotion-oriented coping had the largest effects in the model. Results of this study underscore the importance of augmenting reasons for living and purpose in life among suicidal or potentially suicidal persons.     

One ‘knows’: self-rated health and telomere length among ex-prisoners of war

Abstract

Objective: Ill-health and early mortality are amongst the most significant ramifications of trauma. Furthermore, trauma alters the subjective perception and experience of the body. The aim of this study is to examine the extent to which deteriorations in perceived health among traumatised individuals are associated with cellular health as manifested in telomere length.

Methods: Specifically, 88 former prisoners of war (ex-POWs) evaluated their health (self-rated health; SRH) at 18 (T1), 35 (T2) and 42 (T3) years after the war, and were assessed for telomere length at T3. Health behaviour, BMI, morbidity and PTSD were also examined at T3.

Results: The findings demonstrated that SRH was cross-sectionally correlated with telomere length. Furthermore, a significant sequential indirect effect was found, in which worse SRH in T1 was associated with shorter telomere length at T3, through worse SRH at T2 and at T3.

Conclusions: These findings demonstrate that long-term deteriorations in the subjective evaluations of health are implicated in actual cellular health among individuals exposed to trauma.     

Coping Strategies and Psychological Outcomes: The Moderating Effects of Personal Resiliency

Certain coping strategies alleviate stress and promote positive psychological outcomes, whereas others exacerbate stress and promote negative psychological outcomes. However, the efficacy of any given coping strategy may also depend on personal resiliency. This study examined whether personal resiliency moderated the effects of task-oriented, avoidance-oriented, and emotion-oriented coping strategies on measures of depression, anxiety, stress, positive affect, negative affect, and satisfaction with life. Results (N = 424 undergraduates) showed higher personal resiliency was associated with greater use of task-oriented coping strategies, which were in turn associated with more adaptive outcomes, and less reliance on nonconstructive emotion-oriented strategies, which in turn were associated with poorer psychological outcomes. In addition, individual differences in personal resiliency moderated the effects of task-oriented coping on negative affect and of emotion-oriented coping on negative affect and depression. Specifically, proactive task-oriented coping was associated with greater negative affect for people lower in personal resiliency. Moreover, high personal resiliency attenuated the negative effects of emotion-oriented coping on depression and negative affect. The effects of avoidance-oriented coping were mixed and were not associated with or dependent on levels of personal resiliency.     

Empowering high‐risk clients to attain a better quality of life: a career resiliency framework

Career counselors frequently encounter clients who are at high risk for career and life development difficulties. Research suggests there is a connection between resiliency and successful career development in high‐risk clients. Many high‐risk individuals have poor decision‐making skills and lack motivation to succeed in life and career development. This article describes a career resiliency framework in which career resiliency is best understood within the context of psychological resiliency. Specifically, this article explicates how career counseling from a resiliency theory perspective may promote successful career development for populations dealing with multiple barriers.     

Promoting adolescent sense of coherence: Testing models of risk,protection, and resiliency

Sense of coherence (SOC) is a dispositional trait that has been linked to well‐being in a broad range of populations and contexts. Little is known, however, about the factors associated with SOC development and maintenance across the lifespan. Conceptualized as a condition of resiliency, SOC in adolescents was explored via measures of risk and protection as reported on by 8th and 10th grade students (N = 1619). Employing cumulative indexes of protection and risk, analyses focused on testing four models of resiliency. Further, the relative and cumulative effects of protection and risk were explored across ecological domains. Analyses revealed support for the compensatory model of resiliency for males and females, while the challenge model also was supported for females. Analyses also revealed that protection and risk influencing SOC emerge at multiple domains for males and females. In addition, protective factors present at multiple domains were related to higher SOC while risk factors present at multiple domains were related to lower SOC regardless of gender. Results suggest a resiliency framework that considers multiple ecological domains is useful for understanding SOC in adolescents. Implications for additional research are presented. Copyright © 2008 John Wiley & Sons, Ltd.     

Religiosity and Spirituality as Resiliency Resources: Moderation,Mediation, or Moderated Mediation?

A growing body of literature indicates a modestly positive association between religiosity and spirituality as predictors of psychological health (anxiety and depression), suggesting they serve as personal resiliency factors. The purpose of this study was to expand our understanding of the relationships among these constructs. Using Lazarus's Transactional Model of Stress as a theoretical framework, we examined: (a) the extent to which spirituality and religiosity mediated and/or moderated the association between perceived stress and psychological health and (b) whether there was a moderated (religiosity) mediation (spirituality) between stress and health. The Perceived Stress Scale, Daily Spiritual Experiences Scale, Religious Commitment Inventory, and Hospital Anxiety and Depression Scale were administered to measure the following constructs: stress, spirituality, religiosity, and psychological health. This study utilized a nonexperimental, quantitative, correlational, cross‐sectional, moderated‐mediation design, and included a convenience sample of 331 research participants. Both spirituality and religiosity moderated stress and health. However, only spirituality partially mediated the relationship. In addition, religiosity did not moderate the mediating effects of spirituality. Overall, this study confirmed the role of both religiosity and spirituality as effective resiliency resources.     

Chronic Stress as a Mediator of Acute Stress: The Case of Hurricane Hugo1

This study explored one mechanism through which acute disaster stress (injury, life threat, property damage, loss) may produce lasting psychological distress (depression, anxiety, somatization, hostility). More specifically, the study examined the mediating roles of seven domains of chronic stress (marital, parental, filial, financial, occupational, ecological, physical) within a sample of 930 disaster victims and controls. The results provided strong support for the hypothesis that chronic stress mediates the long-term effects of acute disaster stress on psychological distress. The main effects of loss, though limited in strength, were completely explained by victims’ higher financial, marital, filial, and physical stress. The effects of injury, though quite strong, were largely mediated by these same domains of chronic stress. Likewise, the effects of life threat were largely mediated by all these domains plus ecological stress. A mediational model was not appropriate for understanding the consequences of property damage because it did not exhibit a main effect on psychological distress.     

Emotion regulation and biological stress responding: associations with worry,rumination, and reappraisal

ABSTRACT

Individual differences in the habitual use of emotion regulation strategies may play a critical role in understanding psychological and biological stress reactivity and recovery in depression and anxiety. This study investigated the relation between the habitual use of different emotion regulation strategies and cortisol reactivity and recovery in healthy control individuals (CTL; n?=?33) and in individuals diagnosed with social anxiety disorder (SAD; n?=?41). The tendency to worry was associated with increased cortisol reactivity to a stressor across the full sample. Rumination was not associated with cortisol reactivity, despite its oft-reported similarities to worry. Worry and rumination, however, were associated with increased cortisol during recovery from the stressor. The only difference between CTL and SAD participants was observed for reappraisal. In the CTL but not in the SAD group, reappraisal predicted recovery, such that an increased tendency to reappraise was associated with greater cortisol recovery. These results suggest an important role of the habitual use of emotion regulation strategies in understanding biological stress reactivity and recovery.     

Individual contributory factors in teacher stress: The role of achievement striving and occupational commitment

Workplace stress and its impact upon retention levels are becoming an increasing concern within the teaching profession ( Brown, Davis, & Johnson, 2002 ; Jarvis, 2002 ). Research has largely focused upon the effects of environmental factors, whilst noting that it is the interplay between the individual and the environment which may hold the key to understanding this problem ( Cox, 1978 ; Parkes, 1994 ). Identifying individual contributory factors is essential in understanding why, under the same environmental conditions, some people suffer much greater levels of stress than others. This study examined the influence of Type A behaviour, personal achievement strivings, occupational commitment, gender and nature/experience of teaching on perceived workplace stress within the teaching profession (N = 95). It was predicted that perceived stress would be strongest amongst those reporting higher levels of these factors. A multiple regression analysis indicated that there was a positive relationship between Type A behaviour, personal achievement strivings, and perceived stress. The relationship between perceived stress and occupational commitment, however, was found to be negative. The possible explanations for these findings, and potential implications, are discussed. Future research plans are outlined for exploring the relationships between these individual contributory factors and environmental stressors.     

Stress, glucocorticoids, and memory: a meta-analytic review

Although a strong psychoneuroendocrine linkage exists between stress, glucocorticoids and memory, the relationship is not always straightforward. Eighty-eight effect sizes and 1642 participants from 28 studies were meta-analyzed for the effects of stress on memory performance and glucocorticoid activation. Analyses showed that stress was associated with glucocorticoid activation and declarative memory decline. In animal studies, predator stress affected memory performance more than physical stress. In human studies, males showed higher cortisol levels than females in response to stress. Further, the correlation between cortisol levels and memory deficits was stronger in studies using laboratory stressors than those examining long term effects of chronic exposure to rising basal levels of glucocorticoids and chronic life stressors. It was concluded that, although the relationship between stress, glucocorticoids, and memory loss was empirically supported, there were other factors, such as stress condition and gender, as well as individual differences within groups, that influenced the association between these variables, and warrant further examination.     

Memory Aging Research: Real-Life and Laboratory Relationships

Memory, more so than any other cognitive function, seems to be impaired by the processes associated with normal and neuropathological aging. In fact, conventional wisdom suggests that age-related and disease-related memory decrements are both universal and irreversible. The articles contained in this section of Applied Cognitive Psychology, challenge these assumptions. They show that certain types of memory are spared in both healthy elderly adults and demented individuals, and that successful intervention programs based upon implicit memory techniques may be used to enhance the memorial abilities of severely demented patients. Furthermore, these articles illustrate the dynamic interplay between basic and applied memory research from a developmental perspective.     

The interaction of stressful life events and chronic strains on community mental health

One of the possible adaptive costs of coping with stress is diminished capacity to respond to subsequent adaptive demands. This paper examined the complex interplay between major life events and one source of chronic strain. Residents of the greater Los Angeles metropolitan area exposed to higher levels of smog, who had also experienced a recent stressful life event, exhibited poorer mental health than those exposed to pollution who had not experienced a recent stressful life event. There were, however, no direct effects of smog levels on mental health. These patterns of results were replicated in both a cross-sectional and a longitudinal study. The interplay of psychosocial vulnerability and environmental conditions is discussed.     

Cognitive enhancement by drugs in health and disease

Attempts to improve cognitive function in patients with brain disorders have become the focus of intensive research efforts. A recent emerging trend is the use of so-called cognitive enhancers by healthy individuals. Here, we consider some of the effects - positive and negative - that current drugs have in neurological conditions and healthy people. We conclude that, to date, experimental and clinical studies have demonstrated relatively modest overall effects, most probably because of substantial variability in response both across and within individuals. We discuss biological factors that might account for such variability and highlight the need to improve testing methods and to extend our understanding of how drugs modulate specific cognitive processes at the systems or network level.