Opening Skinner’s Box: an Introduction

Behavior analysts have redefined the subject matter of psychology, redesigned the experiments used to study that subject matter, renamed almost every part of the world pertaining to that subject matter, and created specialized organizations and journals. It is not surprising, then, that only a happy few ever hear what behavior analysts say. One problem is that we need to publish outside of the box, so to speak. Preaching to the choir ensures that the products of our scientific behavior affect only a few people, limits the variety of reinforcers we are likely to encounter, and limits the likelihood that the products of our scientific behavior will reinforce the behavior of others. Publishing in a wider variety of outlets can lead to greater visibility for behavior-analytic research and practice, increase the impact of our published work, and build clout for scholars in colleges and universities.     

Detectable Neuropsychological Differences in Early Preclinical Alzheimer’s Disease: A Meta-Analysis

The development of methods for in vivo detection of cerebral beta amyloid retention and tau accumulation have been increasingly useful in characterizing preclinical Alzheimer’s disease (AD). While the association between these biomarkers and eventual AD has been demonstrated among cognitively intact older adults, the link between biomarkers and neurocognitive ability remains unclear. We conducted a meta-analysis to test the hypothesis that cognitively intact older adults would show statistically discernable differences in neuropsychological performance by amyloid status (amyloid negative = A-, amyloid positive = A+). We secondarily hypothesized a third group characterized by either CSF tau pathology or neurodegeneration, in addition to amyloidosis (A+/N+ or Stage 2), would show lower neuropsychology scores than the amyloid positive group (A+/N- or Stage 1) when compared to the amyloid negative group. Pubmed, PsychINFO, and other sources were searched for relevant articles, yielding 775 total sources. After review for inclusion/exclusion criteria, duplicates, and risk of bias, 61 studies were utilized in the final meta-analysis. Results showed A+ was associated with poorer performance in the domains of global cognitive function, memory, language, visuospatial ability, processing speed, and attention/working memory/executive functions when compared to A-. A+/N+ showed lower performances on memory measures when compared to A+/N- in secondary analyses based on a smaller subset of studies. Results support the notion that neuropsychological measures are sensitive to different stages of preclinical AD among cognitively intact older adults. Further research is needed to determine what constitutes meaningful differences in neuropsychological performance among cognitively intact older adults.     

Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease

A wealth of evidence demonstrates that a prodromal period of Alzheimer’s disease (AD) exists for some years prior to the appearance of significant cognitive and functional declines required for the clinical diagnosis. This prodromal period of decline is characterized by a number of different neuropsychological and brain changes, and reliable identification of individuals prior to the development of significant clinical symptoms remains a top priority of research. In this review we provide an overview of those neuropsychological changes. In particular, we examine specific domains of cognition that appear to be negatively affected during the prodromal period of AD, and we review newer analytic strategies designed to examine cognitive asymmetries or discrepancies between higher-order cognitive functions versus fundamental skills. Finally, we provide a critical examination of the clinical concept of Mild Cognitive Impairment and offer suggestions for an increased focus on the impact of cerebrovascular disease (CVD) and CVD risk during the prodromal period of AD.     

Jung’s Axioms: An Introduction to Jung’s “Note on Number”

This article is an introduction to C. G. Jung’s handwritten note on natural numbers (in this issue), which became the basis of Marie-Louise von Franz’s book Number and Time. I present the historical background of Jung’s note and discuss part of its content using mostly Jung’s own words.     

Preembryo Personhood: An Assessment of the President’s Council Arguments

The President’s Council on Bioethics has addressed the moral status of human preembryos in its reports on stem cell research and human therapeutic cloning. Although the Council has been criticized for being hand-picked to favor the right-to-life viewpoint concerning human preembryos, it has embraced the idea that the right-to-life position should be defended in secular terms. This is an important feature of the Council’s work, and it demonstrates a recognition of the need for genuine engagement between opposing sides in the debate over stem cell research. To promote this engagement, the Council has stated in secular terms several arguments for the personhood of human preembryos. This essay presents and critiques those arguments, and it concludes that they are unsuccessful. If the best arguments in support of the personhood of human preembryos have been presented by the Council, then there are no reasonable secular arguments in support of that view.     

Spoken Narrative Assessment: A Supplementary Measure of Children’s Creativity

This study developed a spoken narrative (i.e., storytelling) assessment as a supplementary measure of children’s creativity. Both spoken and gestural contents of children’s spoken narratives were coded to assess their verbal and nonverbal creativity. The psychometric properties of the coding system for the spoken narrative assessment were investigated with 30 Cantonese-speaking children aged six to nine. The internal consistency and the intercoder agreement were good. In addition, children’s scores on the 3 coded variables were moderately correlated with their creativity-relevant skills as measured by Alternate Uses Task (Guilford, 1967) and subjective ratings of creativity provided by judges. Children with higher verbal skills, as measured by Similarities (The Wechsler Intelligence Scale for Children – 4th Edition (Hong Kong); WISC-IV HK), also scored higher in the speech composite of the coding system. The findings showed that the coding system of the spoken narrative assessment is reliable and valid for measuring children’s creativity objectively. An age-related norm will be established in future.