Individual differences in cardiac vagal tone are associated with differential neural responses to facial expressions at different spatial frequencies: An ERP and sLORETA study

A previous study has shown that greater cardiac vagal tone, reflecting effective self-regulatory capacity, was correlated with superior visual discrimination of fearful faces at high spatial frequency Park et al. (Biological Psychology 90:171?C178, 2012b). The present study investigated whether individual differences in cardiac vagal tone (indexed by heart rate variability) were associated with different event-related brain potentials (ERPs) in response to fearful and neutral faces. Thirty-six healthy participants discriminated the emotion of fearful and neutral faces at broad, high, and low spatial frequencies, while ERPs were recorded. Participants with low resting heart rate variability??characterized by poor functioning of regulatory systems??exhibited significantly greater N200 activity in response to fearful faces at low spatial frequency and greater LPP responses to neutral faces at high spatial frequency. Source analyses??estimated by standardized low-resolution brain electromagnetic tomography (sLORETA)??tended to show that participants with low resting heart rate variability exhibited increased source activity in visual areas, such as the cuneus and the middle occipital gyrus, as compared with participants with high resting heart rate variability. The hyperactive neural activity associated with low cardiac vagal tone may account for hypervigilant response patterns and emotional dysregulation, which heightens the risk of developing physical and emotional problems.     

Individual differences in physiological flexibility predict spontaneous avoidance

People often regulate their emotions by resorting to avoidance, a putatively maladaptive strategy. Prior work suggests that increased psychopathology symptoms predict greater spontaneous utilisation of this strategy. Extending this work, we examined whether heightened resting cardiac vagal tone (which reflects a general ability to regulate emotions in line with contextual demands) predicts decreased spontaneous avoidance. In Study 1, greater resting vagal tone was associated with reduced spontaneous avoidance in response to disgust-eliciting pictures, beyond anxiety and depression symptoms and emotional reactivity. In Study 2, resting vagal tone interacted with anxiety and depression symptoms to predict spontaneous avoidance in response to disgust-eliciting film clips. The positive association between symptoms and spontaneous avoidance was more pronounced among participants with reduced resting vagal tone. Thus, increased resting vagal tone might protect against the use of avoidance. Our findings highlight the importance of assessing both subjective and biological processes when studying individual differences in emotion regulation.     

学前儿童迷走神经活动与情绪反应、情绪调节及冲动性的关系

Porges的多迷走神经理论提出迷走神经活动(vagal activity)与儿童的情绪及社会行为密切联系,已有研究探讨了儿童迷走神经活动与儿童的情绪反应及调节的关系,但研究结论不够清晰,需要进一步研究澄清。本研究选取93名4-6岁学前儿童被试,运用生理测量手段与呼吸性窦性心律不齐(respiratory sinus arrhythmia,RSA)分析的方法,采用父母报告的学前儿童情绪反应强度、情绪调节能力、冲动性为结果变量,进一步探讨儿童迷走神经活动(以基线RSA、RSA撤出、RSA恢复为指标)与情绪反应、情绪调节及冲动性的关系。研究发现:(1)基线RSA与儿童情绪反应强度显著负相关,与儿童情绪调节能力显著正相关,基线RSA是儿童情绪反应强度显著负向预测因子,是儿童情绪调节能力的显著正向预测因子;(2)RSA撤出、RSA恢复性与儿童冲动性显著负相关,是儿童冲动性显著负向预测因子。研究结果支持了Porges的多迷走神经理论,表明迷走神经活动与儿童情绪反应、情绪调节及冲动性密切联系。     

Physiology and functioning: Parents' vagal tone, emotion socialization, and children's emotion knowledge

This study examined relationships among parents’ physiological regulation, their emotion socialization behaviors, and their children’s emotion knowledge. Parents’ resting cardiac vagal tone was measured, and parents provided information regarding their socialization behaviors and family emotional expressiveness. Their 4- or 5-year-old children (N = 42) participated in a laboratory session in which their knowledge of emotional facial expressions and situations was tested and their own resting vagal tone was monitored. Results showed that parents’ vagal tone was related to their socialization behaviors, and several parent socialization variables were related to their children’s emotion knowledge. These findings suggest that parents’ physiological regulation may affect the emotional development of their children by influencing their parenting behaviors.     

2~6岁儿童心迷走紧张的发展

考察2岁、4岁和6岁3个组共104名有效被试,在基线状态下的基线迷走紧张以及与年龄相符的中等压力任务下的迷走抑制的发展。结果发现,基线迷走紧张与迷走抑制有不同的发展模式：4岁组、6岁组儿童的基线迷走紧张显著地高于2岁组,而4岁组与6岁组之间没有显著差异,基线心跳周期随年龄的增长而相应增长;迷走抑制没有年龄差异,6岁组的基线对任务的心跳周期变化显著地大于2岁组的心跳周期变化     

Child and mother cardiac vagal tone: continuity, stability, and concordance across the first 5 years

In this prospective longitudinal study, vagal tone and heart period were measured at 2 months and at 5 years in children and their mothers to evaluate the development of vagal regulation at rest and during an environmental task. Child baseline vagal tone and heart period were discontinuous; mother baseline vagal tone was discontinuous, but heart period was continuous. Group mean baseline-to-task change in vagal tone and heart period were continuous in both children and mothers. Children reached adult levels of baseline vagal tone by 5 years and did not differ from their mothers in baseline-to-task change in vagal tone or heart period. Baseline vagal tone tended to be stable, but baseline heart period and baseline-to-task change in vagal tone and heart period were unstable in children; both were stable in mothers. Baseline-to-task change in vagal tone showed consistent child-mother concordance. These findings contribute to understanding psychophysiological development, especially the ontogenesis of the vagal system and its regulatory capacity.     

Resting Heart Rate,Vagal Tone,and Reactive and Proactive Aggression in Chinese Children

Abundant research conducted in Western contexts has shown that biological risk factors such as low resting heart rate (HR) might be related to childhood aggression. However, it was unclear (1) how resting HR, as well as other markers of cardiac functions such as resting vagal tone, may be related to subtypes of aggression such as reactive and proactive aggression, and (2) whether the HR-aggression relation can be replicated in non-Western contexts. Therefore, this study examined the concurrent and prospective relations between resting HR, vagal tone, and Chinese children’s reactive and proactive aggression. Participants were 183 children (M age?=?7.64 years, 91 girls) recruited from an elementary school in Zhenjiang, PRC. Children’s resting HR and vagal tone were assessed in the second grade (T1). Teachers rated children’s reactive and proactive aggression in the second (T1) and fourth grade (T2). Results showed that lower resting HR at T1 was associated with higher reactive and proactive aggression at T1 and T2, and higher vagal tone was associated with lower HR, which in turn was related to higher reactive and proactive aggression at T1 and T2. Lower vagal tone was directly related to higher reactive but not proactive aggression at T1 and T2, whereas lower HR was related to higher reactive aggression at T2 for children with low or moderate vagal tone but was not for children with high vagal tone. These psychophysiological findings from a non-Western context add additional support for both similarities and differences between reactive and proactive aggression in childhood.     

Stressing the feedback: attention and cardiac vagal tone during a cognitive stress task

Objectives: The present study examined relationships among gaze behaviour and cardiac vagal tone using a novel stress-inducing task.

Methods: Participants’ (N?=?40) eye movements and heart rate variability (HRV) were measured during an unsolvable computer-based task randomly presenting feedback of “Right” and “Wrong” answers distinctly onscreen after each trial. Subgroups were created on the basis of more frequent eye movements to the right (“Correct”-Attenders; n?=?23) or wrong (“Incorrect”-Attenders; n?=?17) areas onscreen.

Results: Correct-Attenders maintained HRV from baseline to the stress task. In contrast, Incorrect-Attenders spent significantly more time viewing “Wrong” feedback, exhibited a reduction in HRV during the stress condition (p?Conclusions: Results demonstrate that pervasive attention to negative feedback (“Wrong”) elicits perseverative stress and negative self-evaluations among university students. This study highlights the potential for studying attentional biases and emotional distress through combined measures of gaze behaviour and cardiac vagal tone.     

Touch attenuates infants’ physiological reactivity to stress

Animal studies demonstrate that maternal touch and contact regulate infant stress, and handling during periods of maternal deprivation attenuates the stress response. To measure the effects of touch on infant stress reactivity during simulated maternal deprivation, 53 dyads were tested in two paradigms: still‐face (SF) and still‐face with maternal touch (SF+T). Maternal and infant cortisol levels were sampled at baseline, reactivity, and recovery and mother’s and infant’s cardiac vagal tone were measured during the free play, still‐face, and reunion episodes of the procedure. Cortisol reactivity was higher among infants in the SF condition and while cortisol decreased at recovery for infants in the SF+T, it further increased for those in the SF. Vagal tone showed a greater suppression when SF was not accompanied by maternal touch. Touch synchrony during free play was associated with higher infant vagal tone, whereas touch myssynchrony – maternal tactile stimulation while the infant gaze averts – correlated with higher maternal and infant cortisol. In humans, as in mammals, the provision of touch during moments of maternal unavailability reduces infants’ physiological reactivity to stress.     

Interactive effect of long-term mental stress and cardiac stress reactivity on carotid intima-media thickness: the Cardiovascular Risk in Young Finns study

The present study examined the interaction between vital exhaustion and cardiac reactivity and recovery on preclinical atherosclerosis assessed by carotid intima-media thickness (IMT) in young men and women. We measured heart rate (HR), respiratory sinus arrhythmia (RSA), and pre-ejection period (PEP) in response to mental arithmetic and speech tasks. Vital exhaustion and carotid IMT were also measured. Significant associations were observed for men aged 28-37 years, but not for men aged 22-25 years, nor for women in these age groups. It was shown that, among highly exhausted men in the older age group, lower HR reactivity was related to greater IMT. Our results also imply that, among non-exhausted men in this age group, slow HR and RSA recovery after acute stress predicted higher IMT. These results suggest that long-term stress as assessed by vital exhaustion is a risk only if it has resulted in ineffective cardiac stress reactivity. Autonomic imbalance resulting from chronic stress may be the common mechanism linking vital exhaustion and cardiac responsiveness to an increased risk of atherosclerosis.     

Toward a social psychophysiology of vagally mediated heart rate variability: Concepts and methods in self‐regulation,emotion, and interpersonal processes

Theory and research on self‐regulation, emotional adjustment, and interpersonal processes focus increasingly on parasympathetic functioning, using measures of vagally mediated heart rate variability (vmHRV) or respiratory sinus arrhythmia (RSA). This review describes models of vmHRV in these areas, and issues in measurement and analysis. We propose a framework organizing theory and research as examining (a) vmHRV as an individual difference or a situational response, and (b) resting, reactive, or recovery levels. Evidence supports interpretation of individual differences in resting vmHRV as a broad biomarker for adaptive functioning, but its specificity and underlying mechanisms require elaboration. Individual differences in vagal reactivity (i.e., trait‐like differences in vmHRV decreases during challenge or stress) are less commonly studied in adults and results are mixed. Many stressors and challenges evoke temporary decreases in vmHRV, and in some research self‐regulatory effort evokes increases. In a smaller literature, positive interpersonal experiences and some restorative processes increase resting vmHRV, whereas depletion of self‐regulatory capacity through related effort decreases it. Greater attention to conceptual distinctions regarding vmHRV constructs and several methodological issues will strengthen future research. Importantly, researchers should exercise caution in equating vmHRV with specific psychosocial constructs, especially in the absence of converging assessments and precise experimental manipulations.     

Individual differences in vagal regulation moderate associations between daily affect and daily couple interactions

Previous research suggests that cardiac vagal regulation (indexed by respiratory sinus arrhythmia, or RSA) provides a physiological substrate for affect regulation, which presumably underlies adaptive interpersonal functioning.The authors tested these associations in the context of daily interactions between 68 cohabiting couples. Participants underwent a laboratory assessment of RSA during rest and also during a series of psychological stressors. Subsequently, they kept daily measures of affect and interaction quality for 21 days. Individual differences in baseline and stress levels of RSA moderated within-person associations between daily affect and the quality of couple interactions. The pattern of results differed for women versus men. Men with lower vagal tone or higher vagal reactivity had stronger associations between daily negative affect and daily negative interactions, and men with higher vagal tone had more positive daily interactions overall. Women with higher vagal tone had stronger associations between daily positive affect and daily positive interactions.     

Effect of worrisome and relaxing thinking on fearful emotional processing

This study replicated and extended previous data suggesting that worry inhibits emotional processing of fearful imagery. Female participants categorized as either victimization-fearful (N = 24) or victimization and speech-fearful (N = 27) completed trials of worrisome or relaxing thinking and tone-cued imagery. For each trial, participants engaged in 30 s of relaxing or worrisome (speech or victimization) thinking and then imagined speech or victimization fear scenes for 15 s. Heart rate and facial electromyography activity at the corrugator supercilii region were measured during the think and imagery periods to estimate degree of emotional processing of the fear imagery. Consistent with earlier findings, there was greater heart rate suppression during fearful imagery after a period of worry as opposed to relaxation. This finding, however, may have been the result of physiological differences between worrisome and relaxation thinking. Corrugator activation during thinking showed a similar pattern as the heart rate data while corrugator activation during fearful imagery was dependent on the baseline employed. These data, in combination with the imagery ratings data, suggest that worry may be an unsuccessful strategy for avoiding the physiological activation associated with emotional processing.     

Distinguishing youths at risk for anxiety disorders from self‐reported BIS sensitivity and its psychophysiological concomitants

The aim of the study was to explore the psychophysiological concomitants of self‐reported behavioral inhibition system (BIS) sensitivity in adolescents (12 to 17 years old) supposed to be at risk for anxiety disorders. Twenty participants with high scores in self‐reported BIS sensitivity (at‐risk group) were matched in age and sex to 20 participants scoring in the normal range in BIS sensitivity (control group). Negative affect, negative emotion regulation style, and anxiety symptomatology were assessed by means of self‐reported measures. Cardiac and electrodermal response signals were recorded during baseline, paced breathing, exposure to an attentional task with response cost and fear‐relevant slides conditions. The at‐risk group exhibited higher scores on measures of negative affect, negative emotion regulation style, and anxiety symptomatology than their control counterparts. After controlling for negative styles of emotion regulation, groups did not differ in skin conductance reactivity during the attentional task with response cost, but participants at risk exhibited more nonspecific skin conductance responses than the control group during baseline recording. Regarding the cardiac concomitants, participants at risk presented lower vagal tone at resting conditions as compared to participants in the control group. Additionally, at‐risk participants exhibited lower flexibility across experimental conditions in heart rate and cardiac sample entropy measures than participants in the control group. These findings add knowledge on psychophysiological concomitants of BIS sensitivity and are discussed in light of associations between temperament and development of anxiety disorders in youth. They show how psychophysiological patterns observed in resting conditions could be useful endophenotypes to reliably detect individuals at risk before the disorder onset.     

Effects of worry on physiological and subjective reactivity to emotional stimuli in generalized anxiety disorder and nonanxious control participants

The present study examined the effect of worry versus relaxation and neutral thought activity on both physiological and subjective responding to positive and negative emotional stimuli. Thirty-eight participants with generalized anxiety disorder (GAD) and 35 nonanxious control participants were randomly assigned to engage in worry, relaxation, or neutral inductions prior to sequential exposure to each of four emotion-inducing film clips. The clips were designed to elicit fear, sadness, happiness, and calm emotions. Self reported negative and positive affect was assessed following each induction and exposure, and vagal activity was measured throughout. Results indicate that worry (vs. relaxation) led to reduced vagal tone for the GAD group, as well as higher negative affect levels for both groups. Additionally, prior worry resulted in less physiological and subjective responding to the fearful film clip, and reduced negative affect in response to the sad clip. This suggests that worry may facilitate avoidance of processing negative emotions by way of preventing a negative emotional contrast. Implications for the role of worry in emotion avoidance are discussed.     

Self-esteem and autonomic physiology: parallels between self-esteem and cardiac vagal tone as buffers of threat

In this article a potential physiological connection to self-esteem is suggested: cardiac vagal tone, the degree of influence on the heart by the vagus, a primary nerve of the parasympathetic nervous system. This hypothesis emerges from parallels between the two literatures that suggest both self-esteem and cardiac vagal tone function to provide protection from threat responding. This article reviews these literatures and evidence and preliminary findings that suggest in some contexts self-esteem and cardiac vagal tone may exert an influence on each other. Last, the article discusses theoretical and applied health implications of this potential physiological connection to self-esteem.     

The effect of ethanol on stress-induced tachycardia

A study was designed to answer the questions if low doses of ethanol would reduce stress induced increases in heart rates, if covariations would be observed between ethanol induced changes in heart rates and changes in emotional states and mental performance and if tolerance to ethanol or other personality factors would influence the ethanol induced cardiac effects. Forty-four male students with a history of high and low alcohol consumption according to questionnaire scores were matched for extraversion and neuroticism and then assigned to a group receiving either 0.8 g/kg of ethanol or a placebo drink. A stress condition of mental arithmetic was applied prior to and 45 minutes after ingestion of the drink. Heart rates and ratings of emotional states by adjective check lists were recorded before and after each stress session. A significant reduction of stress induced heart rate increases in both high and low drinking groups but no ethanol dependent change of resting heart rates were observed. Reductions of autonomic stress response by ethanol were weakly but positively correlated to respective reductions of affective stress responses and impairment of the quality of mental performance. High trait anxiety subjects seemed to benefit more from ethanol with respect to reductions of cardiac and emotional arousal than low anxious subjects.     

Autonomic reactivity during viewing of an unpleasant film.

The effect of an aversive, high-arousing film on heart rate, respiratory sinus arrhythmia, and electrogastrographic activity (EGG) was investigated. Previous studies have indicated a larger heart-rate deceleration for visual stimuli depicting surgery or blood compared to neutral content, and this phenomenon is similar to the bradycardia observed in animals in response to fear. The heart-rate deceleration is clearly parasympathetically driven, and it is considered a general index of attention. An accurate index of cardiac vagal tone can be obtained by means of quantification of the amplitude of respiratory sinus arrhythmia. The relationship between cardiac vagal tone and EGG is complex, but animal research has shown that suppressing vagal activity dampens gastric motility. We have investigated whether a movie depicting surgery is associated with greater heart-rate deceleration, larger increase in respiratory sinus arrhythmia, and greater increase in EGG activity compared to a neutral movie. In addition, if both respiratory sinus arrhythmia and EGG are indices of vagal tone, a positive correlation between these physiological responses was expected. Analysis indicated an effect of the surgery movie on heart rate and respiratory sinus arrhythmia, but not on EGG activity. Moreover, the expected correlation was not found. Implications for future studies are discussed.     

Cardiac autonomic reactivity and recovery in predicting carotid atherosclerosis: the cardiovascular risk in young Finns study.

The present study examined the association of cardiac autonomic task-induced reactivity and recovery to preclinical atherosclerosis. Thirty-three men and 33 women aged 24-39 years participated in the ongoing epidemiological Cardiovascular Risk in Young Finns study. The authors measured heart rate (HR), respiratory sinus arrhythmia (RSA), and preejection period (PEP) during the mental arithmetic and speech tasks in 1999. Carotid atherosclerosis was assessed by measuring the thickness of the common carotid artery intima-media complex (IMT) with ultrasound in 2001. Higher HR, RSA, and PEP reactivity were associated with lower IMT values even after adjusting for cardiovascular risk factors (lipid levels, obesity, and blood pressure). In addition, better HR recovery after the mental arithmetic task was associated with lower IMT values, and this association persisted after all adjustments. Thus, higher task-induced cardiac autonomic reactivity and better HR recovery were related to less preclinical atherosclerosis. The authors concluded that cardiac pattern of reactivity and quick recovery may be associated with better cardiovascular health, and therefore all reactivity occurring in challenging situations should not automatically be considered as potentially pathological.