Maturation of action monitoring from adolescence to adulthood: an ERP study

This study investigated the development of the frontal lobe action-monitoring system from late childhood and adolescence to early adulthood using ERP markers of error processing. Error negativity (ERN) and correct response negativity (CRN) potentials were recorded while adolescents and adults (aged 12-22 years, n = 23) performed two forced-choice visual reaction time tasks of differing complexity. Significant age differences were seen for behavioural and ERP responses to complex (infrequent, incompatible) trials: adolescents elicited an error negativity of reduced magnitude compared with adults. Furthermore, in contrast to adults, adolescents showed a non-significant differentiation between response-locked ERP components elicited by correct (CRN) and error responses (ERN). Behaviourally, adolescents corrected fewer errors in incompatible trials, and with increasing age there was greater post-error slowing. In conclusion, the neural systems underlying action-monitoring continue to mature throughout the second decade of life, and are associated with increased efficiency for fast error detection and correction during complex tasks.     

Error monitoring dysfunction across the illness course of schizophrenia

Response monitoring abnormalities have been reported in chronic schizophrenia patients, but it is unknown whether they predate the onset of psychosis, are present in early stages of illness, or are late-developing abnormalities associated with illness progression. Response-synchronized event-related potentials (ERP) recorded during a picture-word matching task yielded error-related negativity (ERN), correct-response negativity (CRN), and error positivity (Pe) from 84 schizophrenia patients (SZ), 48 clinical high risk patients (CHR), and their age-matched healthy controls (HC; n = 110 and 88, respectively). A sub-sample of 35 early illness schizophrenia patients (ESZ) was compared to 93 age-matched HC and the CHR patients (after statistically removing the effects of normal aging). Relative to HC, 1) SZ, ESZ, and CHR had smaller ERNs, and 2) SZ and ESZ had larger CRNs and smaller Pes. Within the SZ, longer illness duration was associated with larger CRNs but was unrelated to ERN or Pe. CHR and ESZ did not differ on ERN or CRN, although Pe was smaller in ESZ than CHR. These results indicate that while ERN, CRN, and Pe abnormalities are present early in the illness, only the ERN abnormality is evident prior to psychosis onset, and only the CRN abnormality appears to worsen progressively over the illness course. Brain regions subserving response monitoring may be compromised early in the illness and possibly during its clinical prodrome.     

The relationship between cognitive performance and electrophysiological indices of performance monitoring

Studies of electrophysiological indices of performance monitoring, such as the error-related negativity (ERN), posterror positivity (Pe), and N2 components of the event-related potential (ERP), suggest that increased ERN and Pe amplitudes and decreased N2 amplitudes are associated with better cognitive flexibility and cognitive control abilities; however, few studies have directly examined the relationship between cognitive performance and ERP indices of performance monitoring. We examined the neuropsychological profile of 89 healthy individuals who performed a modified flanker task. The neuropsychological domains tested included memory, verbal fluency, and attention/executive functioning. Pearson’s correlations and multiple regression analyses showed a significant relationship between measures of attention/executive functioning and ERN amplitude, even when negative affect, reaction time interference, and posterror slowing were controlled. N2 amplitude related only to posterror slowing. The amplitude of the Pe was not significantly related to any cognitive domains. These findings are consistent with recent work indicating that performance monitoring requires attention skills and cognitive flexibility. Implications for the conflict-monitoring and reinforcement-learning theories are discussed.     

ERP correlates of performance monitoring in elderly

Previous studies on performance monitoring repeatedly found attenuated error-related negativities (Ne/ERN) in elderly, while findings for the correct-related negativity (Nc/CRN) are inconsistent. The present study aimed at clarifying inconsistent Nc/CRN results in elderly. Therefore, a refined design was employed to control for potential influences on the Nc/CRN, namely decision uncertainty and partial error processing. Further, we intended to study Nc/CRN variations with trial compatibility that were found in previous studies for younger but not for older adults. Results revealed increased Nc/CRN and decreased Ne/ERN amplitudes in older compared to younger adults. While the Ne/ERN was larger than the Nc/CRN in younger adults, both components were similar-sized in older adults. Further, a modulation of Nc/CRN amplitudes between compatible and incompatible trials was observed in younger adults, but was absent in older adults. Reduced differentiation of response-related negativities with response accuracy or stimulus compatibility in elderly suggests a reduced adaptation of associated processes to changing demands. Further, this might also point to different processes reflected by Nc/CRN and Ne/ERN and to reduced error-specific monitoring but increased general or strategic monitoring in elderly.     

Performance monitoring in obsessive–compulsive disorder: A temporo-spatial principal component analysis

Hyperactive performance monitoring is a robust finding in obsessive–compulsive disorder (OCD). Patients show increased amplitudes of the error-related negativity (ERN) and correct-related negativity (CRN). Recently, two temporo-spatial factors were shown to contribute to both ERPs in healthy individuals. In the present study, it was investigated whether the factor structure underlying ERN and CRN is similar in OCD and which factors differ between groups. A principal component analysis (PCA) was employed to investigate the temporo-spatial factor structure of ERN and CRN. Twenty-six OCD patients and 26 healthy controls conducted a flanker task. EEG data were analyzed as conventional ERP components and as factor scores derived from temporo-spatial PCA. ERP results showed expected increases in ERN and CRN amplitudes in OCD patients. For both groups, the PCA confirmed the assumed factor structure of a central and a fronto-parietal factor contributing to ERN and CRN. Factor scores of both factors were differently affected by response correctness in OCD. Alterations in factor scores indicate increased activity in both an outcome-independent monitoring process and an error-sensitive process, contributing to overactive performance monitoring in OCD.     

Individual differences in working memory capacity predict action monitoring and the error-related negativity

Neuroscience suggests that the anterior cingulate cortex (ACC) is responsible for conflict monitoring and the detection of errors in cognitive tasks, thereby contributing to the implementation of attentional control. Though individual differences in frontally mediated goal maintenance have clearly been shown to influence outward behavior in interference-rich contexts, it is unclear whether corresponding differences exist in neural responses that arise out of the ACC. To investigate this possibility, we conducted an electrophysiological study using a variant of the Simon Task, recording event-related potentials (ERPs) in healthy normal individuals with varying working memory capacity (high vs. low spans; a behavioral proxy for variability in goal maintenance). Primary analyses focused on the magnitude of the error-related negativity (ERN), a response-locked ERP component associated with the commission of errors thought to arise because of action monitoring in the ACC. Our results revealed that frontally mediated working memory capacity may alter error monitoring by the ACC, with high spans showing a greater ERN than low spans. These individual differences were also observed in the posterror positivity, a response-locked ERP component associated with updating cognitive strategies, suggesting greater awareness of errors with increased working memory capacity. These results are interpreted within 2-process models of attentional control, suggesting individuals with greater working memory capacity may better maintain task goals by more strongly biasing neural activity in frontal-executive networks.     

Response-monitoring dysfunction in schizophrenia: an event-related brain potential study

Error-monitoring abnormalities may underlie positive symptoms of schizophrenia. Response-synchronized event-related potentials during picture-word matching yielded error- and correct-response-related negativity (ERN, CRN) and positivity (Pe, Pc) and preresponse lateralized readiness potentials (LRP) from 18 schizophrenic patients and 18 controls. Both groups responded faster to matches than nonmatches, although patients were generally slower and made more errors to nonmatches. Compared with controls, patients, particularly with paranoid subtype, had smaller ERNs and larger CRNs, which were indistinguishable. LRPs showed evidence of more response conflict before errors than before correct responses in controls but not patients. Despite ERN/CRN abnormalities, post-error slowing and Pe were normal in patients, suggesting a dissociation of ERN and error awareness. Anterior cingulate and dorsolateral prefrontal cortical dysfunction in schizophrenia are implicated.     

Response monitoring, the error-related negativity, and differences in social behavior in autism

Children with autism not only display social impairments but also significant individual differences in social development. Understanding the source of these differences, as well as the nature of social impairments, is important for improved diagnosis and treatments for these children. Current theory and research suggests that individual differences in response monitoring, a specific function of the anterior cingulate cortex (ACC), may contribute to social-emotional and social-cognitive impairments and individual differences in autism. To examine this hypothesis, we used a modified flanker task to assess an ERP index of response monitoring, the error-related negativity (ERN), in a sample of higher function children with autism (HFA) and an IQ-matched control sample. The results revealed a significant Diagnostic group by Verbal IQ interaction on ERN amplitude indicating that the most verbally capable HFA children displayed significantly larger ERN amplitudes than did the control children. Within the HFA sample, greater ERN amplitude was also related to parent reports of fewer symptoms of social interaction impairments, fewer internalizing problems, but more externalizing problems, although these associations were reduced to nonsignificance when medication status was controlled. The latter results complement previous observations from imaging studies of a significant association between ACC activity and social symptoms and impairments in autism. The implications of these results for future research on brain-behavior relations, as well as treatment related research with children with autism are discussed.     

Alcohol effects on performance monitoring and adjustment: affect modulation and impairment of evaluative cognitive control

Alcohol is known to impair self-regulatory control of behavior, though mechanisms for this effect remain unclear. Here, we tested the hypothesis that alcohol's reduction of negative affect (NA) is a key mechanism for such impairment. This hypothesis was tested by measuring the amplitude of the error-related negativity (ERN), a component of the event-related brain potential (ERP) posited to reflect the extent to which behavioral control failures are experienced as distressing, while participants completed a laboratory task requiring self-regulatory control. Alcohol reduced both the ERN and error positivity (Pe) components of the ERP following errors and impaired typical posterror behavioral adjustment. Structural equation modeling indicated that effects of alcohol on both the ERN and posterror adjustment were significantly mediated by reductions in NA. Effects of alcohol on Pe amplitude were unrelated to posterror adjustment, however. These findings indicate a role for affect modulation in understanding alcohol's effects on self-regulatory impairment and more generally support theories linking the ERN with a distress-related response to control failures.     

Development of action monitoring through adolescence into adulthood: ERP and source localization

In this study we examined the development of three action monitoring event-related potentials (ERPs) - the error-related negativity (ERN/Ne), error positivity (P(E)) and the N2 - and estimated their neural sources. These ERPs were recorded during a flanker task in the following groups: early adolescents (mean age = 12 years), late adolescents (mean age = 16 years), and adults (mean age = 29 years). The amplitudes of the ERN/Ne and N2 were greater in the adult and late adolescent groups than in the early adolescent group. Both of these components had neural sources in the anterior cingulate cortex (ACC). Although P(E) was present across groups, P(E) amplitude was greater in the late adolescent group compared to the adult group and also had neural sources in the ACC. ERN/Ne amplitude was related to post-error slowing across age groups; it was related to task performance only in the adult group. These findings are discussed in light of the role of the maturation of the ACC in the development of action monitoring processes.     

Electrophysiological analysis of error monitoring in schizophrenia

In this study, the authors sought to determine whether abnormalities exhibited by schizophrenia patients in event-related potentials associated with self-monitoring--the error-related negativity (ERN) and the correct response negativity (CRN)--persist under conditions that maximize ERN amplitude and to examine relationships between the ERN and behavior in schizophrenia. Participants performed a flanker task under 2 contingencies: one encouraging accuracy and another emphasizing speed. Compared with healthy participants, in schizophrenia patients the ERN was reduced in the accuracy condition, and the CRN was enhanced in the speed condition. The amplitude of a later ERP component, the error positivity, did not differ between groups in either task condition. Reduced self-correction and increased accuracy following errors were associated with larger ERNs in both groups. Thus, ERN generation appears to be abnormal in schizophrenia patients even under conditions demonstrated to maximize ERN amplitude; however, functional characteristics of the ERN appear to be intact.     

Cross-task individual differences in error processing: Neural,electrophysiological, and genetic components

The error-related negativity (ERN) and error positivity (Pe) are electrophysiological markers of error processing thought to originate in the medial frontal cortex. Previous studies using probabilistic reinforcement showed that individuals who learn more from negative than from positive feedback (negative learners) had larger ERNs than did positive learners. These findings support the dopamine (DA) reinforcement-learning hypothesis of the ERN and associated computational models. However, it remains unclear (1) to what extent these effects generalize to tasks outside the restricted probabilistic reinforcement-learning domain and (2) whether there is a dopaminergic source of these effects. To address these issues, we tested subjects’ reinforcement-learning biases behaviorally and recorded EEG during an unrelated recognition memory experiment. Initial recognition responses were speeded, but the subjects were subsequently allowed to self-correct their responses. We found that negative learners, as assessed via probabilistic learning, had larger ERNs in the recognition memory task, suggestive of a common underlying enhanced error-processing mechanism. Negative learners also had enhanced Pes when selfcorrecting errors than did positive learners. Moreover, the ERN and Pe components contributed independently to negative learning. We also tested for a dopaminergic genetic basis of these ERP components. We analyzed the COMT val/met polymorphism, which has been linked to frontal DA levels. The COMT genotype affected Pe (but not ERN) magnitude; met/met homozygotes showed enhanced Pes to self-corrected errors, as compared with val carriers. These results are consistent with a role for the Pe and frontal monoamines in error awareness.     

错误相关负波的神经起源及其影响因素

与个体做出错误反应相伴的错误相关ERP成分叫错误相关负波 (error-related negativity, ERN),当前冲突监控理论、表征失匹配理论和强化学习理论从不同的角度对ERN的神经机制进行解释,各理论间并非完全相互排斥。目前大部分研究认为ERN定位于扣带回,部分研究则出现其它脑区的激活,然而,扣带回与其它脑区存在复杂的神经功能联系,ERN 电位很可能是多个脑区电活动在头颅的综合表现,而非某一脑区的单独表现。ERN的神经机制受到实验任务、被试年龄及其意识水平等因素的影响。未来要推动实验室研究走向临床应用,发现与诊断脑电波异常的病人和毒品易复吸人群。     

Affective and cognitive modulation of performance monitoring: Behavioral and ERP evidence

This study investigates the effects of negative affect on performance monitoring. EEG was acquired during a lateralized, numeric Stroop working memory task that featured task-irrelevant aversive and neutral pictures between stimuli. Performance accuracy showed a right-hemisphere advantage for stimuli that followed aversive pictures. Response-locked event-related potentials (ERPs) from accurate trials showed an early negative component (CRN; correct response/conflict-related negativity) followed by a positive wave comparable to the Pe (error positivity). The CRN was bi-peaked with an earlier peak that was sensitive to aversive pictures during early portions of the experiment and a later peak that increased with error likelihood later in the experiment. Pe amplitude was increased with aversive pictures early in the experiment and was sensitive to picture type, Stroop interference, and hemisphere of stimulus delivery during later trials. This suggests that ERP indices of performance monitoring, the CRN and Pe, are dynamically modulated by both affective and cognitive demands.     

Preverbal error-monitoring in stutterers and fluent speakers

This study was designed to characterize the brain system that monitors speech in people who stutter and matched controls. We measured two electrophysiological peaks associated with action-monitoring: the error-related negativity (ERN) and the error positivity (Pe). Both the ERN and Pe were reliably observed after errors in a rhyming task and a nonverbal flanker task, replicating previous reports of a language-monitoring ERN and demonstrating that the Pe can also be elicited by phonological errors. In the rhyming task, stutterers showed a heightened ERN peak regardless of whether they actually committed an error. Similar results, though only marginally significant, were obtained from the flanker task. These results support the vicious cycle hypothesis, which posits that stuttering results from over-monitoring the speech plan. The elevation of the ERN in stutterers and the similarity of the results between the flanker and rhyming tasks implies that speech-monitoring may rely on the same neural substrate as action-monitoring.     

Effects of task-relevant incentives on the electrophysiological correlates of error processing in major depressive disorder

Major depressive disorder (MDD) is associated with action-monitoring dysfunction—particularly, disrupted error processing. Whether such dysregulation is further modulated by task incentives is largely unknown. The goal of this study was to investigate possible dysfunctions in error processing in MDD as a function of varying task incentives and clinical profile. To this end, we recorded the error-related negativity (ERN) and error positivity (Pe) in 18 MDD participants and 18 healthy controls during a Stroop task that intermixed no-incentive and reward trials. Relative to controls, MDD participants showed (1) larger ERN irrespective of task incentives, and (2) reduced Pe during reward (but not no-incentive) trials. Moreover, among MDD participants, Pe amplitudes were negatively correlated with depression severity and clinical symptoms. The present findings highlight distinct effects of task incentives on electrophysiological components of error processing and are interpreted within current theories of action monitoring and incentive processing in depression.     

The effects of uncertainty in error monitoring on associated ERPs

A series of experiments were conducted to address the effect of uncertainty regarding performance for predicting the likelihood of a correct-response negativity (CRN) in addition to error-related negativity (ERN). In Study 1, 18 healthy young adults completed letter discrimination tasks during single and dual attention conditions designed to manipulate response certainty. In the second study, the same participants completed easy and difficult tone discrimination tasks designed to influence stimulus certainty. In the third study, task difficulty was manipulated to produce different error rates without altering certainty. Studies 1 and 2 indicated that error and correct responses are processed more similarly when uncertainty is present (i.e., ERN approximately CRN). Furthermore, uncertainty was associated with attenuation of the ERN and enhancement of the CRN, consistent with an error detection hypothesis. Study 3 indicated that task difficulty alone does not influence the ERN or likelihood of a CRN. These results offer support for the error detection account of the ERN and establish the role of uncertainty in predicting the CRN, as postulated by .     

Oops!.. I did it again: an ERP and behavioral study of double-errors

To understand the sequealae of action monitoring failures, most previous studies have focused on neural (e.g., the ERN and Pe) and behavioral (e.g., post-error slowing) measures associated with correct trials that precede and follow errors. However, trials that precede and follow errors are not always correct, and no study to date has examined RT and ERP indices in double-error sequences that could shed additional light on multiple response monitoring failures. In the present study, we examined ERP and behavioral data surrounding double-errors to explore the possibility that double-errors could either result from the failed detection of the first error, or from a reduction in compensatory post-error behavioral adjustments. Results indicate a normal ERN and Pe surrounding double-errors; however, errors that followed errors were characterized by reduced post-error reaction time slowing. These data are discussed in terms of existing response monitoring data, and in terms of the utility of double-errors to shed light on distinct types of response monitoring failures.     

Anxiety not only increases,but also alters early error-monitoring functions

Anxiety has profound influences on a wide range of cognitive processes, including action monitoring. Eventrelated brain potential (ERP) studies have shown that anxiety can boost early error detection mechanisms, as reflected by an enhanced error-related negativity (ERN) following errors in high-anxious, as compared with low-anxious, participants. This observation is consistent with the assumption of a gain control mechanism exerted by anxiety onto error-related brain responses within the dorsal anterior cingulate cortex (ACC). However, whether anxiety simply enhances or, rather, alters early error detection mechanisms remains unsolved. In this study, we compared the performance of low-versus high-trait-anxious participants during a go/no-go task while high-density EEG was recorded. The two groups showed comparable behavioral performance, although levels of state anxiety increased following the task for high-anxious participants only. ERP results confirmed that the ERN/Ne to errors was enhanced for high-anxious, relative to low-anxious, participants. However, complementary topographic analyses revealed that the scalp map of the ERN/Ne was not identical between the two groups, suggesting that anxiety did not merely increase early error detection mechanisms, but also led to a qualitative change in the early appraisal of errors. Inverse solution results confirmed a shift within the ACC for the localization of neural generators underlying the ERN/Ne scalp map in high-anxious participants, corroborating the assumption of an early effect of anxiety on early error-monitoring functions. These results shed new light on the dynamic interplay between anxiety and error-monitoring functions in the human brain.     

Respond,don’t react: The influence of mindfulness training on performance monitoring in older adults

A sizeable body of literature demonstrates positive effects of mindfulness training on brain, behavior, and psychological processes in both novice and expert practitioners as compared to non-meditators. However, only more recently has research begun to examine the specific mechanisms by which mindfulness exerts these effects. In the current study, we used event-related potentials (error-related negativity (ERN), error positivity (Pe)) to test the hypothesis that performance monitoring is one such mechanism. We conducted a randomized controlled trial in healthy older adults (n = 36), relevant because markers of performance monitoring are known to decline with normal aging. Compared to an active control condition, mindfulness participants showed an increase in the ERN, without an increase in the Pe. Participants in both groups reported a reduction in self-report of anxiety and self-judgment of one’s own mental functioning, indicating the subjective impression of benefit from each intervention type. The current results are important insofar as they support the purported self-regulatory functions of mindfulness (i.e., learning to respond, not react), as well as demonstrating that such positive effects can be obtained in an older adult sample, both of which have important implications for intervention.