Sexually dimorphic effect of an acute smoking manipulation on skin resistance but not on heart-rate during a cognitive verbal task

In a two-day, two-session experiment where smokers male and female college-student subjects worked on a cognitive verbal task during either the first or second day, and on a cognitive spatial task on the second or first day, smoking was manipulated as an acute independent variable by requiring 10+ hours of pre-experimental abstention, and providing a cigarette during the 15-minute rest period between the two sessions. Non-smoker female and male subjects underwent the same experiment, and hence served as controls for the effects of this acute-smoking manipulation. Overall adaptation (decreased arousal) to the experiment was manifested in a significant increase in skin resistance level (SRL) in all subjects, but when this adaptation effect was statistically controlled, there was a significant smokers by sex interaction during the verbal task only, such that SRL was increased by the cigarette in males, but decreased in females. In contrast, the same analysis indicated only a marked increase in heart-rate (HR) due to smoking, which was unaffected either by sex or by whether the task was the verbal or the (easier) spatial one. We interpret the SRL results as reflecting a sex difference in the direction of transient psychological arousal, and discuss it in relation to evidence in the literature based on self reports, and to evidence (based on HR in this study and on blood pressure in other studies) on physiological (cardiovascular) arousal.     

Sexually dimorphic effect of an acute smoking manipulation on skin resistance but not on heart-rate during a cognitive verbal task.

In a two-day, two-session experiment where smokers male and female college-student subjects worked on a cognitive verbal task during either the first or second day, and on a cognitive spatial task on the second or first day, smoking was manipulated as an acute independent variable by requiring 10+ hours of pre-experimental abstention, and providing a cigarette during the 15-minute rest period between the two sessions. Non-smoker female and male subjects underwent the same experiment, and hence served as controls for the effects of this acute-smoking manipulation. Overall adaptation (decreased arousal) to the experiment was manifested in a significant increase in skin resistance level (SRL) in all subjects, but when this adaptation effect was statistically controlled, there was a significant smokers by sex interaction during the verbal task only, such that SRL was increased by the cigarette in males, but decreased in females. In contrast, the same analysis indicated only a marked increase in heart-rate (HR) due to smoking, which was unaffected either by sex or by whether the task was the verbal or the (easier) spatial one. We interpret the SRL results as reflecting a sex difference in the direction of transient psychological arousal, and discuss it in relation to evidence in the literature based on self reports, and to evidence (based on HR in this study and on blood pressure in other studies) on physiological (cardiovascular) arousal. Key Words: Electrodermal activity, heart-rate, psychological vs. physiological, verbal and spatial cognitive tasks.     

Effects of Smoking Urge on Generation of Smoking-Related Information1

Despite widespread research, the role of smoking urge in relapse remains unclear. The present study examined the effect of a smoking-urge manipulation on the generation of smoking-related information. During each of 2 experimental sessions, smokers were given 90 s to list as many positive characteristics of smoking, and then 90 s to list as many negative characteristics as they could. Results indicated that experimental manipulations designed to elicit an urge to smoke increased the number of positive but not negative aspects of smoking. This selective accessing of positive information related to cigarette use during an urge may increase the likelihood of smoking. Results are interpreted with respect to extant models of drug urge and Kunda's (1990) theory of motivated reasoning.     

Multiple sessions of systolic blood pressure biofeedback: Its effects on ability to control systolic pressure during training,after training,and its effects on pulse rate

Seventy-one normotensive subjects participated in four training sessions in which they were either (a) instructed to increase their blood pressure, (b) instructed to decrease their blood pressure, or (c) not instructed to change their blood pressure. The subjects either (a) were provided with biofeedback concerning systolic blood pressure or (b) were not provided with biofeedback concerning systolic blood pressure. After the last training session, subjects participated in a transfer session in which they were again instructed concerning changes in pressure but were not provided with biofeedback. Analyses conducted on data from the training and transfer sessions indicated that subjects who were instructed to increase pressure and given biofeedback to aid them showed higher pressure than subjects in other conditions and that there were no differences among those other conditions; that is, biofeedback was effective for teaching subjects to increase pressure but was not effective for teaching subjects to decrease pressure. Additional training sessions did not add to the effect achieved in the first training session. During training sessions, subjects who were instructed to increase pressure showed higher heart rates than subjects in other conditions. The results raise questions concerning the interpretation of earlier experiments that did not include no-treatment, instructions-only, and attention control conditions.     

DEVELOPMENT AND EVALUATION OF TREATMENT PARADIGMS FOR THE SUPPRESSION OF SMOKING BEHAVIOR1

A multiple-baseline component-analysis design was employed to assess the effectiveness of three treatment programs for suppressing the cigarette smoking behavior of 24 subjects. Satiation, cognitive control, and contingent shock procedures were evaluated. The results demonstrated a consistent relationship between contingent shock and suppression of smoking. It was further indicated that subjects should be exposed to the number of sessions necessary to achieve total suppression in order to gain maximally from treatment and to avoid relapse. Neither the satiation component nor the cognitive control component was correlated with clear, permanent decrements in smoking frequencies. To date, no other treatment program has demonstrated the dramatic effects of the contingent shock procedures used in the present study.     

Temporal contiguity in electric aversion therapy for cigarette smoking

Seventy dependent heavy smokers (32 cigarettes per day) were randomly assigned to one of five treatment and control procedures: (1) electric aversion therapy, involving ten 20-trial sessions of shocks contiguous with the smoking act. (2) simulated electric aversion. with non-contiguous shocks, (3) non-shock smoking sessions, to control for stimulus satiation and negative practice effects. (4) simple support and attention from therapist, (5) no-treatment. Before treatment, simple ‘self-monitoring’ and ‘self-control’ reduced cigarette consumption by an average of 12% (p < 0.001) and 26% (p < 0.001) respectively. Thirty-four of the 56 treated subjects (61%) were able to stop smoking compared with two out of fourteen (14%) of the no-treatment controls (p < 0.005). Treatment was highly effective at reducing and stopping smoking during the 4-week course and for 2 weeks afterwards (p < 0.005). Its effect was rapid, but not immediate. Outcome was virtually decided after 1 week (five sessions); subjects who had not stopped or almost stopped at this stage were most unlikely to respond later on (p < 0.001). All four treatments were equally effective, regular attendance for 15 min of simple support being as effective as the treatments involving additional 45-min sessions with a second therapist. The effects of contiguous vs non-contiguous shocks did not differ. A motor response was conditioned in 19 of the 28 subjects who received shocks but this was therapeutically irrelevant. The clinical outcome depended on the kind of subject rather than the kind of treatment. Those who were depressed, with poor psychiatric adjustment and a high Eysenck-Scale P score tended to do badly, while those who initially expressed high confidence in the outcome were more likely to succeed (p < 0.001). It is concluded that traditional conditioning processes do not contribute significantly to the clinical response of human subjects to electric aversion therapy for cigarette smoking.     

A procedure for studying the within-session onset of human drug discrimination.

The purpose of the present study was to develop a procedure for measuring the within-session onset of human drug discrimination. During daily sessions, under double-blind conditions, caffeine-abstinent adults ingested a letter-coded capsule containing 178 mg caffeine or placebo. Trials were presented at 30-s intervals, beginning immediately after drug ingestion and continuing for 60 min. On each trial, subjects could guess which of their two letter-coded drugs they had received by pressing a left button (for one drug) or right button (for the other drug); subjects could also press a center "no guess" button instead of guessing. Each trial ended after one button press. After each session, subjects were told which drug they had received. Subjects earned one point (worth $0.10 per point) for each correct guess. Subjects lost either 0, 1, or 10 points for each incorrect guess; the point-loss contingencies were varied in random order across sessions. Discrimination earnings accumulated across all sessions. The point-loss contingencies decreased random responding and delayed the discrimination time course. Overall, this procedure provided an orderly and relatively continuous measure of the within-session onset of drug discrimination and should have a range of applications in understanding the human behavioral pharmacology of drugs.     

Self-control of smoking—II effects of cue salience and source of delay imposition on the effectiveness of training under increasing delay

Imposed increasing delay of cigarette puffs has been shown to facilitate smoking inhibition. Hypothetical mechanisms involved (frustration extinction or rehearsal of coping responses) imply that increased temptation cue salience and decreased degree of external control in increasing delay training, should facilitate smoking inhibition. After three pre-test delay tolerance trials, all subjects were cued to pace their smoking in an increasing sequence of delay. During treatment the cigarette temptation cues were either visible or hidden. Delays were either self-imposed but cued by the experimenter or the delays were physically imposed by the experimenter. Post-test consisted of three delay tolerance trials. Pre-test to post-test improvement was significantly facilitated by cue salience and reduced external control. No significant interaction effects were obtained. Cue salience significantly reduced the self-reported aversiveness and GSRs during self-control trials. Implications for treatment were advanced.     

Differential ethanol olfactory experiences affect ethanol ingestion in preweanlings but not in older rats

Preweanling (21 days old) and adult (60-80 days old) rats were exposed to ethanol odor either paired with the early stages of apomorphine-induced toxicosis, paired with the recovery from toxicosis, or unpaired with the induction of distress. Twenty four hours later, ethanol preferences were measured in a spatial olfactory test (ethanol vs lemon odor) or a drinking test (5.6% v/v ethanol vs 0.25% w/v citric acid solutions). During the olfactory test both young and adult rats expressed substantial ethanol odor aversions when previously exposed to this odor paired with toxicosis. However, changes in ethanol intake became apparent only in preweanling subjects. Preweanlings which received the ethanol odor paired with illness drank significantly less of the ethanol solution relative to controls, while subjects experiencing the odor paired with recovery from distress significantly increased their consumption of the ethanol solution. These prior aversive and appetitive olfactory experiences had no effect upon ethanol intake in adult rats. These results implicate both an ontogenetic and a sensorial factor in the regulation of ethanol intake.     

Weanlings' transfer of conditioned ethanol aversion from olfaction to ingestion depends on the unconditioned stimulus

Weanling (21-day-old) rats were exposed to an alcohol odor paired with either an interoceptive (apomorphine-induced illness) or exteroceptive (footshock-induced distress) reinforcer. Twenty-four hours later, ethanol preferences were measured in a locational olfactory test (ethanol vs lemon odor) or an ingestion test (5.6% v/v ethanol vs 0.25% v/v citric acid solution). Weanling rats expressed substantial olfactory aversions, independent of the reinforcer employed in conditioning. During the drinking test, however, only rats that had experienced the ethanol odor paired with internal malaise showed a significant reduction in the intake of the ethanol solution when compared to unpaired controls. Furthermore, rats that had experienced the ethanol odor paired with external distress drank significantly more of the ethanol solution than their controls. These results provide further evidence that olfactory experiences with ethanol can lead to changes in ethanol ingestion, and indicate that the nature of the unconditioned stimulus is critical in establishing the ingestive effect.     

Effects of delta 9-THC on marijuana smoking, dose choice, and verbal report of drug liking.

The effects of delta 9-tetrahydrocannabinol content of marijuana on cigarette smoking, dose choice, and verbal report of drug "liking" by adult males living in a residential laboratory were investigated. Marijuana cigarettes were available during programmed intervals while subjects were engaged in recreational activities. The tetrahydrocannabinol content of the cigarettes remained constant each day, but was changed across days. Subjects provided written ratings of drug liking at the end of each day. In the first study, placebo or active (2.3% delta 9-tetrahydrocannabinol) marijuana cigarettes were available for 1-, 2-, or 3-day intervals at varying times of day. The number of cigarettes smoked was unrelated to tetrahydrocannabinol content, although verbal reports of drug liking were consistently higher when marijuana cigarettes containing tetrahydrocannabinol were smoked. In a second study, a choice procedure, consisting of four 3-day blocks of 2 sample days and 1 choice day, was used. On sampling days, subjects smoked cigarettes varying in tetrahydrocannabinol content (0.0, 2.0, and 3.5%, w/w); on choice days they were allowed to choose between the two previously sampled doses. The number of cigarettes was not consistently related to tetrahydrocannabinol content. Ratings of drug liking were increased when marijuana cigarettes contained tetrahydrocannabinol, but ratings of marijuana containing 2.0% and 3.5% of the compound were similar. In contrast, subjects consistently chose the 3.5% dose over either the 0.0% or 2.0% dose. Dose choice was more sensitive to tetrahydrocannabinol content than either reports of drug liking or numbers of cigarettes smoked.     

Oral drug self-administration in rhesus monkeys: interactions between drug amount and fixed-ratio size.

During daily 3-hr sessions, 5 rhesus monkeys drank drug solutions and water that were concurrently available. The drug solutions were: 1 milligram per milliliter (mg/mL) pentobarbital (2 monkeys), 1 mg/mL pentobarbital plus 0.5% ethanol (1 monkey), 1 mg/mL pentobarbital plus 1% ethanol (1 monkey), and 8% ethanol (1 monkey). The drug solution and water were available under identical two-component tandem fixed-ratio continuous-reinforcement N schedules. Two variables were manipulated: the size of the fixed-ratio component and the number of liquid deliveries (N) in the second component. Deliveries of the drug solution maintained higher rates of responding than did deliveries of the drug vehicle, water. The number of drug deliveries per session increased with increases in the number of deliveries per fixed ratio and decreased with increases in fixed-ratio size. Analysis of the results in terms of the proportion of deliveries to responses showed that the number of drug deliveries per session was directly related to the size of this quotient. Finally, when fixed-ratio size was repeatedly doubled, the following orderly relationship emerged: The greater the number of available drug deliveries per fixed ratio, the less was the percent decrease in the number of fixed ratios completed per session. It was concluded that increases in the number of liquid deliveries per fixed ratio resulted in increases in reinforcing efficacy.     

CO-WORKER SOCIAL SUPPORT IN A WORKSITE SMOKING CONTROL PROGRAM

We evaluated the effects of adding a social support component to a worksite controlled smoking treatment program. Twenty-four participants were randomly assigned to either a controlled smoking or a controlled smoking plus partner support condition. Within a multiple baseline across behaviors design, smokers in both conditions made efforts to achieve sequential 50% reductions in: (a) nicotine content of brand smoked, (b) number of cigarettes smoked per day, and (c) percentage of each cigarette smoked. Self-monitoring records, laboratory analyses of spent cigarette butts, and carbon monoxide determinations indicated that both conditions were effective in producing significant reductions in each of the three target behaviors and in carbon monoxide levels. All participants who quit smoking during the program maintained their abstinence at a 6-month follow-up, and those who did not quit were smoking less at follow-up than they had at pretest on all dependent variables. However, few differences were observed between controlled smoking and controlled smoking plus partner support conditions either during treatment or at the 6-month follow-up. Results are discussed with regard to previous worksite studies, future directions for research on social support, and variables that may have mediated treatment outcome.     

Effects of cigarette smoking on lexical decision-making

10 habitual smokers, aged 19-25 yr., were randomly assigned to smoke either a very low nicotine "Placebo" cigarette (.05-mg nicotine delivery as estimated by the FTC method) or a Nicotine cigarette (.7-mg estimated nicotine delivery). Each participant was asked to abstain from smoking for 4 to 7 hr. prior to testing. After completing a presmoking test of lexical decision-making, participants smoked either a Nicotine or Placebo cigarette and were then retested for reaction times and accuracy on the lexical decision test. When presented the most difficult lexical decisions, participants responded significantly faster after smoking a Nicotine cigarette than they did before smoking; smoking a Placebo cigarette did not affect reaction times. Response accuracy was unaffected by smoking either kind of cigarette. These results suggest that smoking a nicotine cigarette may improve attention or memory retrieval after several hours of smoking abstinence.     

Measuring the stop point of rapid smoking

A method and an apparatus are described for measuring the point at which subjects elect to stop smoking when cigarette smoke is delivered more rapidly than in typical smoking. The device allows either the subject or the experimenter to control the volume of smoke and the interval between puffs. The device delivers reliable quantities of particulate matter from cigarette smoke. Subjects retested a week apart exhibited consistent stopping points.     

The effect of companion on consumption of ethanol solution in cats

Social influences on drinking ethanol solution were studied in two cats (“drinkers”) who voluntarily drank small amounts of 10% ethanol solution in milk and three other cats (“nondrinkers”) who served as companions to the drinkers. A 15-minute sesion was conducted daily in a compartment divided into two even parts with a transparent Plexiglass partition. The cats were introduced to the compartment either singly or in pairs. Each pair consisted either of two drinkers or one drinker and one nondrinker. Each cat of the pair was placed in one part of the compartment; the cats could see each other, but they could not make physical contact. Each drinker was offered 10% ethanol solution in milk, while each nondrinker was given plain milk, and the amount of consumption was measured. A series of five to ten sessions with a drinker was followed by a series of sessions with a nondrinker or with no companion. There were a total of 13 series of sessions for each drinker. A statistical analysis of the data showed that, in most series, the mean amount of consumption of ethanol solution was significantly higher in the presence of a companion (either drinker or nondrinker) than in its absence.     

Nicotine fading,self-monitoring and cigarette fading to produce cigarette abstinence or controlled smoking

This study developed and evaluated a smoking-treatment program. Twelve subjects were randomly assigned to one of two groups within a multiple baseline design. Subjects were first given a nicotine-fading and self-monitoring procedure for 3 weeks in which they changed their cigarette brands each week to ones containing progressively less nicotine and tar and plotted their daily intake of the two substances. Those subjects unable to quit smoking were then given a cigarette-fading procedure in which they systematically reduced the number of cigarettes smoked for 3 weeks. The study had two goals: (1) to achieve a reasonable percentage of abstinence; and (2) to reduce non-abstainers' smoking to a ‘safer’ level by having them smoke very low tar and nicotine cigarettes. The 12-month follow-up results revealed that 33% of the subjects were abstinent and all non-abstainers were smoking cigarettes lower in tar and nicotine than their baseline brands. Half the non-abstainers had decreased their smoking rate relative to baseline while the other half had increased. The subjects decreased their daily nicotine intake by 13.3 mg (81.6% reduction from baseline) and tar intake by 218.2 mg (85.5% reduction from baseline). These results suggest that the study's goals were achieved and that the non-aversive combined procedure could be used to treat not only habitual smokers but also those with cardiovascular and respiratory problems who cannot be treated by smoking-cessation procedures that use cigarette smoke as the aversive stimulus. Finally, a least-restrictive model for treating smoking is proposed and discussed.     

Low-dose caffeine discrimination and self-reported mood effects in normal volunteers.

A caffeine versus placebo discrimination procedure was used to determine the lowest caffeine dose that could produce discrimination and self-reported mood effects in normal volunteers. During daily sessions under double-blind conditions, caffeine-abstinent subjects orally ingested a capsule containing 178 mg caffeine or placebo. Before beginning discrimination training, the compounds were identified to subjects by letter codes. Fifteen, 30, and 45 min after capsule ingestion, subjects guessed the capsule's letter code. Correct guesses at 45 min earned money. After each session, subjects received a supplementary capsule containing caffeine or placebo to ensure that, within each phase of the study, subjects received the same daily dose of caffeine equal to the training dose. Five of the 15 subjects acquired the caffeine versus placebo discrimination within the first 20 sessions (greater than or equal to 75% correct); 6 other subjects acquired the discrimination with additional training. Nine subjects who acquired the discrimination were subsequently trained at progressively lower caffeine doses. In general, the lowest dose to produce discrimination (greater than or equal to 75% correct) was also the lowest dose to produce self-reported mood effects: 4 subjects showed discrimination and self-reported mood effects at 100 mg caffeine, 2 at 56 mg, 1 at 32 mg, and 1 at 18 mg. One of these subjects also showed self-reported mood effects at 10 mg. The present study documents discriminative stimulus and self-reported mood effects of caffeine at doses below those previously shown to affect any behavior in normal volunteers.     

Experimental evidence for a causal relationship between smoking lapse and relapse

In this study, the authors prospectively evaluated the impact of a smoking lapse on relapse probability. After 4 days of smoking abstinence, 60 smokers were randomly assigned to smoke 5 nicotine-containing or 5 denicotinized cigarettes, or to remain abstinent (no lapse) during a 4-hr time period. Afterward, smoking abstinence was encouraged with monetary incentives, and smoking behavior was tracked for 6 days. Relative to the no-lapse condition, exposure to either of the cigarette types more than doubled the probability of subsequent smoking. Smoking outcomes did not differ between nicotine-containing and denicotinized cigarettes. The data suggest that stimulus factors may play an important role in lapse to relapse processes.