The psychobiology of stress

Stressful life experience can have significant effects on a variety of physiological systems, including the autonomic nervous system, the hypothalamic-pituitary-adrenal axis, and the immune system. These relationships can be bidirectional; for example, immune cell products can act on the brain, altering mood and cognition, potentially contributing to depression. Although acute physiological alterations may be adaptive in the short term, chronic or repeated provocation can result in damage to health. The central dogma in the field of stress research assumes a stereotyped physiological response to all stressors (the generality model). However, increasing evidence suggests that specific stressful conditions and the specific way an organism appraises these conditions can elicit qualitatively distinct emotional and physiological responses (the integrated specificity model). For example, appraisals of threat (vs. challenge), uncontrollability, and negative social evaluation have been shown to provoke specific psychobiological responses. Emotional responses appear to have specific neural substrates, which can result in differentiated alterations in peripheral physiological systems, so that it is incorrect to presume a uniform stress response.     

积极情绪加速心血管反应恢复的自主神经活动机制

通过对不同情绪唤醒状态下的心率变异性（HRV）和呼吸性窦性心率不齐（RSA）分析,探讨了积极情绪加速高唤醒消极情绪引起的心血管反应向基线恢复的自主神经活动机制。实验表明：与在观看高唤醒恐惧影片结束后观看悲伤影片和中性视频比较,观看高唤醒恐惧影片结束后观看快乐影片加速了高唤醒恐惧影片引起的心率、指脉等心血管反应向基线的恢复;与在观看高唤醒恐惧影片结束后观看悲伤视频和中性视频材料比较,观看高唤醒恐惧影片结束观看快乐影片后的恢复期,被试的迷走神经激活水平迅速增强,迷走神经激活水平甚至超过基线期。因此,积极情绪加速高唤醒消极情绪刺激引起的心血管反应向基线恢复,其自主神经活动机制是在积极情绪状态下个体有更强的迷走神经激活。     

Selective unilateral autonomic activation: implications for psychiatry

Research advances have led to three methods for selectively activating one half of the autonomic nervous system in humans. The first method is an ancient yogic technique called unilateral forced nostril breathing (UFNB) that employs forced breathing through only one nostril while closing off the other. The second method works by stimulation of an autonomic reflex point on the fifth intercostal space near the axilla. The most recent method employs unilateral vagus nerve stimulation (VNS) via the mid-inferior cervical branch and requires surgical implantation of a wire and pacemaker. UFNB is non-invasive and seems to selectively activate the ipsilateral branch of the sympathetic nervous system with a possible compensation effect leading to contralateral VNS. UFNB and VNS have been employed to treat psychiatric disorders. While UFNB has been studied for its potential effects on the endogenous ultradian rhythms of the autonomic and central nervous system, and their tightly coupled correlates, VNS has yet to be studied in this regard. This article reviews these three methods and discusses their similarities, putative mechanisms, their studied effects on the endogenous autonomic nervous system and central nervous system rhythms, and their implications for the treatment of psychiatric disorders.     

情绪自主神经特异性研究及进展

研究者们已发现情绪之间存在某些可靠的自主神经差异,至少对某些情绪来说,其自主神经反应是特异的。但是已经获得的实验结果还远远不够用于确定最后的特异性情绪自主神经反应模式。而且,自主神经活动的潜在成分和模式并没有得到穷尽。情绪生理特异性研究应该扩展到多个外周系统以及中枢神经系统。     

Review of some sex-related effects of forced unilateral nostril breathing on the autonomic nervous system

Sex-related effects of forced unilateral nostril breathing on the autonomic nervous system are considered. Recent studies described the effects of such breathing on autonomic activity as sex-specific as in prior studies.     

Central and autonomic nervous system integration in emotion

Emotions involve physiological responses that are regulated by the brain. The present paper reviews the empirical literature on central nervous system (CNS) and autonomic nervous system (ANS) concomitants of emotional states, with a focus on studies that simultaneously assessed CNS and ANS activity. The reviewed data support two primary conclusions: (1) numerous cortical and subcortical regions show co-occurring activity with ANS responses in emotion, and (2) there may be reversed asymmetries on cortical and subcortical levels with respect to CNS/ANS interrelations. These observations are interpreted in terms of a model of neurovisceral integration in emotion, and directions for future research are presented.     

The efficacy of progressive relaxation in systematic desensitization and a proposal for an alternative competitive response--the relaxation response.

The theoretical basis of systematic desensitization is reciprocal inhibition in which an alternative, competitive response to anxiety is conditioned to arousal-producing, phobic stimuli. Abbreviated training in progressive relaxation is believed to serve as a competitive response to anxiety by decreasing autonomic nervous system activity. However, physiologic studies of progressive relaxation have not substantiated that its practice is associated with such decreased autonomic activity. Consequently, the use of progressive relaxation has been a confounding factor in the determination of the function of reciprocal inhibition in systematic desensitization. To confirm and refine the theoretical constructs of reciprocal inhibition, it is necessary to test the effects of a response which is competitive to the anxiety response. Such a response may be the relaxation response which is characterized by physiologic changes consistent with decreased autonomic nervous system activity. Derived from meditational practices, techniques which ehcit the relaxation response incorporate the element of focused attention which has been implicated as a critical factor in systematic desensitization. Thus, the use of the relaxation response should be a more appropriate method than progressive relaxation if the therapeutic usefulness of systematic desensitization is indeed due to reciprocal inhibition.     

Some acute effects of d-lysergic acid diethylamide on the rat

There is a wealth of literature available on the psychosis-like effects of very small doses of d-lysergic acid diethylamide (LSD-25) in human subjects. It is reported that the drug produces profound changes in emotional behaviour, feelings of depersonalization, visual and auditory hallucinations, catharsis-like episodes and slight changes in autonomic nervous system activity.

The present experiment investigates the possibility of relating the behavioural disturbances induced by LSD-25 to known physiological data. Variation in the latency and running times of trained albino rats is examined. It is demonstrated that latency scores are directly affected by the cerebral concentration of the drug; and that sensory thresholds appear to be raised. It is further shown that when the level of stimulation is raised the rats appear to behave normally.     

Age differences in emotional reactivity: the sample case of sadness

Past studies have suggested that the intensity of subjective reactions to emotion-arousing stimuli remains stable, whereas the magnitude of autonomic reactions declines with age. The goal of the present studies was to investigate whether this evidence will generalize to newly edited films dealing with age-relevant themes such as the loss of loved ones. In Study 1, greater self-reported sadness was found in older than in younger adults in response to all films. Findings of Study 2, which were based on an independent sample, replicated those of Study 1. In addition, 6 indicators of autonomic nervous system activity were assessed. Young and old adults did not differ in their autonomic reactions to the films. This evidence suggests that when older people are exposed to stimuli featuring themes that are relevant to their age group, they show greater subjective and physiological reactions than would be expected on the basis of past research.     

Anticipatory Stress Influences the Immune System: Evidence from ChemotherapyAssociated Blood Samples in Cancer Patients

Anticipatory reactions are hypothesized to affect physiological conditions through multiple processing systems. To determine whether anticipatory reactions include the immune system, immune variables from 73 patients treated with immunomodulating chemotherapy for breast or ovarian cancer were studied in a hospital treatment setting and compared with samples obtained in the patients' homes 2 days earlier. The number of white blood cells increased significantly between samples. Increases were also observed in the counts and proportions of granulocytes, while decreases were observed in the counts and proportions of lymphoyctes. No changes were observed in a healthy control group. The nervous system executes regulatory effects on the formation and distribution of leukocytes. Such mechanisms render psychological influences on blood samples possible, including samples that form the basis for decisions related to cancer treatment. The immune changes observed are discussed in relation to mechanisms and adaptive values of anticipation and neurally mediated impacts on the immune system.     

Forebrain emotional asymmetry: a neuroanatomical basis?

There is considerable psychophysiological evidence to indicate that the left and right halves of the human forebrain differentially associate with particular emotions and affective traits. A neurobiological model is needed. Here I propose that forebrain emotional asymmetry is anatomically based on an asymmetrical representation of homeostatic activity that originates from asymmetries in the peripheral autonomic nervous system. This proposal builds on recent evidence indicating that lateralized, higher-order re-representations of homeostatic sensory activity provide a foundation for subjective human feelings. It can subsume differing views of emotion and the forebrain because it suggests that emotions are organized according to the fundamental principle of autonomic opponency for the management of physical and mental energy.     

Effect of partition board color on mood and autonomic nervous function

The purpose of this study was to evaluate the effects of the presence or absence (control) of a partition board and its color (red, yellow, blue) on subjective mood ratings and changes in autonomic nervous system indicators induced by a video game task. The increase in the mean Profile of Mood States (POMS) Fatigue score and mean Oppressive feeling rating after the task was lowest with the blue partition board. Multiple-regression analysis identified oppressive feeling and error scores on the second half of the task as statistically significant contributors to Fatigue. While explanatory variables were limited to the physiological indices, multiple-regression analysis identified a significant contribution of autonomic reactivity (assessed by heart rate variability) to Fatigue. These results suggest that a blue partition board would reduce task-induced subjective fatigue, in part by lowering the oppressive feeling of being enclosed during the task, possibly by increasing autonomic reactivity.     

Towards a neural basis of music perception

Music perception involves complex brain functions underlying acoustic analysis, auditory memory, auditory scene analysis, and processing of musical syntax and semantics. Moreover, music perception potentially affects emotion, influences the autonomic nervous system, the hormonal and immune systems, and activates (pre)motor representations. During the past few years, research activities on different aspects of music processing and their neural correlates have rapidly progressed. This article provides an overview of recent developments and a framework for the perceptual side of music processing. This framework lays out a model of the cognitive modules involved in music perception, and incorporates information about the time course of activity of some of these modules, as well as research findings about where in the brain these modules might be located.     

正负性情绪的自主神经反应及应用

情绪可以唤醒自主神经系统, 伴随有一系列的生理变化。从基础研究的角度来看, 正负性情绪可以诱发心血管系统(如心率、血压、心率变异性)、皮肤电系统(如皮肤电导水平)、呼吸系统(如呼吸阻力、每分通气量)和其他系统(如瞳孔直径、胃肌电等)的活动及其变化。在应用研究方面, 正负性情绪诱发的自主神经反应可以应用在多个领域, 主要包括用户体验中的情绪测量、基于生理信号的人-机情感交互系统的开发, 以及消费者态度和偏好的测查等。对于现有研究结果中存在的分歧, 从被试的个体差异、诱导范式的不一致性和诱导效果的可靠性, 以及刺激材料属性的多样化等方面进行了分析, 指出了未来研究应该注意的问题。     

Effects of stimulation by three-dimensional natural images on prefrontal cortex and autonomic nerve activity: a comparison with stimulation using two-dimensional images

Empirical evidence suggests that three-dimensional (3D) images of nature promote physiological relaxation in humans by providing more realistic effects compared with two-dimensional (2D) images. However, no studies have evaluated the physiological relaxation effects of nature-derived 3D images on prefrontal cortex and autonomic nerve activity. The present study aimed to clarify the physiological relaxation effects of visual stimulation by 3D flower images on prefrontal cortex and autonomic nerve activity. Nineteen male university students (22.2 ± 0.6 years) were presented with 3D and 2D images of the water lily for 90 s. Prefrontal cortex activity was measured using near-infrared spectroscopy, while autonomic nerve activity was measured using heart rate variability (HRV). Psychological effects were determined using a modified semantic differential method (SD). Compared with visual stimulation by 2D images, that by 3D images resulted in a significant decrease in oxyhemoglobin concentration in the right prefrontal cortex, lower sympathetic activity as calculated by the ratio of the low-frequency to high-frequency HRV component, and a significantly greater realistic feeling as evidenced by higher SD ratings. In conclusion, visual stimulation by realistic 3D floral images promotes physiological relaxation more effectively than the corresponding 2D image.     

细胞因子和抑郁症

在心理神经免疫学领域,越来越多的证据表明神经和免疫之间存在双向交流通路,免疫系统可能在一些心理精神障碍中具有重要作用。“抑郁症的细胞因子假说”认为细胞因子作为神经调质,可能在抑郁症的病因和病理过程中具有重要作用。这个假说得到了很多证据的支持。而在动物身上应用前炎性细胞因子也能够引起与人类抑郁症行为症状非常类似的“病态行为”。研究认为外周细胞因子通过信号传导进入脑内与中枢产生的细胞因子共同作用于下丘脑－垂体－肾上腺轴和5－羟色胺系统,从而导致抑郁症。细胞因子的中枢效应可以解释很多抑郁症状,“抑郁症的细胞因子假说”为探讨抑郁症状的机制和治疗抑郁症提供了一个新的视角     

Depression, autonomic function, and cardiorespiratory fitness: comment on Hughes, et al. (2010)

A recent paper by Hughes and colleagues suggested that dysfunction of the autonomic nervous system in depressed cardiac patients was partly explained by reduced physical activity and fitness. Other data demonstrate that exercise training and improvements in fitness not only lead to improvements in autonomic function in coronary patients but also reduce depression and depression-related increased mortality.     

Attention deficit disorder and allergy: a neurochemical model of the relation between the illnesses

Empirical studies suggest that allergies play an etiological role in a small subgroup of children who suffer from attention deficit-hyperactivity disorder (ADHD). Research indicates that allergic reactions results in cholinergic hyperresponsiveness and beta-adrenergic hyporesponsiveness in the autonomic nervous system. Evidence is reviewed that similar imbalances in central nervous system cholinergic/adrenergic activity play a causal role in manic and depressive behaviors. It is hypothesized that allergic reactions engender cholinergic/adrenergic activity imbalances in the central nervous system, leading to poorly regulated arousal levels and ADHD behaviors in some children.     

Intergroup Contact Facilitates Physiological Recovery following Stressful Intergroup Interactions

A growing body of research has demonstrated the importance of intergroup contact in reducing fear, threat and anxiety in intergroup domains. Here we focus on the regulatory benefits of intergroup contact. We hypothesized that past intergroup contact would facilitate recovery from a stressful intergroup evaluation. White and Black participants completed a stressful evaluative task in the presence of two White or two Black interviewers while autonomic nervous system and hormonal responses were assessed. When examining how participants recovered after the stressful task, intergroup contact predicted faster physiological recovery for both autonomic and neuroendocrine reactivity. The importance of recovery from stress for physiological resilience in diverse contexts is discussed.